海洋微生物代谢产物中抗肿瘤活性物质的研究进展
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摘要
海洋微生物特殊的生存环境造就了其独特的代谢方式,从海洋微生物代谢产物中发现具有良好生理活性的抗肿瘤先导化合物已经成为海洋药物开发的研究热点。本文综述了近年来从海洋微生物中发现的结构新颖的具有抗肿瘤活性的代谢产物。
The special living environment of marine microorganisms has created its unique metabolic mode. The anti-tumor lead compounds with good physiological activity from marine microbial metabolites have become a research hotspot in marine drug development. This paper reviews the novel structurally important metabolites with antitumor activity found in marine microorganisms in recent years.
The special living environment of marine microorganisms has created its unique metabolic mode. The anti-tumor lead compounds with good physiological activity from marine microbial metabolites have become a research hotspot in marine drug development. This paper reviews the novel structurally important metabolites with antitumor activity found in marine microorganisms in recent years.
引文
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[3]Sithranga B N,Kathiresan K.Anticancer drugs from marine flora:an overview[J].Journal of Oncology,2010,2010:214186.
[4]Fu P,Legako A,La S,MacMillan J B.Discovery,Characterization and Analogue Synthesis of Bohemamine Dimers Generated by Non‐enzymatic Biosynthesis[J].Chemistry-A European Journal,2016,22(10):3491-3495.
[5]Williams D E,Dalisay D S,Li F,et al.Nahuoic Acid AProduced by a Streptomyces sp.Isolated From a Marine Sediment Is a Selective SAM-Competitive Inhibitor of the Histone Methyltransferase SETD8[J].Organic Letters,2013,15(2):414-417.
[6]Williams D E,Izard F,Arnould S,et al.Structures of Nahuoic Acids B-E Produced in Culture by a Streptomyces sp.Isolated from a Marine Sediment and Evidence for the Inhibition of the Histone Methyl Transferase SETD8 in Human Cancer Cells by Nahuoic Acid A[J].The Journal of Organic Chemistry,2016,81(4):1324-1332.
[7]Hu Y,Macmillan J B.Erythrazoles A-B,Cytotoxic Benzothiazoles from a Marine-Derived Erythrobacter sp.[J].Organic Letters,2011,13(24):6580-6583.
[8]Trzoss L,Fukuda T,Costalotufo L V,et al.Seriniquinone,a selective anticancer agent,induces cell death by autophagocytosis,targeting the cancer-protective protein dermcidin[J].Proceedings of the National Academy of Sciences of the United States of America,2014,111(41):14687-14692.
[9]Nair V,Schuhmann I,Anke H,et al.Marine Bacteria,XLVII-Psychrotolerant Bacteria from Extreme Antarctic Habitats as Producers of Rare Bis-and Trisindole Alkaloids[J].Planta Med,2016,82(9-10):910-918.
[10]Igarashi Y,Asano D,Sawamura M,et al.Ulbactins Fand G,Polycyclic Thiazoline Derivatives with Tumor Cell Migration Inhibitory Activity from Brevibacillus sp.[J].Organic Letters,2016,18(7):1658-1661.
[11]Liao L,Lee J H,You M,et al.Penicillipyrones A and B,Meroterpenoids from a Marine-Derived Penicillium sp.Fungus[J].Journal of Natural Products,2014,77(2):406-410.
[12]Asiri I A M,Badr J M,Youssef D T A.Penicillivinacine,antimigratory diketopiperazine alkaloid from the marine-derived fungus Penicillium vinaceum[J].Phytochemistry Letters,2015,13:53-58.
[13]Shang Z,Li L,Esposito B P,et al.New PKS-NRPStetramic acids and pyridinone from an Australian marine-derived fungus,Chaunopycnis sp.[J].Organic&Biomolecular Chemistry,2015,13(28):7795-7802.
[14]Wu G,Yu G,Kurtán T,et al.Versixanthones A-F,Cytotoxic Xanthone-Chromanone Dimers from the Marine-Derived Fungus Aspergillus versicolor HDN1009.[J].Journal of Natural Products,2015,78(11):2691-2698.
[15]Blunt J W,Copp B R,Keyzers R A,et al.Marine natural products[J].Natural Product Reports,2016,33:382-431.
[16]Blunt J W,Copp B R,Keyzers R A,et al.Marine natural products[J].Natural Product Reports,2017,34:235-294.
[17]Blunt J W,Carroll A R,Copp B R,et al.Marine natural products[J].Natural Product Reports,2018,35:8-53.
[18]Simmons T L,Andrianasolo E,Mcphail K,et al.Marine natural products as anticancer drugs.[J].Molecular Cancer Therapeutics,2005,4(2):333-342.
[19]Molinski T F,Dalisay D S,Lievens S L,Saludes J P.Drug development from marine natural products.[J].Nature Reviews Drug Discovery,2009,8:69-85.
[20]陈钢,朱卫.海洋微生物抗肿瘤活性物质研究进展[J].浙江海洋学院学报(自然科学版),2008,27(3):321-326.