没食子酸的生物学功能及在畜禽生产中的应用
|
摘要
近年来,集约化养殖伴随的畜禽健康以及环境污染问题日益突出,寻找非抗生素的解决方案是当前养殖业的重要任务。研究发现植物源生物活性物质可改善畜禽机体和肠道健康。没食子酸是一种天然存在的含酚环有机酸,具有抑菌、抗氧化、抗炎症和抗肿瘤等生物学功效,并且在饲粮中添加没食子酸也可调节畜禽生长并改善健康状况。本文简述了没食子酸的生物学功能及其调控畜禽生产的研究进展,以期为没食子酸在畜禽养殖生产中的应用提供理论依据和应用参考。
In recent years,the issues of livestock and poultry health and environmental pollution associated with the intensive breeding industry have become increasingly prominent.Thus,it is an important task to find the effective strategies aiming to improve health status of animals and limit the usage of antibiotics in the current livestock and poultry industry.Previous studies demonstrated that plant-derived bioactive substances could improve the systemic and intestinal health of livestock and poultry.Gallic acid is a naturally organic phenolic acid,which has a diverse range of biological effects such as anti-bacterial,anti-oxidant,anti-inflammatory,anti-tumor,etc.In addition,dietary gallic acid can regulate the growth performance and improve health status of livestock and poultry.In this paper,the research progress in biological functions of gallic acid and its regulatory effects on livestock and poultry production were reviewed,which may provide the scientific evidence and application reference for the application of gallic acid in livestock and poultry production.
In recent years,the issues of livestock and poultry health and environmental pollution associated with the intensive breeding industry have become increasingly prominent.Thus,it is an important task to find the effective strategies aiming to improve health status of animals and limit the usage of antibiotics in the current livestock and poultry industry.Previous studies demonstrated that plant-derived bioactive substances could improve the systemic and intestinal health of livestock and poultry.Gallic acid is a naturally organic phenolic acid,which has a diverse range of biological effects such as anti-bacterial,anti-oxidant,anti-inflammatory,anti-tumor,etc.In addition,dietary gallic acid can regulate the growth performance and improve health status of livestock and poultry.In this paper,the research progress in biological functions of gallic acid and its regulatory effects on livestock and poultry production were reviewed,which may provide the scientific evidence and application reference for the application of gallic acid in livestock and poultry production.
引文
[1]PAPATSIROS V G,CHRISTODOULOPOULOS G,FILIPPOPOULOS L C.The use of organic acids in monogastric animals(swine and rabbits)[J].Journal of Cell and Animal Biology,2012,6(10):154-159.
[2]CASTANON J I R.History of the use of antibiotic as grow th promoters in European poultry feeds[J].Poultry Science,2007,86(11):2466-2471.
[3]柯发敏.没食子酸的研究进展[J].泸州医学院学报,2011,34(4):440-442.
[4]郑曙明,黄建军,吴青,等.复方五倍子有效成分的分离鉴定及抑菌活性研究[J].水生生物学报,2010,34(1):57-64.
[5]高雅,李骅,王四旺,等.没食子酸的药理作用及其药物代谢动力学研究进展[J].西北药学杂志,2014,29(4):435-438.
[6]罗媛,杨武,孙慧园,等.没食子酸和原儿茶酸在大鼠肠道菌群中的代谢研究[J].沈阳药科大学学报,2017,34(1):43-47.
[7]孙慧园,覃小丽,梅朝叶,等.头花蓼有效组分中没食子酸、原儿茶酸在模式生物斑马鱼中的代谢研究[J].中国药理学通报,2017,33(3):388-393.
[8]LIPIN'SKI K,MAZUR M,ANTOSZKIEWICZ Z,et al.Polyphenols in monogastric nutrition-a review[J].Annals of Animal Science,2017,17(1):41-58.
[9]张雅丽,李建科,刘柳,等.五倍子没食子酸研究进展[J].食品工业科技,2013,34(10):386-390.
[10]SHAO D Y,LI J,LI J,et al.Inhibition of gallic acid on the grow th and biofilm formation of Escherichia coli and Streptococcus mutans[J].Journal of Food Science,2015,80(6):M1299-M1305.
