海洋生物来源血管紧张素转换酶抑制肽的研究进展
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摘要
血管紧张素转化酶(angiotensin converting enzyme,ACE)抑制剂通过抑制ACE活性能够降低血压。目前人工合成ACE抑制药物已开发并应用到降血压的治疗中,但会带来多种副作用。食源性ACE抑制肽与合成抑制剂相比因其副作用小、安全性高等特点,成为ACE抑制肽研究的热点。由于独特的生活环境与巨大的存在数量,海洋生物具有与陆地生物截然不同的化学结构及丰富的生物活性成分。海洋生物来源ACE抑制肽的研究为食源性ACE抑制肽的筛选提供了基础。本文结合海洋生物来源ACE抑制肽的作用机制及制备流程,对鱼类、软体动物、虾类、藻类及海绵、海蜇、粗刺参等不同生物来源的ACE抑制肽制备工艺进行了综述,并对海洋生物的综合开发利用进行了概括。
Angiotensin converting enzyme(ACE) inhibitors can reduce blood pressure by inhibiting ACE activity. At present, synthetic ACE inhibitors have been developed and applied to the treatment of blood pressure lowering, but will bring many side effects. Compared with synthetic inhibitors, foodborne ACE inhibitory peptides have become a hotspot in the research of ACE inhibitory peptides because of their less side-effects and high safety. Because of its unique living environment and large number of living organisms, marine organisms have distinct chemical structures and abundant bioactive components from terrestrial organisms. The study of ACE inhibitory peptides from marine organisms provides a basis for the screening of foodborne ACE inhibitory peptides. Based on the mechanism and preparation process of ACE inhibitory peptides from marine organisms, this paper reviewed the preparation process of ACE inhibitory peptides from different biological sources, such as fish, molluscs, shrimp, algae and sponges, jellyfish, sea cucumber, etc, and the comprehensive development and utilization of marine organisms were summarized.
Angiotensin converting enzyme(ACE) inhibitors can reduce blood pressure by inhibiting ACE activity. At present, synthetic ACE inhibitors have been developed and applied to the treatment of blood pressure lowering, but will bring many side effects. Compared with synthetic inhibitors, foodborne ACE inhibitory peptides have become a hotspot in the research of ACE inhibitory peptides because of their less side-effects and high safety. Because of its unique living environment and large number of living organisms, marine organisms have distinct chemical structures and abundant bioactive components from terrestrial organisms. The study of ACE inhibitory peptides from marine organisms provides a basis for the screening of foodborne ACE inhibitory peptides. Based on the mechanism and preparation process of ACE inhibitory peptides from marine organisms, this paper reviewed the preparation process of ACE inhibitory peptides from different biological sources, such as fish, molluscs, shrimp, algae and sponges, jellyfish, sea cucumber, etc, and the comprehensive development and utilization of marine organisms were summarized.
引文
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[3]Liu Z,Dong S,Xu J,et al.Production of cysteine-rich antimicrobial peptide by digestion of oyster(Crassostrea gigas)with alcalase and bromelin[J].Food Control,2008,19(3):231-235.
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[6]Lignitto L,Cavatorta V,Balzan S,et al.Angiotensin-converting enzyme inhibitory activity of water-soluble extracts of Asiago d'allevo cheese[J].Int Dairy J,2010,20(1):11-17.
[7]Wang FJ,Yin XY,Regenstein JM,et al.Separation and purification of angiotensin-I-converting enzyme(ACE)inhibitory peptides from walnuts(Juglans regia L.)meal[J].Eur Food Res Technol,2016,242(6):911-918.
[8]操德群,何艳丽,余虹,等.海洋生物ACE抑制肽研究进展[J].核农学报,2017,31(5):927-937.Cao DQ,He YL,Yu H,et al.Advance on angiotensin-I-converting enzyme inhibitory peptides from marine resources[J].J Nucl Agric Sci,2017,31(5):927-937.
