疏风解毒胶囊联合抗生素治疗慢性支气管炎急性加重期的临床观察
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摘要
目的探究疏风解毒胶囊联合抗生素治疗慢性支气管炎急性发作期的临床效果。方法选取2016年3月～2017年5月我院收治的36例慢性支气管炎急性发作期患者作为研究对象,按照随机数字表法分为对照组(18例)与研究组(18例)。对照组仅予以左氧氟沙星胶囊治疗,研究组在此基础上联合使用疏风解毒胶囊治疗,比较两组临床的疗效、症状体征、降钙素原(PCT)及C-反应蛋白(CRP)水平。结果治疗后,研究组的总有效率(94.44%)高于对照组(66.67%),差异有统计学意义(P<0.05);研究组的症状体征改善时间均短于对照组,差异有统计学意义(P<0.05);治疗前,两组患者的PCT、CRP水平比较,差异无统计学意义(P>0.05);治疗后,两组患者的PCT、CRP水平低于治疗前,且研究组患者的PCT、CRP水平低于对照组,差异均有统计学意义(P<0.05)。结论疏风解毒胶囊联合抗生素治疗有助于减轻慢性支气管炎急性加重期患者的炎症反应,进而加速改善症状体征,提高机体恢复水平。
Objective To explore the clinical effect of Shufeng Jiedu Capsule combined with antibiotics in the treatment of acute exacerbation of chronic bronchitis. Methods Thirty-six patients with acute exacerbation of chronic bronchitis treated in our hospital from March 2016 to May 2017 were selected as the subjects, and divided into control group(18 cases) and study group(18 cases) according to the random number table method. The control group was only treated with Levofloxacin Capsules, while the research group was treated with Shufeng Jiedu Capsule on basis of the control group. The clinical efficacy, symptoms and signs, procalcitonin(PCT) and C-reactive protein(CRP) levels were compared between the two groups. Results After treatment, the total effective rate of the study group(94.44%) was higher than that of the control group(66.67%), and the difference was statistically significant(P<0.05). The improvement time of the symptoms and signs in the study group were shorter than those of the control group, and the differences were statistically significant(P<0.05). Before treatment, the PCT and CRP levels of the two groups were not significantly different(P>0.05). After treatment, the PCT and CRP levels of the two groups were lower than those before treatment, and the PCT and CRP levels of the study group were lower than those of the control group, and the differences were statistically significant(P<0.05). Conclusion Shufeng Jiedu Capsule combined with antibiotic regimen is helpful to alleviate inflammation in patients with acute exacerbation of chronic bronchitis, thereby accelerating the improvement of symptoms and signs, and improving the recovery level of the body.
Objective To explore the clinical effect of Shufeng Jiedu Capsule combined with antibiotics in the treatment of acute exacerbation of chronic bronchitis. Methods Thirty-six patients with acute exacerbation of chronic bronchitis treated in our hospital from March 2016 to May 2017 were selected as the subjects, and divided into control group(18 cases) and study group(18 cases) according to the random number table method. The control group was only treated with Levofloxacin Capsules, while the research group was treated with Shufeng Jiedu Capsule on basis of the control group. The clinical efficacy, symptoms and signs, procalcitonin(PCT) and C-reactive protein(CRP) levels were compared between the two groups. Results After treatment, the total effective rate of the study group(94.44%) was higher than that of the control group(66.67%), and the difference was statistically significant(P<0.05). The improvement time of the symptoms and signs in the study group were shorter than those of the control group, and the differences were statistically significant(P<0.05). Before treatment, the PCT and CRP levels of the two groups were not significantly different(P>0.05). After treatment, the PCT and CRP levels of the two groups were lower than those before treatment, and the PCT and CRP levels of the study group were lower than those of the control group, and the differences were statistically significant(P<0.05). Conclusion Shufeng Jiedu Capsule combined with antibiotic regimen is helpful to alleviate inflammation in patients with acute exacerbation of chronic bronchitis, thereby accelerating the improvement of symptoms and signs, and improving the recovery level of the body.
引文
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[11]杨多华,宋德香,奚晴超,等.疏风解毒胶囊联合丹参川芎嗪注射液治疗慢性阻塞性肺疾病急性加重期的临床研究[J].现代药物与临床,2017,32(7):1264-1268.
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[13]孟健,胡烜翀.疏风解毒胶囊联合头孢他啶治疗慢性支气管炎急性发作发热患者90例观察[J].世界中西医结合杂志,2017,12(7):997-1000.
[14]韩亚辉,武凯歌,张薇薇,等.疏风解毒胶囊联合西药治疗慢性支气管炎急性发作期临床观察[J].中国中医急症,2016,25(12):2373-2375.
[15]王发辉,林石宁,吴达会,等.疏风解毒胶囊对慢性阻塞性肺疾病急性加重期患者IL-8和TNF-α的影响[J].中国中医急症,2016,25(11):2171-2173.
[2]唐万云,曾玉英,汪秀玲.金水六君煎与三拗方合用辅助西药治疗慢性支气管炎急性加重期临床观察[J].中国实验方剂学杂志,2016,(17):145-149.
[3]欧强,宁惠明.疏风解毒胶囊在临床疾病治疗中的应用[J].世界中医药,2017,12(10):2539-2542.
[4]谢军.疏风解毒胶囊治疗急性气管-支气管炎(风热犯肺证)的临床观察[J].中国中医急症,2016,25(10):1929-1931.
[5]刘根元.合理应用抗生素对老年慢性支气管炎急性加重期肺功能改善的影响[J].中国实用医药,2016,11(5):188-189.
[6]桑晓惠.老年慢性支气管炎急性加重期合理应用抗生素及护理[J].临床研究,2016,(1):159-160.
[7]陈镜文.丹参注射液联合抗生素对慢性支气管炎急性发作期治疗效果观察[J].中国现代医药杂志,2017,19(6):64-66.
[8]王耀伟.老年慢性支气管炎在急性加重期合理应用抗生素治疗的临床效果[J].北方药学,2017,14(8):41-42.
[9]孙洪伟,刘雪林,宋春艳.五拗汤加味联合头孢噻肟钠治疗老年慢性支气管炎急性加重期疗效观察[J].河北医学,2016,22(4):651-653.
[10]程旺强.莫西沙星联合氨溴索对慢性支气管炎急性加重期炎症因子的影响[J].社区医学杂志,2018,16(2):37-38.
[11]杨多华,宋德香,奚晴超,等.疏风解毒胶囊联合丹参川芎嗪注射液治疗慢性阻塞性肺疾病急性加重期的临床研究[J].现代药物与临床,2017,32(7):1264-1268.
[12]任庆伟.疏风解毒胶囊联合抗生素治疗慢性支气管炎急性加重期临床观察[J].中国中医急症,2016,25(8):1571-1573.
[13]孟健,胡烜翀.疏风解毒胶囊联合头孢他啶治疗慢性支气管炎急性发作发热患者90例观察[J].世界中西医结合杂志,2017,12(7):997-1000.
[14]韩亚辉,武凯歌,张薇薇,等.疏风解毒胶囊联合西药治疗慢性支气管炎急性发作期临床观察[J].中国中医急症,2016,25(12):2373-2375.
[15]王发辉,林石宁,吴达会,等.疏风解毒胶囊对慢性阻塞性肺疾病急性加重期患者IL-8和TNF-α的影响[J].中国中医急症,2016,25(11):2171-2173.