稳心颗粒联合小剂量雌激素替代疗法治疗围绝经期心律失常临床研究
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摘要
目的:观察稳心颗粒联合小剂量雌激素替代疗法治疗围绝经期心律失常的临床疗效。方法:纳入160例气阴两虚型围绝经期心律失常患者作为研究对象,按照随机数字表法分为对照组和研究组各80例,对照组予以小剂量雌激素替代治疗,研究组予以稳心颗粒联合小剂量雌激素替代疗法治疗,检测2组患者治疗前后的血清卵泡生成素(FSH)、雌二醇(E2)和黄体生成素(LH)水平,观察2组患者临床症状和24 h动态心电图的改善情况。记录患者治疗期间药物不良反应的发生情况。结果:治疗后,研究组临床疗效和早搏疗效均优于对照组,差异均有统计学意义(P <0.05)。2组血清FSH、LH水平均较治疗前降低,E2水平均高于治疗前,差异均有统计学意义(P <0.01)。研究组血清FSH、LH水平均低于对照组,血清E2水平高于对照组,差异均有统计学意义(P <0.01)。2组早搏次数、ST段下降幅度、ST段下降持续时间和平均心率均较治疗前减少(P <0.01),研究组各指标值均低于对照组(P <0.01)。2组药物不良反应发生率比较,差异无统计学意义(P> 0.05)。结论:稳心颗粒联合小剂量雌激素替代疗法可有效改善围绝经期心律失常患者的激素分泌水平,缓解围绝经期相关临床症状,提高临床疗效,且不增加药物不良反应。
Objective: To observe the clinical effect of Wenxin granules combined with low-dose estrogen replacement therapy for perimenopausal arrhythmia. Methods:Included 160 cases of patients with perimenopausal arrhythmia with qi-yin deficiency syndrome as study subjects and divided them into the control group and the study group according to random number table,80 cases in each group. The control group received low-dose estrogen replacement therapy,and the study group was given Wenxin granules combined with low-dose estrogen replacement therapy. Detected the levels of serum follicle-stimulating hormone(FSH), estradiol(E2) and luteinizing hormone(LH) in tho two groups before and after treatment,and observed the improvement of clinical symptoms and dynamic electrocardiogram in 24 h of patients in the two groups.Recorded the occurrence of adverse drug reactions of patients during the treatment. Results: After treatment, the clinical effect and premature beats of the study group were better than those in the control group,differences being significant(P <0.05). The levels of serum FSH and LH in the two groups were lower than those before treatment;the E2 level was higher than that before treatment,differences being significant(P < 0.01). The levels of serum FSH and LH in the study group were lower than those in the control group; the serum E2 level was higher than that in the control group, differences being significant(P < 0.01). The number of premature beats,ST segment decline,duration time of ST segment decline and average heart rate in the two groups were lower than those before treatment(P < 0.01);the values of each index in the study group were lower than those in the control group(P < 0.01). There was no significant difference being found in the comparison of the incidence of adverse drug reactions between the two groups(P > 0.05). Conclusion: The application of Wenxin granules combined with low-dose estrogen replacement therapy can effectively improve the hormone metabolism level in patients with perimenopausal arrhythmia,alleviate the clinical symptoms during perimenopause,and promote the clinical effect. It does not increase adverse drug reactions.
Objective: To observe the clinical effect of Wenxin granules combined with low-dose estrogen replacement therapy for perimenopausal arrhythmia. Methods:Included 160 cases of patients with perimenopausal arrhythmia with qi-yin deficiency syndrome as study subjects and divided them into the control group and the study group according to random number table,80 cases in each group. The control group received low-dose estrogen replacement therapy,and the study group was given Wenxin granules combined with low-dose estrogen replacement therapy. Detected the levels of serum follicle-stimulating hormone(FSH), estradiol(E2) and luteinizing hormone(LH) in tho two groups before and after treatment,and observed the improvement of clinical symptoms and dynamic electrocardiogram in 24 h of patients in the two groups.Recorded the occurrence of adverse drug reactions of patients during the treatment. Results: After treatment, the clinical effect and premature beats of the study group were better than those in the control group,differences being significant(P <0.05). The levels of serum FSH and LH in the two groups were lower than those before treatment;the E2 level was higher than that before treatment,differences being significant(P < 0.01). The levels of serum FSH and LH in the study group were lower than those in the control group; the serum E2 level was higher than that in the control group, differences being significant(P < 0.01). The number of premature beats,ST segment decline,duration time of ST segment decline and average heart rate in the two groups were lower than those before treatment(P < 0.01);the values of each index in the study group were lower than those in the control group(P < 0.01). There was no significant difference being found in the comparison of the incidence of adverse drug reactions between the two groups(P > 0.05). Conclusion: The application of Wenxin granules combined with low-dose estrogen replacement therapy can effectively improve the hormone metabolism level in patients with perimenopausal arrhythmia,alleviate the clinical symptoms during perimenopause,and promote the clinical effect. It does not increase adverse drug reactions.
