复方丹参滴丸治疗血瘀型老年性高血压病临床疗效观察
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摘要
目的:观察复方丹参滴丸治疗血瘀型老年性高血压病的疗效。方法:将120例老年高血压患者随机分成两组,各60例(对照组由于个人原因脱落3例),两组均予以常规降压药,治疗组加服复方丹参滴丸,疗程16周,治疗前后分别行血压监测、血液流变学指标、生活质量评估等疗效检查。结果:治疗后治疗组总有效率为83.33%,对照组为80.70%,两组治疗总有效率比较,差异有统计学意义(P<0.05)。两组患者治疗后全血黏度(高切、低切、中切)、血浆黏度、红细胞压积和红细胞聚集指数均成下降状态,治疗组全血黏度(高切、低切、中切)、血浆黏度、红细胞压积和红细胞聚集指数明显低于对照组,两组比较差异有统计学意义(P<0.05)。两组患者经治疗后杜氏高血压生活质量量表各维度积分经过检验后,治疗组生理症状、躯体化症状、生气或活力、睡眠状况维度方面明显优于对照组(P<0.01),人际关系敏感、敌对两项优于对照组(P<0.05),其余各项比较差异无统计学意义(P>0.05)。结论:复方丹参滴丸治疗瘀血阻络型老年性高血压的临床疗效更好。
Objective :To observe the curative effect of compound Danshen Dripping Pills in the treatment of blood stasis type senile hypertension. Methods :120 elderly hypertensive patients were randomly divided into two groups,60 cases each(the control group fell off due to personal reasons in 3 cases). Both groups were treated with conventional antihypertensive drugs. The treatment group was supplemented with compound Danshen Dripping Pills for 16 weeks. Blood pressure monitoring,hemorheology,quality of life assessment and other efficacy tests were performed before and after treatment. Results :The total effective rate was 83.33% in the treatment group and 80.70% in the control group. The total effective rate was statistically significant(P<0.05). The blood viscosity indexes of the two groups were significantly decreased after treatment. The whole blood viscosity(high cut,low cut,medium cut),plasma viscosity,hematocrit and erythrocyte aggregation index decreased in both groups. The whole blood viscosity(high cut,low cut,medium cut),plasma viscosity,hematocrit and erythrocyte aggregation index were significantly lower in the treatment group than that in the control group(P<0.05). After the treatment,the scores of each dimension of Duchenne hypertension quality of life in the treatment group were significantly better than those in the control group(P<0.01),including physiological symptoms,somatization symptoms,vitality and sleeping status(P<0.01),interpersonal sensitivity and hostility(P<0.05),and other items had no statistical significance(P>0.05). Conclusion :Compound Danshen Dripping Pills is more effective in the treatment of senile hypertension with blood stasis type.
Objective :To observe the curative effect of compound Danshen Dripping Pills in the treatment of blood stasis type senile hypertension. Methods :120 elderly hypertensive patients were randomly divided into two groups,60 cases each(the control group fell off due to personal reasons in 3 cases). Both groups were treated with conventional antihypertensive drugs. The treatment group was supplemented with compound Danshen Dripping Pills for 16 weeks. Blood pressure monitoring,hemorheology,quality of life assessment and other efficacy tests were performed before and after treatment. Results :The total effective rate was 83.33% in the treatment group and 80.70% in the control group. The total effective rate was statistically significant(P<0.05). The blood viscosity indexes of the two groups were significantly decreased after treatment. The whole blood viscosity(high cut,low cut,medium cut),plasma viscosity,hematocrit and erythrocyte aggregation index decreased in both groups. The whole blood viscosity(high cut,low cut,medium cut),plasma viscosity,hematocrit and erythrocyte aggregation index were significantly lower in the treatment group than that in the control group(P<0.05). After the treatment,the scores of each dimension of Duchenne hypertension quality of life in the treatment group were significantly better than those in the control group(P<0.01),including physiological symptoms,somatization symptoms,vitality and sleeping status(P<0.01),interpersonal sensitivity and hostility(P<0.05),and other items had no statistical significance(P>0.05). Conclusion :Compound Danshen Dripping Pills is more effective in the treatment of senile hypertension with blood stasis type.
