细菌群体感应调控多样性及群体感应淬灭
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摘要
群体感应(Quorum sensing, QS)是细菌通过信号分子分泌、识别,从而调控基因水平转移、毒力因子分泌、芽孢产生及生物膜形成等群体行为的细胞交流机制。干扰信号分子的分泌、识别,可以阻断群体感应,实现群体淬灭。群体淬灭(Quorum quenching, QQ)是目前致病性控制、致腐性预防以及生物膜污染削减的重要策略之一。本文以群体感应信号分泌-识别-响应为主线,将群体感应分为等级、平行及竞争型三类调控方式,并对其特征进行了详细阐述;同时,探讨了信号分子类似物、信号分子降解酶剂、信号受体激活剂/抑制剂等策略在不同调控方式淬灭中的适用性;最后,对群体感应调控及淬灭进行了展望,以期为丰富细菌群体感应认知、促进群体淬灭应用提供参考。
Quorum sensing(QS) is cell-density dependent cell-to-cell communication in bacteria. In this process,bacteria secrete and recognize the QS signals, and then coordinate the gene expressions in group level for gene transferring, virulence factor secretion, spore production, biofilm formation and so on. Interfering with any part of the process could block QS. Quorum quenching(QQ) is one of the important strategies for the control of pathogenicity, prevention of spoilage and inhibition of biofilm pollution. In this paper, according to the principal axis of secretion-recognition-response of quorum-sensing signals, bacterial QS network was divided into three types: hierarchical, parallel and competitive ones. Firstly, their characteristics were elaborated. Then, the strategies of QQ containing signal competition, signal degradation, and receptors/key proteins activation or inhibition as well as their applications were discussed. Finally, the advance for QS research was prospected. This review was beneficial to enrich the knowledge of bacteria QS and promote the application of QQ.
Quorum sensing(QS) is cell-density dependent cell-to-cell communication in bacteria. In this process,bacteria secrete and recognize the QS signals, and then coordinate the gene expressions in group level for gene transferring, virulence factor secretion, spore production, biofilm formation and so on. Interfering with any part of the process could block QS. Quorum quenching(QQ) is one of the important strategies for the control of pathogenicity, prevention of spoilage and inhibition of biofilm pollution. In this paper, according to the principal axis of secretion-recognition-response of quorum-sensing signals, bacterial QS network was divided into three types: hierarchical, parallel and competitive ones. Firstly, their characteristics were elaborated. Then, the strategies of QQ containing signal competition, signal degradation, and receptors/key proteins activation or inhibition as well as their applications were discussed. Finally, the advance for QS research was prospected. This review was beneficial to enrich the knowledge of bacteria QS and promote the application of QQ.
引文
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[38]Liu HB,Lee JH,Kim JS,Park S.Inhibitors of the Pseudomonas aeruginosa quorum-sensing regulator,QscR.Biotechnology and Bioengineering,2010,106(1):119-126.
[39]Bobadilla Fazzini RA,Skindersoe ME,Bielecki P,Puchalka J,Givskov M,Martins dos Santos VAP.Protoanemonin:a natural quorum sensing inhibitor that selectively activates iron starvation response.Environmental Microbiology,2013,15(1):111-120.
[40]Persson T,Hansen TH,Rasmussen TB,Skinders?ME,Givskov M,Nielsen J.Rational design and synthesis of new quorum-sensing inhibitors derived from acylated homoserine lactones and natural products from garlic.Organic&Biomolecular Chemistry,2005,3(2):253-262.
[41]Maisuria VB,Lopez-de Los Santos Y,Tufenkji N,Déziel E.Cranberry-derived proanthocyanidins impair virulence and inhibit quorum sensing of Pseudomonas aeruginosa.Scientific Reports,2016,6:30169.
[42]Paczkowski JE,Mukherjee S,McCready AR,Cong JP,Aquino CJ,Kim H,Henke BR,Smith CD,Bassler BL.Flavonoids suppress Pseudomonas aeruginosa virulence through allosteric inhibition of quorum-sensing receptors.Journal of Biological Chemistry,2017,292(10):4064-4076.