引文
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[5]沈秋生.二仙汤合交泰丸加减治疗围绝经期心悸50例临床观察[J].湖南中医杂志,2014,30(12):58-59.
[6]毛恩平.低剂量雌激素替代疗法治疗围绝经期综合征的疗效分析[J].中西医结合心血管病电子杂志,2016,4(25):193.
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[9]吴金秀.围绝经期综合症应用小剂量雌激素联合孕激素治疗的临床效果观察[J].实用妇科内分泌杂志(电子版),2017,4(11):63-64.
[10]赵涛,赵步长,伍海勤,等.稳心颗粒处方组分的心血管药理研究进展[J].光明中医,2014,29(3):642-644.
[11]王庆丰,姚水华.倍他乐克与稳心颗粒联合治疗心律失常疗效观察[J].新中医,2017,49(4):19-21.
[12]杨相挺,王振中.稳心颗粒联合倍他乐克治疗冠心病心律失常疗效观察[J].新中医,2017,49(1):19-21.
[13]陆庆,胡道卿.稳心颗粒治疗女性更年期心律失常疗效观察[J].陕西中医,2015,36(3):286-287.
[14]杨林,姚福梅,纪焕春.参松养心胶囊联合比索洛尔治疗围绝经期心律失常的临床观察[J].中华中医药学刊,2017,35(3):738-740.
[15]张屏.步长稳心颗粒合并雌激素治疗更年期综合征的临床研究[J].中国医药导报,2009,6(5):42-43.
[16]阎秀静,王翠萍.小剂量激素替代联合中药治疗围绝经期妇女心血管疾病的疗效分析[J].实用预防医学,2012,19(4):581-582.
[2]龙英.小剂量激素替代疗法联合参龙宁心胶囊治疗围绝经期心血管疾病的疗效观察[J].实用心脑肺血管病杂志,2014,22(9):120-121.
[3]曹泽毅.中华妇产科学[M].2版.北京:人民卫生出版社,2007:2530-2537.
[4]杨敏,李灿东,李红,等.围绝经期综合征中医证素与性激素水平的相关研究[J].中华中医药杂志,2012,27(2):366-368.
[5]沈秋生.二仙汤合交泰丸加减治疗围绝经期心悸50例临床观察[J].湖南中医杂志,2014,30(12):58-59.
[6]毛恩平.低剂量雌激素替代疗法治疗围绝经期综合征的疗效分析[J].中西医结合心血管病电子杂志,2016,4(25):193.
[7]梁彩平.低剂量雌激素替代疗法治疗围绝经期综合征的疗效及其对患者体内激素水平的影响[J].临床合理用药杂志,2016,9(27):62-63.
[8]苗艳华.围绝经期综合症应用小剂量雌激素联合孕激素治疗的临床效果观察[J].中国卫生产业,2014,13(34):104-105.
[9]吴金秀.围绝经期综合症应用小剂量雌激素联合孕激素治疗的临床效果观察[J].实用妇科内分泌杂志(电子版),2017,4(11):63-64.
[10]赵涛,赵步长,伍海勤,等.稳心颗粒处方组分的心血管药理研究进展[J].光明中医,2014,29(3):642-644.
[11]王庆丰,姚水华.倍他乐克与稳心颗粒联合治疗心律失常疗效观察[J].新中医,2017,49(4):19-21.
[12]杨相挺,王振中.稳心颗粒联合倍他乐克治疗冠心病心律失常疗效观察[J].新中医,2017,49(1):19-21.
[13]陆庆,胡道卿.稳心颗粒治疗女性更年期心律失常疗效观察[J].陕西中医,2015,36(3):286-287.
[14]杨林,姚福梅,纪焕春.参松养心胶囊联合比索洛尔治疗围绝经期心律失常的临床观察[J].中华中医药学刊,2017,35(3):738-740.
[15]张屏.步长稳心颗粒合并雌激素治疗更年期综合征的临床研究[J].中国医药导报,2009,6(5):42-43.
[16]阎秀静,王翠萍.小剂量激素替代联合中药治疗围绝经期妇女心血管疾病的疗效分析[J].实用预防医学,2012,19(4):581-582.