白芍总苷胶囊治疗轻型系统性红斑狼疮临床观察
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摘要
目的探讨轻型系统性红斑狼疮治疗中应用白芍总苷的效果。方法选取60例轻型系统性红斑狼疮患者,随机分为对照组(30例)与观察组(30例),其中对照组给予硫酸羟氯喹联合醋酸泼尼松片治疗,观察组在对照组的基础上加用白芍总苷胶囊,对比2组疗效。结果观察组的总有效率为96. 7%,高于对照组的总有效率80. 0%(P <0. 05);观察组的不良反应发生率为3. 3%,低于对照组的不良反应发生率6. 7%(P> 0. 05);观察组的血沉、补体C3、补体C4指标改善度优于对照组(P <0. 05)。结论轻型系统性红斑狼疮的常规用药治疗中加用白芍总苷,能够提高治疗的有效性,改善免疫指标,且不会增加并发症发生率。
Objective To explore the effect of total paeony glycosides in the treatment of mild systemic lupus erythematosus( SLE).Methods 60 patients with mild SLE were selected,and all patients were randomly divided into control group( n = 30) and observation group( n = 30). The control group was treated with hydroxychloroquine sulfate combined with prednisone acetate tablets. The observation group was treated with total paeony glycosides capsule on the basis of the control group. The clinical effect of the two groups was compared.Results The overall effective rate of the observation group was 96. 7%,which was higher than 80. 0% of the control group( P < 0. 05).The adverse reaction rate of the observation group was 3. 3%,which was lower than 6. 7% of the control group( P > 0. 05). The improvement of ESR,complement C3 and complement C4 in the observation group was better than that in the control group( P < 0. 05).Conclusion Total Paeony Glucosides can improve the efficacy of routine medication for mild systemic lupus erythematosus and immune indexes,and do not increase the incidence of complications.
Objective To explore the effect of total paeony glycosides in the treatment of mild systemic lupus erythematosus( SLE).Methods 60 patients with mild SLE were selected,and all patients were randomly divided into control group( n = 30) and observation group( n = 30). The control group was treated with hydroxychloroquine sulfate combined with prednisone acetate tablets. The observation group was treated with total paeony glycosides capsule on the basis of the control group. The clinical effect of the two groups was compared.Results The overall effective rate of the observation group was 96. 7%,which was higher than 80. 0% of the control group( P < 0. 05).The adverse reaction rate of the observation group was 3. 3%,which was lower than 6. 7% of the control group( P > 0. 05). The improvement of ESR,complement C3 and complement C4 in the observation group was better than that in the control group( P < 0. 05).Conclusion Total Paeony Glucosides can improve the efficacy of routine medication for mild systemic lupus erythematosus and immune indexes,and do not increase the incidence of complications.
引文
[1]李智,杨红俊,谢其冰.白芍总苷胶囊联合他克莫司治疗系统性红斑狼疮的临床研究[J].现代药物与临床,2018,33(6):1513-1517.
[2]邵建兵.白芍总苷治疗系统性红斑狼疮疗效及患者生活质量改善效果观察[J].中国民族民间医药,2017,26(4):108-109.
[3] ZHAO M,LIANG G,LUO S,et al. Effect of total glucosides of peony on expression and DNA methylation status of ITGAL gene in CD4(+)T cells of systemic lupus erythematosus[J]. Zhong Nan Da Xue Xue Bao Yi Xue Ban,2012,37(5):463-468.
[4]冯萍珍,冀林华,李玉玲.环磷酰胺结合白芍总苷治疗系统性红斑狼疮的临床效果研究[J].检验医学与临床,2017,14(Z2):113-114.
[5]黄丽.综合护理在重症系统性红斑狼疮患者冲击治疗中的应用效果[J].临床合理用药杂志,2017,10(33):175-176.
[6]田微.泼尼松结合环磷酰胺在系统性红斑狼疮患者治疗中的应用研究[J].中外医学研究,2017,15(29):58-59.
[7]张丽华,庞丽霞.环磷酰胺结合泼尼松应用于系统性红斑狼疮治疗中的疗效与安全性分析[J].临床医药文献电子杂志,2017,12(15):2924.
[8]王丹,王上上.白芍总苷治疗系统性红斑狼疮的疗效及对CD11a表达的影响[J].中国麻风皮肤病杂志,2015,31(11):659-661.
[2]邵建兵.白芍总苷治疗系统性红斑狼疮疗效及患者生活质量改善效果观察[J].中国民族民间医药,2017,26(4):108-109.
[3] ZHAO M,LIANG G,LUO S,et al. Effect of total glucosides of peony on expression and DNA methylation status of ITGAL gene in CD4(+)T cells of systemic lupus erythematosus[J]. Zhong Nan Da Xue Xue Bao Yi Xue Ban,2012,37(5):463-468.
[4]冯萍珍,冀林华,李玉玲.环磷酰胺结合白芍总苷治疗系统性红斑狼疮的临床效果研究[J].检验医学与临床,2017,14(Z2):113-114.
[5]黄丽.综合护理在重症系统性红斑狼疮患者冲击治疗中的应用效果[J].临床合理用药杂志,2017,10(33):175-176.
[6]田微.泼尼松结合环磷酰胺在系统性红斑狼疮患者治疗中的应用研究[J].中外医学研究,2017,15(29):58-59.
[7]张丽华,庞丽霞.环磷酰胺结合泼尼松应用于系统性红斑狼疮治疗中的疗效与安全性分析[J].临床医药文献电子杂志,2017,12(15):2924.
[8]王丹,王上上.白芍总苷治疗系统性红斑狼疮的疗效及对CD11a表达的影响[J].中国麻风皮肤病杂志,2015,31(11):659-661.