2017年山东省菏泽市百日咳流行病学监测研究
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摘要
目的了解2017年菏泽市百日咳流行病学特征,为百日咳诊断、监测与预防控制提供科学依据。方法依据百日咳网络报告系统、个案调查与实验室检测等相关资料进行描述性研究。结果 2017年菏泽市共报告百日咳诊断病例88例,发病率0.9 397/10万,无死亡病例。病例相对集中又高度散发,分布于全市9县区的8县区的49个乡镇(办事处)的83个行政村(社区)。百日咳个案调查率100.00%。急性期血清标本采集率62.50%,急性期血清百日咳外毒素抗原(PT) Ig M阳性率67.27%,急性期血清PT Ig G阳性率83.64%;急性期鼻咽拭子标本采集率3.14%,均未培养出百日咳杆菌,均进行了实时荧光聚合酶链反应(Real-time PCR)检测,未检测到百日咳杆菌基因序列;百日咳实验室确诊率52.27%。结论 2017年菏泽市百日咳诊断、监测与预防控制取得了一些成绩,但仍存在不少问题。建议继续加强百日咳监测与百白破疫苗接种,尤其是要改进实验室检测。
Objective To understand the epidemiological feature of of pertussis of 2017 in Heze,and to provide scientific basis for the diagnosis,monitoring,prevention and control of pertussis.Methods Descriptive research was carried out according to the information of pertussis network report system,case investigation and laboratory test.Results In 2017,a total of 88 cases of pertussis were reported in Heze,with a incidence of 0.9 397/100 000 and no deaths.The cases are relatively concentrated and highly sporadic,distributed in 83 administrative villages(communities) in 49 towns(offices) in 8 counties of 9 districts of the city.The pertussis case investigation rate was 100.00%.The collection rate of serum samples in the acute phase was 62.50%,the positive rate of serum PT Ig M in the acute phase was 67.27%,and the positive rate of serum PT IgG in the acute phase was83.64%.The collection rate of nasopharyngeal swabs in the acute phase was 3.14%,and no pertussis bacilli were cultured.Real-time fluorescence polymerase chain reaction(Real-time PCR) detection was performed in all samples,and no pertussis bacilli gene sequence was detected.The laboratory diagnosis rate of pertussis was 52.27%.Conclusion In 2017,some achievements have been made in the diagnosis,monitoring and prevention and control of pertussis in Heze,but there are still many problems.It is recommended to continue to strengthen pertussis surveillance and pertussis vaccination,especially to improve laboratory testing.
Objective To understand the epidemiological feature of of pertussis of 2017 in Heze,and to provide scientific basis for the diagnosis,monitoring,prevention and control of pertussis.Methods Descriptive research was carried out according to the information of pertussis network report system,case investigation and laboratory test.Results In 2017,a total of 88 cases of pertussis were reported in Heze,with a incidence of 0.9 397/100 000 and no deaths.The cases are relatively concentrated and highly sporadic,distributed in 83 administrative villages(communities) in 49 towns(offices) in 8 counties of 9 districts of the city.The pertussis case investigation rate was 100.00%.The collection rate of serum samples in the acute phase was 62.50%,the positive rate of serum PT Ig M in the acute phase was 67.27%,and the positive rate of serum PT IgG in the acute phase was83.64%.The collection rate of nasopharyngeal swabs in the acute phase was 3.14%,and no pertussis bacilli were cultured.Real-time fluorescence polymerase chain reaction(Real-time PCR) detection was performed in all samples,and no pertussis bacilli gene sequence was detected.The laboratory diagnosis rate of pertussis was 52.27%.Conclusion In 2017,some achievements have been made in the diagnosis,monitoring and prevention and control of pertussis in Heze,but there are still many problems.It is recommended to continue to strengthen pertussis surveillance and pertussis vaccination,especially to improve laboratory testing.
引文
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[7]蓝岳云,姜宪尘,尹志英,等.衢州市健康人群百日咳和白喉毒素抗体水平监测分析[J].浙江预防医学,2016,28(4):395-397.
[8]陈辉,吴楠,鞠长燕,等.深圳市南山区健康人群百日咳抗体水平及疫苗免疫成功率监测分析[J].微生物学免疫学进展,2015,43(2):21-24.
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[10]韩立红.定西市3~7岁儿童百日咳、腮腺炎、乙肝抗体水平监测结果分析[J].中国初级卫生保健,2017,31(4):59-60.
[11]王代良. 1976-2013年四川省高县百日咳流行态势及特征分析[J].寄生虫病与感染性疾病,2014,12(2):69-72.
[12]常利民,郑治敬,翟春艳. 2010-2012年天津市宁河县百日咳流行特征及直接经济负担分析[J].中国生物制品学杂志,2014,27(5):684-686.
[13]王增国,马超锋,闫永平.全球百日咳重现及中国百日咳相关研究现状[J].中国疫苗和免疫,2016,22(3):345-349.
[14]张平,徐颖华.百日咳细胞免疫的研究进展[J].中国生物制品学杂志,2013,26(7):1029-1033.
[15]刘定昌,杨翠菊,罗启松,等.德宏州2004-2013年百日咳流行病学及控制效果分析[J].医学动物防制,2014,30(12):1327-1329.
[2]瞿建俊,邱德山. 2005-2013年潍坊市百日咳流行病学分析[J].预防医学论坛,2014,20(5):627-628.
[3]宋凯军,刘铁诚,张先慧,等.山东省济南市医疗机构百日咳诊断能力调查[J].中国疫苗和免疫,2016,22(5):533-536.
[4]蒋凤,穆秋玥,张大勇,等. 2004-2013年贵州省百日咳报告病例的流行病学特征分析[J].现代预防医学,2015,42(11):1927-1930.
[5]李玉峰,尹遵栋,李艺星,等.百日咳疫苗保护效果及持久性的研究进展[J].中国疫苗和免疫,2017,23(2):230-233.
[6]宁桂军,吴丹,李军宏,等.全球2010-2014年白喉、破伤风和百日咳免疫预防和发病水平现况分析[J].中国疫苗和免疫,2016,22(2):159-164.
[7]蓝岳云,姜宪尘,尹志英,等.衢州市健康人群百日咳和白喉毒素抗体水平监测分析[J].浙江预防医学,2016,28(4):395-397.
[8]陈辉,吴楠,鞠长燕,等.深圳市南山区健康人群百日咳抗体水平及疫苗免疫成功率监测分析[J].微生物学免疫学进展,2015,43(2):21-24.
[9]李怡秋,喻文雅,闫玉英.石家庄市健康人群百日咳抗体水平分析[J].现代预防医学,2015,42(23):4377-4391.
[10]韩立红.定西市3~7岁儿童百日咳、腮腺炎、乙肝抗体水平监测结果分析[J].中国初级卫生保健,2017,31(4):59-60.
[11]王代良. 1976-2013年四川省高县百日咳流行态势及特征分析[J].寄生虫病与感染性疾病,2014,12(2):69-72.
[12]常利民,郑治敬,翟春艳. 2010-2012年天津市宁河县百日咳流行特征及直接经济负担分析[J].中国生物制品学杂志,2014,27(5):684-686.
[13]王增国,马超锋,闫永平.全球百日咳重现及中国百日咳相关研究现状[J].中国疫苗和免疫,2016,22(3):345-349.
[14]张平,徐颖华.百日咳细胞免疫的研究进展[J].中国生物制品学杂志,2013,26(7):1029-1033.
[15]刘定昌,杨翠菊,罗启松,等.德宏州2004-2013年百日咳流行病学及控制效果分析[J].医学动物防制,2014,30(12):1327-1329.