土源性线虫苯并咪唑抗药性基因的研究进展
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摘要
在热带及亚热带地区,土源性线虫钩虫、蛔虫、鞭虫感染广泛存在,尤其是在儿童当中。目前,主要的防治措施是对土源性线虫流行地区及高危人群进行定期驱虫治疗。然而,长期、大规模的使用这些药物引起人们对抗药性的担忧。在兽医线虫中,长期使用苯并咪唑类药物对家畜进行驱虫已经导致驱虫药抗药性的出现。苯并咪唑的抗药性被认为与β微管蛋白在密码子200、198、167处的基因突变有关。本文在广泛查阅文献的基础上,对国内外现阶段苯并咪唑抗药性基因研究进展进行综合概括介绍。
Infections with soil-transmitted helminths(hookworms, roundworms, and whipworms) are widespread in tropical and subtropical regions, and especially among children. At present, prevention and treatment measures mainly involve regular deworming treatment in endemic areas and for high-risk groups. However, long-term and large-scale use of these drugs raises concerns about drug resistance. Long-term use of benzimidazoles to control nematodes in livestock has led to the emergence of resistance to anthelmintic drugs. The resistance of benzimidazole is thought to be related to mutations in microtubule proteins at codons 200, 198, and 167. Based on an extensive review of the literature, this paper provides a comprehensive overview of advances in the study of benzimidazole resistance genes at home and abroad.
Infections with soil-transmitted helminths(hookworms, roundworms, and whipworms) are widespread in tropical and subtropical regions, and especially among children. At present, prevention and treatment measures mainly involve regular deworming treatment in endemic areas and for high-risk groups. However, long-term and large-scale use of these drugs raises concerns about drug resistance. Long-term use of benzimidazoles to control nematodes in livestock has led to the emergence of resistance to anthelmintic drugs. The resistance of benzimidazole is thought to be related to mutations in microtubule proteins at codons 200, 198, and 167. Based on an extensive review of the literature, this paper provides a comprehensive overview of advances in the study of benzimidazole resistance genes at home and abroad.
引文
[1] 龙波, 陈仕国, 马显光, 等. 单核苷酸多态性检测技术的研究[J]. 激光杂志, 2011, 32(5): 48-9.
[2] WHO, 2011. WHO Working to overcome the global impact of neglected tropical diseases-First WHO report on neglected tropical diseases[R]. Geneva:World Health O-rganization, 2011.
[3] 世界卫生组织. 水与文化[R/OL]. http://www.who.int/water_sanitation_health/Water&cultureChinese. pdf.
[4] 世界卫生组织, 联合国儿童基金会. 恶劣的环境卫生威胁公共卫生[N/OL]. http://www. who. int/mediacentre/news/releases/2008/pr08/zh/.
[5] World Health Organization(WHO). Facts and Figures:water sanitation and hygiene links to heal-th[R/OL]. http://www. who. int/water_sanitation_health/factsfigures2005.pdf/.
[6] Hotez PJ, Brindley PJ, Bethony JM, et al. Helminth infections:the great neglected tropical diseases[J]. J Clin Invest, 2008, 118(4): 1311-21.
[7] 王威,马霄,王虎,张静宵,等.青海省平安县人体土源性线虫感染监测分析[J].中国病原生物学杂志, 2017, 12(7): 附页3-4.
[8] 倪碧娴,沈明学,徐祥珍,等.2006-2015年江苏省土源性线虫病监测结果分析[J]. 中国病原生物学杂志, 2017, 12(12): 1197-202.
[9] Ayoya MA, Spiekermann Brouwer GM, Traore AK, et al. Determinants of anemia among pregnant women in Mali[J]. Food Nutr Bull, 2006, 27(1): 3-11.
[10] Stoltzfus RJ, Albonico M, Chwaya HM, et al. Effects of the Zanzibar school-based deworming program on iron status of children[J]. Am J Clin Nutr, 1998, 68(1): 179-86.
[11] Bleakley H. Disease and develo-pment:evidence from hookworm eradication in the American South[J]. Q J Econ, 2007, 122(1): 73-112.
[12] Keiser J, Utzinger J. Efficacy of current drugs against soil-transmitted helminth infections: systematic review and meta-analysis[J]. JAMA, 2008, 299(16): 1937-48.
[13] Coles GC. 世界兽医寄生虫学促进协会对驱蠕虫药抗药性的检测方法[J]. 中国兽医寄生虫病, 1996, 4(1):60-1.
[14] 王权, 沈杰.寄生线虫抗药性检测技术研究进展[J]. 中国兽医寄生虫病, 1997, 5(4): 50-1.
[15] Jackson F, Coop RL. The development of anthelmintic resistance in sheep nematodes[J]. Parasitology, 2000, 120(7): S95-107.
