早期唐氏筛查相关血液指标对妊娠结局的反应意义研究
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摘要
目的:研究与分析早期唐氏筛查相关血液指标对妊娠结局的反应意义。方法:选取2016年10月—2018年9月8 800例早期唐氏筛查孕妇为研究对象,将其进行唐氏筛查相关血液指标(血清AFP、β-hCG及uE3)的检测,比较不同血清AFP、β-hCG及uE3检测结果者的妊娠结局,并以多因素Logistic回归分析处理上述血清AFP、β-hCG及uE3指标与妊娠结局的关系。结果:异常血清AFP、β-hCG及uE3孕妇妊娠期的异常率与胎儿异常发生率均高于正常检测结果的孕妇,差异均有统计学意义(P<0.05)。多因素Logistic回归分析显示,血清AFP、β-hCG及uE3与妊娠结局有密切的关系。结论:早期唐氏筛查相关血液指标对妊娠结局的反应意义较高,具有较高的临床检测价值。
Objective:To study and analyze the response significance of early Down's screening related blood indexes for the pregnancy outcome.Method:8 800 pregnant women during the time of October 2016 to September 2018 were selected as the study objects.The Down's screening related blood indexes(serum AFP,β-hCG and uE3)were measured.The pregnancy outcome of pregnant women with different detection results of AFP,β-hCG and uE3 were compared,the relationship between serum AFP,β-hCG and uE3 and pregnancy outcome were analyzed with multivariate Logistic regression analysis.Result:The pregnancy abnormality rate and fetal abnormality rate of pregnant women with abnormal serum AFP,β-hCG and uE3 were higher than those of pregnant women with normal test results,the differences were statistically significant(P<0.05).The multivariate Logistic regression analysis showed the serum AFP,β-hCG and uE3 all had close relationship to the pregnancy outcome.Conclusion:The early Down's screening related blood indexes have higher significance in response to pregnancy outcome and have higher clinical detection value.
Objective:To study and analyze the response significance of early Down's screening related blood indexes for the pregnancy outcome.Method:8 800 pregnant women during the time of October 2016 to September 2018 were selected as the study objects.The Down's screening related blood indexes(serum AFP,β-hCG and uE3)were measured.The pregnancy outcome of pregnant women with different detection results of AFP,β-hCG and uE3 were compared,the relationship between serum AFP,β-hCG and uE3 and pregnancy outcome were analyzed with multivariate Logistic regression analysis.Result:The pregnancy abnormality rate and fetal abnormality rate of pregnant women with abnormal serum AFP,β-hCG and uE3 were higher than those of pregnant women with normal test results,the differences were statistically significant(P<0.05).The multivariate Logistic regression analysis showed the serum AFP,β-hCG and uE3 all had close relationship to the pregnancy outcome.Conclusion:The early Down's screening related blood indexes have higher significance in response to pregnancy outcome and have higher clinical detection value.
引文
[1]赵予韬,刘举珍,赵新明,等.孕妇唐氏筛查结果中人绒毛膜促性腺激素增高与妊娠结局的关系分析[J].标记免疫分析与临床,2017,24(1):26-28.
[2]赵丽,肖建平,杨岚,等.唐氏筛查单项指标人绒毛膜促性腺激素水平增高孕妇妊娠结局分析[J].中国全科医学,2015,18(27):3304-3307.
[3]李欣,王丹.唐氏筛查在妊娠中期高龄孕产妇中的应用效果及对妊娠结局的影响[J].实验与检验医学,2017,35(3):390-392.
[4]陈杰英,黎璐珊.唐氏血清学指标与子宫动脉血流的相关性及其对不良妊娠结局的预测价值[J].临床医学,2018,38(3):20-22.
[5]郭瑜.孕中期唐氏血清学筛查对妊娠结局的影响研究[J].黑龙江医学,2016,40(3):285-286.
[6]Kim S M,Yun H G,Kim R Y,et al.Maternal serum placental growth factor combined with second trimester aneuploidy screening to predict small-for-gestation neonates without preeclampsia[J].Taiwan J Obstet Gyne,2017,56(6):801-805.
[7]夏英华.唐氏筛查单项指标人绒毛膜促性腺激素水平增高孕妇妊娠结局探讨[J/OL].临床检验杂志(电子版),2018,7(1):137.
[8]Settiyanan T,Wanapirak C,Sirichotiyakul S,et al.Association between isolated abnormal levels of maternal serum unconjugated estriol in the second trimester and adverse pregnancy outcomes[J].J Matern Fetal Neonatal Med,2016,29(13):2093-2097.
[9]吴杰,曾海燕.妊娠中期唐氏综合征血清学筛查与妊娠结局的研究[J].齐齐哈尔医学院学报,2015,36(12):1723-1725.
[10]韦稚.血清学检查在高龄孕妇产前唐氏综合征筛查中价值的探讨[J].中国计划生育学杂志,2016,24(3):187-189.
[11]Downs E M,Behrendt N J.Sonographic assessment of a pregnancy complicated by a rare presentation of twin reversed arterial perfusion sequence[J].J Ultrasound Med,2014,33(10):1865-1868.
[12]陈芳,朱斌.孕中期唐氏筛查高危与不良妊娠结局的分析[J].中国现代药物应用,2017,11(16):56-57.
