兰索拉唑在胃溃疡患者中的应用效果及对组织修复相关因子表达的影响研究
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摘要
目的:研究兰索拉唑在胃溃疡患者中的应用效果及对组织修复相关因子表达的影响。方法:选取2017年2月-2018年7月的90例胃溃疡患者为研究对象,将其随机分为对照组(奥美拉唑组)45例和观察组(兰索拉唑组)45例。比较两组治疗后不同时间的临床疗效、治疗前后的症状积分及组织修复相关因子表达情况。结果:观察组治疗后不同时间的临床疗效均优于对照组,差异均有统计学意义(P<0.05),治疗前两组的症状积分及组织修复相关因子表达情况比较,差异均无统计学意义(P>0.05),治疗后不同时间的观察组的各症状积分均低于对照组,组织修复相关因子表达情况均高于对照组,差异均有统计学意义(P<0.05)。结论:兰索拉唑在胃溃疡患者中的应用效果较好,且对组织修复相关因子表达的影响较好,在胃溃疡患者中具有较高的应用价值。
Objective:To study the application effect of lansoprazole in the patients with gastric ulcer and influence for the expression of tissue repair related factors.Method:90 patients with gastric ulcer from February2017 to July 2018 were selected and randomly divided into control group(Omeprazole group)45 cases and observation group(Lansoprazole group)45 cases.The clinical effect at different time after the treatment,symptom scores and tissue repair related factors before and after the treatment of two groups were compared.Result:The clinical effect of the observation group at different time after the treatment were better than those of the control group,the differences were statistically significant(P<0.05).The symptom scores and tissue repair related factors of two groups before the treatment were compared,the differences were no statistically significant(P>0.05).The symptom scores of the observation group at different time after the treatment were lower than those of the control group,and the tissue repair related factors expression of the observation group were all higher than those of the control group,the differences were statistically significant(P<0.05).Conclusion:The application effect of Lansoprazole in the patients with gastric ulcer is better,and its influence for the expression of tissue repair related factors is better.It has higher application value in the patients with gastric ulcer.
Objective:To study the application effect of lansoprazole in the patients with gastric ulcer and influence for the expression of tissue repair related factors.Method:90 patients with gastric ulcer from February2017 to July 2018 were selected and randomly divided into control group(Omeprazole group)45 cases and observation group(Lansoprazole group)45 cases.The clinical effect at different time after the treatment,symptom scores and tissue repair related factors before and after the treatment of two groups were compared.Result:The clinical effect of the observation group at different time after the treatment were better than those of the control group,the differences were statistically significant(P<0.05).The symptom scores and tissue repair related factors of two groups before the treatment were compared,the differences were no statistically significant(P>0.05).The symptom scores of the observation group at different time after the treatment were lower than those of the control group,and the tissue repair related factors expression of the observation group were all higher than those of the control group,the differences were statistically significant(P<0.05).Conclusion:The application effect of Lansoprazole in the patients with gastric ulcer is better,and its influence for the expression of tissue repair related factors is better.It has higher application value in the patients with gastric ulcer.
引文
[1]陈月红,马良,陈鉴.胃苏颗粒联合兰索拉唑治疗活动性胃溃疡临床观察[J].中华中医药学刊,2018,36(6):1506-1510.
[2]杨亚莉.奥美拉唑、泮托拉唑、兰索拉唑治疗胃溃疡的疗效及不良反应[J].甘肃医药,2018,37(6):537-538.
[3]李鑫.铝碳酸镁联合兰索拉唑与单用兰索拉唑治疗幽门螺杆菌相关性胃溃疡的疗效对比[J].现代消化及介入诊疗,2018,23(2):178-180.
[4]罗炎杰,王晓辉,李宇奇,等.兰索拉唑与奥美拉唑治疗活动期胃溃疡的效果及对血清抗氧化因子的影响[J].现代生物医学进展,2018,23(7):1369-1371.