[16] Chandrawathani, PJ, Waller, Adnan M, et al. Evolution of high level: Multiple anthelmintic resistance[J]. Trop Anim Health Prod, 2003, 35(1): 17-25.
[17] 张宗泽. 中国地区捻转血矛线虫苯并咪唑类抗药性相关基因Ⅰ型β微管蛋白编码基因多样性的研究[D]. 武汉: 华中农业大学, 2017.
[18] Jürgen Krückena,Kira Fraundorfer,Jean Claude Mugisha,et al.Reduced efficacy of albendazole against Ascaris lumbricoides in schoolchildren[J]. Int J Parasitol Drugs Drug Resist, 2017,7(3):262-71.
[19] Soukhathammavong PA,Sayasone S,Phongluxa K,et al. Low Efficacy of Single-Dose Albendazole and Mebendazole against Hookworm and Effect on Concomitant Helminth Infection in Lao PDR[J]. PLoS Negl Trop Dis, 2012,6(1):e1417.
[20] Aissatou D, Carli MH, Thomas SC, et al. Association between response to albendazole treatment and β-tubulin genotype frequencies in soil-transmitted helminths[J]. PLoS Negl Trop Dis, 2013, 7(5): e2247.
[21] 柏家林, 蔡葵蒸, 何进全. P糖蛋白介导的寄生虫抗药性及其逆转的研究进展[J]. 中国兽医科学, 2010, 40(10): 1085-92.
[22] 章涛, 沈一. 苯并咪唑对线虫的作用及线虫抗药性机制的研究进展[J]. 国外医学寄生虫分册, 1996, 23(2): 49-50.
[23] 高俊峰, 侯美如, 王丽坤, 等. 家畜寄生线虫耐药性及检测方法研究进展[J]. 黑龙江畜牧兽医, 2015(7): 63-5.
[24] Kaplan RM, Vidyashankar AN. An inconvenient truth:Global worming and anthelmintic resistance[J]. Vet Parasitol, 2012, 186(1): 70-8.
[25] Calvete C, Uriarte J. Improving the detection of anthelminticresistance:evalution of feacal egg count reduction test procedures suitable for farm routins[J]. Vet Parasitol, 2013, 196(3): 438-52.
[26] Levecke B, Speybroeck N, Dobson RJ, et al. Novel insights in thefeacal egg count reduction test for monitoring drug efficacy against soil-transmitted helminthsin large-scale treatment programs[J]. PLoS Negl Trop Dis, 2011, 5(12): e1427.
[27] S. Chandra, A. Prasad, M. Sankar, et al. Molecular diagnosis of benzimidazole resistance in Haemonchus contortus in sheep from different geographic regions of North India[J]. Vet World, 2014, 7(5): 337-41.
[28] Andrew CK, Katie C, Neil HB, et al. Relative level of thiabendazole resistanceassociated with the E198A and F200Y SNPs in larvae of a multidrug resistant isolate of Haemonchus contortus[J]. Int J Parasitol Drugs Drug Resist, 2012, 2(12): 92-7.
[29] Marc G, Ronald K, Pascal M. Phenotyping and genotyping of Haemonchus contortus isolates reveals a new putative candidate mutation for benzimidazole resistance in nematodes[J]. Vet Parasitol, 2007, 144(3): 313-20.
[30] Elard L, Humbert JF. Importance of the mutation of amino acid 200 of the isotype 1 β-tubulin gene in the benzimidazole resistance of the small-ruminant parasite Teladorsagia circumcincta[J]. Parasitol Res, 1999, 85(6): 452-6.
[2] WHO, 2011. WHO Working to overcome the global impact of neglected tropical diseases-First WHO report on neglected tropical diseases[R]. Geneva:World Health O-rganization, 2011.
[3] 世界卫生组织. 水与文化[R/OL]. http://www.who.int/water_sanitation_health/Water&cultureChinese. pdf.
[4] 世界卫生组织, 联合国儿童基金会. 恶劣的环境卫生威胁公共卫生[N/OL]. http://www. who. int/mediacentre/news/releases/2008/pr08/zh/.
[5] World Health Organization(WHO). Facts and Figures:water sanitation and hygiene links to heal-th[R/OL]. http://www. who. int/water_sanitation_health/factsfigures2005.pdf/.
[6] Hotez PJ, Brindley PJ, Bethony JM, et al. Helminth infections:the great neglected tropical diseases[J]. J Clin Invest, 2008, 118(4): 1311-21.
[7] 王威,马霄,王虎,张静宵,等.青海省平安县人体土源性线虫感染监测分析[J].中国病原生物学杂志, 2017, 12(7): 附页3-4.
[8] 倪碧娴,沈明学,徐祥珍,等.2006-2015年江苏省土源性线虫病监测结果分析[J]. 中国病原生物学杂志, 2017, 12(12): 1197-202.
