小花清风藤化学成分的分离与鉴定
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摘要
目的研究小花清风藤Sabia parviflora的化学成分。方法利用多种色谱技术进行分离,运用现代光谱技术鉴定化合物结构。结果从小花清风藤中分离得到15个化合物,分别鉴定为邻苯二甲酸二(2-乙基己)酯(1)、邻苯二甲酸二丁酯(2)、豨莶精醇(3)、蔗糖(4)、丁香醛(5)、香草醛(6)、黄花菜木脂素C(7)、克罗酰胺(8)、(-)-lyoniresinol(9)、狗牙花脂素(10)、丁香树脂醇(11)、seslignanoccidentaliol A(12)、左旋丁香树脂醇-4-O-β-D-葡萄糖苷(13)、(-)-simulanol(14)、(-)-7R,8S-dehydrodiconiferyl alcohol(15)。结论化合物1~15均为首次从该属植物中分离得到。
Objective To study the chemical constituents from the Sabia parviflora. Methods Various column chromatographic techniques were used to separate and purify the chemical constituents which structures were elucidated by spectral analysis. Results Fifteen compounds were isolated and identified as bis(2-ethylhexyl) benzene-1,2-dicarboxylate(1), dibutyl phthalate(2), darutigenol(3), sucrose(4), 3,5-dimethoxy-4-hydroxybenzaldehyde(5), vanillin(6), cleomiscosin C(7), grossamide(8),(-)-lyoniresino(9), ervatamisin(10),(+)-syringaresinol(11), seslignanoccidentaliol A(12),(+)-syringaresinol-4-O-β-D-glucopyranoside(13),(-)-simulanol(14), and(-)-7 R,8 S-dehydrodiconiferyl alcohol(15). Conclusion All the compounds are isolated from the genus of Sabia for the first time.
Objective To study the chemical constituents from the Sabia parviflora. Methods Various column chromatographic techniques were used to separate and purify the chemical constituents which structures were elucidated by spectral analysis. Results Fifteen compounds were isolated and identified as bis(2-ethylhexyl) benzene-1,2-dicarboxylate(1), dibutyl phthalate(2), darutigenol(3), sucrose(4), 3,5-dimethoxy-4-hydroxybenzaldehyde(5), vanillin(6), cleomiscosin C(7), grossamide(8),(-)-lyoniresino(9), ervatamisin(10),(+)-syringaresinol(11), seslignanoccidentaliol A(12),(+)-syringaresinol-4-O-β-D-glucopyranoside(13),(-)-simulanol(14), and(-)-7 R,8 S-dehydrodiconiferyl alcohol(15). Conclusion All the compounds are isolated from the genus of Sabia for the first time.
引文
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[2]唐继芳,邓朝义,卢永成.黔西南州小花清风藤资源分布及利用状况调查[J].贵州林业科技,2002,30(3):8-10.
[3]中国科学院中国植物志编辑委员会.中国植物志[M].北京:科学出版社,1985.
[4]刘易蓉,邱晓春,陈惠.小花清风藤保肝作用实验研究[J].中国药房,2008,19(30):2341-2342.
[5]邓云飞.中国清风藤属Sabia Colebr.(清风藤科)的订正[J].热带亚热带植物学报,2001,9(1):45-48.
[6]曲新艳,张会敏,张晓娟,等.小花清风藤水提物体内抗流感病毒的研究[J].生物技术通讯,2015,26(6):802-804.
[7]杨莹,张永萍,梁光义.小花清风藤胶囊的保肝作用研究及其急毒实验[J].中国现代应用药学,2013,30(11):1166-1170.
[8]温迪,孙庆文,潘国吉,等.清风藤属药用植物研究进展[J].贵州科学,2016,34(3):25-31.
[9]刘易蓉,梁光义,张永萍.清风藤属药用植物的研究概况[J].贵阳中医学院学报,2006,28(1):50-52.
[10]Katade S R,Pawar P V,Tungikar V B,et al.Larvicidal activity of bis(2-ethylhexyl)benzene-1,2-dicarboxylate from Sterculia guttata seeds against two mosquito species[J].Chem Biodiver,2006,3(1):49-53.
[11]王亚威,李志峰,何明珍,等.天麻化学成分研究[J].中草药,2013,44(21):2974-2976.
[12]侴桂新,王峥涛.豨莶草化学成分研究[J].中国药学杂志,2006,41(24):1854-1857.
[13]关放,王军宪,杨云.美观马先蒿化学成分的研究[J].中药材,2004,27(12):920-921.
[14]文屏,韩慧英,王乃利,等.毛杭子梢化学成分的研究[J].中草药,2008,39(8):1143-1145.
[15]王岩,张海宁,王文婧,等.椿皮化学成分的研究[J].中草药,2012,43(4):649-652.
[16]石金敏,李震,敬林林,等.黄秋葵氯仿部位化学成分研究[J].中国医药工业杂志,2012,43(12):987-990.
[17]吴兆圆,李蓉涛.碎米花杜鹃根的化学成分研究[J].天然产物研究与开发,2011,23(2):253-257.
[18]Lajide L,Escoubas P,Mizutani J.Termite antifeedant activity in Xylopia aethiopica[J].Cheminform,1995,40(4):1101-1104.
[19]Xiong L,Zhu C G,Li Y R,et al.Lignans and neolignans from Sinocalamus affinis and their absolute configurations[J].J Nat Prod,2011,74(5):1188-1200.
[20]Wan M N H W S,Ahmad F,Yen K H,et al.Anticholinesterase and anti-inflammatory constituents from Beilschmiedia pulverulenta Kosterm[J].Nat Prod Sci,2016,22(4):225-230.
[21]Xiong L,Zhu C G,Li Y R,et al.Lignans and neolignans from Sinocalamus affinis and their absolute configurations[J].J Nat Prod,2011,74(5):1188-1200.
[22]高巍,杨柳,李慧慧,等.杯鞘石斛的化学成分研究[J].中国现代中药,2015,17(4):311-314.
[23]Hong S S,Han X H,Hwang J S,et al.Lignans from the stem barks of Kalopanax septemlobus[J].Nat Prod Sci,2006,12(4):201-204.