复方红花泡腾颗粒的体外透皮吸收性能考察
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摘要
目的:考察复方红花泡腾颗粒的体外透皮吸收性能。方法:采用扩散池法进行体外透皮吸收试验,通过UV测定接收液中乌头总碱含量,筛选合适的接收液及接收液温度,考察复方红花泡腾颗粒的经皮给药效果。结果:选取生理盐水为接收液,接收液温度32℃,复方红花泡腾颗粒的透皮吸收效果优于提取液及普通颗粒制剂。结论:复方红花泡腾颗粒制剂具有良好的透皮吸收效果。
Objective: To investigate in vitro transdermal absorption properties of compound safflower effervescent granules.Method: In vitro transdermal absorption experiment was performed through diffusion cell method,the content of total alkaloids from Aconitum carmichaeli was determined by UV in order to choose suitable receiving liquid and receiving liquid temperature,then transdermal effect of compound safflower effervescent granules was investigated.Result: Physiological saline was selected as receiving liquid with temperature at 32 ℃,transdermal absorption effect of compound safflower effervescent granules was better than extraction liquid and common granules.Conclusion: Compound safflower effervescent granules had good transdermal absorption effect.
Objective: To investigate in vitro transdermal absorption properties of compound safflower effervescent granules.Method: In vitro transdermal absorption experiment was performed through diffusion cell method,the content of total alkaloids from Aconitum carmichaeli was determined by UV in order to choose suitable receiving liquid and receiving liquid temperature,then transdermal effect of compound safflower effervescent granules was investigated.Result: Physiological saline was selected as receiving liquid with temperature at 32 ℃,transdermal absorption effect of compound safflower effervescent granules was better than extraction liquid and common granules.Conclusion: Compound safflower effervescent granules had good transdermal absorption effect.
引文
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[2]《全国中草药汇编》编写组.全国中草药汇编.上册[M].北京:人民卫生出版社,1975:207.
[3]薛玲,张惠云,秦林,等.川乌与白芍配伍前后对大鼠佐剂关节炎的影响[J].中国中药杂志,2000,25(3):175.
[4]吴亚男.川归护心经皮给药制剂的研究[D].天津:天津大学,2006:35.
[5]王晶.氢溴酸东食若碱微乳透皮制剂的研究[D].上海:第二军医大学军队卫生学,2008:38.
[6]李文兰,王艳萍,季宇彬,等.渗透促进剂对川乌总生物碱和新乌头碱透皮吸收的影响[J].中国药学杂志,2007,42(17):1316.
[7]李玲慧.双黄巴布剂的研制与体外透皮吸收研究[D].广州:广州中医药大学,2010:35.
[8]丁乐,董建,杨人泽.凝胶材料配比对丁香罗勒油透皮凝胶体外透皮性能的影响[J].中国实验方剂学杂志,2012,18(24):63.
[9]薛强强.川红足浴泡腾颗粒药学研究及沙棘原粉制备工艺研究[D].太原:山西医科大学,2012:10.
[10]王亚静.马钱子透皮吸收制剂的研究[D].天津:天津大学,2006:11.
[11]祁艳,陈军,李磊,等.不同促渗剂对马钱子碱贴剂体外透皮吸收的影响[J].中国药房,2011,22(3):195.