间充质干细胞诱导分化为皮肤附属器的研究进展
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摘要
临床患者由于外伤、严重烧伤及瘢痕切除等导致大面积皮肤缺损时面临自体皮肤移植供体不足的难题,且组织工程皮肤因皮肤附属器的缺失,导致汗液无法排出、毛发丧失等使患者生存质量和心理健康受到严重影响。随着再生医学的发展,间充质干细胞因其来源丰富、低免疫原性、体外扩增能力强及具有多向分化潜能的优势逐渐成为组织工程皮肤种子细胞来源的研究热点。本文就MSCs向毛囊、汗腺、皮脂腺等皮肤附属器的诱导分化作一综述。
引文
[1]刘亚玲,金岩,聂鑫,等.人组织工程全层活性皮肤在深度烧伤创面的临床应用[J].第四军医大学学报,2004,25(3):224-228.
[2]金岩,张勇杰,刘源,等.修复皮肤缺损的人工皮肤的制备方法:中国,200510042719.2[P]. 2009-02-18.
[3] Fellows CR, Matta C, Zakany R, et al. Adipose, Bone Marrow and Synovial Joint-Derived Mesenchymal Stem Cells for Cartilage Repair[J]. Frontiers in Genetics, 2016, 7(Pt 6):213.
[4] Niu CC, Lin SS, Yuan LJ, et al. Identification of mesenchymal stem cells and osteogenic factors in bone marrow aspirate and peripheral blood for spinal fusion by flow cytometry and proteomic analysis[J]. Journal of Orthopaedic Surgery and Research,2014, 9(1):32.
[5] Nam SM, Maeng YS, Kim EK, et al. Ex Vivo Expansion of Human Limbal Epithelial Cells Using Human Placenta-Derived and Umbilical Cord-Derived Mesenchymal Stem Cells[J]. Stem Cells International, 2017(3):4206187.
[6] Dabrowski FA, Burdzinska A, Kulesza A, et al. Comparison of the paracrine activity of mesenchymal stem cells derived from human umbilical cord, amniotic membrane and adipose tissue[J]. Journal of Obstetrics and Gynaecology Research, 2017, 43(11):1758-1768.
[7] Mohr S, Portmann-Lanz CB, Schoeberlein A, et al. Generation of an osteogenic graft from human placenta and placenta-derived mesenchymal stem cells[J]. Reproductive Sciences, 2010, 17(11):1006-1015.
[8] Heng L, Fan HS, Sun J, et al.Chondrogenic differentiation of mesenchymal stem cells induced by collagen-based hydrogel:an in vivo study[J]. Journal of Biomedical Materials Research Part A, 2010, 93(2):783-792.
[9] Barbagallo I, Vanella L, Distefano A, et al. Moringa oleifera Lam. improves lipid metabolism during adipogenic differentiation of human stem cells[J]. European Review for Medical and Pharmacological Sciences, 2016, 20(24):5223-5232.
[10] Gu SR, Kang YG, Shin JW, et al. Simultaneous engagement of mechanical stretching and surface pattern promotes cardiomyogenic differentiation of human mesenchymal stem cells[J]. Journal of Bioscience and Bioengineering, 2017, 123(2):252-258.
[11] Elahi KC, Gerd K, Meitem AA, et al. Human mesenchymal stromal cells from different sources diverge in their expression of cell surface proteins and display distinct differentiation patterns[J]. Stem Cells Int, 2016, 2016:5646384.
[12] Fu MH, Li CL, Lin HL, et al. Stem cell transplantation therapy in Parkinson’s disease[J]. Springerplus, 2015, 4(1):597.
[13] Zhu Y, Guan YM, Huang HL, et al. Human umbilical cord blood mesenchymal stem cell transplantation suppresses inflammatory responses and neuronal apoptosis during early stage of focal cerebral ischemia in rabbits[J]. Acta Pharmacologica Sinica,2014, 35(5):585-591.
[14]晏娟娟,高传玉,高永举,等.自体骨髓间充质干细胞移植治疗扩张型心肌病的临床观察[J].中华实用诊断与治疗杂志,2012,26(6):544-546.
[15] Sürder D, Schwitter J, Moccetti T, et al. Cell-based therapy for myocardial repair in patients with acute myocardial infarction:rationale and study design of the SWiss multicenter Intracoronary Stem cells Study in Acute Myocardial Infarction(SWISS-AMI)[J]. American Heart Journal, 2010, 160(1):58-64.
[16] Martínez ML, Escario E, Poblet E, et al. Hair follicle-containing punch grafts accelerate chronic ulcer healing:A randomized controlled trial[J]. Journal of the American Academy Dermatology,2016, 75(5):1007-1014.
