红肉及加工肉制品与结直肠癌风险关系的研究进展
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摘要
近年来我国结直肠癌的发病率和死亡率逐年上升。据研究,结直肠癌发生率的升高可能与红肉及加工肉制品消费的增长具有一定相关性,但该关联性一直存在争议。为此,本文分析了现阶段研究红肉及加工肉制品与结直肠癌相关性的方法及其局限性,并综述了与红肉及加工肉制品相关的潜在结直肠癌致病因素,为确定结直肠癌及其他癌症与红肉及加工肉制品之间的关系提供了新的思路。
In recent years,the morbidity and mortality of colorectal cancer in China are increasing year by year. According to the studies,the increase in the incidence of colorectal cancer may be related to the growth of consumption of red meat and processed meat products. However,this correlation has been controversial. Therefore,the current research methods and their limitations of studying the correlation between red meat/processed meat products and colorectal cancer,as well as the potential risk factors of colorectal cancer relating to red meat/processed meat were reviewed in this paper. It provides a prospective to determine the relationship between cancers and red meat/processed meat products.
In recent years,the morbidity and mortality of colorectal cancer in China are increasing year by year. According to the studies,the increase in the incidence of colorectal cancer may be related to the growth of consumption of red meat and processed meat products. However,this correlation has been controversial. Therefore,the current research methods and their limitations of studying the correlation between red meat/processed meat products and colorectal cancer,as well as the potential risk factors of colorectal cancer relating to red meat/processed meat were reviewed in this paper. It provides a prospective to determine the relationship between cancers and red meat/processed meat products.
引文
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[3]Alisson-Silva F,Kawanishi K,Varki A.Human risk of diseases associated with red meat intake:Analysis of current theories and proposed role for metabolic incorporation of a non-human sialic acid[J].Molecular Aspects of Medicine,2016,51:16-30.
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[5]Hebels D G,Sveje K M,de Kok M C,et al.Red meat intake-induced increases in fecal water genotoxicity correlate with pro-carcinogenic gene expression changes in the human colon[J].Food & Chemical Toxicology,2012,50(2):95-103.
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[7]Parnaud G,Peiffer G,Taché S,et al.Effect of meat(beef,chicken,and bacon)on rat colon carcinogenesis[J].Nutrition & Cancer,1998,32(3):165-173.
[8]Samha M.Processed and unprocessed red meat and risk of colorectal cancer:Analysis by tumor location and modification by time[J].PloSOne,2015,10(8):e0135959.
[9]Hassler S,Sj?lander P,Gr?nberg H,et al.Cancer in the sami population of sweden in relation to lifestyle and genetic factors[J].European Journal of Epidemiology,2008,23(4):273-280.
[10]Ibáňez-Sanz G,Díez-Villanueva A,Alonso M H,et al.Risk model for colorectal cancer in spanish population using environmental and genetic factors:Results from the MCC-spain study[J].Scientific Reports,2017,7:43263.
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[13]唐金陵,杨祖耀,毛琛.大型随机对照试验:精准流行病学研究的典范与陷阱[J].中华流行病学杂志,2017(10):1299-1304.
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[16]马文韬,陈曦,刘婷婷,等.中国人结直肠癌中APC基因的突变检测[C]//全国肿瘤流行病学和肿瘤病因学学术会议论文集.2015.
[17]叶志金,郑力,亓翠玲,等.APCMin/+结直肠癌癌前病变小鼠模型的生物学特性[J].临床与实验病理学杂志,2011,27(4):393-395.
[18]Caderni G,Femia A P,Giannini A,et al.Identification of mucin-depleted foci in the unsectioned colon of azoxymethane-treated rats correlation with carcinogenesis[J].Cancer Research,2003,63(10):2388.
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[20]Santarelli R L,Vendeuvre J L,Naud N,et al.Meat processing and colon carcinogenesis:Cooked,nitrite-treated,and oxidized high-heme cured meat promotes mucin-depleted foci in rats[J].Cancer Prevention Research,2010,3(7):852-864.
[21]Santarelli R L,Naud N,Taché S,et al.Calcium inhibits promotion by hot dog of 1,2-dimethylhydrazine-induced mucin-depleted foci in rat colon[J].International Journal of Cancer,2013,133(11):2533-2541.
[22]杨永鹏,董萍,丁克祥,等.不同血清浓度及介质对体外培养小鼠成纤维细胞L929细胞系生长曲线和细胞形态的影响[J].国际老年医学杂志,2010,31(6):241-249.
[23]Reinartz J,Bechtel M J,Kramer M D.Tumor necrosis factor-α-induced apoptosis in a human keratinocyte cell line(hacat)is counteracted by transforming growth factor-α[J].Experimental Cell Research,1996,228(2):334-340.
[24]Araújo J R,Gon?alves P,Martel F.Chemopreventive effect of dietary polyphenols in colorectal cancer cell lines[J].Nutrition Research,2011,31(2):77-87.
[25]Liu Z,Uesaka T,Watanabe H,et al.High fat diet enhances colonic cell proliferation and carcinogenesis in rats by elevating serum leptin.[J].INT J ONCOL,2001,19(5):1009-1014.
