基于食品液态体系的功能因子靶向传输系统的构建及其释放研究
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摘要
功能因子的储藏稳定性和控制释放是通过一定的微囊化控释传输系统来实现的。本研究采用挤出滚圆和流化床薄膜包衣技术,构建了基于液态食品体系的醋酸酯抗消化淀粉薄膜包衣微丸传输系统,分别考察了不同厚度的醋酸酯淀粉薄膜包衣微丸在酸奶中储藏过程及体外模拟人体消化道运转过程中功能因子的释放规律及微丸表面包衣膜层的微观形貌变化。研究表明,在相同的储藏时间下,包衣厚度越大,微丸表面包衣膜层越完好,越能有效阻止功能因子的释放;当醋酸酯抗消化淀粉包衣增重达到9.94%时,其中的功能因子在储藏22d不释放;同时,在酸奶中储藏不同时间后,不同包衣厚度的微丸在模拟消化道中运转时的表面形貌变化与其释放情况相符。研究为筛选适合液态食品体系的功能因子控释传输载体材料及控释传输系统的构建奠定了基础。
The storage stability and controlled release of bioactive compounds were achieved through microencapsulation controlled release delivery system. The film-coated microparticle delivery systems for liquid food based on resistant starch acetate(RSA) were established by the methods of extrusion-spheronisation and fluid-bed spray coating. The releasing properties during yoghurt storage and in vitro simulated gastrointestinal tract environment of RSA-coated microparticles with different thickness were investigated. Results showed that under the same storage time, the larger coating thickness was, the more intact coating layer would be, which could prevent the release of bioactive compounds.When the thickness of the film-coated is 9.94%, the bioactive compounds did not release during storage for 22 days. Additionally, after storage in yogurt, the change of the surface morphology of microparticle with different coating thickness in the simulated gastrointestinal tract environment was consistent with their release. The results provide a theoretical basis and basic data for screening suitable carrier materials for bioactive compounds and its target-controlled delivery system for liquid foods.
The storage stability and controlled release of bioactive compounds were achieved through microencapsulation controlled release delivery system. The film-coated microparticle delivery systems for liquid food based on resistant starch acetate(RSA) were established by the methods of extrusion-spheronisation and fluid-bed spray coating. The releasing properties during yoghurt storage and in vitro simulated gastrointestinal tract environment of RSA-coated microparticles with different thickness were investigated. Results showed that under the same storage time, the larger coating thickness was, the more intact coating layer would be, which could prevent the release of bioactive compounds.When the thickness of the film-coated is 9.94%, the bioactive compounds did not release during storage for 22 days. Additionally, after storage in yogurt, the change of the surface morphology of microparticle with different coating thickness in the simulated gastrointestinal tract environment was consistent with their release. The results provide a theoretical basis and basic data for screening suitable carrier materials for bioactive compounds and its target-controlled delivery system for liquid foods.
引文
[1]孙远明.食品营养学[M].北京:科学出版社,2006SUN Yuan-ming.Food nutrition[M].Beijing:Science Press,2006
[2]钟耀广.功能性食品[M].北京:化学工业出版社,2004ZHONG Yao-guang.Functional food[M].Beijing:Chemical Industry Press,2004
[3]Roberfroid M B.Defining functional foods[M].Functional Foods,2000
[4]Granato D,Branco G F,Nazzaro F,et al.Functional foods and nondairy probiotic food development:trends,concepts,and products[J].Comprehensive Reviews in Food Science&Food Safety,2010,9(3):292-302
[5]De Vos P,Faas M M,Spasojevic M,et al.Encapsulation for preservation of functionality and targeted delivery of bioactive food components[J].International Dairy Journal,2010,20(4):292-302
[6]Palzer S.Food structures for nutrition,health and wellness[J].Trends in Food Science&Technology,2009,20(5):194-200
[7]Englyst H N,Kingman S M,Cummings J H.Classification and measurement of nutritionally important starch fractions[J].European journal of clinical nutrition,1992,46:S33-50
[8]Zhang G,Hamaker B R.Slowly digestible starch:concept,mechanism,and proposed extended glycemic index[J].Critical reviews in food science and nutrition,2009,49(10):852-867
[9]Tarvainen M,Sutinen R,Peltonen S,et al.Starch acetate-a novel film-forming polymer for pharmaceutical coatings[J].J Pharm Sci,2010,91(1)
[10]Nara S,Komiya T.Studies on the relationship between water-satured state and crystallinity by the diffraction method for moistened potato starch[J].Starch‐St?rke,1983,35(12):407-410
[11]陈玲.淀粉口服结肠靶向生物粘附载体材料及其释放行为研究[D].广州:华南理工大学,2009Chen Ling.Starch oral colon targeting bioadhesive material and its release behavior[D].Guangzhou:South China University of Technology,2009
[2]钟耀广.功能性食品[M].北京:化学工业出版社,2004ZHONG Yao-guang.Functional food[M].Beijing:Chemical Industry Press,2004
[3]Roberfroid M B.Defining functional foods[M].Functional Foods,2000
[4]Granato D,Branco G F,Nazzaro F,et al.Functional foods and nondairy probiotic food development:trends,concepts,and products[J].Comprehensive Reviews in Food Science&Food Safety,2010,9(3):292-302
[5]De Vos P,Faas M M,Spasojevic M,et al.Encapsulation for preservation of functionality and targeted delivery of bioactive food components[J].International Dairy Journal,2010,20(4):292-302
[6]Palzer S.Food structures for nutrition,health and wellness[J].Trends in Food Science&Technology,2009,20(5):194-200
[7]Englyst H N,Kingman S M,Cummings J H.Classification and measurement of nutritionally important starch fractions[J].European journal of clinical nutrition,1992,46:S33-50
[8]Zhang G,Hamaker B R.Slowly digestible starch:concept,mechanism,and proposed extended glycemic index[J].Critical reviews in food science and nutrition,2009,49(10):852-867
[9]Tarvainen M,Sutinen R,Peltonen S,et al.Starch acetate-a novel film-forming polymer for pharmaceutical coatings[J].J Pharm Sci,2010,91(1)
[10]Nara S,Komiya T.Studies on the relationship between water-satured state and crystallinity by the diffraction method for moistened potato starch[J].Starch‐St?rke,1983,35(12):407-410
[11]陈玲.淀粉口服结肠靶向生物粘附载体材料及其释放行为研究[D].广州:华南理工大学,2009Chen Ling.Starch oral colon targeting bioadhesive material and its release behavior[D].Guangzhou:South China University of Technology,2009