尿液有形成分分析仪及其在尿常规自动化分析中的应用进展
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摘要
介绍了尿液有形成分分析仪的发展历程及研究现状,分析了临床常见的尿液有形成分分析仪的分类、工作原理、性能特点、临床应用及其优缺点。指出了集全自动尿液有形成分分析仪(以全视野实景沉渣形态显示技术为原理、采用一次性计数板)和尿液干化学分析仪一体化的全自动尿液分析检测系统是今后尿液有形成分分析仪发展的必然方向。
The development history and research status of the urine formed elements analyzer were introduced. The clinically available analyzers had the indexes analyzed including classification, working principle, performances, clinical application, advantages and disadvantages. It's pointed out the future trends involved in automatic analyzer with full-vision realistic displaying technique and disposable counting plate as well as automatic urine analysis and test system integrating urine chemical analyzer. [Chinese Medical Equipment Journal,2019,40(5):96-102]
The development history and research status of the urine formed elements analyzer were introduced. The clinically available analyzers had the indexes analyzed including classification, working principle, performances, clinical application, advantages and disadvantages. It's pointed out the future trends involved in automatic analyzer with full-vision realistic displaying technique and disposable counting plate as well as automatic urine analysis and test system integrating urine chemical analyzer. [Chinese Medical Equipment Journal,2019,40(5):96-102]
引文
[1]MCMAHON B A,KOYNER J L.Risk stratification for acute kidney injury:are biomarkers enough?[J].Adv Chronic Kidney Dis,2016,23(3):167-178.
[2]VILAJELIU A,SEQUERA V G,GARCIA-BASTEIRO A L,et al.Immunogenicity and immunization costs of adjuvanted versus non-adjuvanted hepatitis B vaccine in chronic kidney disease patients[J].Hum Vaccin Immunother,2016,12(9):2 317-2 321.
[3]MOON K H,KO I K,YOO J J,et al.Kidney diseases and tissue engineering[J].Methods,2016,99:112-119.
[4]KOCER D,SARIGUZEL F M,CIRACI M Z,et al.Diagnostic accuracy of a new urinalysis system,DongJiu,for diagnosis of urinary tract infection[J].Ann Clin Lab Sci,2015,45(6):686-691.
[5]KANEGAYE J T,JACOB J M,MALICKI D.Automated urinalysis and urine dipstick in the emergency evaluation of young febrile children[J].Pediatrics,2014,134(3):523-529.
[6]ALMADHOUN M D,EL-HALEES A.Automated recognition of urinary microscopic solid particles[J].J Med Eng Technol,2014,38(2):104-110.
[7]从玉隆,马骏龙,张时民.实用尿液分析技术与临床[M].北京:人民卫生出版社,2013.
[8]翟菊萍,彭群新,严洁尘,等.迪瑞FUS-200全自动尿沉渣分析仪的应用评价[J].中国血液流变学杂志,2011,21(4):714-716,727.
[9]CUI M,JU S P,SHI Y J,et al.Performance verification of the Iris iQ200 sprint automated urine microscopy analyzer in a hospital routine laboratory[J].Clin Lab,2017,63(10):1 607-1 612.
[10]BAKAN E,OZTURK N,BAYGUTALP N K,et al.Comparison of Cobas 6500 and Iris IQ200 fully-automated urine analyzers to manual urine microscopy[J].Biochem Med(Zagreb),2016,26(3):365-375.
[11]王丹微,倪军.UF-1000i全自动尿有形成分分析仪对血尿检测的携带污染分析[J].医疗卫生装备,2017,38(7):101-103.
[12]INIGO M,COELLO A,FERNANDEZ-RIVAS G,et al.Direct identification of urinary tract pathogens from urine samples,combining urine screening methods and matrix-assisted laser desorption ionization-time of flight mass spectrometry[J].J Clin Microbiol,2016,54(4):988-993.
[13]HUYSAL K,BUDAK Y U,KARACA A U,et al.Diagnostic accuracy of uriSed automated urine microscopic sediment analyzer and dipstick parameters in predicting urine culture test results[J].Biochem Med(Zagreb),2013,23(2):211-217.