[5]李美姗,魏鑫,吕士红.兰索拉唑三联疗法与铝碳酸镁联用对幽门螺旋杆菌相关性胃溃疡患者的临床疗效和安全性评价[J].抗感染药学,2018,15(1):115-117.
[6]Mizokami Y,Oda K,Funao N,et al.Vonoprazan prevents ulcer recurrence during long-term NSAID therapy:randomised,lansoprazole-controlled non-inferiority and single-blind extension study[J].Gut,2018,67(6):1042-1051
[7]陈晓芳.兰索拉唑对胃溃疡患者血浆多种因子表达的影响研究[J].中国继续医学教育,2017,9(2):153-155.
[8]杜方杰,刘勇,卢贤敏,等.兰索拉唑三联疗法用于幽门螺杆菌相关性胃溃疡的临床观察[J].中国药房,2017,28(24):3354-3357.
[9]闫同庆,陈国庆.奥美拉唑与兰索拉唑治疗活动期胃溃疡患者的临床疗效分析[J].海峡药学,2017,29(10):157-158.
[10]Mishima K,Kitoh H,Ohkawara B,et al.Lansoprazole Upregulates Polyubiquitination of the TNF Receptor-Associated Factor 6 and Facilitates Runx2-mediated Osteoblastogenesis[J].EBioMedicine,2015,2(12):2046-2061.
[11]Nur Azlina M F,Qodriyah H M S,Chua K H,et al.Comparison between tocotrienol and omeprazole on gastric growth factors in stress-exposed rats[J].World J Gastroenterol,2017,23(32):5887-5894.
[12]李应杰,曹桂芳.磷酸铝凝胶联合兰索拉唑治疗幽门螺杆菌阳性胃溃疡的临床研究[J].现代药物与临床,2017,32(1):67-70.
[13]申妮,张永利,刘鹏飞,等.兰索拉唑与奥美拉唑对胃溃疡患者氧化应激水平和内皮功能的影响[J].现代生物医学进展,2017,17(15):2884-2887.
[14]胡艺,刘菲,袁颖华,等.质子泵抑制剂兰索拉唑和奥美拉唑对胃溃疡患者MDA,SOD及NO的影响[J].现代生物医学进展,2017,17(17):3274-3277.
[15]董浩,金世禄,朱凤鸣,等.磷酸铝凝胶联合兰索拉唑对Hp阳性胃溃疡患者HP清除率及血清MMP-9、GAS水平变化的影响[J].中国地方病防治杂志,2017,32(9):1057,1059.
[16]Marcin Magierowski,Katarzyna Magierowska,Magdalena Hubalewska-Mazgaj,et al.Carbon monoxide released from its pharmacological donor,tricarbonyldichlororuthenium(II)dimer,accelerates the healing of pre-existing gastric ulcers[J].Br J Pharmacol,2017,174(20):3654-3668.
[17]仲云,郭建.丹参注射液对胃溃疡患者氧化应激相关指标的影响分析[J].国际医药卫生导报,2015,21(16):2426-2428.
[18]李效宇.兰索拉唑对胃溃疡患者血清丙二醛抗氧化酶超氧化物歧化酶和一氧化氮水平的影响[J].中华实用诊断与治疗杂志,2015,29(10):1034-1035.
[19]王江,周永学,谢勇波.半夏泻心汤拆方对胃溃疡大鼠胃黏膜修复因子EGF、VEGF表达的影响及方中寒热并用配伍意义的研究[J].中华中医药学刊,2015,33(11):2700-2702.
[20]哈小琴,郭文家,张萍,等.肝细胞生长因子基因治疗促进乙酸性胃溃疡组织再生修复的效果[J].中国生物制品学杂志,2017,30(10):1046-1049.
[2]杨亚莉.奥美拉唑、泮托拉唑、兰索拉唑治疗胃溃疡的疗效及不良反应[J].甘肃医药,2018,37(6):537-538.
[3]李鑫.铝碳酸镁联合兰索拉唑与单用兰索拉唑治疗幽门螺杆菌相关性胃溃疡的疗效对比[J].现代消化及介入诊疗,2018,23(2):178-180.
