肠道菌群与脊柱关节炎相关性的研究进展
摘要
肠道菌群与脊柱关节炎的关系一直是研究的热点,对脊柱关节炎患者中菌群的研究有利于了解脊柱关节炎的发病机制,以及制定疾病的早期诊断和治疗策略。体外细菌培养的方法严重制约了这方面的研究,随着全基因组测序技术的发展,对肠道菌群的研究变得方便。本文通过对以往关于脊柱关节炎可能机制、动物模型以及菌群调节治疗的回顾,来探究脊柱关节炎与肠道菌群的相关性。
引文
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[7]Card TR,Langan SM,Chu TP.Extra-gastrointestinal manifestations of inflammatory bowel disease may be less common than previously reported[J].Dig Dis Sci,2016,61(9):2619-2626.
[8]Praet LV,Jans L,Carron P.Degree of bone marrow oedema in sacroiliac joints of patients with axial spondyloarthritis is linked to gut inflammation and male sex:results from the GIANT cohort[J].Ann Rheum Dis,2014,73(6):1186-1189.
[9]Martínezgonzález O,Canterohinojosa J,Paulesastre P,et al.Intestinal permeability in patients with ankylosing spondylitis and their healthy relatives[J].Br J Rheumatol,1994,33(7):644-647.
[10]Morris G,Berk M,Carvalho AF,et al.The role of microbiota and intestinal permeability in the pathophysiology of autoimmune and neuroimmune processes with an emphasis on inflammatory bowel disease type 1diabetes and chronic fatigue syndrome[J].Curr Pharm Des,2016,22(40):6058-6075.
[11]Ciccia F,Guggino G,Rizzo A,et al.Type 3innate lymphoid cells producing IL-17and IL-22are expanded in the gut,in the peripheral blood,synovial fluid and bone marrow of patients with ankylosing spondylitis[J].Ann Rheum Dis,2015,74(9):1739.
[12]Ebringer A,Ghuloom M.Ankylosing spondylitis,HLA-B27,and klebsiella:Cross reactivity and antibody studies[J].Ann Rheum Dis,1986,45(8):703-704.
[13]van Bohemen CG,Grumet FC,Zanen HC.Identification of HLA-B27M1and-M2cross-reactive antigens in Klebsiella,Shigella and Yersinia[J].Immunology,1984,52(4):607-610.
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[16]Stone MA,Payne U,Schentag C,et al.Comparative immune responses to candidate arthritogenic bacteria do not confirm a dominant role for Klebsiella pneumonia in the pathogenesis of familial ankylosing spondylitis[J].Rheumatology(Oxford),2004,43(2):148-155.
[17]Alexander JS,Ganta VC,Jordan PA,et al.Gastrointestinal lymphatics in health and disease[J].Pathophysiology,2010,17(4):315-335.
[18]Obata T,Goto Y,Kunisawa J,et al.Indigenous opportunistic bacteria inhabit mammalian gut-associated lymphoid tissues and share a mucosal antibody-mediated symbiosis[J].Proc Natl Acad Sci U S A,2010,107(16):7419-7424.
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[22]van Kruiningen HJ,Colombel JF.The forgotten role of lymphangitis in Crohn's disease[J].Gut,2008,57(1):1-4.
[23]信建峰,孙宇光,夏松,等.直接淋巴管造影术在原发性乳糜尿诊断中的应用[J].中华医学杂志,2013,93(28):2212-2214.
[24]Taurog JD,Richardson JA,Croft JT,et al.The germfree state prevents development of gut and joint inflammatory disease in HLA-B27transgenic rats[J].J Exp Med,1994,180(6):2359-2364.
[25]Lin P,Bach M,Asquith M,et al.HLA-B27and human beta2-microglobulin affect the gut microbiota of transgenic rats[J].PLoS One,2014,9(8):e105684.
[26]Dhaenens M,Fert I,Glatigny S,et al.Dendritic cells from spondylarthritis-prone HLA-B27-transgenic rats display altered cytoskeletal dynamics,classⅡmajor histocompatibility complex expression and viability[J].Arthritis&Rheumatology,2009,60(9):2622-2632.
[27]Utriainen L,Firmin D,Wright P,et al.Expression of HLAB27causes loss of migratory dendritic cells in a rat model of spondylarthritis[J].Arthritis Rheum,2012,64(10):3199-3209.
[28]Asquith MJ,Stauffer P,Davin S,et al.Perturbed mucosal immunity and dysbiosis accompany clinical disease in a rat model of spondyloarthritis[J].Arthritis Rheum,2016,68(9):2151-2162.
