微血管性心绞痛患者血清Galectin-3水平变化及临床意义
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摘要
目的考察微血管性心绞痛(MVA)患者血清半乳糖凝集素-3(Galectin-3)水平变化,探究其与MVA发病的关系。方法选取2015年1月至2018年1月于濮阳市人民医院心血管内科确诊为MVA患者93例,另随机抽取相同年龄段因胸痛入院但冠状动脉造影、运动平板试验未见异常的患者93例作为对照组。测定所有受试者血清中Galectin-3、超敏C反应蛋白(hs-CRP)、内皮素-1(ET-1)和一氧化氮(NO)水平以及相关生理生化指标。并利用Pearson相关分析法分析Galectin-3与其他指标的相关性。结果MVA患者高血压、糖尿病占比显著高于对照组(P<0.05),且MVA患者空腹血糖水平显著高于对照组(P<0.05)。MVA患者Galectin-3、hs-CRP和ET-1水平显著高于对照组(P<0.05),NO水平显著低于对照组(P<0.05)。Pearson相关分析表明Galectin-3水平与空腹血糖、hs-CRP、ET-1水平呈正相关(r=0.456、0.598、0.426;P<0.05),与NO水平呈负相关(r=-0.488;P<0.05)。结论 MVA患者血清Galectin-3水平上升,可作为MVA患者中微血管纤维化和预测炎症和微血管内皮功能的重要指标。
Objective To observe the changes of serum Galectin-3 level in patients with microvascular angina(MVA), and discuss the relationship between Galectin-3 level and MVA invasion. Methods MVA patients(n=93)were chosen into MVA group and patients(n=93) hospitalized due to chest pain with normal results of coronary angiography(CAG) and treadmill exercise test(TET) were randomly chosen into control group from Department of Cardiovascular Medicine of People's Hospital of Puyang City in Henan Province from Jan. 2015 to Jan. 2018. The levels of serum Galectin-3, high sensitivity C-reactive protein(hs-CRP), endothelin-1(ET-1), nitric oxide(NO)and relative physiological and biochemical indexes were detected in all groups. The correlation among Galectin-3 and other indexes was analyzed by using Pearson correlation analysis. Results The proportions of patients with hypertension and diabetes(P<0.05), and level of fasting blood glucose(FBG, P<0.05) were significantly higher in MVA group than those in control group. The levels of Galectin-3, hs-CRP and ET-1 were significantly higher(P<0.05) and NO level was significantly lower(P<0.05) in MVA group than those in control group. The results of Pearson correlation analysis showed that Galectin-3 was positively correlated to FBG, hs-CRP and ET-1(r=0.456,r=0.598, r=0.426; P<0.05) and negatively correlated to NO(r=-0.488; P<0.05). Conclusion The increase of serum Galectin-3 level can be taken as an important index for microvascular fibrosis and predicting inflammation and microvascular endothelial function in MVA patients.
Objective To observe the changes of serum Galectin-3 level in patients with microvascular angina(MVA), and discuss the relationship between Galectin-3 level and MVA invasion. Methods MVA patients(n=93)were chosen into MVA group and patients(n=93) hospitalized due to chest pain with normal results of coronary angiography(CAG) and treadmill exercise test(TET) were randomly chosen into control group from Department of Cardiovascular Medicine of People's Hospital of Puyang City in Henan Province from Jan. 2015 to Jan. 2018. The levels of serum Galectin-3, high sensitivity C-reactive protein(hs-CRP), endothelin-1(ET-1), nitric oxide(NO)and relative physiological and biochemical indexes were detected in all groups. The correlation among Galectin-3 and other indexes was analyzed by using Pearson correlation analysis. Results The proportions of patients with hypertension and diabetes(P<0.05), and level of fasting blood glucose(FBG, P<0.05) were significantly higher in MVA group than those in control group. The levels of Galectin-3, hs-CRP and ET-1 were significantly higher(P<0.05) and NO level was significantly lower(P<0.05) in MVA group than those in control group. The results of Pearson correlation analysis showed that Galectin-3 was positively correlated to FBG, hs-CRP and ET-1(r=0.456,r=0.598, r=0.426; P<0.05) and negatively correlated to NO(r=-0.488; P<0.05). Conclusion The increase of serum Galectin-3 level can be taken as an important index for microvascular fibrosis and predicting inflammation and microvascular endothelial function in MVA patients.
