从毒瘀理论探讨慢性阻塞性肺疾病合并肺动脉高压
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摘要
以慢性阻塞性肺疾病(COPD)合并肺动脉高压(PH)的现代病理生理为切入点进行分析,追溯"毒瘀"的源流及目前的研究现状,认为毒瘀理论与COPD合并PH有较强的相关性,其中毒邪侵犯机体是导致COPD发病的重要因素;毒邪日久,煎熬津血,发为血瘀,瘀久可再生内毒,两者互为因果,相互交阻,最终导致COPD合并PH;基于其毒瘀相互搏结的特点,解毒祛瘀法是治疗该病的关键方法。
Thinking from the perspective of modern pathology and physiology of chronic obstructive pulmonary disease(COPD) complicated with pulmonary hypertension(PH),the authors traced back to the origin and status quo of toxin and blood stasis. It is believed that there exits a relatively strong correlation between COPD complicated with PH and the theory of toxin and blood stasis,among which toxin-evil invading body is an important factor leading to the onset of COPD. Furthermore,toxin-evil retains so long that it will exhaust body fluid and blood to produce blood stasis,which then progressively results in internal toxin if lingering for a long time. As reciprocal causation, they mutually obstruct and stagnate, eventually causing COPD complicated with PH. Based on the feature of Intermingled toxin and blood stasis,the method of eliminating toxin and removing stasis is the key to treating this disease.
Thinking from the perspective of modern pathology and physiology of chronic obstructive pulmonary disease(COPD) complicated with pulmonary hypertension(PH),the authors traced back to the origin and status quo of toxin and blood stasis. It is believed that there exits a relatively strong correlation between COPD complicated with PH and the theory of toxin and blood stasis,among which toxin-evil invading body is an important factor leading to the onset of COPD. Furthermore,toxin-evil retains so long that it will exhaust body fluid and blood to produce blood stasis,which then progressively results in internal toxin if lingering for a long time. As reciprocal causation, they mutually obstruct and stagnate, eventually causing COPD complicated with PH. Based on the feature of Intermingled toxin and blood stasis,the method of eliminating toxin and removing stasis is the key to treating this disease.
引文
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[3]李雪英,胡苏萍,陈国忠,等.炎症反应与慢性阻塞性肺疾病相关肺动脉高压及其血液高凝状态的关系[J].山东医药,2017,57(1):71-73.
[4]谭俊斌.肺功能血气分析和炎症因子在慢性阻塞性肺疾病急性加重期患者中的相关性研究[J].黑龙江医学,2016,40(6):508-509.
[5]周妍卉,鲁军体.清肺化痰方联合活血化瘀法治疗肺炎疗效及对血清炎性因子水平影响[J].陕西中医,2017,38(2):199-200.
[6]孙乃林.利咽解毒颗粒的抗炎解热作用研究[J].湖北中医杂志,2005,27(12):3-4.
[7]张文江,姚明江,张旭丽.祛瘀解毒方治疗慢性阻塞性肺疾病稳定期临床观察[J].中国中医急症,2013,22(8):1323-1325.
[2]Chaouat A,Bugnet AS,Kadaoui N,et al.Severe pulmonary hypertension and chronic obstructive pulmonary disease[J].American Journal of Respiratory and Critical Care Medicine,2005,172(2):189.
[3]李雪英,胡苏萍,陈国忠,等.炎症反应与慢性阻塞性肺疾病相关肺动脉高压及其血液高凝状态的关系[J].山东医药,2017,57(1):71-73.
[4]谭俊斌.肺功能血气分析和炎症因子在慢性阻塞性肺疾病急性加重期患者中的相关性研究[J].黑龙江医学,2016,40(6):508-509.
[5]周妍卉,鲁军体.清肺化痰方联合活血化瘀法治疗肺炎疗效及对血清炎性因子水平影响[J].陕西中医,2017,38(2):199-200.
[6]孙乃林.利咽解毒颗粒的抗炎解热作用研究[J].湖北中医杂志,2005,27(12):3-4.
[7]张文江,姚明江,张旭丽.祛瘀解毒方治疗慢性阻塞性肺疾病稳定期临床观察[J].中国中医急症,2013,22(8):1323-1325.