引文
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[21]伍新诚,马晓聪,卓小媛,等.复方丹参滴丸联合曲美他嗪治疗冠心病心绞痛疗效和安全性Meta分析[J].辽宁中医药大学学报,2017,19(4):72-77.
[22]王志健.复方丹参滴丸对急性冠脉综合症患者血脂和hsCRP的影响[J].中华全科医学,2013,11(10):1546-1547.
[23]诸葛丽敏,吴清,楼正家.复方丹参滴丸对急性冠脉综合症患者CRP及血管内皮功能的影响[J].浙江中医学院学报,2005,29(5):13-15.
[24]马荣伟,邹大进,王奇金.复方丹参滴丸对2型糖尿病患者颈动脉内中膜的影响[J].中国中西医结合杂志,2010,30(8):41-42.
[2]中国高血压防治指南修订委员会.中国高血压防治指南(2010修订版)[J].中华高血压杂志,2011,19(18):701-742.
[3]冯丽,王进,陈慧娟.活血化瘀治疗老年高血压病浅探[J].河南中医药学刊,1999,14(5):12.
[4]程志清.老年高血压病证治特点[J].浙江中医学院学报,1999,23(6):14-15.
[5]中国高血压防治指南修订委员会.中国高血压防治指南[M].北京:人民卫生出版社,2006:19-20.
[6]国家中医药管理局.中医新药临床研究指导原则(试行)[M].北京:中国医药科技出版社,2002:73-77.
[7]李辉,徐贵成,刘坤,等.高血压病相关病证的临床调查分析[J].中西医结合心脑血管病杂志,2003,19(3):14-17.
[8]林剑荣.自拟补肾降压方联合西药治疗老年性高血压84例观察[J].内蒙古中医药,2014,33(22):72-73.
[9]李子木,佟玲,赵刚.三子养阴汤结合西药治疗老年高血压患者临床疗效观察[J].辽宁中医药大学学报,2015,17(10):104-106.
[10]覃裕旺.中西医结合治疗老年性高血压临床观察[J].辽宁中医药大学学报,2008(6):158-159.
[11]余天泰.活血化瘀治疗高血压病的临床观察[J].福建中医药,1991,22(2):19.
[12]陈晓炎,郑碧辉,韦瑞焕.高血压病Ⅱ期甲襞微循环与中医血瘀证[J].光明中医,2001,16(5):21-23.
[13]欧亚龙.高血压病与血瘀证的实验研究[J].四川中医,1991,9(6):4.
[14]赵明,孙立新,徐素芝.活血化瘀软胶囊治疗脑梗死伴发颈动脉粥样硬化斑块的临床观察[J].河北中医,2009,31(2):191-192.
[15]吴乃峰,阎希军.复方丹参滴丸的质量研究[J],中国药房,1992,3(6):3.
[16]王怡,高秀梅,张伯礼,等.复方丹参滴丸治疗心血管疾病的药理与临床研究[J].天津中医学院学报,2002,21(3):53-54.
[17]祝国光,罗瑞芝,郭治昕.复方丹参滴丸抗血小板活化及聚集性研究进展[J].中国心血管病杂志,2007,12(2):149-151.
[18]谷家立.降脂抗凝对高血压肾病的影响[J].中国社区医师:医学专业,2012,14(8):5.
[19]杨志刚,陈阿琴,俞颂东.三七药理研究新进展[J].上海中医药杂志,2005(4):59-62.
[20] HUANG YS,YANG ZC,YAN BG,et al. Improvement of early postburn cardiac function by use of Panax notoginseng and immediate total escharexcision in one operation[J].Burns,1999,25:35-41.
[21]伍新诚,马晓聪,卓小媛,等.复方丹参滴丸联合曲美他嗪治疗冠心病心绞痛疗效和安全性Meta分析[J].辽宁中医药大学学报,2017,19(4):72-77.
[22]王志健.复方丹参滴丸对急性冠脉综合症患者血脂和hsCRP的影响[J].中华全科医学,2013,11(10):1546-1547.
[23]诸葛丽敏,吴清,楼正家.复方丹参滴丸对急性冠脉综合症患者CRP及血管内皮功能的影响[J].浙江中医学院学报,2005,29(5):13-15.
[24]马荣伟,邹大进,王奇金.复方丹参滴丸对2型糖尿病患者颈动脉内中膜的影响[J].中国中西医结合杂志,2010,30(8):41-42.