[17]王慧君,柏树令.毛囊培养上清液诱导大鼠骨髓间充质干细胞分化的研究[J].解剖学报,2008,39(3):386-389.
[18] Bu ZY, Wu LM, Yu XH, et al. Isolation and characterization of in vitro culture of hair follicle cells differentiated from umbilical cord blood mesenchymal stem cells[J]. Experimental and Therapeutic Medicine,2017, 14(1):303-307.
[19]赵曼,他维玮,哈小琴,等.异体移植工程细胞对大鼠烧伤创面愈合中皮肤附属器作用[J].中华实用诊断与治疗杂志,2011,25(9):846-849.
[20] Mansilla E, Spretz R, Larsen G, et al. Outstanding survival and regeneration process by the use of intelligent acellular dermal matrices and mesenchymal stem cells in a burn pig model[J].Transplantation Proceedings, 2010, 42(10):4275-4278.
[21] Huang S, Lu G, Wu Y, et al. Mesenchymal stem cells delivered in a microsphere-based engineered skin contribute to cutaneous wound healing and sweat gland repair[J]. Journal of Dermatological Science,2012, 66(1):29-36.
[22] Ai L, Weng LX, Sun TZ, et al. Heat-shocked sweat gland cells induce the phenotype transformation of human bone marrow mesenchymal stem cells[J]. Chinese Journal of Tissue Engineering Research,2013, 17(6):985-991.
[23]许永安,黄沙,付小兵,等.特定微环境诱导人脐带沃顿胶间充质干细胞向汗腺样细胞分化的实验研究[J].解放军医学杂志,2011, 36(3):211-214.
[24]李海红,付小兵,王君,等.骨髓间充质干细胞分化为皮肤附属器细胞的初步实验研究[J].中国修复重建外科杂志,2006,20(6):675-678.
[25] Zhong XH, Wang MG, Zhao LP, et al. Differentiation of bone marrow mesenchymal stem cells into the cells of skin appendages in diabetic wound[J]. Journal of Clinical Rehabilitative Tissue Engineering Research, 2010, 14(6):1019-1022.
[26] Shi S, Jia S, Liu J, et al. Accelerated Regeneration of Skin Injury by Co-transplantation of Mesenchymal Stem Cells from Wharton’s Jelly of the Human Umbilical Cord Mixed with Microparticles[J].Cell Biochemistry and Biophysics, 2015, 71(2):951-956.
[27] Ball SG, Shuttleworth AC, Kielty CM. Direct cell contact influences bone marrow mesenchymal stem cell fate[J]. The International Journal of Biochemistry&Cell Biology, 2004, 36(4):714-727.
[2]金岩,张勇杰,刘源,等.修复皮肤缺损的人工皮肤的制备方法:中国,200510042719.2[P]. 2009-02-18.
[3] Fellows CR, Matta C, Zakany R, et al. Adipose, Bone Marrow and Synovial Joint-Derived Mesenchymal Stem Cells for Cartilage Repair[J]. Frontiers in Genetics, 2016, 7(Pt 6):213.
[4] Niu CC, Lin SS, Yuan LJ, et al. Identification of mesenchymal stem cells and osteogenic factors in bone marrow aspirate and peripheral blood for spinal fusion by flow cytometry and proteomic analysis[J]. Journal of Orthopaedic Surgery and Research,2014, 9(1):32.
[5] Nam SM, Maeng YS, Kim EK, et al. Ex Vivo Expansion of Human Limbal Epithelial Cells Using Human Placenta-Derived and Umbilical Cord-Derived Mesenchymal Stem Cells[J]. Stem Cells International, 2017(3):4206187.
[6] Dabrowski FA, Burdzinska A, Kulesza A, et al. Comparison of the paracrine activity of mesenchymal stem cells derived from human umbilical cord, amniotic membrane and adipose tissue[J]. Journal of Obstetrics and Gynaecology Research, 2017, 43(11):1758-1768.
[7] Mohr S, Portmann-Lanz CB, Schoeberlein A, et al. Generation of an osteogenic graft from human placenta and placenta-derived mesenchymal stem cells[J]. Reproductive Sciences, 2010, 17(11):1006-1015.
[8] Heng L, Fan HS, Sun J, et al.Chondrogenic differentiation of mesenchymal stem cells induced by collagen-based hydrogel:an in vivo study[J]. Journal of Biomedical Materials Research Part A, 2010, 93(2):783-792.