[43]Vikram A,Jesudhasan PR,Jayaprakasha GK,Pillai SD,Patil BS.Citrus limonoids interfere with Vibrio harveyi cell-cell signalling and biofilm formation by modulating the response regulator LuxO.Microbiology,2011,157(1):99-110.
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[2]Mukherjee S,Moustafa D,Smith CD,Goldberg JB,Bassler BL.The RhlR quorum-sensing receptor controls Pseudomonas aeruginosa pathogenesis and biofilm development independently of its canonical homoserine lactone autoinducer.PLoS Pathogens,2017,13(7):e1006504.
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[4]Reen FJ,Gutiérrez-Barranquero JA,Parages ML,O'Gara F.Coumarin:a novel player in microbial quorum sensing and biofilm formation inhibition.Applied Microbiology and Biotechnology,2018,102(5):2063-2073.
[5]Wang JF,Ding LL,Li K,Huang H,Hu HD,Geng JJ,Xu K,Ren HQ.Estimation of spatial distribution of quorum sensing signaling in sequencing batch biofilm reactor(SBBR)biofilms.Science of the Total Environment,2018,612:405-414.
[6]Wang MZ,Lai BM,Dandekar AA,Yang YS,Li N,Yin J,Shen DS.Nitrogen-source stabilization of quorum sensing in the Pseudomonas aeruginosa bioaugmentation strain SD-1.Applied and Environmental Microbiology,2017,83(16):AEM.00870-17.
[7]Lai BM,Zhang K,Shen DS,Wang MZ,Shentu JL,Li N.Control of the pollution of antibiotic resistance genes in soils by quorum sensing inhibition.Environmental Science and Pollution Research,2017,24(6):5259-5267.
[8]Kalia VC.Quorum sensing inhibitors:an overview.Biotechnology Advances,2013,31(2):224-245.
[9]Singh PK,Yadav VK,Kalia M,Dohare S,Sharma D,Agarwal V.Pseudomonas aeruginosa auto inducer3-oxo-C12-HSLexerts bacteriostatic effect and inhibits Staphylococcus epidermidis biofilm.Microbial Pathogenesis,2017,110:612-619.
[10]Lai BM,Yan HC,Wang MZ,Li N,Shen DS.A common evolutionary pathway for maintaining quorum sensing in Pseudomonas aeruginosa.Journal of Microbiology,2018,56(2):83-89.
[11]Lee J,Zhang LH.The hierarchy quorum sensing network in Pseudomonas aeruginosa.Protein&Cell,2015,6(1):26-41.
[12]McGlacken GP,McSweeney CM,O’Brien T,Lawrence SE,Elcoate CJ,Reen FJ,O’Gara F.Synthesis of 3-halo-analogues of HHQ,subsequent cross-coupling and first crystal structure of Pseudomonas quinolone signal(PQS).Tetrahedron Letters,2010,51(45):5919-5921.
[13]Reen FJ,Mooij MJ,Holcombe LJ,McSweeney CM,McGlacken GP,Morrissey JP,O’Gara F.The Pseudomonas quinolone signal(PQS),and its precursor HHQ,modulate interspecies and interkingdom behaviour.FEMS Microbiology Ecology,2011,77(2):413-428.
[14]Lee J,Wu JE,Deng YY,Wang J,Wang C,Wang JH,Chang CQ,Dong YH,Williams P,Zhang LH.A cell-cell communication signal integrates quorum sensing and stress response.Nature Chemical Biology,2013,9(5):339-343.
[15]Diggle SP,Matthijs S,Wright VJ,Fletcher MP,Chhabra SR,Lamont IL,Kong XL,Hider RC,Cornelis P,Cámara M,Williams P.The Pseudomonas aeruginosa 4-quinolone signal molecules HHQ and PQS play multifunctional roles in quorum sensing and iron entrapment.Chemistry&Biology,2007,14(1):87-96.