[11]LPEZ-ROMERO J C,VALENZUELA-MELENDRES M,JUNEJA V K,et al.Effects and interactions of gallic acid,eugenol and temperature on thermal inactivation of Salmonella spp.in ground chicken[J].Food Research International,2017,103:289-294.
[12]BORGES A,FERREIRA C,SAAVEDRA MJ,et al.Antibacterial activity and mode of action of ferulic and gallic acids against pathogenic bacteria[J].Microbial Drug Resistance,2013,19(4):256-265.
[13]DAZ-GMEZ R,LPEZ-SOLS R,OBREQUE-SLIER E,et al.Comparative antibacterial effect of gallic acid and catechin against Helicobacter pylori[J].LWT-Food Science and Technology,2013,54(2):331-335.
[14]王广娟.五倍子没食子酸的提取、纯化及抑菌效果研究[D].硕士学位论文.保定:河北农业大学,2010.
[15]张雅丽.五倍子没食子酸的制备、抑菌作用及机理研究[D].硕士学位论文.西安:陕西师范大学,2013.
[16]KANG MS,OH J S,KANG I C,et al.Inhibitory effect of methyl gallate and gallic acid on oral bacteria[J].Journal of Microbiology,2008,46(6):744-750.
[17]YEN G C,DUH P D,TSAI H L.Antioxidant and prooxidant properties of ascorbic acid and gallic acid[J].Food Chemistry,2002,79(3):307-313.
[18]谢晓艳,刘洪涛,张吉,等.没食子酸体外抗氧化作用研究[J].重庆医科大学学报,2011,36(3):319-322.
[19]FLORA S J S.Structural,chemical and biological aspects of antioxidants for strategies against metal and metalloid exposure[J].Oxidative Medicine and Cellular Longevity,2009,2(4):191-206.
[20]VERGAUWEN H,PRIMS S,DEGROOTE J,et al.In vitro investigation of six antioxidants for pig diets[J].Antioxidants,2016,5(4):E41.
[21]KIMY J.Antimelanogenic and antioxidant properties of gallic acid[J].Biological and Pharmaceutical Bulletin,2007,30(6):1052-1055.
[22]KROES B H,VAN DEN BERG A J,VAN UFFORD H C Q,et al.Anti-inflammatory activity of gallic acid[J].Planta Medica,1992,58(6):499-504.
[23]黄丽华,侯林,薛海南,等.没食子酸通过拮抗脂多糖诱导的TLR4/NF-κB活化抑制RAW264.7巨噬细胞炎性反应[J].细胞与分子免疫学杂志,2016,32(12):1610-1614.
[24]JIANG D X,ZHANG MH,ZHANG Q,et al.Influence of gallic acid on porcine neutrophils phosphodiesterase 4,IL-6,TNF-αand rat arthritis model[J].Journal of Integrative Agriculture,2015,14(4):758-764.
[25]PANDURANGAN A K,MOHEBALI N,ESA N M,et al.Gallic acid suppresses inflammation in dextran sodium sulfate-induced colitis in mice:possible mechanisms[J].International Immunopharmacology,2015,28(2):1034-1043.
[26]VERMA S,SINGH A,MISHRA A.Gallic acid:molecular rival of cancer[J].Environmental Toxicology and Pharmacology,2013,35(3):473-485.
[27]AHN C B,JUNG W K,PARK S J,et al.Gallic Acidg-chitosan modulates inflammatory responses in LPSstimulated RAW264.7 cells via NF-κB,AP-1,and MAPK pathways[J].Inflammation,2016,39(1):366-374.
[28]CORREA L B,PDUA T A,SEITO L N,et al.Antiinflammatory effect of methyl gallate on experimental arthritis:inhibition of neutrophil recruitment,production of inflammatory mediators,and activation of macrophages[J].Journal of Natural Products,2016,79(6):1554-1566.
[29]YOU B R,PARK W H.Gallic acid-induced lung cancer cell death is related to glutathione depletion as well as reactive oxygen species increase[J].Toxicology in Vitro,2010,24(5):1356-1362.
