穴位贴敷治疗风寒闭肺型晚期肺癌咳喘
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摘要
目的观察穴位贴敷治疗风寒闭肺型晚期肺癌咳喘的临床疗效。方法纳入2017年1月至2018年1月晚期肺癌患者80例,随机分为治疗组和对照组,各40例,对照组给予常规三代头孢类抗生素抗感染及抗炎止咳化痰解痉平喘治疗,具体用药:头孢哌酮钠舒巴坦钠2 g,2次/d,地塞米松+氨茶碱+氨溴索,疗程10 d;治疗组在对照组基础上给与肺俞、定喘等穴位贴敷连续治疗10 d,观察治疗前后咳嗽症状积分、中医症状量表评分、KPS生活质量评分、不良反应。结果 1)2组治疗后治疗组咳嗽症状评分为(2.25±1.82)分,对照组为(3.20±1.20)分,2组比较具有统计学意义(P <0.05);2)2组治疗后中医症状量表评分治疗组为(8.01±5.23)分,对照组为(11.50±5.84)分,2组比较具有统计学意义(P <0.05);3)2组治疗前后KPS生活质量评分比较具有用统计学意义(P <0.05),治疗组未出现不良反应。结论穴位贴敷治疗风寒闭肺型晚期肺癌咳喘效果显著,值得临床应用推广。
Objective To observe the clinical observation of acupoint application in the treatment of advanced lung cancer of wind-cold attacking lung with cough and asthma. Methods 80 patients with lung cancer January 2017 to January 2018 were randomly divided into the treatment group(n = 40) and the control group(n = 40). The control group was was treated with Routine three generation cephalosporins and antitussive and phlegm treatment, specific medication: cefoperazone sodium sulbactam sodium 2 g twice a day, dexamethasone, Aminophyiline Injection and Ambroxol for 10 days. On the basis of the control group, the treatment group was treated with acupoint application such as Feishu and Dingchuan for 10 days. The score of cough symptoms, the symptom scale of Chinese medicine, the quality of life of KPS, and the adverse reaction were observed before and after the treatment. Results After treatment,the score of cough symptoms in the treatment group was(2.25±1.82), and the control group was(3.20±1.20), which was statistically significant(P < 0.05). After treatment, the score of TCM symptom scale in the treatment group was(8.01±5.23), and the control group was(11.50±5.84), which was statistically significant(P < 0.05). The quality of life score of KPS before and after treatment was statistically significant(P < 0.05), but there was no adverse reaction in the treatment group(P < 0.05). Conclusion Acupoint application is effective in the treatment of advanced lung cancer of wind-cold attacking lung with cough and asthma. It is worthy of clinical application and promotion.
Objective To observe the clinical observation of acupoint application in the treatment of advanced lung cancer of wind-cold attacking lung with cough and asthma. Methods 80 patients with lung cancer January 2017 to January 2018 were randomly divided into the treatment group(n = 40) and the control group(n = 40). The control group was was treated with Routine three generation cephalosporins and antitussive and phlegm treatment, specific medication: cefoperazone sodium sulbactam sodium 2 g twice a day, dexamethasone, Aminophyiline Injection and Ambroxol for 10 days. On the basis of the control group, the treatment group was treated with acupoint application such as Feishu and Dingchuan for 10 days. The score of cough symptoms, the symptom scale of Chinese medicine, the quality of life of KPS, and the adverse reaction were observed before and after the treatment. Results After treatment,the score of cough symptoms in the treatment group was(2.25±1.82), and the control group was(3.20±1.20), which was statistically significant(P < 0.05). After treatment, the score of TCM symptom scale in the treatment group was(8.01±5.23), and the control group was(11.50±5.84), which was statistically significant(P < 0.05). The quality of life score of KPS before and after treatment was statistically significant(P < 0.05), but there was no adverse reaction in the treatment group(P < 0.05). Conclusion Acupoint application is effective in the treatment of advanced lung cancer of wind-cold attacking lung with cough and asthma. It is worthy of clinical application and promotion.
引文
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[9]崔淑华,李娜,邢燕军,等.白芥子不同配比穴位贴敷对支气管哮喘患者免疫球蛋白及嗜酸粒细胞的影响[J].中医杂志,2014,55(6):935-936.
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[11]侯晓琳,邱智东.延冰片的化学成分及药理作用研究进展[J].长春中医药大学学报,2016,32(6):1306-1308.
[12]姜雪,孙森凤,王悦.麻黄成分及其药理作用研究进展[J].化工时刊,2017,31(5):28-30.
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[14]张学梅,刘凡亮,梁文波,等.白芥子提取物的镇咳、祛痰及平喘作用研究[J].中草药,2003,34(7):635-636.
[15]刘中良.从费伯雄内伤咳嗽辨治思路探讨肺癌咳嗽的治疗[J].中医学报,2015,30(1):10-13.
[16]马天姝,王富春.穴位敷贴疗法治疗慢性阻塞性肺疾病[J].吉林中医药,2017,37(3):217-219.
[2]谢立芳.三子养亲汤加味治疗肺癌晚期咳喘52例[J].陕西中医,2013,34(9):1176-1179.
[3]中华医学会呼吸病学分会哮喘学组.咳嗽的诊断与治疗指南(2009版)[J].中华结核和呼吸杂志,2009,32(6):407-414.
[4]郑筱英.中药新药临床研究指导原则(试行)[S].北京:中国医药科技出版社,2002:4.
[5]刘鲁炯,黎林,江淳涓.加用复方龙星片治疗感冒后咳嗽的临床研究[J].天津中医药,2015,32(11):660-663.
[6]中华人民共和国卫生部.中药新药临床研究指导原则[M].北京:中华人民共和国卫生部,1997:86-88.
[7]马云淑,罗艳梅,潘琦.麻黄的透皮吸收与白芥子促透皮作用的实验研究[J].中国医药学报,2002,17(1):59-60.
[8]董玉启,于华,王春华.北细辛根化学成分研究[J].天津中医药,2017,34(12):845-847.
[9]崔淑华,李娜,邢燕军,等.白芥子不同配比穴位贴敷对支气管哮喘患者免疫球蛋白及嗜酸粒细胞的影响[J].中医杂志,2014,55(6):935-936.
[10]钦敬茹,徐祖红,王中奇.王中奇老师运用麻黄附子细辛汤治疗肺癌经验[J].吉林中医药,2018,38(4):402-405.
[11]侯晓琳,邱智东.延冰片的化学成分及药理作用研究进展[J].长春中医药大学学报,2016,32(6):1306-1308.
[12]姜雪,孙森凤,王悦.麻黄成分及其药理作用研究进展[J].化工时刊,2017,31(5):28-30.
[13]赵雪艳,蔡霞,胡正海.甘遂生物学、化学成分和药理作用研究进展[J].中草药,2014,45(10):3029-3033.
[14]张学梅,刘凡亮,梁文波,等.白芥子提取物的镇咳、祛痰及平喘作用研究[J].中草药,2003,34(7):635-636.
[15]刘中良.从费伯雄内伤咳嗽辨治思路探讨肺癌咳嗽的治疗[J].中医学报,2015,30(1):10-13.
[16]马天姝,王富春.穴位敷贴疗法治疗慢性阻塞性肺疾病[J].吉林中医药,2017,37(3):217-219.