脑梗死后患者认知障碍与血清脑源性神经营养因子和神经元特异性烯醇化酶表达的关系
摘要
目的观察脑梗死后认知障碍与血清中脑源性神经营养因子(BDNF)和神经元特异性烯醇化酶(NSE)表达的关系。方法 30例无明显器质性病变的成人血清作为对照组,106例脑梗死的患者作为观察组,依据蒙特利尔认知评估(Mo CA)评分情况将观察组分为认知障碍组76例和非认知障碍组30例,同时应用酶联免疫吸附(ELISA)法检测两组血清中BDNF和NSE的表达。结果认知障碍组血清BDNF的表达明显低于非认知障碍组,血清NSE的表达明显高于非认知障碍组(均P<0.05)。线性相关分析显示观察组认知障碍评分与BDNF和NSE的表达有一定相关性。结论脑梗死患者血清中BDNF和NSE的表达异常,部分患者存在认知障碍,其与BDNF和NSE的表达具有一定的相关性。
引文
1徐晓云,黄蕾,胡晖,等.脑血管病危险因素与脑梗死后认知障碍相关性的研究[J].中华物理医学与康复杂志,2003;25(7):422-5.
2 Zhang Y,Qiu B,Wang J,et al.Effects of BDNF-transfected BMSCs on neural functional recovery and synaptophysin expression in rats with cerebral infarction[J].Mol Neurobiol,2017;54(5):3813-24.
3 Nakajo Y,Dong Y,Takahashi JC,et al.ERV enhances spatial learning and prevents the development of infarcts,accompanied by upregulated BDNF in the cortex[J].Brain Res,2015;16(10):110-23.
4 刘斌,姜敏,张晋霞.急性脑梗死患者认知障碍的临床特征分析[J].山东医药,2009;49(33):5-7.
5 Kalidas K,Behrouz R.Inherited metabolic disorders and cerebral infarction[J].Expert Rev Neurotherapeut,2014;8(11):1731-41.
6 Yaroglu KS,Yesilbas O,Ersoy M,et al.Cerebral infarction and femoral venous thrombosis detected in a patient with diabetic ketoacidosis and heterozygous factorⅤLeiden G1691A and PAI-1 4G/5G mutations[J].J Pediatric Endocrinol Metabol,2015;28(9-10):1183-6.
7 Schneider JA,Wilson RS,Cochran EJ,et al.Relation of cerebral infarctions to dementia and cognitive function in older persons[J].Neurology,2003;60(7):1082-8.
8 王江川,张志强,沈世鑫.老年脑梗死后痴呆危险因素的临床研究[J].中华老年心脑血管病杂志,2007;9(5):308-10.
9 侯莉,王颖琦,刘伟,等.认知行为疗法对脑梗死患者血清中BDNF和COR含量的影响[J].中国循证心血管医学杂志,2015;7(5):669-71.
10 Lazzaro VD,Pellegrino G,Pino GD,et al.Val66Met BDNF gene polymorphism influences human motor cortex plasticity in acute stroke[J].Brain Stimulation,2014;8(1):92-6.
11 Li ST,Pan J,Hua XM,et al.Endothelial nitric oxide synthase protects neurons against ischemic injury through regulation of brain-derived neurotrophic factor expression[J].CNS Neurosci Ther,2014;20(2):154-64.
12 秦锦标,杨明华,栾丽芹.脑梗死后认知功能障碍患者血清BDNF水平及氟西汀的治疗作用[J].中风与神经疾病杂志,2013;30(1):49-51.
13 黄艮彬,魏寿忠,姚龙腾,等.脑出血患者血清NSE、S100β蛋白与认知功能障碍相关性研究[J].脑与神经疾病杂志,2012;20(4):251-5.
14 杜重浪,刘向丽,唐娟妮.脑出血患者血清NSE、S100蛋白水平与认知功能障碍和预后相关性[J].中国美容医学,2012;21(12):129.
15 李国辉.老年脑血管病患者血清神经元特异性烯醇化酶、S100蛋白水平与认知功能障碍和腺苷钴胺治疗预后的相关性[J].中国老年学杂志,2013;33(17):4169-70.
16 Li K,Jia JJ,Wang ZF,et al.Elevated serum levels of NSE and S-100βcorrelate with increased risk of acute cerebral infarction in Asian populations[J].Med Sci Monit,2014;21(2):1879-88.
