多种细胞学方法联合检查不明原因渗出性胸腔积液的诊断价值
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摘要
目的探讨传统制片、液基薄层制片及细胞蜡块三者联合对不明原因胸腔渗出性积液的检查价值及临床意义。方法对南华大学附属南华医院126例不明原因渗出性胸腔积液,采用传统制片、液基薄层制片及细胞蜡块三种方法联合检查,并对其诊断结果进行分析对比。结果传统制片、液基薄层制片以及细胞蜡块分别检出癌性胸腔积液28例、31例及63例,细胞蜡块癌性积液检出率明显高于传统及液基薄层制片(50%:22.2%:24.6%),差异有显著性。结论细胞蜡块切片法的癌性胸腔积液检出率明显升高,加做免疫组化还有助于明确癌细胞的分化方向和原发部位,与其他筛查方法联合使用既可提高确诊率,还可减少不必要的检查,具有很高的临床应用价值。
Objective To investigate the diagnostic value and clinical significance of multiple cytological methods for combination in patients with unexplained exudative pleural effusion.Methods 126 cases of unexplained pleural exudative effusion were performed with cytology,the liquid-based cytology and the cell block paraffin section examination.The results were analyzed retrospectively.Results 28 cases,31 cases and 63 cases were diagnosed malignant tumor by cytology,the liquid-based cytology and the cell block paraffin section examination.The detection rate of the cell block paraffin section examination was significantly higher than that of the cytology and the liquid-based cytology examination(50%:22.2%:24.6%).Conclusion Cell block paraffin section combined with immuno-cytochemical staining could improve the percentage of positive diagnosis and also be useful in delineation of the primary origins of the tumor cells.The combination of this technique with other cytology screening methods not only improves the positive diagnosis rate,but also reduces the unnecessary examinations.And that has certain value in clinical application.
Objective To investigate the diagnostic value and clinical significance of multiple cytological methods for combination in patients with unexplained exudative pleural effusion.Methods 126 cases of unexplained pleural exudative effusion were performed with cytology,the liquid-based cytology and the cell block paraffin section examination.The results were analyzed retrospectively.Results 28 cases,31 cases and 63 cases were diagnosed malignant tumor by cytology,the liquid-based cytology and the cell block paraffin section examination.The detection rate of the cell block paraffin section examination was significantly higher than that of the cytology and the liquid-based cytology examination(50%:22.2%:24.6%).Conclusion Cell block paraffin section combined with immuno-cytochemical staining could improve the percentage of positive diagnosis and also be useful in delineation of the primary origins of the tumor cells.The combination of this technique with other cytology screening methods not only improves the positive diagnosis rate,but also reduces the unnecessary examinations.And that has certain value in clinical application.
引文
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[6]Khan S,Omar T,Michelow P.Effectivenesss of the cell block technique in diagnostic cytopathology[J].J Cytol,2012,29(3):177.