光学相干弹性成像研究现状与展望
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摘要
弹性成像技术是以软组织的杨氏模量、剪切模量、应力与应变等弹性参量为成像对象的技术。伴随着光学相干层析成像(OCT)的发展,光学相干弹性成像(OCE)由于其微米级别的分辨率,实时的图像处理以及非侵入式成像得到人们的青睐。综述了OCE的分类以及当今主流的几种OCE技术及其弹性图像重构的问题。探讨了OCE中施加机械负载方法和位移估算、应变估计的方法。OCE对检测组织临床上和病理上的机械特性拥有强大的潜力,特别是在诊断癌症,心血管疾病和眼科疾病上。总结了OCE研究和发展状况,并对其发展前景进行了展望。
Elastography is a technique based on Young′s modulus,shear modulus,stain and stress in soft tissue.With the development of optical coherent tomography(OCT),optical coherence elastography(OCE) becomes popular because of its micron meter level resolution,real-time image processing and noninvasive imaging.The classification of OCE,several kinds of dominant OCE and elastography reconstruction are reviewed.The method of applying mechanical load and estimating displacement and strain is discussed.OCE has a great potential in detecting the clinical and pathological mechanical properties,especially in the diagnosis of cancer,cardiovascular disease and eye disease.The research development of OCE is summarized and its prospect is also discussed.
Elastography is a technique based on Young′s modulus,shear modulus,stain and stress in soft tissue.With the development of optical coherent tomography(OCT),optical coherence elastography(OCE) becomes popular because of its micron meter level resolution,real-time image processing and noninvasive imaging.The classification of OCE,several kinds of dominant OCE and elastography reconstruction are reviewed.The method of applying mechanical load and estimating displacement and strain is discussed.OCE has a great potential in detecting the clinical and pathological mechanical properties,especially in the diagnosis of cancer,cardiovascular disease and eye disease.The research development of OCE is summarized and its prospect is also discussed.
引文
1 Xie Bo.Research of Quasi-static 3D Ultrasound Elastography[D].South China University of Technology,2013.12-14.谢波.准静态三维超声弹性成像方法研究[D].华南理工大学,2013.12-14.
2 Cai Weirui.A Research on the Technique of Magnetic Resonance Elastography based on Pneumatic Driver[D].Changsha:Hunan University,2012.22-25.蔡葳蕤.基于气动激励的磁共振弹性成像技术研究[D].长沙:湖南大学,2012.22-25.
3 Ophir J,Alam S K,Garra B,et al..Elastography:ultrasonic estimation and imaging of the elastic properties of tissues[J].Proceedings of the Institution of Mechanical Engineers,1999,213(3):203-233.
4 Liang X,Oldenburg A L,Crecea V,et al..Optical micro-scale mapping of dynamic biomechanical tissue properties[J].Optics Express,2008,16(15):11052-11065.
5 Adie S G,Kennedy B F,Armstrong J,et al..Audio frequency in vivo optical coherence elastography[J].Physics in Medicine and Biology,2009,54(10):3129-3139.
6 Kennedy B F,Hillman T R,Mc Laughlin R A,et al..In vivo dynamic optical coherence elastography using a ring actuator[J].Optics Express,2009,17(24):21762-21772.
7 Li C,Guan G,Cheng X,et al..Quantitative elastography provided by surface acoustic waves measured by phasesensitive optical coherence tomography[J].Optics Letters,2012,37(4):722-724.
8 Scruby C B,Drain L E.Laser ultrasonics techniques and applications[M].Boca Raton:CRC Press,1990.57-59.
9 Wang H C,Fleming S,Lee Y C,et al..Laser ultrasonic surface wave dispersion technique for non-destructive evaluation of human dental enamel[J].Optics Express,2009,17(18):15592-15607.
10 Schneider D,Schwarz T.A photoacoustic method for characterising thin films[J].Surface and Coatings Technology,1997,91(1):136-146.