[4]罗炎杰,王晓辉,李宇奇,等.兰索拉唑与奥美拉唑治疗活动期胃溃疡的效果及对血清抗氧化因子的影响[J].现代生物医学进展,2018,23(7):1369-1371.
[5]李美姗,魏鑫,吕士红.兰索拉唑三联疗法与铝碳酸镁联用对幽门螺旋杆菌相关性胃溃疡患者的临床疗效和安全性评价[J].抗感染药学,2018,15(1):115-117.
[6]Mizokami Y,Oda K,Funao N,et al.Vonoprazan prevents ulcer recurrence during long-term NSAID therapy:randomised,lansoprazole-controlled non-inferiority and single-blind extension study[J].Gut,2018,67(6):1042-1051
[7]陈晓芳.兰索拉唑对胃溃疡患者血浆多种因子表达的影响研究[J].中国继续医学教育,2017,9(2):153-155.
[8]杜方杰,刘勇,卢贤敏,等.兰索拉唑三联疗法用于幽门螺杆菌相关性胃溃疡的临床观察[J].中国药房,2017,28(24):3354-3357.
[9]闫同庆,陈国庆.奥美拉唑与兰索拉唑治疗活动期胃溃疡患者的临床疗效分析[J].海峡药学,2017,29(10):157-158.
[10]Mishima K,Kitoh H,Ohkawara B,et al.Lansoprazole Upregulates Polyubiquitination of the TNF Receptor-Associated Factor 6 and Facilitates Runx2-mediated Osteoblastogenesis[J].EBioMedicine,2015,2(12):2046-2061.
[11]Nur Azlina M F,Qodriyah H M S,Chua K H,et al.Comparison between tocotrienol and omeprazole on gastric growth factors in stress-exposed rats[J].World J Gastroenterol,2017,23(32):5887-5894.
[12]李应杰,曹桂芳.磷酸铝凝胶联合兰索拉唑治疗幽门螺杆菌阳性胃溃疡的临床研究[J].现代药物与临床,2017,32(1):67-70.
[13]申妮,张永利,刘鹏飞,等.兰索拉唑与奥美拉唑对胃溃疡患者氧化应激水平和内皮功能的影响[J].现代生物医学进展,2017,17(15):2884-2887.
[14]胡艺,刘菲,袁颖华,等.质子泵抑制剂兰索拉唑和奥美拉唑对胃溃疡患者MDA,SOD及NO的影响[J].现代生物医学进展,2017,17(17):3274-3277.
[15]董浩,金世禄,朱凤鸣,等.磷酸铝凝胶联合兰索拉唑对Hp阳性胃溃疡患者HP清除率及血清MMP-9、GAS水平变化的影响[J].中国地方病防治杂志,2017,32(9):1057,1059.
[16]Marcin Magierowski,Katarzyna Magierowska,Magdalena Hubalewska-Mazgaj,et al.Carbon monoxide released from its pharmacological donor,tricarbonyldichlororuthenium(II)dimer,accelerates the healing of pre-existing gastric ulcers[J].Br J Pharmacol,2017,174(20):3654-3668.
[17]仲云,郭建.丹参注射液对胃溃疡患者氧化应激相关指标的影响分析[J].国际医药卫生导报,2015,21(16):2426-2428.
[18]李效宇.兰索拉唑对胃溃疡患者血清丙二醛抗氧化酶超氧化物歧化酶和一氧化氮水平的影响[J].中华实用诊断与治疗杂志,2015,29(10):1034-1035.
[19]王江,周永学,谢勇波.半夏泻心汤拆方对胃溃疡大鼠胃黏膜修复因子EGF、VEGF表达的影响及方中寒热并用配伍意义的研究[J].中华中医药学刊,2015,33(11):2700-2702.
[20]哈小琴,郭文家,张萍,等.肝细胞生长因子基因治疗促进乙酸性胃溃疡组织再生修复的效果[J].中国生物制品学杂志,2017,30(10):1046-1049.