[30]KAUR M,VELMURUGAN B,RAJAMANICKAMS,et al.Gallic acid,an active constituent of grape seed extract,exhibits anti-proliferative,pro-apoptotic and anti-tumorigenic effects against prostate carcinoma xenograft grow th in nude mice[J].Pharmaceutical Research,2009,26(9):2133-2140.
[31]李沐涵,殷美琦,冯靖涵,等.没食子酸抗肿瘤作用研究进展[J].中医药信息,2011,28(1):109-111.
[32]CHEN H M,WU Y C,CHIA Y C,et al.Gallic acid,a major component of Toona sinensis leaf extracts,contains a ROS-mediated anti-cancer activity in human prostate cancer cells[J].Cancer Letters,2009,286(2):161-171.
[33]KOBAYASHI H,OIKAWA S,HIRAKAWA K,et al.Metal-mediated oxidative damage to cellular and isolated DNA by gallic acid,a metabolite of antioxidant propyl gallate[J].Mutation Research/Genetic Toxicology and Environmental Mutagenesis,2004,558(1/2):111-120.
[34]HSU C L,LO W H,YEN G C.Gallic acid induces apoptosis in 3T3-L1 pre-adipocytes via a fas-and mitochondrial-mediated pathway[J].Journal of Agricultural and Food Chemistry,2007,55(18):7359-7365.
[35]YOU B R,HWAJIN M,HAN Y H,et al.Gallic acid inhibits the grow th of HeLa cervical cancer cells via apoptosis and/or necrosis[J].Food and Chemical Toxicology,2010,48(5):1334-1340.
[36]GREEN D R,REED J C.Mitochondria and apoptosis[J].Science,1998,281(5381):1309-1312.
[37]EFSA Panel on Additives and Products or Substances Used in Animal Feed(FEEDAP).Scientific Opinion on the safety and efficacy of benzyl alcohols,aldehydes,acids,esters and acetals(chemical group 23)when used as flavourings for all animal species[J].EFSA Journal,2012,10(7):2785.
[38]STARCˇEVIC'K,KRSTULOVIC'L,BROZIC'D,et al.Production performance,meat composition and oxidative susceptibility in broiler chicken fed with different phenolic compounds[J].Journal of the Science of Food and Agriculture,2015,95(6):1172-1178.
[39]MAEK T,STARCˇEVIC'K,MIKULEC Zˇ.The influence of the addition of thymol,tannic acid or gallic acid to broiler diet on grow th performance,serum malondialdehyde value and cecal fermentation[J].European Poultry Science,2014,78:1-8.
[40]SAMUEL K G,WANG J,YUE H Y,et al.Effects of dietary gallic acid supplementation on performance,antioxidant status,and jejunum intestinal morphology in broiler chicks[J].Poultry Science,2017,96(8):2768-2775.
[41]SALAHEEN S,KIMS W,HALEY B J,et al.Alternative grow th promoters modulate broiler gut microbiome and enhance body weight gain[J].Front in Microbiology,2017,8:2088.
[42]韩国清,朱晓彤,束刚,等.自由基清除剂对仔猪生长及血液氧化代谢相关指标的影响[J].畜牧与兽医,2012,44(Suppl.1):274-275.
[43]LEE K H,JUNG S,KIMH J,et al.Effect of dietary supplementation of the combination of gallic and linoleic acid in thigh meat of broilers[J].Asian-Australasian Journal of Animal Sciences,2012,25(11):1641-1648.
[44]JUNG S,HAN B H,NAMK,et al.Effect of dietary supplementation of gallic acid and linoleic acid mixture or their synthetic salt on egg quality[J].Food Chemistry,2011,129(3):822-829.
[45]HANCZAKOWSKA E,S'WIATKIEWICZ M.Gallic acid or sage extract supplement in feed mixtures for finishing pigs[J].Journal of Animal and Feed Sciences,2005,14(1):353-356.
[46]赵广永.没食子酸对肉牛瘤胃发酵、营养物质消化及氮排放的影响[C]//中国畜牧兽医学会动物营养学分会第十二次动物营养学术研讨会论文集.北京:中国农业大学出版社,2016:489.