[9]Ferreira SH.A bradykinin-potentiating factor(bpf)present in the venom of bothrops jararca[J].Br J Pharmacol,1965,24(1):163.
[10]Ondetti MA,Rubin B,Cushman DW.Design of specific inhibitors of angiotensin-converting enzyme:new class of orally active antihypertensive agents[J].Science,1977,196(4288):441-444.
[11]Cheung HS,Cushman DW.Inhibition of homogeneous angiotensin-converting enzyme of rabbit lung by synthetic venom peptides of Bothrops jararaca[J].BBA-Proteins Proteom,1973,293(2):451-463.
[12]Wang S,Lin LM,Wu YN,et al.Angiotensin I converting enzyme(ACE)inhibitory activity and antihypertensive effects of grass carp peptides[J].Food Sci Biotechnol,2014,23(5):1661-1666.
[13]Hong F,Junling H,Yi S,et al.The effects of angiotensin-converting enzyme-inhibitory peptide LAP on the left common carotid artery remodeling in spontaneously hypertensive rats[J].Irish J Med Sci,2013,182(4):711-718.
[14]Ngai N,Tsai FY,Coruzzi G.Characterization of ACE-inhibitory Peptide from hydrolysis product of egg yolk protein and its hypotensive effect in SHR rat[J].Nipponyo Shokuryo Gakkaishi,2006,59(1):15-19.
[15]Lee SY,Hur SJ.Antihypertensive peptides from animal products,marine organisms,and plants[J].Food Chem,2017,228(3):506-517.
[16]Sun L,Wu S,Zhou L,et al.Separation and characterization of angiotensin I converting enzyme(ACE)inhibitory peptides from saurida elongata proteins hydrolysate by IMAC-Ni2[J].Mar Drugs,2017,15(2):29-39.
[17]Wang X,Chen H,Fu X,et al.A novel antioxidant and ACE inhibitory peptide from rice bran protein:Biochemical characterization and molecular docking study[J].LWT-Food Sci Technol,2017:75(3):93-99.
[18]Jang A,Lee M.Purification and identification of angiotensin converting enzyme inhibitory peptides from beef hydrolysates[J].Meat Sci,2005,69(4):653-661.
[19]Norris R,Poyarkov A,O'keeffe MB,et al.Characterisation of the hydrolytic specificity of Aspergillus niger derived prolyl endoproteinase on bovine beta-casein and determination of ACE inhibitory activity[J].Food Chem,2015,156(3):29-36.
[20]Norris R,O'keeffe MB,Poyarkov A,et al.Peptide identification and angiotensin converting enzyme(ACE)inhibitory activity in prolyl endoproteinase digests of bovine alpha(s)-casein[J].Food Chem,2015,188(3):210-217.
[21]Fujita H,Yoshikawa M.LKPNM:a prodrug-type ACE-inhibitory peptide derived from fish protein[J].Immunopharmacology,1999,44(1-2):123-127.
[22]Intarasirisawat R,Benjakul S,Wu J,et al.Isolation of antioxidative and ACE inhibitory peptides from protein hydrolysate of skipjack(Katsuwana pelamis)roe[J].J Funct Food,2013,5(4):1854-1862.
[23]Lee JK,Jeon J,Byun H.Antihypertensive effect of novel angiotensin Iconverting enzyme inhibitory peptide from chum salmon(Oncorhynchus keta)skin in spontaneously hypertensive rats[J].J Funct Food,2014,7(3):381-389.
[24]Gu R,Li C,Liu W,et al.Angiotensin I-converting enzyme inhibitory activity of low-molecular-weight peptides from Atlantic salmon(Salmo salar L.)skin[J].Food Res Int,2011,44(5):1536-1540.
[25]Himaya SWA,Ngo D,Ryu B,et al.An active peptide purified from gastrointestinal enzyme hydrolysate of Pacific cod skin gelatin attenuates angiotensin-1 converting enzyme(ACE)activity and cellular oxidative stress[J].Food Chem,2012,132(4):1872-1882.
