填精补肾养血疏肝方联合中药外敷治疗卵巢早衰的临床研究
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摘要
目的:探讨填精补肾养血疏肝方内服与中药外敷联合治疗卵巢早衰的临床疗效。方法:选取2015年2月-2018年1月于我院就诊的卵巢早衰患者84例,随机等分为观察组(42例)与对照组(42例),对照组予以人工周期法治疗,观察组在此基础上予以填精补肾养血疏肝方内服与中药外敷联合治疗,对比两组治疗效果。结果:观察组患者的治疗总有效率显著高于对照组(P <0.05)。观察组患者治疗后的子宫内膜厚度、子宫体积、卵巢体积显著大于对照组(P <0.05)。观察组患者治疗后的促卵泡生成素(Follicle-Stimulating Hormone,FSH)、促黄体生成素(Luteinizing Hormone,LH)水平显著低于对照组,雌二醇(Estradiol,E_2)水平显著高于对照组(P <0.05)。观察组患者治疗后的CD4~+、CD4~+/CD8~+水平显著高于对照组,CD8~+水平显著低于对照组(P <0.05)。结论:填精补肾养血疏肝方内服与中药外敷联合治疗可有效改善卵巢早衰患者的卵巢储备功能,调节患者的内分泌及免疫功能,治疗疗效显著,值得进一步在临床上推荐使用。
Objective: To investigate efficacy of the Tianjing Bushen Yangxue Shugan prescription(填精补肾养血疏肝方) plus TCM external application on premature ovarian failure. Methods: February 2015-January 2018, 84 cases were divided into 2 groups,42 cases in each. The control group was given artificial adjustment of menstrual cycle therapy; and the observation group was given the Tianjing Bushen Yangxue Shugan prescription plus TCM external application more. Results: The total efficiency in the observation group was significantly higher(P<0.05). After treatment, the endometrial thickness, uterine volume, and ovarian volume in the observation group were significantly greater(P<0.05). After treatment, the levels of FSH and LH in the observation group were significantly lower, and the level of E_2 was significantly higher than the control group(P<0.05). After treatment, the levels of CD4~+ and CD4~+/CD8~+ in the observation group were significantly higher than those in the control group, and the level of CD8~+ was significantly lower than that in the control group(P<0.05). Conclusion: The tianjing Bushen Yangxue Shugan prescription plus TCM external application on premature ovarian failure show a good effect, regulate endocrine and immune function, is worthy of clinical promotion.
Objective: To investigate efficacy of the Tianjing Bushen Yangxue Shugan prescription(填精补肾养血疏肝方) plus TCM external application on premature ovarian failure. Methods: February 2015-January 2018, 84 cases were divided into 2 groups,42 cases in each. The control group was given artificial adjustment of menstrual cycle therapy; and the observation group was given the Tianjing Bushen Yangxue Shugan prescription plus TCM external application more. Results: The total efficiency in the observation group was significantly higher(P<0.05). After treatment, the endometrial thickness, uterine volume, and ovarian volume in the observation group were significantly greater(P<0.05). After treatment, the levels of FSH and LH in the observation group were significantly lower, and the level of E_2 was significantly higher than the control group(P<0.05). After treatment, the levels of CD4~+ and CD4~+/CD8~+ in the observation group were significantly higher than those in the control group, and the level of CD8~+ was significantly lower than that in the control group(P<0.05). Conclusion: The tianjing Bushen Yangxue Shugan prescription plus TCM external application on premature ovarian failure show a good effect, regulate endocrine and immune function, is worthy of clinical promotion.
引文
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[2]苏慧敏.健脾补肾方对卵巢早衰患者内分泌及免疫功能的影响分析[J/OL].实用妇科内分泌杂志(电子版),2016,3(09):28,30.
[3]袁亚敏,王宏峰.中医药治疗卵巢早衰临床研究进展[J].辽宁中医药大学学报,2015,17(08):222-224.
[4]刘敏,郑永新,王惠兰.补肾通经方加中药外敷治疗卵巢早衰疗效观察[J].陕西中医,2015,36(07):785-786.
[5]崔骞,冀志芹,冯擎.温肾助阳益气养血方配合人工周期疗法治疗肾阳虚型卵巢早衰疗效观察[J].中国中西医结合杂志,2013,33(12):1642-1644.
[6]杨蓉,陈莹.陈莹补肾填精治疗卵巢早衰及卵巢储备功能低下[J].实用中医内科杂志,2015,29(01):10-12.
[7]徐晓琴,徐向荣.补肾中药对卵巢早衰患者卵巢储备功能及免疫调节影响的研究[J].中华全科医学,2014,12(12):2004-2006.
[8]金焱,李大剑,刘春丽,等.自拟补肾调经汤配合耳穴贴压治疗70例肾虚肝郁型卵巢早衰的临床观察[J].安徽医药,2014,18(02):331-334.