[14]BAKAN E,BAYRAKTUTAN Z,BAYGUTALP N K,et al.Evaluation of the analytical performances of Cobas 6500 and Sysmex UN series automated urinalysis systems with manual microscopic particle counting[J].Biochem Med(Zagreb),2018,28(2):020712.
[15]KOURI T T,MAKKONEN P.External quality assessment of urine particle identification:a Northern European experience[J].Clin Chem Lab Med,2015,53(Suppl 2):s1 489-s1 493.
[16]LEE W,HA J S,RYOO N H.Comparison of the automated cobas u 701 urine microscopy and UF-1000i flow cytometry systems and manual microscopy in the examination of urine sediments[J].J Clin Lab Anal,2016,30(5):663-671.
[17]ALTEKIN E,KADICESME O,AKAN P,et al.New generation IQ-200 automated urine microscopy analyzer compared with KOVA cell chamber[J].J Clin Lab Anal,2010,24(2):67-71.
[18]YUKSEL H,KILIC E,EKINCI A,et al.Comparison of fully automated urine sediment analyzers H800-FUS100 and LabUMat-UriSed with manual microscopy[J].J Clin Lab Anal,2013,27(4):312-316.
[19]殷贤斌,胡晓武,谢萍,等.科宝XS全自动尿液有形成分分析仪的性能评价[J].医疗卫生装备,2016,37(7):93-96.
[20]MANONI F,GESSONI G,ALESSIO M G,et al.Gender’s equality in evaluation of urine particles:results of a multicenter study of the Italian Urinalysis Group[J].Clin Chim Acta,2014,427:1-5.
[21]MUNOZ-ALGARRA M,MARTINEZ-RUIZ R,ORDEN-MARTINEZ B.[Evaluation of the Sysmex UF-1000i automated system for the diagnosis of urinary tract infection][J].Enferm Infecc Microbiol Clin,2013,31(1):29-31.
[22]SHANG Y J,WANG Q Q,ZHANG J R,et al.Systematic review and meta-analysis of flow cytometry in urinary tract infection screening[J].Clin Chim Acta,2013,424:90-95.
[23]崔薇薇,梅燕萍,聂珍琳,等.迪瑞FUS-2000全自动尿液分析仪检测尿液红细胞、白细胞的性能评价[J].医疗卫生装备,2017,38(8):82-85.
[24]ARMBRUSTER D A,OVERCASH D R,REYES J.Clinical chemistry laboratory automation in the 21st century-amat victoria curam(Victory loves careful preparation)[J].Clin Biochem Rev,2014,35(3):143-153.
[25]黄福达,杨志钊,张秀明,等.UF-1000i全自动尿液有形成分分析仪性能评价[J].检验医学,2011,26(8):560-563.
[26]宋晓冬,丁旭,贾向新,等.尿常规复检规则的探讨[J].中国临床研究,2011,24(12):1 148-1 150.
[27]AVCI D,LEBLEBICIOGLU M K,POYRAZ M,et al.A new method based on Adaptive Discrete Wavelet Entropy Energy and Neural Network Classifier(ADWEENN)for recognition of urine cells from microscopic images independent of rotation and scaling[J].J Med Syst,2014,38(2):7.
[28]殷贤斌,王敏,胡晓武,等.全自动尿沉渣分析仪FUS-2000的性能评价[J].中华全科医学,2015,13(12):2 023-2 025.
[29]SHAH A P,COBB B T,LOWER D R,et al.Enhanced versus automated urinalysis for screening of urinary tract infections in children in the emergency department[J].Pediatr Infect Dis J,2014,33(3):272-275.
[30]魏运梅,易光明,熊军.COBIO全自动尿液分析工作站性能评价[J].检验医学,2012,27(7):531-533.
[31]ANDERLINI R,MANIERI G,LUCCHI C,et al.Automated urinalysis with expert review for incidental identification of atypical urothelial cells:an anticipated bladder carcinoma diagnosis[J].Clin Chim Acta,2015,451(Pt B):252-256.
