孕产妇抗磷脂抗体水平检测及其临床意义
摘要
目的通过检测孕中期孕妇抗磷脂抗体(APLs),探讨APLs与病理妊娠的关系及临床意义。方法对有特定指征的653例孕妇及598例健康孕妇分别检测抗心磷脂抗体(ACL)、抗β2糖蛋白Ⅰ(β2GPⅠ)和狼疮样抗凝物(LA)水平,计算APLs阳性率并进行比较。结果观察组APLs阳性率为14.24%,对照组APLs阳性率为0.84%,差异有统计学意义(χ2=77.70,P<0.05)。结论 APLs异常孕妇极易导致病理妊娠,孕妇孕中期及时检测APLs,有助于早发现、早干预孕妇妊娠病理状态,提高孕产质量及新生儿生存质量。
引文
[1]BERTOLACCINI M L,AMENGUAL O,ANDREOLI L,et al.14thinternational congresson antiphospholipid antibodiestask force.Report on antiphospholipid syndrome laboratory diagnostics and trends[J].Auto Immun Rev,2014,13:917-930.
[2]ABRAHAMS V M,CHAMLEY L W,SALMON J E.E-merging treatment models in rheumatology:antiphospholipid syndrome and pregnancy:pathogenesis to translation[J].Arthritis Rheumatol,2017,69(9):1710-1721.
[3]宋宁,张蜀澜,胡朝军,等.2013年全国116家实验室抗磷脂抗体检测比对分析[J].中华临床免疫和变态反应杂志,2016,10(1):28-32.
[4]顾丹天,夏春梅,安长新,等.47例习惯性流产女性抗心磷脂、抗精子及抗子宫内膜抗体的分析[J].新疆医科大学学报,2013,26(3):279-280.
[5]SACCONE G,BERGHELLA V,MARUOTTI G M,et al.Antiphospholipid antibody profile based obstetric outcomes of primary antiphospholipid syndrome:the PREG-NANTS study[J].Am J Obstet Gynecol,2017,216(5):525-537.
[6]张蜀澜,吴子燕,张文,等.抗磷脂综合征病态妊娠患者中抗磷脂抗体谱的临床意义[J/CD].中华临床实验室管理电子杂志,2017,5(4):226-231.
[7]HOTH J J,WELLS J D,JONES S E,et al.Complement mediates a primed inflammatory response after traumatic lung injury[J].J Trauma Acute Care,2014,76(3):608-609.
[8]许柯青,贠艳丽,崔文贤.抗磷脂抗体阳性早孕女性妊娠早期炎性因子、补休及凝血功能检测的临床意义[J].广西医科大学学报,2017,34(7):1084-1086.
[9]SHOENFELD Y,MERONI P L,GERSHWIN M E.Autoantibodies[M].3rd Edition.Amsterdam:Elsevier,2014:512-515.
[10]刘畅,于若寒,刘湘源.产科抗磷脂综合征诊疗所面临的挑战[J].内科急危重症杂志,2017,23(2):105-108.
[2]ABRAHAMS V M,CHAMLEY L W,SALMON J E.E-merging treatment models in rheumatology:antiphospholipid syndrome and pregnancy:pathogenesis to translation[J].Arthritis Rheumatol,2017,69(9):1710-1721.
[3]宋宁,张蜀澜,胡朝军,等.2013年全国116家实验室抗磷脂抗体检测比对分析[J].中华临床免疫和变态反应杂志,2016,10(1):28-32.
[4]顾丹天,夏春梅,安长新,等.47例习惯性流产女性抗心磷脂、抗精子及抗子宫内膜抗体的分析[J].新疆医科大学学报,2013,26(3):279-280.
[5]SACCONE G,BERGHELLA V,MARUOTTI G M,et al.Antiphospholipid antibody profile based obstetric outcomes of primary antiphospholipid syndrome:the PREG-NANTS study[J].Am J Obstet Gynecol,2017,216(5):525-537.
[6]张蜀澜,吴子燕,张文,等.抗磷脂综合征病态妊娠患者中抗磷脂抗体谱的临床意义[J/CD].中华临床实验室管理电子杂志,2017,5(4):226-231.
[7]HOTH J J,WELLS J D,JONES S E,et al.Complement mediates a primed inflammatory response after traumatic lung injury[J].J Trauma Acute Care,2014,76(3):608-609.
[8]许柯青,贠艳丽,崔文贤.抗磷脂抗体阳性早孕女性妊娠早期炎性因子、补休及凝血功能检测的临床意义[J].广西医科大学学报,2017,34(7):1084-1086.
[9]SHOENFELD Y,MERONI P L,GERSHWIN M E.Autoantibodies[M].3rd Edition.Amsterdam:Elsevier,2014:512-515.
[10]刘畅,于若寒,刘湘源.产科抗磷脂综合征诊疗所面临的挑战[J].内科急危重症杂志,2017,23(2):105-108.