[9] Barbagallo I, Vanella L, Distefano A, et al. Moringa oleifera Lam. improves lipid metabolism during adipogenic differentiation of human stem cells[J]. European Review for Medical and Pharmacological Sciences, 2016, 20(24):5223-5232.
[10] Gu SR, Kang YG, Shin JW, et al. Simultaneous engagement of mechanical stretching and surface pattern promotes cardiomyogenic differentiation of human mesenchymal stem cells[J]. Journal of Bioscience and Bioengineering, 2017, 123(2):252-258.
[11] Elahi KC, Gerd K, Meitem AA, et al. Human mesenchymal stromal cells from different sources diverge in their expression of cell surface proteins and display distinct differentiation patterns[J]. Stem Cells Int, 2016, 2016:5646384.
[12] Fu MH, Li CL, Lin HL, et al. Stem cell transplantation therapy in Parkinson’s disease[J]. Springerplus, 2015, 4(1):597.
[13] Zhu Y, Guan YM, Huang HL, et al. Human umbilical cord blood mesenchymal stem cell transplantation suppresses inflammatory responses and neuronal apoptosis during early stage of focal cerebral ischemia in rabbits[J]. Acta Pharmacologica Sinica,2014, 35(5):585-591.
[14]晏娟娟,高传玉,高永举,等.自体骨髓间充质干细胞移植治疗扩张型心肌病的临床观察[J].中华实用诊断与治疗杂志,2012,26(6):544-546.
[15] Sürder D, Schwitter J, Moccetti T, et al. Cell-based therapy for myocardial repair in patients with acute myocardial infarction:rationale and study design of the SWiss multicenter Intracoronary Stem cells Study in Acute Myocardial Infarction(SWISS-AMI)[J]. American Heart Journal, 2010, 160(1):58-64.
[16] Martínez ML, Escario E, Poblet E, et al. Hair follicle-containing punch grafts accelerate chronic ulcer healing:A randomized controlled trial[J]. Journal of the American Academy Dermatology,2016, 75(5):1007-1014.
[17]王慧君,柏树令.毛囊培养上清液诱导大鼠骨髓间充质干细胞分化的研究[J].解剖学报,2008,39(3):386-389.
[18] Bu ZY, Wu LM, Yu XH, et al. Isolation and characterization of in vitro culture of hair follicle cells differentiated from umbilical cord blood mesenchymal stem cells[J]. Experimental and Therapeutic Medicine,2017, 14(1):303-307.
[19]赵曼,他维玮,哈小琴,等.异体移植工程细胞对大鼠烧伤创面愈合中皮肤附属器作用[J].中华实用诊断与治疗杂志,2011,25(9):846-849.
[20] Mansilla E, Spretz R, Larsen G, et al. Outstanding survival and regeneration process by the use of intelligent acellular dermal matrices and mesenchymal stem cells in a burn pig model[J].Transplantation Proceedings, 2010, 42(10):4275-4278.
[21] Huang S, Lu G, Wu Y, et al. Mesenchymal stem cells delivered in a microsphere-based engineered skin contribute to cutaneous wound healing and sweat gland repair[J]. Journal of Dermatological Science,2012, 66(1):29-36.
[22] Ai L, Weng LX, Sun TZ, et al. Heat-shocked sweat gland cells induce the phenotype transformation of human bone marrow mesenchymal stem cells[J]. Chinese Journal of Tissue Engineering Research,2013, 17(6):985-991.
[23]许永安,黄沙,付小兵,等.特定微环境诱导人脐带沃顿胶间充质干细胞向汗腺样细胞分化的实验研究[J].解放军医学杂志,2011, 36(3):211-214.
[24]李海红,付小兵,王君,等.骨髓间充质干细胞分化为皮肤附属器细胞的初步实验研究[J].中国修复重建外科杂志,2006,20(6):675-678.
[25] Zhong XH, Wang MG, Zhao LP, et al. Differentiation of bone marrow mesenchymal stem cells into the cells of skin appendages in diabetic wound[J]. Journal of Clinical Rehabilitative Tissue Engineering Research, 2010, 14(6):1019-1022.
[26] Shi S, Jia S, Liu J, et al. Accelerated Regeneration of Skin Injury by Co-transplantation of Mesenchymal Stem Cells from Wharton’s Jelly of the Human Umbilical Cord Mixed with Microparticles[J].Cell Biochemistry and Biophysics, 2015, 71(2):951-956.
[27] Ball SG, Shuttleworth AC, Kielty CM. Direct cell contact influences bone marrow mesenchymal stem cell fate[J]. The International Journal of Biochemistry&Cell Biology, 2004, 36(4):714-727.