[13]南燕燕,李娜,董智力.孕中期唐氏筛查血清标志物及miR-200C与病理妊娠的关系[J].临床和实验医学杂志,2018,17(2):188-192.
[14]方巍.孕中期妇女2950例唐氏综合征筛查结果分析[J].基层医学论坛,2016,20(12):1640-1641.
[15]李霞.妊娠中期AFP、Freeβ-HCG、uE3联检对胎儿唐氏综合征筛查的影响分析[J].中国优生与遗传杂志,2015,35(5):56-57.
[16]牛红玲,陈永宏.血清标志物AFP、F-βhCG与不良妊娠结局的相关性分析[J].中国妇幼保健,2015,30(33):5751-5753.
[17]丁小莉,陈兰,钟燕.初产妇孕期BMI及孕中期血清AFP、β-HCG、uE3水平对不良妊娠结局的影响[J].贵州医科大学学报,2017,42(4):490-494.
[18]邹彦,陈璐,夏隽.初产妇BMI、AFP、β-HCG、uE3水平与妊娠结局的相关性分析[J].中国实用医刊,2018,45(7):96-99.
[19]李东明,黄昌园,周晖登.孕中期羊水母体血清甲胎蛋白水平与不良妊娠结局分析[J].右江医学,2015,43(4):419-421.
[20]刘彩丽,司雯,牛萍.孕中期初产妇血清AFP、β-HCG、uE3、Inhibin-A联合检测对不良妊娠结局的指导作用[J].泰山医学院学报,2018,39(3):330-331.
[2]赵丽,肖建平,杨岚,等.唐氏筛查单项指标人绒毛膜促性腺激素水平增高孕妇妊娠结局分析[J].中国全科医学,2015,18(27):3304-3307.
[3]李欣,王丹.唐氏筛查在妊娠中期高龄孕产妇中的应用效果及对妊娠结局的影响[J].实验与检验医学,2017,35(3):390-392.
[4]陈杰英,黎璐珊.唐氏血清学指标与子宫动脉血流的相关性及其对不良妊娠结局的预测价值[J].临床医学,2018,38(3):20-22.
[5]郭瑜.孕中期唐氏血清学筛查对妊娠结局的影响研究[J].黑龙江医学,2016,40(3):285-286.
[6]Kim S M,Yun H G,Kim R Y,et al.Maternal serum placental growth factor combined with second trimester aneuploidy screening to predict small-for-gestation neonates without preeclampsia[J].Taiwan J Obstet Gyne,2017,56(6):801-805.
[7]夏英华.唐氏筛查单项指标人绒毛膜促性腺激素水平增高孕妇妊娠结局探讨[J/OL].临床检验杂志(电子版),2018,7(1):137.
[8]Settiyanan T,Wanapirak C,Sirichotiyakul S,et al.Association between isolated abnormal levels of maternal serum unconjugated estriol in the second trimester and adverse pregnancy outcomes[J].J Matern Fetal Neonatal Med,2016,29(13):2093-2097.
[9]吴杰,曾海燕.妊娠中期唐氏综合征血清学筛查与妊娠结局的研究[J].齐齐哈尔医学院学报,2015,36(12):1723-1725.
[10]韦稚.血清学检查在高龄孕妇产前唐氏综合征筛查中价值的探讨[J].中国计划生育学杂志,2016,24(3):187-189.
[11]Downs E M,Behrendt N J.Sonographic assessment of a pregnancy complicated by a rare presentation of twin reversed arterial perfusion sequence[J].J Ultrasound Med,2014,33(10):1865-1868.
[12]陈芳,朱斌.孕中期唐氏筛查高危与不良妊娠结局的分析[J].中国现代药物应用,2017,11(16):56-57.
[13]南燕燕,李娜,董智力.孕中期唐氏筛查血清标志物及miR-200C与病理妊娠的关系[J].临床和实验医学杂志,2018,17(2):188-192.
[14]方巍.孕中期妇女2950例唐氏综合征筛查结果分析[J].基层医学论坛,2016,20(12):1640-1641.
[15]李霞.妊娠中期AFP、Freeβ-HCG、uE3联检对胎儿唐氏综合征筛查的影响分析[J].中国优生与遗传杂志,2015,35(5):56-57.
[16]牛红玲,陈永宏.血清标志物AFP、F-βhCG与不良妊娠结局的相关性分析[J].中国妇幼保健,2015,30(33):5751-5753.
[17]丁小莉,陈兰,钟燕.初产妇孕期BMI及孕中期血清AFP、β-HCG、uE3水平对不良妊娠结局的影响[J].贵州医科大学学报,2017,42(4):490-494.
[18]邹彦,陈璐,夏隽.初产妇BMI、AFP、β-HCG、uE3水平与妊娠结局的相关性分析[J].中国实用医刊,2018,45(7):96-99.
[19]李东明,黄昌园,周晖登.孕中期羊水母体血清甲胎蛋白水平与不良妊娠结局分析[J].右江医学,2015,43(4):419-421.
[20]刘彩丽,司雯,牛萍.孕中期初产妇血清AFP、β-HCG、uE3、Inhibin-A联合检测对不良妊娠结局的指导作用[J].泰山医学院学报,2018,39(3):330-331.