[47]YANG J Y,ZHANG H J,WANG J,et al.Effects of dietary grape proanthocyanidins on the grow th performance,jejunum morphology and plasma biochemical indices of broiler chicks[J].Animal,2016,11(5):762-770.
[48]VIVEROS A,CHAMORRO S,PIZARRO M,et al.Effects of dietary polyphenol-rich grape products on intestinal microflora and gut morphology in broiler chicks[J].Poultry Science,2011,90(3):566-578.
[49]WEI C,YANG K,ZHAO G Y,et al.Effect of dietary supplementation of gallic acid on nitrogen balance,nitrogen excretion pattern and urinary nitrogenous constituents in beef cattle[J].Archives of Animal Nutrition,2016,70(5):416-423.
[50]GEERKENS C H,SCHWEIGGERT R M,STEINGASS H,et al.Influence of apple and citrus pectins,processed mango peels,a phenolic mango peel extract,and gallic acid as potential feed supplements on in vitro total gas production and rumen methanogenesis[J].Journal of Agricultural and Food Chemistry,2013,61(24):5727-5737.
[51]魏晨.没食子酸和缩合单宁对体外瘤胃发酵及肉牛营养物质消化、甲烷产量和氮代谢影响的研究[D].博士学位论文.北京:中国农业大学,2017.
[2]CASTANON J I R.History of the use of antibiotic as grow th promoters in European poultry feeds[J].Poultry Science,2007,86(11):2466-2471.
[3]柯发敏.没食子酸的研究进展[J].泸州医学院学报,2011,34(4):440-442.
[4]郑曙明,黄建军,吴青,等.复方五倍子有效成分的分离鉴定及抑菌活性研究[J].水生生物学报,2010,34(1):57-64.
[5]高雅,李骅,王四旺,等.没食子酸的药理作用及其药物代谢动力学研究进展[J].西北药学杂志,2014,29(4):435-438.
[6]罗媛,杨武,孙慧园,等.没食子酸和原儿茶酸在大鼠肠道菌群中的代谢研究[J].沈阳药科大学学报,2017,34(1):43-47.
[7]孙慧园,覃小丽,梅朝叶,等.头花蓼有效组分中没食子酸、原儿茶酸在模式生物斑马鱼中的代谢研究[J].中国药理学通报,2017,33(3):388-393.
[8]LIPIN'SKI K,MAZUR M,ANTOSZKIEWICZ Z,et al.Polyphenols in monogastric nutrition-a review[J].Annals of Animal Science,2017,17(1):41-58.
[9]张雅丽,李建科,刘柳,等.五倍子没食子酸研究进展[J].食品工业科技,2013,34(10):386-390.
[10]SHAO D Y,LI J,LI J,et al.Inhibition of gallic acid on the grow th and biofilm formation of Escherichia coli and Streptococcus mutans[J].Journal of Food Science,2015,80(6):M1299-M1305.
[11]LPEZ-ROMERO J C,VALENZUELA-MELENDRES M,JUNEJA V K,et al.Effects and interactions of gallic acid,eugenol and temperature on thermal inactivation of Salmonella spp.in ground chicken[J].Food Research International,2017,103:289-294.
[12]BORGES A,FERREIRA C,SAAVEDRA MJ,et al.Antibacterial activity and mode of action of ferulic and gallic acids against pathogenic bacteria[J].Microbial Drug Resistance,2013,19(4):256-265.
[13]DAZ-GMEZ R,LPEZ-SOLS R,OBREQUE-SLIER E,et al.Comparative antibacterial effect of gallic acid and catechin against Helicobacter pylori[J].LWT-Food Science and Technology,2013,54(2):331-335.
[14]王广娟.五倍子没食子酸的提取、纯化及抑菌效果研究[D].硕士学位论文.保定:河北农业大学,2010.
[15]张雅丽.五倍子没食子酸的制备、抑菌作用及机理研究[D].硕士学位论文.西安:陕西师范大学,2013.
[16]KANG MS,OH J S,KANG I C,et al.Inhibitory effect of methyl gallate and gallic acid on oral bacteria[J].Journal of Microbiology,2008,46(6):744-750.