[9] Ayoya MA, Spiekermann Brouwer GM, Traore AK, et al. Determinants of anemia among pregnant women in Mali[J]. Food Nutr Bull, 2006, 27(1): 3-11.
[10] Stoltzfus RJ, Albonico M, Chwaya HM, et al. Effects of the Zanzibar school-based deworming program on iron status of children[J]. Am J Clin Nutr, 1998, 68(1): 179-86.
[11] Bleakley H. Disease and develo-pment:evidence from hookworm eradication in the American South[J]. Q J Econ, 2007, 122(1): 73-112.
[12] Keiser J, Utzinger J. Efficacy of current drugs against soil-transmitted helminth infections: systematic review and meta-analysis[J]. JAMA, 2008, 299(16): 1937-48.
[13] Coles GC. 世界兽医寄生虫学促进协会对驱蠕虫药抗药性的检测方法[J]. 中国兽医寄生虫病, 1996, 4(1):60-1.
[14] 王权, 沈杰.寄生线虫抗药性检测技术研究进展[J]. 中国兽医寄生虫病, 1997, 5(4): 50-1.
[15] Jackson F, Coop RL. The development of anthelmintic resistance in sheep nematodes[J]. Parasitology, 2000, 120(7): S95-107.
[16] Chandrawathani, PJ, Waller, Adnan M, et al. Evolution of high level: Multiple anthelmintic resistance[J]. Trop Anim Health Prod, 2003, 35(1): 17-25.
[17] 张宗泽. 中国地区捻转血矛线虫苯并咪唑类抗药性相关基因Ⅰ型β微管蛋白编码基因多样性的研究[D]. 武汉: 华中农业大学, 2017.
[18] Jürgen Krückena,Kira Fraundorfer,Jean Claude Mugisha,et al.Reduced efficacy of albendazole against Ascaris lumbricoides in schoolchildren[J]. Int J Parasitol Drugs Drug Resist, 2017,7(3):262-71.
[19] Soukhathammavong PA,Sayasone S,Phongluxa K,et al. Low Efficacy of Single-Dose Albendazole and Mebendazole against Hookworm and Effect on Concomitant Helminth Infection in Lao PDR[J]. PLoS Negl Trop Dis, 2012,6(1):e1417.
[20] Aissatou D, Carli MH, Thomas SC, et al. Association between response to albendazole treatment and β-tubulin genotype frequencies in soil-transmitted helminths[J]. PLoS Negl Trop Dis, 2013, 7(5): e2247.
[21] 柏家林, 蔡葵蒸, 何进全. P糖蛋白介导的寄生虫抗药性及其逆转的研究进展[J]. 中国兽医科学, 2010, 40(10): 1085-92.
[22] 章涛, 沈一. 苯并咪唑对线虫的作用及线虫抗药性机制的研究进展[J]. 国外医学寄生虫分册, 1996, 23(2): 49-50.
[23] 高俊峰, 侯美如, 王丽坤, 等. 家畜寄生线虫耐药性及检测方法研究进展[J]. 黑龙江畜牧兽医, 2015(7): 63-5.
[24] Kaplan RM, Vidyashankar AN. An inconvenient truth:Global worming and anthelmintic resistance[J]. Vet Parasitol, 2012, 186(1): 70-8.
[25] Calvete C, Uriarte J. Improving the detection of anthelminticresistance:evalution of feacal egg count reduction test procedures suitable for farm routins[J]. Vet Parasitol, 2013, 196(3): 438-52.
[26] Levecke B, Speybroeck N, Dobson RJ, et al. Novel insights in thefeacal egg count reduction test for monitoring drug efficacy against soil-transmitted helminthsin large-scale treatment programs[J]. PLoS Negl Trop Dis, 2011, 5(12): e1427.
[27] S. Chandra, A. Prasad, M. Sankar, et al. Molecular diagnosis of benzimidazole resistance in Haemonchus contortus in sheep from different geographic regions of North India[J]. Vet World, 2014, 7(5): 337-41.
[28] Andrew CK, Katie C, Neil HB, et al. Relative level of thiabendazole resistanceassociated with the E198A and F200Y SNPs in larvae of a multidrug resistant isolate of Haemonchus contortus[J]. Int J Parasitol Drugs Drug Resist, 2012, 2(12): 92-7.
[29] Marc G, Ronald K, Pascal M. Phenotyping and genotyping of Haemonchus contortus isolates reveals a new putative candidate mutation for benzimidazole resistance in nematodes[J]. Vet Parasitol, 2007, 144(3): 313-20.
[30] Elard L, Humbert JF. Importance of the mutation of amino acid 200 of the isotype 1 β-tubulin gene in the benzimidazole resistance of the small-ruminant parasite Teladorsagia circumcincta[J]. Parasitol Res, 1999, 85(6): 452-6.