盐酸哌甲酯控释片联合卡马西平治疗伴中央颞区棘波的小儿良性癫痫合并多动综合征的疗效
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摘要
目的探讨盐酸哌甲酯控释片(OROS-MPH)联合卡马西平治疗伴中央-颞区棘波良性癫痫(BECTs)合并多动综合征(ADHD)患儿的疗效。方法将BECTs合并ADHD患儿84例随机分为观察组与对照组各42例。两组均接受卡马西平治疗,6个月内脑电图(EEG)稳定后分别加心理行为治疗和心理行为联合OROS-MPH治疗。比较两组临床疗效及不良反应。结果观察组的BECTs总有效率为90.48%,与对照组的92.86%比较差异无统计学意义(P>0.05);观察组的ADHD总有效率为95.24%,显著高于对照组的64.29%(P<0.05);治疗后观察组的PSQ量表评分显著低于对照组(P<0.05)。结论 OROS-MPH联合卡马西平治疗BECTs合并ADH安全可靠,能够有效改善患儿的临床症状。
Objective To investigate the efficacy of osmotic-release oral methylphenidate(OROS-MPH)combined with carbamazepine in the treatment of children with benign epilepsy with centrotemporal spikes(BECTs)complicated with attention deficit hyperactivity disorder(ADHD). Methods 84 cases of children with BECTs complicated with ADHD were randomly divided into observation group and control group,42 cases in each group. Both groups received carbamazepine treatment for 6 months,then received psychological behavior or psychological behavior combined with OROS-MPH treatment respectively after the stabilization of electroencephalogram(EEG)within 6 months. The Parent Symptom Questionnaire of Conner Children's Behavior Questionnaire(PSQ)were evaluated before and after treatment. Results There were no significant deference in total effective rate of BECTs between the observation group(90.48%)and the control group(92.86%)(P>0.05). The total effective rate of ADHD was 95.24% in the observation group,which were significantly higher than that(64.29%)in the control group(P<0.05). After treatment,the scores of PSQ in the observation group was significantly lower than those in the control group(P<0.05). Conclusion OROS-MPH combined with carbamazepine in the treatment of BECTs complicated with ADH is safe and reliable,which can effectively improve the clinical symptoms of patients.
Objective To investigate the efficacy of osmotic-release oral methylphenidate(OROS-MPH)combined with carbamazepine in the treatment of children with benign epilepsy with centrotemporal spikes(BECTs)complicated with attention deficit hyperactivity disorder(ADHD). Methods 84 cases of children with BECTs complicated with ADHD were randomly divided into observation group and control group,42 cases in each group. Both groups received carbamazepine treatment for 6 months,then received psychological behavior or psychological behavior combined with OROS-MPH treatment respectively after the stabilization of electroencephalogram(EEG)within 6 months. The Parent Symptom Questionnaire of Conner Children's Behavior Questionnaire(PSQ)were evaluated before and after treatment. Results There were no significant deference in total effective rate of BECTs between the observation group(90.48%)and the control group(92.86%)(P>0.05). The total effective rate of ADHD was 95.24% in the observation group,which were significantly higher than that(64.29%)in the control group(P<0.05). After treatment,the scores of PSQ in the observation group was significantly lower than those in the control group(P<0.05). Conclusion OROS-MPH combined with carbamazepine in the treatment of BECTs complicated with ADH is safe and reliable,which can effectively improve the clinical symptoms of patients.
引文
1.汪晓翠,杨斌,沈丽伟,等。伴中央颞区棘波的儿童良性癫痫患者注意网络研究。中华神经科杂志,2015;48(5):406-410.
2.陈芳,周农。癫痫儿童合并注意缺陷-多动障碍的治疗进展。中国神经精神疾病杂志,2010;36(7):444-446.
3.李瑾。盐酸哌甲酯控释片与盐酸托莫西汀治疗儿童注意缺陷多动障碍对比研究。中国现代药物应用,2016;10(24):56-57.
4.马燕丽,徐凯丽,陈国洪,等。儿童良性癫痫伴中央颞区棘波患者发作期脑电图特点分析。中国实用神经疾病杂志,2016;19(15):76-78.
5.顾红菲,宁宪嘉。卡马西平、左乙拉西坦对伴中央-颞区棘波的良性癫痫患儿认知功能的影响。中国妇幼保健,2012;27(17):2677-2678.
6.应小明,靖安,叶辉,等。卡马西平联用盐酸哌甲酯控释片治疗儿童良性癫痫伴中央颞区棘波共患注意力缺陷障碍伴多动症的效果观察。中国医师进修杂志,2011;34(22):49-51.
7.陈光福,崔艳丽,陈美清。盐酸哌甲酯控释剂治疗儿童注意缺陷多动障碍的疗效。中华实用儿科临床杂志,2011;26(6):452-454.
8.Baptistaneto L,Dodds A,Rao S.An expert opinion on methylphenidate treatment for attention deficit hyperactivity disorder in pediatric patients with epilepsy.Expert Opin Investig Drugs,2008;17(1):77-84.
9.赵秀莲,王汉艳,冉苗苗,等。卡马西平联用盐酸哌甲酯控释片治疗小儿癫痫合并注意缺陷多动障碍的疗效观察。国际精神病学杂志,2016;43(6):1015-1018.
2.陈芳,周农。癫痫儿童合并注意缺陷-多动障碍的治疗进展。中国神经精神疾病杂志,2010;36(7):444-446.
3.李瑾。盐酸哌甲酯控释片与盐酸托莫西汀治疗儿童注意缺陷多动障碍对比研究。中国现代药物应用,2016;10(24):56-57.
4.马燕丽,徐凯丽,陈国洪,等。儿童良性癫痫伴中央颞区棘波患者发作期脑电图特点分析。中国实用神经疾病杂志,2016;19(15):76-78.
5.顾红菲,宁宪嘉。卡马西平、左乙拉西坦对伴中央-颞区棘波的良性癫痫患儿认知功能的影响。中国妇幼保健,2012;27(17):2677-2678.
6.应小明,靖安,叶辉,等。卡马西平联用盐酸哌甲酯控释片治疗儿童良性癫痫伴中央颞区棘波共患注意力缺陷障碍伴多动症的效果观察。中国医师进修杂志,2011;34(22):49-51.
7.陈光福,崔艳丽,陈美清。盐酸哌甲酯控释剂治疗儿童注意缺陷多动障碍的疗效。中华实用儿科临床杂志,2011;26(6):452-454.
8.Baptistaneto L,Dodds A,Rao S.An expert opinion on methylphenidate treatment for attention deficit hyperactivity disorder in pediatric patients with epilepsy.Expert Opin Investig Drugs,2008;17(1):77-84.
9.赵秀莲,王汉艳,冉苗苗,等。卡马西平联用盐酸哌甲酯控释片治疗小儿癫痫合并注意缺陷多动障碍的疗效观察。国际精神病学杂志,2016;43(6):1015-1018.