中药生殖毒性研究状况
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摘要
中药生殖发育毒性的研究是目前中药毒性领域研究的热点之一。本文总结中药生殖发育毒性研究的现状并就其存在的突出问题进行探讨,发现目前主要通过对古医籍的研究或通过现代实验方法研究中药生殖毒性。本文以"中药""生殖毒性""发育毒性""胚胎毒性"等为检索词,检索2010至2018年中国知网、万方、维普和Pub Med数据库,通过整理总结中药胚胎毒性研究文献,归纳出目前中药胚胎毒性的研究现状及存在的局限性,以期为后续研究提供参考。
The research on the reproductive and developmental toxicity of traditional Chinese medicine( TCM) is one of the hotspots in the field of TCM toxicity. This paper summarizes the status quo of research on reproductive and developmental toxicity of TCM by searching and analyzing the literature and discusses the outstanding problems of its existence. Research or study the reproductive toxicity of TCM through modern experimental methods. In this paper, " Chinese medicine" " reproductive toxicity" " developmental toxicity" and " embryonic toxicity" were used as search terms to search the database of China Knowledge Network,Wanfang,Weipu and PubMed from 2010 to 2018. The current research status and limitations of TCM embryo toxicity are expected to provide reference for subsequent research.
The research on the reproductive and developmental toxicity of traditional Chinese medicine( TCM) is one of the hotspots in the field of TCM toxicity. This paper summarizes the status quo of research on reproductive and developmental toxicity of TCM by searching and analyzing the literature and discusses the outstanding problems of its existence. Research or study the reproductive toxicity of TCM through modern experimental methods. In this paper, " Chinese medicine" " reproductive toxicity" " developmental toxicity" and " embryonic toxicity" were used as search terms to search the database of China Knowledge Network,Wanfang,Weipu and PubMed from 2010 to 2018. The current research status and limitations of TCM embryo toxicity are expected to provide reference for subsequent research.
引文
[1]郑依玲,梅全喜,戴卫波,等.妊娠禁忌中药研究概述[J].中国药房,2018,29(3):421-424.
[2]唐欣,谢晓芳,饶朝龙,等.中药发育毒性研究进展[J].中药与临床,2018,9(4):51-55.
[3]吴焱.浅谈妊娠期常用的中药禁忌[A].中国药学会医院药学专业委员会.第三届全国妇产科药学大会论文集[C].中国药学会医院药学专业委员会:中国药学会,2011:7.
[4]王宇光,金锐,孔祥文,等.中药妊娠期用药的安全性等级研究[J].中国中药杂志,2016,41(1):150-153.
[5]朱淑珍,李银保,陈缵光,等.马兜铃水提液对斑马鱼胚胎的致畸作用和心脏毒性的研究[J].中国野生植物资源,2013,32(6):10-13.
[6]程树军.动物实验替代技术研究进展[J].科技导报,2017,35(24):40-47.
[7]宋殿荣,张崴,赵丽颖,等.基于人胎盘屏障体外模型评价双黄连的胚胎毒性[J].中国药理学与毒理学杂志,2017,31(6):649-654.
[8]祁美娟,石美智,韩永龙.斑马鱼在药学领域的应用研究[J].中国药理学通报,2018,34(7):903-906.
[9]王恩力,董方,刘忠,等.牛蒡子苷元对大鼠和家兔的胚胎-胎仔发育毒性研究[J].药物评价研究,2017,40(3):345-350.
[10]谷颖敏,吴韬奋,黄珍祯,等.雄黄对大鼠和兔的胚胎/胎仔的发育毒性[J].中国药理学与毒理学杂志,2013,27(6):1007-1013.
[11] DALLMANN A,SOLODENKO J,INCE I,et al. Applied concepts in PBPK modeling:How to extend an open systems pharmacology model to the special population of pregnant women.[J]. Cpt Pharmacomet Systems Pharmacol,2018,7(7):419-431.