[29]Ruutu M,Thomas G,Steck R,et al.β-glucan triggers spondylarthritis and Crohn’s disease-like ileitis in SKG mice[J].Arthritis Rheum,2012,64(7):2211-2222.
[30]Benham H,Rehaume LM,Hasnain SZ,et al.Interleukin-23mediates the intestinal response to microbial beta-1,3-glucan and the development of spondyloarthritis pathology in SKG mice[J].Arthritis Rheumatol,2014,66(7):1755-1767.
[31]Capkova J,Hrncir T,Kubatova A,et al.Lipopolysaccharide treatment suppresses spontaneously developing ankylosing enthesopathy in B10.BR male mice:The potential role of interleukin-10[J].BMC Musculoskelet Disord,2012,13(1):110.
[32]Ogrendik M.Treatment of ankylosing spondylitis with moxifloxacin[J].South Med J,2007,100(4):366-370.
[33]Moghimi J,Rezaei AA,Ghorbani R,et al.Efficacy of an acquainted drug in the treatment of inflammatory low back pain:Sulfasalazine under investigation[J].Drug Des Devel Ther,2016,10:3065-3069.
[34]Clegg DO,Reda DJ,Abdellatif M.Comparison of sulfasalazine and placebo for the treatment of axial and peripheral articular manifestations of the seronegative spondylarthropathies:A Department of Veterans Affairs cooperative study[J].Arthritis Rheum,1999,42(11):2325.
[35]Hoentjen F,Welling GW,Harmsen HJ,et al.Reduction of colitis by prebiotics in HLA-B27transgenic rats is associated with microflora changes and immunomodulation[J].Inflamm Bowel Dis,2005,11(11):977-985.
[36]Amdekar S,Singh V,Singh R,et al.Lactobacillus casei reduces the inflammatory joint damage associated with collageninduced arthritis(CIA)by reducing the pro-inflammatory cytokines:Lactobacillus casei:COX-2inhibitor[J].J Clin Immunol,2011,31(2):147-154.
[37]Jenks K,Stebbings S,Burton J,et al.Probiotic therapy for the treatment of spondyloarthritis:A randomized controlled trial[J].J Rheumatol,2010,37(10):2118-2125.
[38]Xu M,Cao H,Wang W,et al.Fecal microbiota transplantation broadening its application beyond intestinal disorders[J].World J Gastroenterol,2015(1):117-126.
[39]Vaughn BP,Vatanen T,Allegretti JR,et al.Increased intestinal microbial diversity following fecal microbiota transplant for active Crohn's disease[J].Inflamm Bowel Dis,2016,22(9):2182-2190.
[40]Wei Y,Zhu W,Gong J,et al.Fecal microbiota transplantation improves the quality of life in patients with inflammatory bowel disease[J].Gastroenterol Res Pract,2015,2015:517597.
[41]Borody TJ,Warren EF,Leis S,et al.Treatment of ulcerative colitis using fecal bacteriotherapy[J].J Clin Gastroenterol,2003,37(1):42-47.
[42]Rossen NG,Fuentes S,van MJ,et al.Findings from a randomized controlled trial of fecal transplantation for patients with ulcerative colitis[J].Gastroenterology,2015,149(1):110-118.
[43]Ebringer A,Wilson C.The use of a low starch diet in the treatment of patients suffering from ankylosing spondylitis[J].Clin Rheumatol,1996,15,1(1):62-66.
[44]Rashid T,Wilson C,Ebringer A.Raised incidence of ankylosing spondylitis among Inuit populations could be due to high HLA-B27association and starch consumption[J].Rheumatol Int,2015,35(6):945-951.
[2]Breban M,Tap J,Leboime A,et al.Faecal microbiota study reveals specific dysbiosis in spondyloarthritis[J].Ann Rheum Dis,2017,76(9):1614-1622.
[3]Tito RY,Cypers H,Joossens M,et al.Brief report:Dialister as a microbial marker of disease activity in spondyloarthritis[J].Arthritis Rheumatol,2017,69(1):114-121.
[4]Yun KL,Mazmanian SK.Has the microbiota played a critical role in the evolution of the adaptive immune system?[J].Science,2010,330(6012):1768-1773.
[5]van PL,Vanf E,Jacques P,et al.Microscopic gut inflammation in axial spondyloarthritis:A multiparametric predictive model[J].Ann Rheum Dis,2013,72(3):414-417.