[16]Xiao GP,He JX,Rahme LG.Mutation analysis of the Pseudomonas aeruginosa mvf R and pqsABCDE gene promoters demonstrates complex quorum-sensing circuitry.Microbiology,2006,152(6):1679-1686.
[17]Mlynek KD,Sause WE,Moormeier DE,Sadykov MR,Hill KR,Torres VJ,Bayles KW,Brinsmade SR.Nutritional regulation of the Sae two-component system by CodY in Staphylococcus aureus.Journal of Bacteriology,2018,200(8):e00012-18.
[18]Giraudo AT,Cheung AL,Nagel R.The sae locus of Staphylococcus aureus controls exoprotein synthesis at the transcriptional level.Archives of Microbiology,1997,168(1):53-58.
[19]Milton DL,Chalker VJ,Kirke D,Hardman A,Cámara M,Williams P.The LuxM homologue VanM from Vibrio anguillarum directs the synthesis of N-(3-hydroxyhexanoyl)homoserine lactone and N-hexanoylhomoserine lactone.Journal of Bacteriology,2001,183(12):3537-3547.
[20]Henke JM,Bassler BL.Three parallel quorum-sensing systems regulate gene expression in Vibrio harveyi.Journal of Bacteriology,2004,186(20):6902-6914.
[21]Lu RF,Osei-Adjei G,Huang XX,Zhang YQ.Role and regulation of the orphan AphA protein of quorum sensing in pathogenic Vibrios.Future Microbiology,2018,13(3):383-391.
[22]Ruwandeepika HAD,Karunasagar I,Bossier P,Defoirdt T.Expression and quorum sensing regulation of Type IIIsecretion system genes of Vibrio harveyi during infection of Gnotobiotic Brine Shrimp.PLoS One,2015,10(12):e0143935.
[23]Jung SA,Chapman CA,Ng WL.Quadruple quorum-sensing inputs control Vibrio cholerae virulence and maintain system robustness.PLoS Pathogens,2015,11(4):e1004837.
[24]Lorenz N,Shin JY,Jung K.Activity,abundance,and localization of quorum sensing receptors in Vibrio harveyi.Frontiers in Microbiology,2017,8:634.
[25]Hurley A,Bassler BL.Asymmetric regulation of quorum-sensing receptors drives autoinducer-specific gene expression programs in Vibrio cholerae.PLoS Genetics,2017,13(5):e1006826.
[26]Omony J,de Jong A,Krawczyk AO,Eijlander RT,Kuipers OP.Dynamic sporulation gene co-expression networks for Bacillus subtilis 168 and the food-borne isolate Bacillus amyloliquefaciens:a transcriptomic model.Microbial Genomics,2018,4(2):e000157.
[27]Grossman AD.Genetic networks controlling the initiation of sporulation and the development of genetic competence in Bacillus subtilis.Annual Review of Genetics,1995,29:477-508.
[28]Okada M,Sato I,Cho SJ,Iwata H,Nishio T,Dubnau D,Sakagami Y.Structure of the Bacillus subtilis quorum-sensing peptide pheromone ComX.Nature Chemical Biology,2005,1(1):23-24.
[29]Gubaev A,Hilbert M,Klostermeier D.The DNA-gate of Bacillus subtilis gyrase is predominantly in the closed conformation during the DNA supercoiling reaction.Proceedings of the National Academy of Sciences of the United States of America,2009,106(32):13278-13283.
[30]Fujiya M,Musch MW,Nakagawa Y,Hu SE,Alverdy J,Kohgo Y,Schneewind O,Jabri B,Chang EB.The Bacillus subtilis quorum-sensing molecule CSF contributes to intestinal homeostasis via OCTN2,a host cell membrane transporter.Cell Host&Microbe,2007,1(4):299-308.