11 Sohn Y,Krishnaswamy S.Mass spring lattice modeling of the scanning laser source technique[J].Ultrasonics,2002,39(8):543-551.
12 Zhu J.Non-contact ndt of concrete structures using air coupled sensors[R].Newmark Structural Engineering Laboratory.University of Illinois at Urbana-Champaign.,2008.
13 Li C,Guan G,Cheng X,et al..Quantitative elastography provided by surface acoustic waves measured by phasesensitive optical coherence tomography[J].Optics Letters,2012,37(4):722-724.
14 Li C,Guan G,Huang Z,et al..Noncontact all-optical measurement of corneal elasticity[J].Optics Letters,2012,37(10):1625-1627.
15 Wang S,Larin K V,Li J,et al..A focused air-pulse system for optical-coherence-tomography-based measurements of tissue elasticity[J].Laser Physics Letters,2013,10(7):075605.
16 Song S,Huang Z,Wang R K.Tracking mechanical wave propagation within tissue using phase-sensitive optical coherence tomography:motion artifact and its compensation[J].Journal of Biomedical Optics,2013,18(12):121505.
17 Song S,Huang Z,Nguyen T M,et al..Shear modulus imaging by direct visualization of propagating shear waves with phase-sensitive optical coherence tomography[J].Journal of Biomedical Optics,2013,18(12):121509.
18 Qi W,Chen R,Chou L,et al..Phase-resolved acoustic radiation force optical coherence elastography[J].Journal of Biomedical Optics,2012,17(11):110505.
19 Kennedy B F,Liang X,Adie S G,et al..In vivo three-dimensional optical coherence elastography[J].Optics Express,2011,19(7):6623-6634.
20 Liang X,Oldenburg A L,Crecea V,et al..Optical micro-scale mapping of dynamic biomechanical tissue properties[J].Optics express,2008,16(15):11052-11065.
21 Kennedy B F,Wojtkowski M,Szkulmowski M,et al..Improved measurement of vibration amplitude in dynamic optical coherence elastography[J].Biomedical Optics Express,2012,3(12):3138-3152.
22 Liang X,Adie S G,John R,et al..Dynamic spectral-domain optical coherence elastography for tissue characterization[J].Optics Express,2010,18(13):14183-14190.
23 Kennedy B F,Koh S H,Mc Laughlin R A,et al..Strain estimation in phase-sensitive optical coherence elastography[J].Biomedical Optics Express,2012,3(8):1865-1879.
24 Crecea V,Oldenburg A L,Liang X,et al..Magnetomotive nanoparticle transducers for optical rheology of viscoelastic materials[J].Optics Express,2009,17(25):23114-23122.
25 Oldenburg A,Toublan F,Suslick K,et al..Magnetomotive contrast for in vivo optical coherence tomography[J].Optics Express,2005,13(17):6597-6614.
26 Kennedy B F,Kennedy K M,Sampson D D.A review of optical coherence elastography:fundamentals,techniques and prospects[J].IEEE J Sel Top Quantum Electron,2014,20(2):7101217.
27 Li C,Guan G,Cheng X,et al..Quantitative elastography provided by surface acoustic waves measured by phasesensitive optical coherence tomography[J].Optics Letters,2012,37(4):722-724.
28 Doyley M M.Model-based elastography:a survey of approaches to the inverse elasticity problem[J].Physics in medicine and biology,2012,57(3):R35-R73.
29 S C Cowin,and S.B.Doty.Tissue Mechanics[M].New York:Springer,2007.113-116.
30 S J Kirkpatrick,D D Duncan.Optical assessment of tissue mechanics[M]//V V Tuchin.handbook of optical biomedical diagnostics.Bellingham:SPIE Press,2002,2(7):1037-108.
31 Ophir J,Alam S K,Garra B,et al..Elastography:ultrasonic estimation and imaging of the elastic properties of tissues[J].Proceedings of the Institution of Mechanical Engineers,Part H:Journal of Engineering in Medicine,1999,213(3):203-233.