[26]Ngo D,Vo T,Ryu B,et al.Angiotensin-I-converting enzyme(ACE)inhibitory peptides from Pacific cod skin gelatin using ultrafiltration membranes[J].Process Biochem,2016,51(10):1622-1628.
[27]Zou P,Wang JL,He GQ,et al.Purification,identification,and in vivo activity of angiotensin I-converting enzyme inhibitory peptide,from ribbonfish(Trichiurus haumela)backbone[J].J Food Sci,2014,79(1):1-7.
[28]Lan X,Liao D,Wu S,et al.Rapid purification and characterization of angiotensin converting enzyme inhibitory peptides from lizard fish protein hydrolysates with magnetic affinity separation[J].Food Chem,2015,182(3):136-142.
[29]Ngo DH,Kang KH,Ryu B,et al.Angiotensin-I converting enzyme inhibitory peptides from antihypertensive skate(Okamejei kenojei)skin gelatin hydrolysate in spontaneously hypertensive rats[J].Food Chem,2015,174(3):37-43.
[30]刘文颖,林峰,金振涛,等.深海鲑鱼皮来源ACE抑制肽的分离及鉴定[J].现代食品科技,2016,32(6):170-176.Liu WY,Lin F,Jin ZT,et al.Separation and identification of ACEinhibitory peptides derived from deep-sea salmon skin[J].Mod Food Sci Technol,2016,32(6):170-176.
[31]Wijesekara I,Qian ZJ,Ryu B,et al.Purification and identification of antihypertensive peptides from seaweed pipefish(Syngnathus schlegeli)muscle protein hydrolysate[J].Food Res Int,2011,44(3):703-707.
[32]Ghassem M,Arihara K,Babji AS,et al.Purification and identification of ACE inhibitory peptides from haruan(Channa striatus)myofibrillar protein hydrolysate using HPLC-ESI-TOF MS/MS[J].Food Chem,2011,129(4):1770-1777.
[33]Ahn C,Jeon Y,Kim Y,et al.Angiotensin I converting enzyme(ACE)inhibitory peptides from salmon byproduct protein hydrolysate by Alcalase hydrolysis[J].Process Biochem,2012,47(12):2240-2245.
[34]Liu R,Zhu Y,Chen J,et al.Characterization of ACE inhibitory peptides from Mactra veneriformis hydrolysate by nano-liquid chromatography electrospray ionization mass spectrometry(Nano-LC-ESI-MS)and molecular docking[J].Mar Drugs,2014,12(7):3917-3928.
[35]Li Y,Sadiq FA,Fu L,et al.Identification of angiotensin I-converting enzyme inhibitory peptides derived from enzymatic hydrolysates of razor clam sinonovacula constricta[J].Mar Drugs,2016,14(6):110.
[36]Wang J,Hu J,Cui J,et al.Purification and identification of a ACEinhibitory peptide from oyster proteins hydrolysate and the antihypertensive effect of hydrolysate in spontaneously hypertensive rats[J].Food Chem,2008,111(2):302-308.
[37]Xie CL,Kim JS,Ha JM,et al.Angiotensin I-converting enzyme inhibitor derived from cross-linked oyster protein[J].Biomed Res Int,2014,2014(379234.
[38]冯晓梅,韩玉谦,赵志强,等.牡蛎酶解产物中多肽的分离纯化及其结构研究[J].中国海洋药物,2009,28(2):1-5.Feng XM,Han YQ,Zhao ZQ,et al.Study of isolation,preparation and structure identification of peptides from hydrolyzates of oyster[J].Chin JMar Drugs,2009,28(2):1-5
[39]Wu Q,Cai Q,Tao Z,et al.Purification and characterization of a novel angiotensin I-converting enzyme inhibitory peptide derived from abalone(Haliotis discus hannai Ino)gonads[J].Eur Food Res Technol,2014,240(1):137-145.
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