[32]FALBO R,SALA M R,SIGNORELLI S,et al.Bacteriuria screening by automated whole-field-image-based microscopy reduces the number of necessary urine cultures[J].J Clin Microbiol,2012,50(4):1 427-1 429.
[33]高淑芳,张雪清,陆波,等.人工镜检与科宝XS全自动尿沉渣分析仪及IQ200尿沉渣分析仪的比较和评价[J].检验医学,2011,26(4):231-234.
[34]INIGO M,COELLO A,FERNANDEZ-RIVAS G,et al.Evaluation of the SediMax automated microscopy sediment analyzer and the Sysmex UF-1000i flow cytometer as screening tools to rule out negative urinary tract infections[J].Clin Chim Acta,2016,456:31-35.
[35]陈曼铌,陈波,康嘉乐,等.LX-8000全自动尿液分析仪在尿液有形成分检测中的性能评价[J].检验医学与临床,2014,11(7):893-895.
[36]陈文举,王乐见,陈军斌,等.LX-3000尿沉渣分析仪诊断肾小球性血尿的临床意义[J].实用医技杂志,2006,13(10):1 705-1 706.
[37]余红俊,庄爱周,任蓉蓉,等.Cobas 6500尿液流水线筛选红细胞白细胞能力分析[J].中国卫生检验杂志,2018,22(22):2 728-2 730.
[38]张时民.尿有形成分检查自动化进展和质量保证[J].中国医疗器械信息,2012(4):13-22.
[39]吴晓华,肖迨,李秋晨,等.全自动尿液分析工作站复检规则的制定及应用评估[J].中华检验医学杂志,2014,37(6):465-468.
[40]刘金祥,丁勇,曹翠云,等.尿红细胞形态判断标准探究[J].检验医学,2017,32(7):582-585.
[41]AHMED A I,BAZ H,LOTFY S.Urinalysis:the automated versus manual techniques;is it time to change?[J].Clin Lab,2016,62(1-2):49-56.
[42]SUN W,XV Z,WANG C,et al.Evaluation of aging and health status in real time based on routine urinalysis using an automated urine analyzer[J].Clin Lab,2015,61(12):1 883-1 887.
[43]KOCER D,SARIGUZEL F M,KARAKUKCU C.Cutoff values for bacteria and leukocytes for urine sediment analyzer FUS200 in culture-positive urinary-tract infections[J].Scand J Clin Lab Invest,2014,74(5):414-417.
[44]MUN P S,TING H N,ONG T A,et al.A study of dielectric properties of proteinuria between 0.2 GHz and 50 GHz[J].PLoS One,2015,10(6):e0130011.
[45]BUSTAMANTE V,MEZA P,ROMAN J C,et al.[Evaluation of an automated streaking system of urine samples for urine cultures][J].Rev Chilena Infectol,2014,31(6):670-675.
[2]VILAJELIU A,SEQUERA V G,GARCIA-BASTEIRO A L,et al.Immunogenicity and immunization costs of adjuvanted versus non-adjuvanted hepatitis B vaccine in chronic kidney disease patients[J].Hum Vaccin Immunother,2016,12(9):2 317-2 321.
[3]MOON K H,KO I K,YOO J J,et al.Kidney diseases and tissue engineering[J].Methods,2016,99:112-119.
[4]KOCER D,SARIGUZEL F M,CIRACI M Z,et al.Diagnostic accuracy of a new urinalysis system,DongJiu,for diagnosis of urinary tract infection[J].Ann Clin Lab Sci,2015,45(6):686-691.
[5]KANEGAYE J T,JACOB J M,MALICKI D.Automated urinalysis and urine dipstick in the emergency evaluation of young febrile children[J].Pediatrics,2014,134(3):523-529.
[6]ALMADHOUN M D,EL-HALEES A.Automated recognition of urinary microscopic solid particles[J].J Med Eng Technol,2014,38(2):104-110.
[7]从玉隆,马骏龙,张时民.实用尿液分析技术与临床[M].北京:人民卫生出版社,2013.