32 Greenleaf J F,Fatemi M,Insana M.Selected methods for imaging elastic properties of biological tissues[J].Annual review of biomedical engineering,2003,5(1):57-78.
33 Parker K J,Doyley M M,Rubens D J.Imaging the elastic properties of tissue:the 20 year perspective[J].Physics in medicine and biology,2012,57(16):5359-5360.
34 Parker K J,Taylor L S,Gracewski S,et al..A unified view of imaging the elastic properties of tissue[J].The Journal of the Acoustical Society of America,2005,117(5):2705-2712.
35 T A Krouskop,T M Wheeler,F Kallel,et al..Elastic moduli of breast and prostate tissues under compression[J].Ultrasonic Imaging,1998,20(4):260-274.
36 B F Kennedy,S H Koh,R A Mc Laughlin,et al..Strain estimation in phase-sensitive optical coherence elastography[J].Biomedical Optics Express,2012,3(8):1865-1879.
37 Zaitsev V Y,Matveev L A,Matveyev A L,et al..Elastographic mapping in optical coherence tomography using an unconventional approach based on correlation stability[J].Journal of Biomedical Optics,2014,19(2):021107.
38 Sun C,Vuong C,Wen X,et al..Preliminary study of digital image correlation based optical coherence elastography[C].SPIE,2013,8802:880207.
39 Parker K J,Taylor L S,Gracewski S,et al..A unified view of imaging the elastic properties of tissue[J].The Journal of the Acoustical Society of America,2005,117(5):2705-2712.
40 Szkulmowski M,Szkulmowska A,Bajraszewski T,et al..Flow velocity estimation using joint spectral and time domain optical coherence tomography[J].Optics Express,2008,16(9):6008-6025.
41 Ding Zhihua,Zhao Chen,Bao Wen,et al..Advances in doppler optical coherence tomography[J].Laser&Optoelectronics Progress,2013,50(8):080005.丁志华,赵晨,鲍文,等.多普勒光学相干层析成像研究进展[J].激光与光电子学进展,2013,50(8):080005.
42 Kallel F,Ophir J.A least-squares strain estimator for elastography[J].Ultrasonic imaging,1997,19(3):195-208.
43 Zhang X,Greenleaf J F.Estimation of tissue′s elasticity with surface wave speed[J].The Journal of the Acoustical Society of America,2007,122(5):2522-2525.
44 Wang Chi,Bi Shubo,Ding Wei,et al..Optical characteristic parameters of gradient-index fiber probe[J].Chinese J Lasers,2012,39(9):0905001.王驰,毕书博,丁卫,等.梯度折射率光纤探针的光学特征参数[J].中国激光,2012,39(9):0905001.
45 Chong Bo,Zhu Yongkai.Method to improve axial resolution of spectral domain optical coherence tomography[J].Acta Optica Sinica,2012,33(2):0217001.崇博,朱永凯.谱域光学相干层析系统轴向分辨率提高方法[J].光学学报,2012,33(2):0217001.
2 Cai Weirui.A Research on the Technique of Magnetic Resonance Elastography based on Pneumatic Driver[D].Changsha:Hunan University,2012.22-25.蔡葳蕤.基于气动激励的磁共振弹性成像技术研究[D].长沙:湖南大学,2012.22-25.
3 Ophir J,Alam S K,Garra B,et al..Elastography:ultrasonic estimation and imaging of the elastic properties of tissues[J].Proceedings of the Institution of Mechanical Engineers,1999,213(3):203-233.
4 Liang X,Oldenburg A L,Crecea V,et al..Optical micro-scale mapping of dynamic biomechanical tissue properties[J].Optics Express,2008,16(15):11052-11065.
5 Adie S G,Kennedy B F,Armstrong J,et al..Audio frequency in vivo optical coherence elastography[J].Physics in Medicine and Biology,2009,54(10):3129-3139.
