透明质酸凝胶联合丁酸氢化可的松乳膏治疗婴幼儿湿疹的临床效果
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摘要
目的探讨透明质酸凝胶联合丁酸氢化可的松乳膏治疗婴幼儿湿疹的临床效果。方法选取2017年1月～2018年1月我院收治的80例湿疹患儿,按照随机数字表法分为对照组和观察组,每组各40例。对照组采用丁酸氢化可的松乳膏治疗,观察组在对照组的基础上联合外用透明质酸凝胶辅助治疗。比较两组患儿的湿疹面积及严重度指数(EASI)评分、临床治疗总有效率及复发率。结果治疗2周后,观察组患儿的EASI评分为(0.93±0.37)分,低于对照组的(1.09±0.28)分,差异有统计学意义(P<0.05)。治疗4周后,观察组患儿的EASI评分为(0.42±0.26)分,低于对照组的(0.56±0.30)分,差异有统计学意义(P<0.05)。观察组患儿的临床治疗总有效率(80.00%)高于对照组(57.50%),差异有统计学意义(P<0.05)。停药1个月后,观察组患儿的复发率(7.50%)低于对照组(25.00%),差异有统计学意义(P<0.05)。结论透明质酸凝胶联合丁酸氢化可的松乳膏应用于婴幼儿湿疹,能明显改善患儿的临床治疗效果,降低复发率,值得推广应用。
Objective To explore the clinical effect of Hyaluronic Acid Gel combined with Butyric Acid Hydrocortisone Cream in the treatment of infantile eczema. Methods A total of 80 children with infantile eczema admitted to our hospital from January 2017 to January 2018 were selected, they were divided into control group and observation group according to random number table method, with 40 cases in each group. The control group was treated with Butyric Acid Hydrocortisone Cream, and the observation group was treated with external Hyaluronic Acid Gel on the basis of the control group. Eczema area and severity index(EASI) score, total effective rate of clinical treatment and recurrence rate were compared between the two groups. Results After two weeks of treatment, the EASI score of the observation group was(0.93±0.37) points, lower than that of the control group for(1.09±0.28) points, the difference was statistically significant(P<0.05). After four weeks of treatment, the EASI score of the observation group was(0.42±0.26) points, lower than(0.56±0.30) points of the control group, the difference was statistically significant(P<0.05). The total effective rate of clinical treatment in the observation group(80.00%) was higher than that in the control group(57.50%), and the difference was statistically significant(P<0.05). One month after withdrawal, the recurrence rate of the observation group(7.50%) was lower than that of the control group(25.00%), the difference was statistically significant(P<0.05). Conclusion Hyaluronic Acid Gel combined with Butyric Acid Hydrocortisone Cream in the treatment of infantile eczema can significantly improve the clinical treatment effect and reduce the recurrence rate, which is worthy of popularization and application.
Objective To explore the clinical effect of Hyaluronic Acid Gel combined with Butyric Acid Hydrocortisone Cream in the treatment of infantile eczema. Methods A total of 80 children with infantile eczema admitted to our hospital from January 2017 to January 2018 were selected, they were divided into control group and observation group according to random number table method, with 40 cases in each group. The control group was treated with Butyric Acid Hydrocortisone Cream, and the observation group was treated with external Hyaluronic Acid Gel on the basis of the control group. Eczema area and severity index(EASI) score, total effective rate of clinical treatment and recurrence rate were compared between the two groups. Results After two weeks of treatment, the EASI score of the observation group was(0.93±0.37) points, lower than that of the control group for(1.09±0.28) points, the difference was statistically significant(P<0.05). After four weeks of treatment, the EASI score of the observation group was(0.42±0.26) points, lower than(0.56±0.30) points of the control group, the difference was statistically significant(P<0.05). The total effective rate of clinical treatment in the observation group(80.00%) was higher than that in the control group(57.50%), and the difference was statistically significant(P<0.05). One month after withdrawal, the recurrence rate of the observation group(7.50%) was lower than that of the control group(25.00%), the difference was statistically significant(P<0.05). Conclusion Hyaluronic Acid Gel combined with Butyric Acid Hydrocortisone Cream in the treatment of infantile eczema can significantly improve the clinical treatment effect and reduce the recurrence rate, which is worthy of popularization and application.