[17]YEN G C,DUH P D,TSAI H L.Antioxidant and prooxidant properties of ascorbic acid and gallic acid[J].Food Chemistry,2002,79(3):307-313.
[18]谢晓艳,刘洪涛,张吉,等.没食子酸体外抗氧化作用研究[J].重庆医科大学学报,2011,36(3):319-322.
[19]FLORA S J S.Structural,chemical and biological aspects of antioxidants for strategies against metal and metalloid exposure[J].Oxidative Medicine and Cellular Longevity,2009,2(4):191-206.
[20]VERGAUWEN H,PRIMS S,DEGROOTE J,et al.In vitro investigation of six antioxidants for pig diets[J].Antioxidants,2016,5(4):E41.
[21]KIMY J.Antimelanogenic and antioxidant properties of gallic acid[J].Biological and Pharmaceutical Bulletin,2007,30(6):1052-1055.
[22]KROES B H,VAN DEN BERG A J,VAN UFFORD H C Q,et al.Anti-inflammatory activity of gallic acid[J].Planta Medica,1992,58(6):499-504.
[23]黄丽华,侯林,薛海南,等.没食子酸通过拮抗脂多糖诱导的TLR4/NF-κB活化抑制RAW264.7巨噬细胞炎性反应[J].细胞与分子免疫学杂志,2016,32(12):1610-1614.
[24]JIANG D X,ZHANG MH,ZHANG Q,et al.Influence of gallic acid on porcine neutrophils phosphodiesterase 4,IL-6,TNF-αand rat arthritis model[J].Journal of Integrative Agriculture,2015,14(4):758-764.
[25]PANDURANGAN A K,MOHEBALI N,ESA N M,et al.Gallic acid suppresses inflammation in dextran sodium sulfate-induced colitis in mice:possible mechanisms[J].International Immunopharmacology,2015,28(2):1034-1043.
[26]VERMA S,SINGH A,MISHRA A.Gallic acid:molecular rival of cancer[J].Environmental Toxicology and Pharmacology,2013,35(3):473-485.
[27]AHN C B,JUNG W K,PARK S J,et al.Gallic Acidg-chitosan modulates inflammatory responses in LPSstimulated RAW264.7 cells via NF-κB,AP-1,and MAPK pathways[J].Inflammation,2016,39(1):366-374.
[28]CORREA L B,PDUA T A,SEITO L N,et al.Antiinflammatory effect of methyl gallate on experimental arthritis:inhibition of neutrophil recruitment,production of inflammatory mediators,and activation of macrophages[J].Journal of Natural Products,2016,79(6):1554-1566.
[29]YOU B R,PARK W H.Gallic acid-induced lung cancer cell death is related to glutathione depletion as well as reactive oxygen species increase[J].Toxicology in Vitro,2010,24(5):1356-1362.
[30]KAUR M,VELMURUGAN B,RAJAMANICKAMS,et al.Gallic acid,an active constituent of grape seed extract,exhibits anti-proliferative,pro-apoptotic and anti-tumorigenic effects against prostate carcinoma xenograft grow th in nude mice[J].Pharmaceutical Research,2009,26(9):2133-2140.
[31]李沐涵,殷美琦,冯靖涵,等.没食子酸抗肿瘤作用研究进展[J].中医药信息,2011,28(1):109-111.
[32]CHEN H M,WU Y C,CHIA Y C,et al.Gallic acid,a major component of Toona sinensis leaf extracts,contains a ROS-mediated anti-cancer activity in human prostate cancer cells[J].Cancer Letters,2009,286(2):161-171.
[33]KOBAYASHI H,OIKAWA S,HIRAKAWA K,et al.Metal-mediated oxidative damage to cellular and isolated DNA by gallic acid,a metabolite of antioxidant propyl gallate[J].Mutation Research/Genetic Toxicology and Environmental Mutagenesis,2004,558(1/2):111-120.
[34]HSU C L,LO W H,YEN G C.Gallic acid induces apoptosis in 3T3-L1 pre-adipocytes via a fas-and mitochondrial-mediated pathway[J].Journal of Agricultural and Food Chemistry,2007,55(18):7359-7365.
