高效液相色谱法测定食品模拟物中偏苯三甲酸酐的含量
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摘要
目的建立高效液相色谱法测定5种食品模拟物中偏苯三甲酸酐迁移量的分析方法。方法以4%(V:V)乙酸溶液、10%(V:V)乙醇溶液、20%(V:V)乙醇溶液、50%(V:V)乙醇溶液、橄榄油分别模拟酸性、水性、酒精类以及油脂类食品,通过高效液相色谱法(high performance liquid chromatography HPLC)测定食品模拟物中的偏苯三甲酸的含量,采用外标法定量,计算出偏苯三甲酸酐的迁移量。结果各模拟物中加标回收率为96.7%~104.0%,相对标准偏差为0.2%~3.7%,水基食品模拟物中该方法的检出限和定量限分别为0.2、0.5 mg/L,橄榄油食品模拟物中该方法的检出限和定量限分别为0.2、0.5 mg/kg。结论该方法具有良好的准确度和精密度,可以准确测定各种食品接触材料中偏苯三甲酸酐的迁移量。
Objective To establish a method for the determination of concentration of trimellitic anhydride in food simulants by high performance liquid chromatography.Methods The 4%(V:V) acetic acid solution,10%(V:V) ethanol solution,20%(V:V) ethanol solution,50%(V:V) ethanol solution,and olive oil were used to simulate acid,water,and alcohol,respectively.The content of trimellitic acid in the food simulants were determined by high performance liquid chromatography(HPLC) and quantified by external standard method to calculate the migration amount of trimellitic anhydride.Results The recoveries were 96.7%-104.0%,the relative standard deviations were 0.2%-3.7%,and the limits of detection and quantification in water-based food simulants were 0.2 mg/L and 0.5 mg/L,respectively.The detection limit and quantitation limits of the method in olive oil food simulants were 0.2 mg/L and 0.5 mg/kg,respectively.Conclusion This method has good accuracy and precision,which can accurately determine the migration amount of trimellitic anhydride in various food contacting materials.
Objective To establish a method for the determination of concentration of trimellitic anhydride in food simulants by high performance liquid chromatography.Methods The 4%(V:V) acetic acid solution,10%(V:V) ethanol solution,20%(V:V) ethanol solution,50%(V:V) ethanol solution,and olive oil were used to simulate acid,water,and alcohol,respectively.The content of trimellitic acid in the food simulants were determined by high performance liquid chromatography(HPLC) and quantified by external standard method to calculate the migration amount of trimellitic anhydride.Results The recoveries were 96.7%-104.0%,the relative standard deviations were 0.2%-3.7%,and the limits of detection and quantification in water-based food simulants were 0.2 mg/L and 0.5 mg/L,respectively.The detection limit and quantitation limits of the method in olive oil food simulants were 0.2 mg/L and 0.5 mg/kg,respectively.Conclusion This method has good accuracy and precision,which can accurately determine the migration amount of trimellitic anhydride in various food contacting materials.
引文
[1]赵小平,李春华.我国偏苯三酸酐行业发展概况及均苯三甲酸产业的开发[J].安徽化工,2016,42(4):5-12.Zhao XP,Li CH.The development of trimellitic anhydride industry in China and the development of the trimellitic acid industry[J].Anhui Chem Ind,2016,42(4):5-12.
[2]冯世良.我国偏苯三酸酐产业发展现状及思考[J].中国石油和化工经济分析,2011,(8):50-53.Feng SL.Development status and thinking of trimellitic anhydride industry in China[J].China Petrol Chem Econ Anal,2011,(8):50-53.
[3]金栋,晓铭.偏苯三酸酐的生产应用及市场前景[J].化工文摘,2009,(4):21-24.Jin D,Xiao M.Production,application and market prospect of trimellitic anhydride[J].Chem Abstr,2009,(4):21-24.
[4]崔小明.偏苯三酸酐的生产和应用[J].杭州化工,2005,35(3):23-27.Cui XM.Production and application of trimellitic anhydride[J].Hangzhou Chem Ind,2005,35(3):23-27.
[5]崔小明.偏苯三酸酐的生产应用及市场前景[J].化工科技市场,2009,32(11):24-28.Cui XM.Production and application of trimellitic anhydride and its market prospects[J].Chem Technol Mark,2009,32(11):24-28.
[6]石晓永,史润萍,卢云.偏苯三酸酐生产技术与应用[J].塑料助剂,2008,(4):19-22.Shi XY,Shi RP,Lu Y.Trimellitic anhydride production technology and application[J].Plastic Add,2008,(4):19-22.
[7]宋云英,燕丰.偏苯三酸酐的生产应用及国内市场分析[J].四川化工,2005,(3):35-39.Song YY,Yan F.Production and application of trimellitic anhydride and domestic market analysis[J].Sichuan Chem Ind,2005,(3):35-39.
[8]GB 9685-2016食品安全国家标准食品接触材料及制品用添加剂使用标准[S].GB 9685-2016 National food safety standard-Standards for the use of additives for food contact materials and products[S].
[9]J?nsson BAG,Welinder H,Pf?ffli P.Determination of cyclic organic acid anhydrides in air using gas chromatography.Part 1.A review[J].Analyst,1996,121(9):1279-1284.
