超声实时组织弹性成像定量分析对肝脏纤维化程度的诊断和鉴别诊断价值
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摘要
目的探讨超声实时组织弹性成像定量分析对肝脏纤维化程度的诊断和鉴别价值。方法回顾性分析60例慢性乙型肝炎患者的临床资料,均经肝穿刺活检确诊,作为研究组。选取同期到本院体检的60例健康对象,作为对照组。两组均行超声实时组织弹性成像定量分析。以肝穿刺活检病理结果为标准,判断超声实时组织弹性成像定量分析对肝脏纤维化的诊断效能。并测算两组实时组织弹性成像参数。结果以肝穿刺活检病理结果为标准,超声实时组织弹性成像定量分析诊断灵敏度为94.74%,特异度为95.45%,准确度为95.00%;研究组平均相对应变值低于对照组,蓝色面积百分比、对比度、偏度、复杂度高于对照组,差异有统计学意义(P <0.05)。结论超声实时组织弹性成像定量分析可为肝脏纤维化程度诊断及鉴别提供较准确依据。
Objective To investigate the value of quantitative analysis of real-time tissue elastography(RTTE) in the diagnosis and differential diagnosis of liver fibrosis.Methods The clinical data of 60 patients with chronic hepatitis B were retrospectively analyzed.All patients were diagnosed by liver biopsy and served as the research group.Sixty healthy people who came to our hospital for physical examination at the same time were selected as control group.Quantitative analysis of real-time tissue elastography was performed in both groups.Based on the pathological results of liver puncture biopsy,the diagnostic efficacy of real-time tissue elastography quantitative analysis for liver fibrosis was evaluated.The real-time tissue elastography parameters of the two groups were measured and calculated.Results According to the pathological results of liver biopsy,the sensitivity,specificity and accuracy of quantitative analysis of real-time tissue elastography were 94.74%,95.45% and 95.00%,respectively.The ARV of study group was lower than that of control group,while AREA,CONT,SKEW and COMP of study group were higher than those of control group(P < 0.05).Conclusion Quantitative analysis of real-time tissue elastography by ultrasound can provide a more accurate method for the diagnosis and differentiation of liver fibrosis.
Objective To investigate the value of quantitative analysis of real-time tissue elastography(RTTE) in the diagnosis and differential diagnosis of liver fibrosis.Methods The clinical data of 60 patients with chronic hepatitis B were retrospectively analyzed.All patients were diagnosed by liver biopsy and served as the research group.Sixty healthy people who came to our hospital for physical examination at the same time were selected as control group.Quantitative analysis of real-time tissue elastography was performed in both groups.Based on the pathological results of liver puncture biopsy,the diagnostic efficacy of real-time tissue elastography quantitative analysis for liver fibrosis was evaluated.The real-time tissue elastography parameters of the two groups were measured and calculated.Results According to the pathological results of liver biopsy,the sensitivity,specificity and accuracy of quantitative analysis of real-time tissue elastography were 94.74%,95.45% and 95.00%,respectively.The ARV of study group was lower than that of control group,while AREA,CONT,SKEW and COMP of study group were higher than those of control group(P < 0.05).Conclusion Quantitative analysis of real-time tissue elastography by ultrasound can provide a more accurate method for the diagnosis and differentiation of liver fibrosis.
引文
[1]许尚文,陈自谦,夏加林,等. MR扩散加权成像与超声弹性成像诊断乙型病毒性肝炎肝纤维化分级的对比研究[J].中华放射学杂志,2016,50(7):518-521.
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[13]孙素娥,蔡鸳,徐金平,等.循证护理对病毒性肝炎患者生活质量和心理状况的影响[J].中国临床保健杂志,2014,17(1):96-97.
[14]刘丽琴,熊慧妮,孙翔,等.实时组织超声弹性成像对肝硬化的应用价值研究[J].肝胆外科杂志,2016,24(5):350-353.
[15]卜凡文,董长城,马强,等.床边经腹彩色多普勒超声介入治疗细菌性肝脓肿的临床观察[J].中国临床保健杂志,2015,18(6):639-640.
[16]郑颖,孟繁坤,徐晓鸾,等.实时组织弹性成像定量分析技术检测病毒性乙型肝炎肝纤维化分期的初步研究[J].北京医学,2018,40(4):338-341.