[12] SHARMA R P,SCHUHMACHER M,KUMAR V. The development of a pregnancy PBPK model for bisphenol A and its evaluation with the available biomonitoring data[J]. Sci Total Environ,2018,6249(5):55-68.
[13]赵云龙,冯蓓,周宜,等.红花妊娠毒性选择性表达的实验研究[J].辽宁中医杂志,2011,38(11):2274-2276.
[14]兴桂华,刘玉章,邹宇,等.莪术对妊娠期大鼠子代发育毒性研究[J].中国实验方剂学杂志,2013,19(3):265-268.
[15]岳苹.生半夏及干姜人参半夏方对小鼠胚胎发育及m ESC分化的影响[D].江苏南京:南京中医药大学,2017.
[16]王薇,刘宇聪,佟丽.麻黄汤等超微饮片与传统饮片对斑马鱼胚胎毒性的比较研究[J].中药新药与临床药理,2011,22(5):488-491.
[17]徐建亚,张衎,谢辉辉,等.生半夏及干姜人参半夏丸对小鼠生殖相关毒性的影响[J].中华中医药杂志,2017,32(7):3154-3157.
[2]唐欣,谢晓芳,饶朝龙,等.中药发育毒性研究进展[J].中药与临床,2018,9(4):51-55.
[3]吴焱.浅谈妊娠期常用的中药禁忌[A].中国药学会医院药学专业委员会.第三届全国妇产科药学大会论文集[C].中国药学会医院药学专业委员会:中国药学会,2011:7.
[4]王宇光,金锐,孔祥文,等.中药妊娠期用药的安全性等级研究[J].中国中药杂志,2016,41(1):150-153.
[5]朱淑珍,李银保,陈缵光,等.马兜铃水提液对斑马鱼胚胎的致畸作用和心脏毒性的研究[J].中国野生植物资源,2013,32(6):10-13.
[6]程树军.动物实验替代技术研究进展[J].科技导报,2017,35(24):40-47.
[7]宋殿荣,张崴,赵丽颖,等.基于人胎盘屏障体外模型评价双黄连的胚胎毒性[J].中国药理学与毒理学杂志,2017,31(6):649-654.
[8]祁美娟,石美智,韩永龙.斑马鱼在药学领域的应用研究[J].中国药理学通报,2018,34(7):903-906.
[9]王恩力,董方,刘忠,等.牛蒡子苷元对大鼠和家兔的胚胎-胎仔发育毒性研究[J].药物评价研究,2017,40(3):345-350.
[10]谷颖敏,吴韬奋,黄珍祯,等.雄黄对大鼠和兔的胚胎/胎仔的发育毒性[J].中国药理学与毒理学杂志,2013,27(6):1007-1013.
[11] DALLMANN A,SOLODENKO J,INCE I,et al. Applied concepts in PBPK modeling:How to extend an open systems pharmacology model to the special population of pregnant women.[J]. Cpt Pharmacomet Systems Pharmacol,2018,7(7):419-431.
[12] SHARMA R P,SCHUHMACHER M,KUMAR V. The development of a pregnancy PBPK model for bisphenol A and its evaluation with the available biomonitoring data[J]. Sci Total Environ,2018,6249(5):55-68.
[13]赵云龙,冯蓓,周宜,等.红花妊娠毒性选择性表达的实验研究[J].辽宁中医杂志,2011,38(11):2274-2276.
[14]兴桂华,刘玉章,邹宇,等.莪术对妊娠期大鼠子代发育毒性研究[J].中国实验方剂学杂志,2013,19(3):265-268.
[15]岳苹.生半夏及干姜人参半夏方对小鼠胚胎发育及m ESC分化的影响[D].江苏南京:南京中医药大学,2017.
[16]王薇,刘宇聪,佟丽.麻黄汤等超微饮片与传统饮片对斑马鱼胚胎毒性的比较研究[J].中药新药与临床药理,2011,22(5):488-491.
[17]徐建亚,张衎,谢辉辉,等.生半夏及干姜人参半夏丸对小鼠生殖相关毒性的影响[J].中华中医药杂志,2017,32(7):3154-3157.