丹红注射液对大鼠深静脉血栓形成模型的作用研究
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摘要
目的考察丹红注射液对大鼠深静脉血栓形成模型的作用。方法以大鼠深静脉血栓形成模型为研究对象,通过检测出血时间、纤维蛋白原含量(FIB)、凝血酶时间(TT)、活化部分凝血活酶时间(APTT)、凝血酶原时间(PT)和血栓重量等指标,全面考察丹红注射液对大鼠深静脉血栓形成模型的改善作用。结果丹红注射液2、1 mL·kg~(-1)剂量下可明显延长模型大鼠的出血时间、凝血酶时间、活化部分凝血活酶时间和凝血酶原时间,显著降低纤维蛋白原含量和静脉血栓的重量。结论丹红注射液对大鼠深静脉血栓形成有明显的改善作用。
Objective To investigate the effects of Danhong Injection on deep venous thrombosis model of rats.Methods Deep venous thrombosis model in rats was adopted and bleeding time,fibrinogen(FIB),thrombin time(TT),activated partial thromboplastin time(APTT),prothrombin time(PT),thrombus weight were determined to investigate the effects of Danhong Injection.Results Bleeding time,TT,PT,APTT were prolonged and FIB,thrombus weight were significantly reduced in model rats with Danhong Injection(2,1 mL·kg~(-1),iv) than those of the control group.Conclusion Danhong Injection has remarkable protective effects on deep venous thrombosis model of rats.
Objective To investigate the effects of Danhong Injection on deep venous thrombosis model of rats.Methods Deep venous thrombosis model in rats was adopted and bleeding time,fibrinogen(FIB),thrombin time(TT),activated partial thromboplastin time(APTT),prothrombin time(PT),thrombus weight were determined to investigate the effects of Danhong Injection.Results Bleeding time,TT,PT,APTT were prolonged and FIB,thrombus weight were significantly reduced in model rats with Danhong Injection(2,1 mL·kg~(-1),iv) than those of the control group.Conclusion Danhong Injection has remarkable protective effects on deep venous thrombosis model of rats.
引文
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[2] 王赏,卢宏.丹红注射液的临床研究进展[J].中国实用神经疾病杂志,2018,21(17):420-421.
[3] 张军,于化玲,鹿艳群.丹红注射液治疗心脑血管疾病的临床应用进展[J].临床医学,2015,6(10):118.
[4] 陶琳璐.丹参、红花药材与丹红注射液指纹图谱相关性研究[J].药学研究,2017,36(1):19-20,24.
[5] 吴鹏,黄晨,冯惠岗.大鼠深静脉血栓形成模型建立及观察[J].中华介入放射学电子杂志,2015,3(2):91-94.
[6] 张智辉,单臻,王文见,等.下腔静脉不同处理方法建立大鼠深静脉血栓形成动物模型的比较[J].中华实验外科杂志,2012,29(9):1840-1842.
[7] QI Y,ZHAO X,LIU H,et al.Identification of a Quality Marker(Q-Marker)of Dan Hong Injection by the Zebrafish Thrombosis Model[J].Molecules,2017,22(9):1443.
[8] ZHAO T,CHANG L,ZHANG B,et al.Specific Combination of Salvianolic Acids As Core Active Ingredients of Dan Hong Injection for Treatment of Arterial Thrombosis and Its Derived Dry Gangrene[J].Front Pharmacol,2017,8(361):1-13.
[9] 王赏.丹红注射液对脑出血大鼠的脑保护作用[D].郑州:郑州大学,2018.