[17]魏占芳,武永萍,马莉莎,等.实时组织超声弹性成像技术对慢性乙型肝炎肝纤维化患者的评估[J].海南医学院学报,2016,22(16):1898-1900.
[18]孟艳,隆仙琴,李杰,等.超声实时组织弹性成像定量分析对肝脏纤维化程度的诊断价值[J].中国临床研究,2017,30(11):1549-1551.
[19]郭静文,陈越峰,周瑞莉,等.实时超声弹性定量参数与肝纤维化分期的相关性[J].循证医学,2016,16(6):352-354.
[20]高秀芳,王一,刘玉珍,等.超声实时组织弹性成像定量分析对慢性乙型肝炎患者肝纤维化程度的诊断价值[J].实用肝脏病杂志,2017,20(6):688-691.
[2]叶俊钊,王伟,廖冰,等.实时剪切波弹性成像诊断慢性乙型肝炎肝纤维化的影响因素[J].实用医学杂志,2016,32(15):2454-2458.
[3]谢文龙,周显礼.肝纤维化的超声诊断进展[J].中国临床研究,2016,29(2):273-275.
[4]郭雯,孙培育.声触诊组织量化技术评估慢性肝纤维化的应用研究[J].中国临床保健杂志,2013,16(6):607-608.
[5]徐秀琴,陈云翔,余文,等.瞬时弹性成像对慢性肝病肝纤维化的诊断价值[J].肝脏,2016,21(11):937-940.
[6]李志艳,孟彦娜,赵志军.超声技术无创评估肝纤维化的临床应用进展[J].传染病信息,2017,30(4):249-252.
[7]凌文武,卢强,邱婷婷,等.肝纤维化的超声诊断应用进展[J].四川医学,2017,38(5):585-588.
[8]中华医学会肝病学分会.慢性乙型肝炎防治指南(2015年版)[J].中华实验和临床感染病杂志:电子版,2015,19(5):1-18. DOI:10. 3969/j. issn. 1674-7380. 2015. 03. 003.
[9]孙月,韦嘉,陆永萍,等.实时剪切波超声弹性成像对慢性乙型病毒性肝炎肝纤维化分期的定量分析[J].昆明医科大学学报,2016,37(11):55-59.
[10]张微,张静,钟思程,等.北京市无偿献血人群乙型肝炎病毒血清流行病学调查分析[J].北京医学,2018,40(3):76-77.
[11]葛娜,何茜.超声弹性成像对肝纤维化分级的评估[J].临床肝胆病杂志,2016,32(12):2379-2382.
[12]谢文龙,周显礼.肝纤维化的超声诊断进展[J].中国临床研究,2016,29(2):273-275.
[13]孙素娥,蔡鸳,徐金平,等.循证护理对病毒性肝炎患者生活质量和心理状况的影响[J].中国临床保健杂志,2014,17(1):96-97.
[14]刘丽琴,熊慧妮,孙翔,等.实时组织超声弹性成像对肝硬化的应用价值研究[J].肝胆外科杂志,2016,24(5):350-353.
[15]卜凡文,董长城,马强,等.床边经腹彩色多普勒超声介入治疗细菌性肝脓肿的临床观察[J].中国临床保健杂志,2015,18(6):639-640.
[16]郑颖,孟繁坤,徐晓鸾,等.实时组织弹性成像定量分析技术检测病毒性乙型肝炎肝纤维化分期的初步研究[J].北京医学,2018,40(4):338-341.
[17]魏占芳,武永萍,马莉莎,等.实时组织超声弹性成像技术对慢性乙型肝炎肝纤维化患者的评估[J].海南医学院学报,2016,22(16):1898-1900.
[18]孟艳,隆仙琴,李杰,等.超声实时组织弹性成像定量分析对肝脏纤维化程度的诊断价值[J].中国临床研究,2017,30(11):1549-1551.
[19]郭静文,陈越峰,周瑞莉,等.实时超声弹性定量参数与肝纤维化分期的相关性[J].循证医学,2016,16(6):352-354.
[20]高秀芳,王一,刘玉珍,等.超声实时组织弹性成像定量分析对慢性乙型肝炎患者肝纤维化程度的诊断价值[J].实用肝脏病杂志,2017,20(6):688-691.