[8]翟菊萍,彭群新,严洁尘,等.迪瑞FUS-200全自动尿沉渣分析仪的应用评价[J].中国血液流变学杂志,2011,21(4):714-716,727.
[9]CUI M,JU S P,SHI Y J,et al.Performance verification of the Iris iQ200 sprint automated urine microscopy analyzer in a hospital routine laboratory[J].Clin Lab,2017,63(10):1 607-1 612.
[10]BAKAN E,OZTURK N,BAYGUTALP N K,et al.Comparison of Cobas 6500 and Iris IQ200 fully-automated urine analyzers to manual urine microscopy[J].Biochem Med(Zagreb),2016,26(3):365-375.
[11]王丹微,倪军.UF-1000i全自动尿有形成分分析仪对血尿检测的携带污染分析[J].医疗卫生装备,2017,38(7):101-103.
[12]INIGO M,COELLO A,FERNANDEZ-RIVAS G,et al.Direct identification of urinary tract pathogens from urine samples,combining urine screening methods and matrix-assisted laser desorption ionization-time of flight mass spectrometry[J].J Clin Microbiol,2016,54(4):988-993.
[13]HUYSAL K,BUDAK Y U,KARACA A U,et al.Diagnostic accuracy of uriSed automated urine microscopic sediment analyzer and dipstick parameters in predicting urine culture test results[J].Biochem Med(Zagreb),2013,23(2):211-217.
[14]BAKAN E,BAYRAKTUTAN Z,BAYGUTALP N K,et al.Evaluation of the analytical performances of Cobas 6500 and Sysmex UN series automated urinalysis systems with manual microscopic particle counting[J].Biochem Med(Zagreb),2018,28(2):020712.
[15]KOURI T T,MAKKONEN P.External quality assessment of urine particle identification:a Northern European experience[J].Clin Chem Lab Med,2015,53(Suppl 2):s1 489-s1 493.
[16]LEE W,HA J S,RYOO N H.Comparison of the automated cobas u 701 urine microscopy and UF-1000i flow cytometry systems and manual microscopy in the examination of urine sediments[J].J Clin Lab Anal,2016,30(5):663-671.
[17]ALTEKIN E,KADICESME O,AKAN P,et al.New generation IQ-200 automated urine microscopy analyzer compared with KOVA cell chamber[J].J Clin Lab Anal,2010,24(2):67-71.
[18]YUKSEL H,KILIC E,EKINCI A,et al.Comparison of fully automated urine sediment analyzers H800-FUS100 and LabUMat-UriSed with manual microscopy[J].J Clin Lab Anal,2013,27(4):312-316.
[19]殷贤斌,胡晓武,谢萍,等.科宝XS全自动尿液有形成分分析仪的性能评价[J].医疗卫生装备,2016,37(7):93-96.
[20]MANONI F,GESSONI G,ALESSIO M G,et al.Gender’s equality in evaluation of urine particles:results of a multicenter study of the Italian Urinalysis Group[J].Clin Chim Acta,2014,427:1-5.
[21]MUNOZ-ALGARRA M,MARTINEZ-RUIZ R,ORDEN-MARTINEZ B.[Evaluation of the Sysmex UF-1000i automated system for the diagnosis of urinary tract infection][J].Enferm Infecc Microbiol Clin,2013,31(1):29-31.
[22]SHANG Y J,WANG Q Q,ZHANG J R,et al.Systematic review and meta-analysis of flow cytometry in urinary tract infection screening[J].Clin Chim Acta,2013,424:90-95.
[23]崔薇薇,梅燕萍,聂珍琳,等.迪瑞FUS-2000全自动尿液分析仪检测尿液红细胞、白细胞的性能评价[J].医疗卫生装备,2017,38(8):82-85.
[24]ARMBRUSTER D A,OVERCASH D R,REYES J.Clinical chemistry laboratory automation in the 21st century-amat victoria curam(Victory loves careful preparation)[J].Clin Biochem Rev,2014,35(3):143-153.
[25]黄福达,杨志钊,张秀明,等.UF-1000i全自动尿液有形成分分析仪性能评价[J].检验医学,2011,26(8):560-563.