[10]Nashed NE,Lindenbaum S.Construction,characteristics and application of a benzene-1,2,4-tricarboxylic acid selective electrode[J].Analyst,1987,112(2):205-207.
[11]Yassine MM,Dabekzlotorzynska E.Determination of benzene polycarboxylic acids in atmospheric aerosols and vehicular emissions by liquid chromatography-mass spectrometry[J].Anal Method,2010,2(2):129-134.
[12]王建玱,肖笑峰,陈彤,等.高效液相色谱-紫外检测法同时测定食品接触材料中7种苯多酸及其衍生物的特定总迁移量[J].色谱,2015,33(8):856-863.Wang JL,Xiao XF,Chen T et al.Simultaneous determination of specific total migration of seven benzoic acids and their derivatives in food contact materials by high performance liquid chromatography-ultraviolet detection[J].Chin J Chromatogr,2015,33(8):856-863.
[13]Standards I.Materials and articles in contact with foodstuffs-plastics substances subject to limitation-Part 13:determination of2,2-bis(4-hydroxyphenyl)propane(bisphenol A)in food stimulants[J].Eur Stand,2006,(2):1-7
[14]GB 31604.40-2016食品安全国家标准食品接触材料及制品顺丁烯二酸及其酸酐迁移量[S].GB 31604.40-2016 National food safety standard-Food contact materials-Determination of maleic acid and maleic anhydride in food simulants[S].
[15]GB 31604.1-2015食品接触材料及制品迁移试验通则[S].GB 31604.1-2015 General rules for food contact materials and product migration tests[S].
[16]GB 5009.156-2016食品接触材料及制品迁移试验预处理通则[S].GB 5009.156-2016 General rules for pretreatment food contact materials and product migration tests[S]
[2]冯世良.我国偏苯三酸酐产业发展现状及思考[J].中国石油和化工经济分析,2011,(8):50-53.Feng SL.Development status and thinking of trimellitic anhydride industry in China[J].China Petrol Chem Econ Anal,2011,(8):50-53.
[3]金栋,晓铭.偏苯三酸酐的生产应用及市场前景[J].化工文摘,2009,(4):21-24.Jin D,Xiao M.Production,application and market prospect of trimellitic anhydride[J].Chem Abstr,2009,(4):21-24.
[4]崔小明.偏苯三酸酐的生产和应用[J].杭州化工,2005,35(3):23-27.Cui XM.Production and application of trimellitic anhydride[J].Hangzhou Chem Ind,2005,35(3):23-27.
[5]崔小明.偏苯三酸酐的生产应用及市场前景[J].化工科技市场,2009,32(11):24-28.Cui XM.Production and application of trimellitic anhydride and its market prospects[J].Chem Technol Mark,2009,32(11):24-28.
[6]石晓永,史润萍,卢云.偏苯三酸酐生产技术与应用[J].塑料助剂,2008,(4):19-22.Shi XY,Shi RP,Lu Y.Trimellitic anhydride production technology and application[J].Plastic Add,2008,(4):19-22.
[7]宋云英,燕丰.偏苯三酸酐的生产应用及国内市场分析[J].四川化工,2005,(3):35-39.Song YY,Yan F.Production and application of trimellitic anhydride and domestic market analysis[J].Sichuan Chem Ind,2005,(3):35-39.
[8]GB 9685-2016食品安全国家标准食品接触材料及制品用添加剂使用标准[S].GB 9685-2016 National food safety standard-Standards for the use of additives for food contact materials and products[S].
[9]J?nsson BAG,Welinder H,Pf?ffli P.Determination of cyclic organic acid anhydrides in air using gas chromatography.Part 1.A review[J].Analyst,1996,121(9):1279-1284.
[10]Nashed NE,Lindenbaum S.Construction,characteristics and application of a benzene-1,2,4-tricarboxylic acid selective electrode[J].Analyst,1987,112(2):205-207.
[11]Yassine MM,Dabekzlotorzynska E.Determination of benzene polycarboxylic acids in atmospheric aerosols and vehicular emissions by liquid chromatography-mass spectrometry[J].Anal Method,2010,2(2):129-134.
[12]王建玱,肖笑峰,陈彤,等.高效液相色谱-紫外检测法同时测定食品接触材料中7种苯多酸及其衍生物的特定总迁移量[J].色谱,2015,33(8):856-863.Wang JL,Xiao XF,Chen T et al.Simultaneous determination of specific total migration of seven benzoic acids and their derivatives in food contact materials by high performance liquid chromatography-ultraviolet detection[J].Chin J Chromatogr,2015,33(8):856-863.
[13]Standards I.Materials and articles in contact with foodstuffs-plastics substances subject to limitation-Part 13:determination of2,2-bis(4-hydroxyphenyl)propane(bisphenol A)in food stimulants[J].Eur Stand,2006,(2):1-7
[14]GB 31604.40-2016食品安全国家标准食品接触材料及制品顺丁烯二酸及其酸酐迁移量[S].GB 31604.40-2016 National food safety standard-Food contact materials-Determination of maleic acid and maleic anhydride in food simulants[S].
[15]GB 31604.1-2015食品接触材料及制品迁移试验通则[S].GB 31604.1-2015 General rules for food contact materials and product migration tests[S].
[16]GB 5009.156-2016食品接触材料及制品迁移试验预处理通则[S].GB 5009.156-2016 General rules for pretreatment food contact materials and product migration tests[S]