[26]GleiM,Klenow S,Sauer J,et al.Hemoglobin and hemin induce DNA damage in human colon tumor cells HT29 clone 19A and in primary human colonocytes[J].Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis,2006,594(1-2):162-171.
[27]Bastide N M,Chenni F,Audebert M,et al.A central role for heme iron in colon carcinogenesis associated with red meat intake[J].Cancer Research,2015,75(5):870-879.
[28]Jiang H H,Tang Y Y,Garg H K H,et al.Concentration-and stage-specific effects of nitrite on colon cancer cell lines[J].Nitric Oxide Biology & Chemistry,2012,26(4):267-273.
[29]李琳娜.青蒿琥酯对中国人源性大肠癌细胞的选择性抑制作用及相关分子机制研究[D].北京:中国人民解放军军事医学科学院,2008.
[30]Antoni D,Hélène Burckel,Josset E,et al.Three-Dimensional cell culture:A breakthrough in vivo[J].International Journal of Molecular Sciences,2015,16(3):5517-5527.
[31]Dean M,Fojo T,Bates S.Tumor stem cells and drug resistance[J].Nature Reviews Cancer,2005,5(4):275-284.
[32]Wodarz A,N?thke I.Cell polarity in development and cancer[J].Nature Cell Biology,2007,9(9):1016-1024.
[33]Friedl P,Wolf K.Tumour-cell invasion and migration:diversity and escape mechanisms[J].Nature Reviews Cancer,2003,3(5):362-374.
[34]Giovannucci E,Goldin B.The role of fat,fatty acids,and total energy intake in the etiology of human colon cancer[J].American Journal of Clinical Nutrition,1997,66(6 Suppl):1564S-1571S.
[35]O’Neill A M,Burrington C M,Gillaspie E A,et al.High-fat Western diet-induced obesity contributes to increased tumor growth in mouse models of human colon cancer[J].Nutrition Research,2016,36(12):1325-1334.
[36]Liu Z,Brooks R S,Ciappio E D,et al.Diet-induced obesity elevates colonic TNF-α in mice and is accompanied by an activation of Wnt signaling:A mechanism for obesity-associated colorectal cancer[J].Journal of Nutritional Biochemistry,2012,23(10):1207-1213.
[37]Day S D,Enos R T,Mcclellan J L,et al.Linking inflammation to tumorigenesis in a mouse model of high-fat-diet-enhanced colon cancer[J].Cytokine,2013,64(1):454-462.
[38]O’Keefe SJ,Li JV,Lahti L,et al.Fat,fibre and cancer risk in African Americans and rural Africans[J].Nature Communications,2015,6:6342.
[39]Gadaleta R M,Garcia-Irigoyen O,Moschetta A.Bile acids and colon cancer:Is FXR the solution of the conundrum?[J].Molecular Aspects of Medicine,2017,56:66.
[40]Farhana L,Nangiamakker P,Arbit E,et al.Bile acid:A potential inducer of colon cancer stem cells[J].Stem Cell Research & Therapy,2016,7(1):181.
[41]Lapré J A,De Vries H T,Koeman J H,et al.The antiproliferative effect of dietary calcium on colonic epithelium is mediated by luminal surfactants and dependent on the type of dietary fat[J].Cancer Research,1993,53(4):784.
[42]Itano O,Yang K,Fan K,et al.Effect of specific nutrients and caloric intake on intestinal tumors in a Western diet mouse model for hereditary colon cancer[J].Cancer Research,2006,66.
[43]Jiang H,Tang Y,Garg H K,et al.Concentration-and stagespecific effects of nitrite on colon cancer cell lines[J].Nitric Oxide Biology and Chemistry,2012,26:267-273.
[44]Hemeryck L,VandenBussche J,Moore S,et al.Does digestion of red meat cause more procarcinogenic DNA adducts in healthy subjects as opposed to white meat?[C]//59th International congress of Meat Science and Technology(ICoMST 2013).Ege University.Food Engineering Department,2013:14-17.
[45]Kobayashi J.Effect of diet and gut environment on the gastrointestinal formation of N-nitroso compounds:A review[J].Nitric Oxide Biology & Chemistry,2017,73.
[46]Lewin M H,Bailey N,Bandaletova T,et al.Red meat enhances the colonic formation of the DNA adduct O6-carboxymethyl guanine:Implications for colorectal cancer risk[J].Cancer Research,2006,66(3):1859-1865.
[47]蔡鲁峰,李娜,杜莎,等.N-亚硝基化合物的危害及其在体内外合成和抑制的研究进展[J].食品科学,2016,37(5):271-277.
[48]Van H T,Vossen E,Hemeryck L Y,et al.Increased oxidative and nitrosative reactions during digestion could contribute to the association between well-done red meat consumption and colorectal cancer[J].Food Chemistry,2015,187:29-36.
[49]Hebels D G,Sveje K M,de Kok M C,et al.N-nitroso compound exposure-associated transcriptomic profiles are indicative of an increased risk for colorectal cancer[J].Cancer Letters,2011,309(1):1.
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