17 王冬欣,张国芬,曹翠芳,等.血管性认知障碍患者血清脑源性神经营养因子水平的变化及其临床意义[J].临床神经病学杂志,2010;23(1):8-10.
18 王冬欣,黄娣,张国华,等.脑源性神经营养因子基因多态性与血管性认知障碍的相关性研究[J].中华老年心脑血管病杂志,2010;12(1):37-9.
19 Kaca-Orynska M,Tomasiuk R,Friedman A.Neuron-specific enolase and S 100B protein as predictors of outcome in ischaemic stroke[J].Neurol Neurochir Pol,2010;44(5):459-63.
2 Zhang Y,Qiu B,Wang J,et al.Effects of BDNF-transfected BMSCs on neural functional recovery and synaptophysin expression in rats with cerebral infarction[J].Mol Neurobiol,2017;54(5):3813-24.
3 Nakajo Y,Dong Y,Takahashi JC,et al.ERV enhances spatial learning and prevents the development of infarcts,accompanied by upregulated BDNF in the cortex[J].Brain Res,2015;16(10):110-23.
4 刘斌,姜敏,张晋霞.急性脑梗死患者认知障碍的临床特征分析[J].山东医药,2009;49(33):5-7.
5 Kalidas K,Behrouz R.Inherited metabolic disorders and cerebral infarction[J].Expert Rev Neurotherapeut,2014;8(11):1731-41.
6 Yaroglu KS,Yesilbas O,Ersoy M,et al.Cerebral infarction and femoral venous thrombosis detected in a patient with diabetic ketoacidosis and heterozygous factorⅤLeiden G1691A and PAI-1 4G/5G mutations[J].J Pediatric Endocrinol Metabol,2015;28(9-10):1183-6.
7 Schneider JA,Wilson RS,Cochran EJ,et al.Relation of cerebral infarctions to dementia and cognitive function in older persons[J].Neurology,2003;60(7):1082-8.
8 王江川,张志强,沈世鑫.老年脑梗死后痴呆危险因素的临床研究[J].中华老年心脑血管病杂志,2007;9(5):308-10.
9 侯莉,王颖琦,刘伟,等.认知行为疗法对脑梗死患者血清中BDNF和COR含量的影响[J].中国循证心血管医学杂志,2015;7(5):669-71.
10 Lazzaro VD,Pellegrino G,Pino GD,et al.Val66Met BDNF gene polymorphism influences human motor cortex plasticity in acute stroke[J].Brain Stimulation,2014;8(1):92-6.
11 Li ST,Pan J,Hua XM,et al.Endothelial nitric oxide synthase protects neurons against ischemic injury through regulation of brain-derived neurotrophic factor expression[J].CNS Neurosci Ther,2014;20(2):154-64.
12 秦锦标,杨明华,栾丽芹.脑梗死后认知功能障碍患者血清BDNF水平及氟西汀的治疗作用[J].中风与神经疾病杂志,2013;30(1):49-51.
13 黄艮彬,魏寿忠,姚龙腾,等.脑出血患者血清NSE、S100β蛋白与认知功能障碍相关性研究[J].脑与神经疾病杂志,2012;20(4):251-5.
14 杜重浪,刘向丽,唐娟妮.脑出血患者血清NSE、S100蛋白水平与认知功能障碍和预后相关性[J].中国美容医学,2012;21(12):129.
15 李国辉.老年脑血管病患者血清神经元特异性烯醇化酶、S100蛋白水平与认知功能障碍和腺苷钴胺治疗预后的相关性[J].中国老年学杂志,2013;33(17):4169-70.
16 Li K,Jia JJ,Wang ZF,et al.Elevated serum levels of NSE and S-100βcorrelate with increased risk of acute cerebral infarction in Asian populations[J].Med Sci Monit,2014;21(2):1879-88.
17 王冬欣,张国芬,曹翠芳,等.血管性认知障碍患者血清脑源性神经营养因子水平的变化及其临床意义[J].临床神经病学杂志,2010;23(1):8-10.
18 王冬欣,黄娣,张国华,等.脑源性神经营养因子基因多态性与血管性认知障碍的相关性研究[J].中华老年心脑血管病杂志,2010;12(1):37-9.
19 Kaca-Orynska M,Tomasiuk R,Friedman A.Neuron-specific enolase and S 100B protein as predictors of outcome in ischaemic stroke[J].Neurol Neurochir Pol,2010;44(5):459-63.