[6]Levine JS,Burakoff R.Extraintestinal manifestations of inflammatory bowel disease[J].Curr Gastroenterol Rep,2001,3(6):295-296.
[7]Card TR,Langan SM,Chu TP.Extra-gastrointestinal manifestations of inflammatory bowel disease may be less common than previously reported[J].Dig Dis Sci,2016,61(9):2619-2626.
[8]Praet LV,Jans L,Carron P.Degree of bone marrow oedema in sacroiliac joints of patients with axial spondyloarthritis is linked to gut inflammation and male sex:results from the GIANT cohort[J].Ann Rheum Dis,2014,73(6):1186-1189.
[9]Martínezgonzález O,Canterohinojosa J,Paulesastre P,et al.Intestinal permeability in patients with ankylosing spondylitis and their healthy relatives[J].Br J Rheumatol,1994,33(7):644-647.
[10]Morris G,Berk M,Carvalho AF,et al.The role of microbiota and intestinal permeability in the pathophysiology of autoimmune and neuroimmune processes with an emphasis on inflammatory bowel disease type 1diabetes and chronic fatigue syndrome[J].Curr Pharm Des,2016,22(40):6058-6075.
[11]Ciccia F,Guggino G,Rizzo A,et al.Type 3innate lymphoid cells producing IL-17and IL-22are expanded in the gut,in the peripheral blood,synovial fluid and bone marrow of patients with ankylosing spondylitis[J].Ann Rheum Dis,2015,74(9):1739.
[12]Ebringer A,Ghuloom M.Ankylosing spondylitis,HLA-B27,and klebsiella:Cross reactivity and antibody studies[J].Ann Rheum Dis,1986,45(8):703-704.
[13]van Bohemen CG,Grumet FC,Zanen HC.Identification of HLA-B27M1and-M2cross-reactive antigens in Klebsiella,Shigella and Yersinia[J].Immunology,1984,52(4):607-610.
[14]Fielder M,Pirt SJ,Tarpey I,et al.Molecular mimicry and ankylosing spondylitis:Possible role of a novel sequence in pullulanase of Klebsiella pneumoniae[J].FEBS Lett,1995,369(2-3):243-248.
[15]Maki-Ikola O,Leirisalo-Repo M,Turunen U,et al.Association of gut inflammation with increased serum IgA class Klebsiella antibody concentrations in patients with axial ankylosing spondylitis(AS):implication for different aetiopathogenetic mechanisms for axial and peripheral AS?[J].Ann Rheum Dis,1997,56(3):180-183.
[16]Stone MA,Payne U,Schentag C,et al.Comparative immune responses to candidate arthritogenic bacteria do not confirm a dominant role for Klebsiella pneumonia in the pathogenesis of familial ankylosing spondylitis[J].Rheumatology(Oxford),2004,43(2):148-155.
[17]Alexander JS,Ganta VC,Jordan PA,et al.Gastrointestinal lymphatics in health and disease[J].Pathophysiology,2010,17(4):315-335.
[18]Obata T,Goto Y,Kunisawa J,et al.Indigenous opportunistic bacteria inhabit mammalian gut-associated lymphoid tissues and share a mucosal antibody-mediated symbiosis[J].Proc Natl Acad Sci U S A,2010,107(16):7419-7424.
[19]O'brien CL,Pavli P,Gordon DM,et al.Detection of bacterial DNA in lymph nodes of Crohn's disease patients using high throughput sequencing[J].Gut,2014,63(10):1596-1606.
[20]Bruggemann A,Burchardt H,Lepsien G.Sonographical findings in Whipple's disease.A case report with regard to the literature[J].Surg Endosc,1992,6(3):138-140.
[21]Scheib JS,Quinet RJ.Whipple’s disease with axial and peripheral joint destruction[J].South Med J,1990,83(6):684-687.
[22]van Kruiningen HJ,Colombel JF.The forgotten role of lymphangitis in Crohn's disease[J].Gut,2008,57(1):1-4.
[23]信建峰,孙宇光,夏松,等.直接淋巴管造影术在原发性乳糜尿诊断中的应用[J].中华医学杂志,2013,93(28):2212-2214.
[24]Taurog JD,Richardson JA,Croft JT,et al.The germfree state prevents development of gut and joint inflammatory disease in HLA-B27transgenic rats[J].J Exp Med,1994,180(6):2359-2364.