6 Kennedy B F,Hillman T R,Mc Laughlin R A,et al..In vivo dynamic optical coherence elastography using a ring actuator[J].Optics Express,2009,17(24):21762-21772.
7 Li C,Guan G,Cheng X,et al..Quantitative elastography provided by surface acoustic waves measured by phasesensitive optical coherence tomography[J].Optics Letters,2012,37(4):722-724.
8 Scruby C B,Drain L E.Laser ultrasonics techniques and applications[M].Boca Raton:CRC Press,1990.57-59.
9 Wang H C,Fleming S,Lee Y C,et al..Laser ultrasonic surface wave dispersion technique for non-destructive evaluation of human dental enamel[J].Optics Express,2009,17(18):15592-15607.
10 Schneider D,Schwarz T.A photoacoustic method for characterising thin films[J].Surface and Coatings Technology,1997,91(1):136-146.
11 Sohn Y,Krishnaswamy S.Mass spring lattice modeling of the scanning laser source technique[J].Ultrasonics,2002,39(8):543-551.
12 Zhu J.Non-contact ndt of concrete structures using air coupled sensors[R].Newmark Structural Engineering Laboratory.University of Illinois at Urbana-Champaign.,2008.
13 Li C,Guan G,Cheng X,et al..Quantitative elastography provided by surface acoustic waves measured by phasesensitive optical coherence tomography[J].Optics Letters,2012,37(4):722-724.
14 Li C,Guan G,Huang Z,et al..Noncontact all-optical measurement of corneal elasticity[J].Optics Letters,2012,37(10):1625-1627.
15 Wang S,Larin K V,Li J,et al..A focused air-pulse system for optical-coherence-tomography-based measurements of tissue elasticity[J].Laser Physics Letters,2013,10(7):075605.
16 Song S,Huang Z,Wang R K.Tracking mechanical wave propagation within tissue using phase-sensitive optical coherence tomography:motion artifact and its compensation[J].Journal of Biomedical Optics,2013,18(12):121505.
17 Song S,Huang Z,Nguyen T M,et al..Shear modulus imaging by direct visualization of propagating shear waves with phase-sensitive optical coherence tomography[J].Journal of Biomedical Optics,2013,18(12):121509.
18 Qi W,Chen R,Chou L,et al..Phase-resolved acoustic radiation force optical coherence elastography[J].Journal of Biomedical Optics,2012,17(11):110505.
19 Kennedy B F,Liang X,Adie S G,et al..In vivo three-dimensional optical coherence elastography[J].Optics Express,2011,19(7):6623-6634.
20 Liang X,Oldenburg A L,Crecea V,et al..Optical micro-scale mapping of dynamic biomechanical tissue properties[J].Optics express,2008,16(15):11052-11065.
21 Kennedy B F,Wojtkowski M,Szkulmowski M,et al..Improved measurement of vibration amplitude in dynamic optical coherence elastography[J].Biomedical Optics Express,2012,3(12):3138-3152.
22 Liang X,Adie S G,John R,et al..Dynamic spectral-domain optical coherence elastography for tissue characterization[J].Optics Express,2010,18(13):14183-14190.
23 Kennedy B F,Koh S H,Mc Laughlin R A,et al..Strain estimation in phase-sensitive optical coherence elastography[J].Biomedical Optics Express,2012,3(8):1865-1879.
24 Crecea V,Oldenburg A L,Liang X,et al..Magnetomotive nanoparticle transducers for optical rheology of viscoelastic materials[J].Optics Express,2009,17(25):23114-23122.
25 Oldenburg A,Toublan F,Suslick K,et al..Magnetomotive contrast for in vivo optical coherence tomography[J].Optics Express,2005,13(17):6597-6614.
26 Kennedy B F,Kennedy K M,Sampson D D.A review of optical coherence elastography:fundamentals,techniques and prospects[J].IEEE J Sel Top Quantum Electron,2014,20(2):7101217.