引文
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[17]Dong H,Wang ZH,Zhang N,et al.Serum Galectin-3 level,not Galectin-1,is associated with the clinical feature and outcome in patients with acute ischemic stroke[J].Oncotarget,2017,8(65):109752-61.
[18]Miyauchi M,Ao M,Furusho H,et al.Galectin-3 Plays an Important Role in Preterm Birth Caused by Dental Infection of Porphyromonas gingivalis[J].Sci Rep,2018,8(1):2867.
[2]Marinescu MA,L?ffler AI,Ouellette M,et al.Coronary Microvascular Dysfunction,MicrovascularAngina,and Treatment Strategies[J].JACCCardiovasc Imaging,2015,8(2):210-20.
[3]Mayr A,Klug G,Mair J,et al.Galectin-3:Relation to infarct scar and left ventricular function after myocardial infarction[J].Int J Cardiol,2013,163(3):335-7.
[4]李一凡.微血管性心绞痛发病机制的研究进展[J].心血管病学进展,2014,35(3):291-4.
[5]Mishra BB,Li Q,Steichen AL,et al.Galectin-3 Functions as an Alarmin:Pathogenic Role for Sepsis Development in Murine Respiratory Tularemia[J].Plos One,2013,8(3):e59616.
[6]Falcone C,Lucibello S,Mazzucchelli I,et al.Galectin-3 plasma levels and coronary artery disease:a new possible biomarker of acute coronary syndrome[J].Int J Immunopathol Pharmacol,2015,24(4):905.
[7]秦月,仲琳,杨军.Galectin-3评估冠心病预后的临床价值[J].国际心血管病杂志,2015,42(3):207-11.
[8]郑蕊,樊官伟,商洪才.冠状动脉微血管性心绞痛发生机制和诱发因素及治疗学研究进展[J].医学综述,2015,21(16):2887-90.
[9]Funasaka T,Raz A,Nangiamakker P.Galectin-3 in angiogenesis and metastasis[J].Glycobiol,2014,24(10):886-91.
[10]de Boer RA,Voors AA,Muntendam P,et al.Galectin-3:a novel mediator of heart failure development and progression[J].Eur J Heart Fail,2014,11(9):811-7.
[11]de Boer RA,van Veldhuisen DJ,Gansevoort RT,et al.The fibrosis marker galectin-3 and outcome in the general population[J].J Intern Med,2012,272(1):55-64.
[12]Gullestad L,Ueland T,Vinge LE,et al.Inflammatory Cytokines in Heart Failure:Mediators and Markers[J].Cardiol,2012,122(1):23-35.
[13]常晓玉.内皮素与一氧化氮联合检测对微血管性心绞痛诊治价值的探讨[J].山西医药杂志,2014,43(22):2683-4.
[14]Agrawal S,Mehta PK,Bairey Merz CN3.Cardiac Syndrome X:update2014[J].Cardiol Clin,2014,32(3):463-78.
[15]Recio-Mayoral A,Rimoldi OE,Camici PG,et al.Inflammation and microvascular dysfunction in cardiac syndrome X patients without conventional risk factors for coronary artery disease[J].JACCCardiovasc Imaging,2013,6(6):660-7.
[16]Kittanakom S,Hill S,Worster A,et al.The utility of galectin-3 and high-sensitivity cardiac troponin assays to predict short-term serious outcomes in patients presenting early after chest-pain onset[J].Clinical Biochemistry,2014,47(12):1151-1.
[17]Dong H,Wang ZH,Zhang N,et al.Serum Galectin-3 level,not Galectin-1,is associated with the clinical feature and outcome in patients with acute ischemic stroke[J].Oncotarget,2017,8(65):109752-61.
[18]Miyauchi M,Ao M,Furusho H,et al.Galectin-3 Plays an Important Role in Preterm Birth Caused by Dental Infection of Porphyromonas gingivalis[J].Sci Rep,2018,8(1):2867.