[25]Lin P,Bach M,Asquith M,et al.HLA-B27and human beta2-microglobulin affect the gut microbiota of transgenic rats[J].PLoS One,2014,9(8):e105684.
[26]Dhaenens M,Fert I,Glatigny S,et al.Dendritic cells from spondylarthritis-prone HLA-B27-transgenic rats display altered cytoskeletal dynamics,classⅡmajor histocompatibility complex expression and viability[J].Arthritis&Rheumatology,2009,60(9):2622-2632.
[27]Utriainen L,Firmin D,Wright P,et al.Expression of HLAB27causes loss of migratory dendritic cells in a rat model of spondylarthritis[J].Arthritis Rheum,2012,64(10):3199-3209.
[28]Asquith MJ,Stauffer P,Davin S,et al.Perturbed mucosal immunity and dysbiosis accompany clinical disease in a rat model of spondyloarthritis[J].Arthritis Rheum,2016,68(9):2151-2162.
[29]Ruutu M,Thomas G,Steck R,et al.β-glucan triggers spondylarthritis and Crohn’s disease-like ileitis in SKG mice[J].Arthritis Rheum,2012,64(7):2211-2222.
[30]Benham H,Rehaume LM,Hasnain SZ,et al.Interleukin-23mediates the intestinal response to microbial beta-1,3-glucan and the development of spondyloarthritis pathology in SKG mice[J].Arthritis Rheumatol,2014,66(7):1755-1767.
[31]Capkova J,Hrncir T,Kubatova A,et al.Lipopolysaccharide treatment suppresses spontaneously developing ankylosing enthesopathy in B10.BR male mice:The potential role of interleukin-10[J].BMC Musculoskelet Disord,2012,13(1):110.
[32]Ogrendik M.Treatment of ankylosing spondylitis with moxifloxacin[J].South Med J,2007,100(4):366-370.
[33]Moghimi J,Rezaei AA,Ghorbani R,et al.Efficacy of an acquainted drug in the treatment of inflammatory low back pain:Sulfasalazine under investigation[J].Drug Des Devel Ther,2016,10:3065-3069.
[34]Clegg DO,Reda DJ,Abdellatif M.Comparison of sulfasalazine and placebo for the treatment of axial and peripheral articular manifestations of the seronegative spondylarthropathies:A Department of Veterans Affairs cooperative study[J].Arthritis Rheum,1999,42(11):2325.
[35]Hoentjen F,Welling GW,Harmsen HJ,et al.Reduction of colitis by prebiotics in HLA-B27transgenic rats is associated with microflora changes and immunomodulation[J].Inflamm Bowel Dis,2005,11(11):977-985.
[36]Amdekar S,Singh V,Singh R,et al.Lactobacillus casei reduces the inflammatory joint damage associated with collageninduced arthritis(CIA)by reducing the pro-inflammatory cytokines:Lactobacillus casei:COX-2inhibitor[J].J Clin Immunol,2011,31(2):147-154.
[37]Jenks K,Stebbings S,Burton J,et al.Probiotic therapy for the treatment of spondyloarthritis:A randomized controlled trial[J].J Rheumatol,2010,37(10):2118-2125.
[38]Xu M,Cao H,Wang W,et al.Fecal microbiota transplantation broadening its application beyond intestinal disorders[J].World J Gastroenterol,2015(1):117-126.
[39]Vaughn BP,Vatanen T,Allegretti JR,et al.Increased intestinal microbial diversity following fecal microbiota transplant for active Crohn's disease[J].Inflamm Bowel Dis,2016,22(9):2182-2190.
[40]Wei Y,Zhu W,Gong J,et al.Fecal microbiota transplantation improves the quality of life in patients with inflammatory bowel disease[J].Gastroenterol Res Pract,2015,2015:517597.
[41]Borody TJ,Warren EF,Leis S,et al.Treatment of ulcerative colitis using fecal bacteriotherapy[J].J Clin Gastroenterol,2003,37(1):42-47.
[42]Rossen NG,Fuentes S,van MJ,et al.Findings from a randomized controlled trial of fecal transplantation for patients with ulcerative colitis[J].Gastroenterology,2015,149(1):110-118.
[43]Ebringer A,Wilson C.The use of a low starch diet in the treatment of patients suffering from ankylosing spondylitis[J].Clin Rheumatol,1996,15,1(1):62-66.
[44]Rashid T,Wilson C,Ebringer A.Raised incidence of ankylosing spondylitis among Inuit populations could be due to high HLA-B27association and starch consumption[J].Rheumatol Int,2015,35(6):945-951.