克拉霉素对细菌生物膜表达阳性慢性鼻-鼻窦炎患者术后感染的效果观察及VAS评分影响分析
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摘要
目的:探究将克拉霉素应用于细菌生物膜表达阳性慢性鼻-鼻窦炎患者术后感染控制中的效果,评价临床应用意义。方法:回顾性分析我院中2015年9月至2018年9月间收入的所有慢性鼻-鼻窦炎患者一般资料,选择94例患者开展研究,均分两组并在每组中录入47例患者。所有患者采用内镜下鼻窦手术进行治疗,实验组患者则在此基础上加用口服克拉霉素进行治疗,对比两组患者的术后感染发生率,评价患者的VAS评分。结果:实验结果显示,实验组患者的VAS评分为(8.2±0.9)分,而对照组患者的VAS评分为(7.1±0.5)分;同时实验组患者的感染事件发生率为1(2.13%)例,而对照组患者的感染事件发生率为8(17.02%)例,差异具有统计学意义(P<0.05)。实验组患者治疗总有效率记录为1(2.13%)例,而对照组患者的感染事件发生率为8(17.02%)例,各数据经对比分析未见明显差异,不具有统计学意义(P<0.05)。结论:在对细菌生物膜表达阳性慢性鼻-鼻窦炎患者采用手术治疗后,应用小剂量克拉霉素口服治疗,具有积极的治疗意义,值得推广使用。
Objective: To investigate the effect of clarithromycin on postoperative infection control of chronic rhinosinusitis patients with positive bacterial biofilm expression, and to evaluate the clinical application significance of clarithromycin in patients with chronic rhinosinusitis. Methods: The general data of all patients with chronic rhinosinusitis from September 2015 to September 2018 in our hospital were analyzed retrospectively. 94 patients with chronic rhinosinusitis were selected and divided into two groups and 47 patients were recorded in each group. All the patients were treated with endoscopic sinus surgery, and the patients in the experimental group were treated with oral clarithromycin on this basis. The incidence of postoperative infection was compared between the two groups, and the VAS scores of the patients were evaluated. Result: The results showed that the VAS score of the experimental group was(8.2±0.9), and the VAS score of the control group was(7.1±0.5); At the same time, the incidence of infection events was 1(2.13%) in the experimental group and 8(17.02%) in the control group, the difference was statistically significant(P<0.05). The total effective rate of treatment was 1(2.13%) in the experimental group and 8(17.02%) in the control group. There was no significant difference between the data and the control group(P<0.05). Conclusion: After surgical treatment for chronic rhinosinusitis patients with positive bacterial biofilm expression, oral treatment with low dose clarithromycin has positive therapeutic effects and is worth popularizing.
Objective: To investigate the effect of clarithromycin on postoperative infection control of chronic rhinosinusitis patients with positive bacterial biofilm expression, and to evaluate the clinical application significance of clarithromycin in patients with chronic rhinosinusitis. Methods: The general data of all patients with chronic rhinosinusitis from September 2015 to September 2018 in our hospital were analyzed retrospectively. 94 patients with chronic rhinosinusitis were selected and divided into two groups and 47 patients were recorded in each group. All the patients were treated with endoscopic sinus surgery, and the patients in the experimental group were treated with oral clarithromycin on this basis. The incidence of postoperative infection was compared between the two groups, and the VAS scores of the patients were evaluated. Result: The results showed that the VAS score of the experimental group was(8.2±0.9), and the VAS score of the control group was(7.1±0.5); At the same time, the incidence of infection events was 1(2.13%) in the experimental group and 8(17.02%) in the control group, the difference was statistically significant(P<0.05). The total effective rate of treatment was 1(2.13%) in the experimental group and 8(17.02%) in the control group. There was no significant difference between the data and the control group(P<0.05). Conclusion: After surgical treatment for chronic rhinosinusitis patients with positive bacterial biofilm expression, oral treatment with low dose clarithromycin has positive therapeutic effects and is worth popularizing.
引文
[1]宋颖,陈嵘,傅敏仪.早期小剂量克拉霉素对慢性鼻-鼻窦炎伴鼻息肉患者术后的疗效分析[J].临床耳鼻咽喉头颈外科杂志,2019,33(01):67-69.
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[3]林涛,周俊香,韦信暖,杨卫远,林芳芳.联用克拉霉素和红外偏振光照射疗法治疗急性鼻-鼻窦炎的效果观察[J].当代医药论丛,2018,16(20):120-122.
[4]郭国平,介华,付利静.长期低剂量克拉霉素联合鼻用激素及鼻腔冲洗治疗复发性鼻窦炎的疗效[J].北方药学,2018,15(10):75-76.
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[6]符牧,杨中川,赵迎彬.克拉霉素治疗CRSwNP的临床效果及对鼻黏膜组织中VEGF水平变化的影响[J].湖南师范大学学报(医学版),2018,15(04):30-33.