引文
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[10]李妍,徐薇,李邻峰.外用糖皮质激素联合含抗菌肽保湿剂对湿疹的疗效观察[J].中华皮肤科杂志,2016,49(10):733-736.
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[12]申春平,鲁文嘉,汪洋,等.湿疹愈乳膏联合润肤剂治疗婴幼儿面部亚急性湿疹的临床研究[J].临床皮肤科杂志,2016,45(12):860-863.
[13]Essendoubi M,Gobinet C,Reynaud R,et al.Human skin penetration of hyaluronic acid of different molecular weights as probed by Raman spectroscopy[J].Skin Res Technol,2016,22(1):55-62.
[14]王俊伟.透明质酸修护生物膜治疗婴儿湿疹效果观察[J].河南医学研究,2016,25(7):1221-1222.
[15]陈君,刘珏,吴黎明.透明质酸凝胶联合丁酸氢化可的松乳膏治疗婴幼儿湿疹100例临床观察[J].中国皮肤性病学杂志,2017,31(1):112-114.
[16]吕忠生,徐明,汪静.丁酸氢化可的松乳膏联合透明质酸修护生物膜治疗亚急性婴儿湿疹临床观察研究[J].临床皮肤科杂志,2016,45(9):665-666.
[2]李强.湿疹治疗的难点及其中医效果观察[J].光明中医,2016,31(13):1956-1957.
[3]贵仁伍,任静,赵润.丁酸氢化可的松乳膏联合维儿康洗液治疗婴幼儿湿疹疗效评价[J].中国药业,2016,25(20):36-38.
[4]卢井发,黄雪娇,曾招林,等.雅漾三重修护特润霜联合丁酸氢化可的松乳膏治疗婴幼儿湿疹特应性皮炎临床观察[J].中国皮肤性病学杂志,2017,31(5):585-587.
[5]田硕,白明,苗明三,等.基于临床病症特点的湿疹动物模型分析[J].中国中药杂志,2018,26(4):853-857.
[6]赵辨.湿疹面积及严重度指数评分法[J].中华皮肤科杂志,2004,37(1):3-4.
[7]史廉.浅析婴幼儿湿疹的治疗及预防[J].饮食保健,2017,4(15):91.
[8]罗金成,宋志强.特应性皮炎的发病机制[J].中华临床免疫和变态反应杂志,2017,11(4):375-381.
[9]朱东宁,贾煜,杨丽娟.益肤透明质酸凝胶治疗婴幼儿湿疹的临床疗效[J].中国妇幼保健,2017,32(20):5023-5026.
[10]李妍,徐薇,李邻峰.外用糖皮质激素联合含抗菌肽保湿剂对湿疹的疗效观察[J].中华皮肤科杂志,2016,49(10):733-736.
[11]李晓瑞,孙立荣,朱丽红.早期综合干预对预防婴儿湿疹的效果[J].中国医药导报,2018,15(3):93-96,106.
[12]申春平,鲁文嘉,汪洋,等.湿疹愈乳膏联合润肤剂治疗婴幼儿面部亚急性湿疹的临床研究[J].临床皮肤科杂志,2016,45(12):860-863.
[13]Essendoubi M,Gobinet C,Reynaud R,et al.Human skin penetration of hyaluronic acid of different molecular weights as probed by Raman spectroscopy[J].Skin Res Technol,2016,22(1):55-62.
[14]王俊伟.透明质酸修护生物膜治疗婴儿湿疹效果观察[J].河南医学研究,2016,25(7):1221-1222.
[15]陈君,刘珏,吴黎明.透明质酸凝胶联合丁酸氢化可的松乳膏治疗婴幼儿湿疹100例临床观察[J].中国皮肤性病学杂志,2017,31(1):112-114.
[16]吕忠生,徐明,汪静.丁酸氢化可的松乳膏联合透明质酸修护生物膜治疗亚急性婴儿湿疹临床观察研究[J].临床皮肤科杂志,2016,45(9):665-666.