27 Li C,Guan G,Cheng X,et al..Quantitative elastography provided by surface acoustic waves measured by phasesensitive optical coherence tomography[J].Optics Letters,2012,37(4):722-724.
28 Doyley M M.Model-based elastography:a survey of approaches to the inverse elasticity problem[J].Physics in medicine and biology,2012,57(3):R35-R73.
29 S C Cowin,and S.B.Doty.Tissue Mechanics[M].New York:Springer,2007.113-116.
30 S J Kirkpatrick,D D Duncan.Optical assessment of tissue mechanics[M]//V V Tuchin.handbook of optical biomedical diagnostics.Bellingham:SPIE Press,2002,2(7):1037-108.
31 Ophir J,Alam S K,Garra B,et al..Elastography:ultrasonic estimation and imaging of the elastic properties of tissues[J].Proceedings of the Institution of Mechanical Engineers,Part H:Journal of Engineering in Medicine,1999,213(3):203-233.
32 Greenleaf J F,Fatemi M,Insana M.Selected methods for imaging elastic properties of biological tissues[J].Annual review of biomedical engineering,2003,5(1):57-78.
33 Parker K J,Doyley M M,Rubens D J.Imaging the elastic properties of tissue:the 20 year perspective[J].Physics in medicine and biology,2012,57(16):5359-5360.
34 Parker K J,Taylor L S,Gracewski S,et al..A unified view of imaging the elastic properties of tissue[J].The Journal of the Acoustical Society of America,2005,117(5):2705-2712.
35 T A Krouskop,T M Wheeler,F Kallel,et al..Elastic moduli of breast and prostate tissues under compression[J].Ultrasonic Imaging,1998,20(4):260-274.
36 B F Kennedy,S H Koh,R A Mc Laughlin,et al..Strain estimation in phase-sensitive optical coherence elastography[J].Biomedical Optics Express,2012,3(8):1865-1879.
37 Zaitsev V Y,Matveev L A,Matveyev A L,et al..Elastographic mapping in optical coherence tomography using an unconventional approach based on correlation stability[J].Journal of Biomedical Optics,2014,19(2):021107.
38 Sun C,Vuong C,Wen X,et al..Preliminary study of digital image correlation based optical coherence elastography[C].SPIE,2013,8802:880207.
39 Parker K J,Taylor L S,Gracewski S,et al..A unified view of imaging the elastic properties of tissue[J].The Journal of the Acoustical Society of America,2005,117(5):2705-2712.
40 Szkulmowski M,Szkulmowska A,Bajraszewski T,et al..Flow velocity estimation using joint spectral and time domain optical coherence tomography[J].Optics Express,2008,16(9):6008-6025.
41 Ding Zhihua,Zhao Chen,Bao Wen,et al..Advances in doppler optical coherence tomography[J].Laser&Optoelectronics Progress,2013,50(8):080005.丁志华,赵晨,鲍文,等.多普勒光学相干层析成像研究进展[J].激光与光电子学进展,2013,50(8):080005.
42 Kallel F,Ophir J.A least-squares strain estimator for elastography[J].Ultrasonic imaging,1997,19(3):195-208.
43 Zhang X,Greenleaf J F.Estimation of tissue′s elasticity with surface wave speed[J].The Journal of the Acoustical Society of America,2007,122(5):2522-2525.
44 Wang Chi,Bi Shubo,Ding Wei,et al..Optical characteristic parameters of gradient-index fiber probe[J].Chinese J Lasers,2012,39(9):0905001.王驰,毕书博,丁卫,等.梯度折射率光纤探针的光学特征参数[J].中国激光,2012,39(9):0905001.
45 Chong Bo,Zhu Yongkai.Method to improve axial resolution of spectral domain optical coherence tomography[J].Acta Optica Sinica,2012,33(2):0217001.崇博,朱永凯.谱域光学相干层析系统轴向分辨率提高方法[J].光学学报,2012,33(2):0217001.