[7]李敬杰.桉柠蒎肠溶软胶囊联合克拉霉素对儿童慢性鼻-鼻窦炎的疗效观察[J].中国中西医结合耳鼻咽喉科杂志,2018,26(04):302-303.
[8]吴淑献,张松,熊武,元红艳,赛翀.低剂量克拉霉素联合糠酸莫米松鼻喷雾剂及鼻腔冲洗在慢性鼻窦炎术后的临床效果观察[J].中国现代药物应用,2018,12(15):157-158.
[9]余琳,毕瑞鹏,张卫杰.鼻窦内窥镜术辅助低剂量克拉霉素治疗慢性鼻-鼻窦炎的疗效及对血清TIgE、ECP、炎性因子的影响[J].重庆医学,2018,47(20):2689-2691,2694.
[10]夏俊,彭丹.丹参多酚酸盐联合克拉霉素治疗鼻咽癌放疗后鼻-鼻窦及咽部损伤的疗效及对患者口腔黏膜CINC-1和TLR-9表达的影响[J].现代中西医结合杂志,2018,27(15):1630-1633.
[11]宋晓.长期小剂量克拉霉素联合鼻用激素及鼻腔冲洗对尘肺与无尘肺慢性鼻窦炎患者的疗效比较[J].临床医学研究与实践,2018,3(03):40-41.
[12]李小蓓.鼻渊合剂对大鼠急性鼻窦炎模型鼻窦黏膜P38MARK信号通路及IL-9/IL-10的影响[A].中华中医药学会耳鼻喉科分会(China Association of Chinese Medicine Department of ENT branch)、世界中联耳鼻喉口腔科专业委员会(World Federation of Chinese Medicine Societies).
[13]张良春,熊世珍,黄维.克拉霉素对细菌生物膜表达阳性慢性鼻-鼻窦炎患者术后感染的疗效分析[J].中华医院感染学杂志,2015,25(15):3455-3457.
[2]刘国新,蔡可可.千金苇茎汤联合西药治疗鼻窦炎(痰瘀阻滞)随机平行对照研究[J].实用中医内科杂志,2018,32(10):60-63.
[3]林涛,周俊香,韦信暖,杨卫远,林芳芳.联用克拉霉素和红外偏振光照射疗法治疗急性鼻-鼻窦炎的效果观察[J].当代医药论丛,2018,16(20):120-122.
[4]郭国平,介华,付利静.长期低剂量克拉霉素联合鼻用激素及鼻腔冲洗治疗复发性鼻窦炎的疗效[J].北方药学,2018,15(10):75-76.
[5]朱钦源,肖红英.长期小剂量克拉霉素联合鼻用激素治疗慢性鼻-鼻窦炎的疗效分析[J].当代医学,2018,24(23):38-40.
[6]符牧,杨中川,赵迎彬.克拉霉素治疗CRSwNP的临床效果及对鼻黏膜组织中VEGF水平变化的影响[J].湖南师范大学学报(医学版),2018,15(04):30-33.
[7]李敬杰.桉柠蒎肠溶软胶囊联合克拉霉素对儿童慢性鼻-鼻窦炎的疗效观察[J].中国中西医结合耳鼻咽喉科杂志,2018,26(04):302-303.
[8]吴淑献,张松,熊武,元红艳,赛翀.低剂量克拉霉素联合糠酸莫米松鼻喷雾剂及鼻腔冲洗在慢性鼻窦炎术后的临床效果观察[J].中国现代药物应用,2018,12(15):157-158.
[9]余琳,毕瑞鹏,张卫杰.鼻窦内窥镜术辅助低剂量克拉霉素治疗慢性鼻-鼻窦炎的疗效及对血清TIgE、ECP、炎性因子的影响[J].重庆医学,2018,47(20):2689-2691,2694.
[10]夏俊,彭丹.丹参多酚酸盐联合克拉霉素治疗鼻咽癌放疗后鼻-鼻窦及咽部损伤的疗效及对患者口腔黏膜CINC-1和TLR-9表达的影响[J].现代中西医结合杂志,2018,27(15):1630-1633.
[11]宋晓.长期小剂量克拉霉素联合鼻用激素及鼻腔冲洗对尘肺与无尘肺慢性鼻窦炎患者的疗效比较[J].临床医学研究与实践,2018,3(03):40-41.
[12]李小蓓.鼻渊合剂对大鼠急性鼻窦炎模型鼻窦黏膜P38MARK信号通路及IL-9/IL-10的影响[A].中华中医药学会耳鼻喉科分会(China Association of Chinese Medicine Department of ENT branch)、世界中联耳鼻喉口腔科专业委员会(World Federation of Chinese Medicine Societies).
[13]张良春,熊世珍,黄维.克拉霉素对细菌生物膜表达阳性慢性鼻-鼻窦炎患者术后感染的疗效分析[J].中华医院感染学杂志,2015,25(15):3455-3457.