[35]YOU B R,HWAJIN M,HAN Y H,et al.Gallic acid inhibits the grow th of HeLa cervical cancer cells via apoptosis and/or necrosis[J].Food and Chemical Toxicology,2010,48(5):1334-1340.
[36]GREEN D R,REED J C.Mitochondria and apoptosis[J].Science,1998,281(5381):1309-1312.
[37]EFSA Panel on Additives and Products or Substances Used in Animal Feed(FEEDAP).Scientific Opinion on the safety and efficacy of benzyl alcohols,aldehydes,acids,esters and acetals(chemical group 23)when used as flavourings for all animal species[J].EFSA Journal,2012,10(7):2785.
[38]STARCˇEVIC'K,KRSTULOVIC'L,BROZIC'D,et al.Production performance,meat composition and oxidative susceptibility in broiler chicken fed with different phenolic compounds[J].Journal of the Science of Food and Agriculture,2015,95(6):1172-1178.
[39]MAEK T,STARCˇEVIC'K,MIKULEC Zˇ.The influence of the addition of thymol,tannic acid or gallic acid to broiler diet on grow th performance,serum malondialdehyde value and cecal fermentation[J].European Poultry Science,2014,78:1-8.
[40]SAMUEL K G,WANG J,YUE H Y,et al.Effects of dietary gallic acid supplementation on performance,antioxidant status,and jejunum intestinal morphology in broiler chicks[J].Poultry Science,2017,96(8):2768-2775.
[41]SALAHEEN S,KIMS W,HALEY B J,et al.Alternative grow th promoters modulate broiler gut microbiome and enhance body weight gain[J].Front in Microbiology,2017,8:2088.
[42]韩国清,朱晓彤,束刚,等.自由基清除剂对仔猪生长及血液氧化代谢相关指标的影响[J].畜牧与兽医,2012,44(Suppl.1):274-275.
[43]LEE K H,JUNG S,KIMH J,et al.Effect of dietary supplementation of the combination of gallic and linoleic acid in thigh meat of broilers[J].Asian-Australasian Journal of Animal Sciences,2012,25(11):1641-1648.
[44]JUNG S,HAN B H,NAMK,et al.Effect of dietary supplementation of gallic acid and linoleic acid mixture or their synthetic salt on egg quality[J].Food Chemistry,2011,129(3):822-829.
[45]HANCZAKOWSKA E,S'WIATKIEWICZ M.Gallic acid or sage extract supplement in feed mixtures for finishing pigs[J].Journal of Animal and Feed Sciences,2005,14(1):353-356.
[46]赵广永.没食子酸对肉牛瘤胃发酵、营养物质消化及氮排放的影响[C]//中国畜牧兽医学会动物营养学分会第十二次动物营养学术研讨会论文集.北京:中国农业大学出版社,2016:489.
[47]YANG J Y,ZHANG H J,WANG J,et al.Effects of dietary grape proanthocyanidins on the grow th performance,jejunum morphology and plasma biochemical indices of broiler chicks[J].Animal,2016,11(5):762-770.
[48]VIVEROS A,CHAMORRO S,PIZARRO M,et al.Effects of dietary polyphenol-rich grape products on intestinal microflora and gut morphology in broiler chicks[J].Poultry Science,2011,90(3):566-578.
[49]WEI C,YANG K,ZHAO G Y,et al.Effect of dietary supplementation of gallic acid on nitrogen balance,nitrogen excretion pattern and urinary nitrogenous constituents in beef cattle[J].Archives of Animal Nutrition,2016,70(5):416-423.
[50]GEERKENS C H,SCHWEIGGERT R M,STEINGASS H,et al.Influence of apple and citrus pectins,processed mango peels,a phenolic mango peel extract,and gallic acid as potential feed supplements on in vitro total gas production and rumen methanogenesis[J].Journal of Agricultural and Food Chemistry,2013,61(24):5727-5737.
[51]魏晨.没食子酸和缩合单宁对体外瘤胃发酵及肉牛营养物质消化、甲烷产量和氮代谢影响的研究[D].博士学位论文.北京:中国农业大学,2017.