[26]宋晓冬,丁旭,贾向新,等.尿常规复检规则的探讨[J].中国临床研究,2011,24(12):1 148-1 150.
[27]AVCI D,LEBLEBICIOGLU M K,POYRAZ M,et al.A new method based on Adaptive Discrete Wavelet Entropy Energy and Neural Network Classifier(ADWEENN)for recognition of urine cells from microscopic images independent of rotation and scaling[J].J Med Syst,2014,38(2):7.
[28]殷贤斌,王敏,胡晓武,等.全自动尿沉渣分析仪FUS-2000的性能评价[J].中华全科医学,2015,13(12):2 023-2 025.
[29]SHAH A P,COBB B T,LOWER D R,et al.Enhanced versus automated urinalysis for screening of urinary tract infections in children in the emergency department[J].Pediatr Infect Dis J,2014,33(3):272-275.
[30]魏运梅,易光明,熊军.COBIO全自动尿液分析工作站性能评价[J].检验医学,2012,27(7):531-533.
[31]ANDERLINI R,MANIERI G,LUCCHI C,et al.Automated urinalysis with expert review for incidental identification of atypical urothelial cells:an anticipated bladder carcinoma diagnosis[J].Clin Chim Acta,2015,451(Pt B):252-256.
[32]FALBO R,SALA M R,SIGNORELLI S,et al.Bacteriuria screening by automated whole-field-image-based microscopy reduces the number of necessary urine cultures[J].J Clin Microbiol,2012,50(4):1 427-1 429.
[33]高淑芳,张雪清,陆波,等.人工镜检与科宝XS全自动尿沉渣分析仪及IQ200尿沉渣分析仪的比较和评价[J].检验医学,2011,26(4):231-234.
[34]INIGO M,COELLO A,FERNANDEZ-RIVAS G,et al.Evaluation of the SediMax automated microscopy sediment analyzer and the Sysmex UF-1000i flow cytometer as screening tools to rule out negative urinary tract infections[J].Clin Chim Acta,2016,456:31-35.
[35]陈曼铌,陈波,康嘉乐,等.LX-8000全自动尿液分析仪在尿液有形成分检测中的性能评价[J].检验医学与临床,2014,11(7):893-895.
[36]陈文举,王乐见,陈军斌,等.LX-3000尿沉渣分析仪诊断肾小球性血尿的临床意义[J].实用医技杂志,2006,13(10):1 705-1 706.
[37]余红俊,庄爱周,任蓉蓉,等.Cobas 6500尿液流水线筛选红细胞白细胞能力分析[J].中国卫生检验杂志,2018,22(22):2 728-2 730.
[38]张时民.尿有形成分检查自动化进展和质量保证[J].中国医疗器械信息,2012(4):13-22.
[39]吴晓华,肖迨,李秋晨,等.全自动尿液分析工作站复检规则的制定及应用评估[J].中华检验医学杂志,2014,37(6):465-468.
[40]刘金祥,丁勇,曹翠云,等.尿红细胞形态判断标准探究[J].检验医学,2017,32(7):582-585.
[41]AHMED A I,BAZ H,LOTFY S.Urinalysis:the automated versus manual techniques;is it time to change?[J].Clin Lab,2016,62(1-2):49-56.
[42]SUN W,XV Z,WANG C,et al.Evaluation of aging and health status in real time based on routine urinalysis using an automated urine analyzer[J].Clin Lab,2015,61(12):1 883-1 887.
[43]KOCER D,SARIGUZEL F M,KARAKUKCU C.Cutoff values for bacteria and leukocytes for urine sediment analyzer FUS200 in culture-positive urinary-tract infections[J].Scand J Clin Lab Invest,2014,74(5):414-417.
[44]MUN P S,TING H N,ONG T A,et al.A study of dielectric properties of proteinuria between 0.2 GHz and 50 GHz[J].PLoS One,2015,10(6):e0130011.
[45]BUSTAMANTE V,MEZA P,ROMAN J C,et al.[Evaluation of an automated streaking system of urine samples for urine cultures][J].Rev Chilena Infectol,2014,31(6):670-675.