[31]Parashar V,Aggarwal C,Federle MJ,Neiditch MB.Rgg protein structure-function and inhibition by cyclic peptide compounds.Proceedings of the National Academy of Sciences of the United States of America,2015,112(16):5177-5182.
[32]Junges R,Salvadori G,Shekhar S,?mdal HA,Periselneris JN,Chen T,Brown JS,Petersen FC.A quorum-sensing system that regulates Streptococcus pneumoniae biofilm formation and surface polysaccharide production.mSphere,2017,2(5):e00324-17.
[33]Khan MSA,Zahin M,Hasan S,Husain FM,Ahmad I.Inhibition of quorum sensing regulated bacterial functions by plant essential oils with special reference to clove oil.Letters in Applied Microbiology,2009,49(3):354-360.
[34]Shepherd RW,Lindow SE.Two dissimilar N-acyl-homoserine lactone acylases of Pseudomonas syringae influence colony and biofilm morphology.Applied and Environmental Microbiology,2009,75(1):45-53.
[35]Corral-Lugo A,Daddaoua A,Ortega A,Espinosa-Urgel M,Krell T.So different and still so similar:the plant compound rosmarinic acid mimics bacterial homoserine lactone quorum sensing signals.Communicative&Integrative Biology,2016,9(2):e1156832.
[36]Kim HS,Lee SH,Byun Y,Park HD.6-Gingerol reduces Pseudomonas aeruginosa biofilm formation and virulence via quorum sensing inhibition.Scientific Reports,2015,5:8656.
[37]Sheffield WP,Eltringham-Smith LJ,Bhakta V.Fusion to human serum albumin extends the circulatory half-life and duration of antithrombotic action of the kunitz protease inhibitor domain of protease nexin 2.Cellular Physiology and Biochemistry,2018,45(2):772-782.
[38]Liu HB,Lee JH,Kim JS,Park S.Inhibitors of the Pseudomonas aeruginosa quorum-sensing regulator,QscR.Biotechnology and Bioengineering,2010,106(1):119-126.
[39]Bobadilla Fazzini RA,Skindersoe ME,Bielecki P,Puchalka J,Givskov M,Martins dos Santos VAP.Protoanemonin:a natural quorum sensing inhibitor that selectively activates iron starvation response.Environmental Microbiology,2013,15(1):111-120.
[40]Persson T,Hansen TH,Rasmussen TB,Skinders?ME,Givskov M,Nielsen J.Rational design and synthesis of new quorum-sensing inhibitors derived from acylated homoserine lactones and natural products from garlic.Organic&Biomolecular Chemistry,2005,3(2):253-262.
[41]Maisuria VB,Lopez-de Los Santos Y,Tufenkji N,Déziel E.Cranberry-derived proanthocyanidins impair virulence and inhibit quorum sensing of Pseudomonas aeruginosa.Scientific Reports,2016,6:30169.
[42]Paczkowski JE,Mukherjee S,McCready AR,Cong JP,Aquino CJ,Kim H,Henke BR,Smith CD,Bassler BL.Flavonoids suppress Pseudomonas aeruginosa virulence through allosteric inhibition of quorum-sensing receptors.Journal of Biological Chemistry,2017,292(10):4064-4076.
[43]Vikram A,Jesudhasan PR,Jayaprakasha GK,Pillai SD,Patil BS.Citrus limonoids interfere with Vibrio harveyi cell-cell signalling and biofilm formation by modulating the response regulator LuxO.Microbiology,2011,157(1):99-110.
[44]Calfee MW,Coleman JP,Pesci EC.Interference with Pseudomonas quinolone signal synthesis inhibits virulence factor expression by Pseudomonas aeruginosa.Proceedings of the National Academy of Sciences of the United States of America,2001,98(20):11633-11637.
[45]Chen TT,Sheng JY,Fu YH,Li MH,Wang JS,Jia AQ.1HNMR-based global metabolic studies of Pseudomonas aeruginosa upon exposure of the quorum sensing inhibitor resveratrol.Journal of Proteome Research,2017,16(2):824-830.
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