重度子痫前期合并胎儿生长受限孕妇妊娠晚期血清氧化蛋白产物和胱抑素C水平表达及其临床意义
|
摘要
目的:探讨重度子痫前期合并胎儿生长受限孕妇妊娠晚期血清氧化蛋白产物(Advanced oxidation protein products,AOPP)和胱抑素C(Cystatin C,Cys-C)水平表达及其临床意义。方法:选取2015年6月-2016年12月就诊本院的重度子痫前期合并胎儿受限的孕妇40例设为研究组,根据预后情况分为预后不良组(28例)和预后良好组(12例),同期选取40例正常晚期妊娠的孕妇为对照组,采用免疫散射浊度法、免疫比浊法检测所有研究对象血清Cys-C和AOPP,比较研究组和对照组血清AOPP和Cys-C表达水平,并分析两者表达水平预测预后情况的临床价值。结果:研究组血清AOPP和Cys-C水平均高于对照组,差异均有统计学意义(P<0.05);预后不良组血清AOPP和Cys-C水平均高于预后良好组,差异均有统计学意义(P<0.05);经Spearman相关性分析,血清AOPP和Cys-C水平与预后情况呈一定相关性(r=0.721 541,P<0.05);ROC曲线分析显示,血清AOPP和Cys-C水平预测重度子痫前期及胎儿生长受限孕妇预后具有良好的评估价值。结论:重度子痫前期及胎儿生长受限孕妇妊娠晚期血清AOPP和Cys-C水平明显升高,且AOPP和Cys-C水平与患者的妊娠结局有着重要的相关性,提示动态监测两者变化趋势有助于评估预后。
Objective:To discuss the expression and significance of serum serum cystatin C and AOPP in severe preeclampsia in combination with fetal growth restriction.Method:40 patients with severe preeclampsia in combination with fetal growth restriction from June 2015 to December 2016 were selected and assigned as research group, according to the prognosis they were devided into poor prognosis group(28 cases) and good prognosis group(12 cases).In the same period, 40 pregnant women with normal late pregnancy were selected and assigned as control group. The serum Cys-C and AOPP of all subjects were detected by immunoassay and turbidimetric method.The serum AOPP and Cys-C expression levels in the research group and the control group were compared.The clinical value of predicting the prognosis of the two groups were analyzed.Result:Serum AOPP and Cys-C levels in research group were higher than those of control group, the differences were statistically significant(P<0.05). Serum AOPP and Cys-C levels of poor prognosis group were higher than those of good prognosis group, the differences were statistically significant(P<0.05).According to Spearman correlation analysis, serum AOPP and Cys-C levels were correlated with prognostic conditions(r=0.721 541,P<0.05).ROC curve analysis showed that the serum AOPP and Cys-C levels predicted the prognosis of pregnant women with severe preeclampsia in combination with fetal growth restriction had good evaluation value.Conclusion:The serum AOPP and Cys-C levels of severe preeclampsia in combination with fetal growth restriction women in the second trimester is higher than normal pregnant women,which is related to genesis of preeclampsia and adverse pregnant outcomes.
Objective:To discuss the expression and significance of serum serum cystatin C and AOPP in severe preeclampsia in combination with fetal growth restriction.Method:40 patients with severe preeclampsia in combination with fetal growth restriction from June 2015 to December 2016 were selected and assigned as research group, according to the prognosis they were devided into poor prognosis group(28 cases) and good prognosis group(12 cases).In the same period, 40 pregnant women with normal late pregnancy were selected and assigned as control group. The serum Cys-C and AOPP of all subjects were detected by immunoassay and turbidimetric method.The serum AOPP and Cys-C expression levels in the research group and the control group were compared.The clinical value of predicting the prognosis of the two groups were analyzed.Result:Serum AOPP and Cys-C levels in research group were higher than those of control group, the differences were statistically significant(P<0.05). Serum AOPP and Cys-C levels of poor prognosis group were higher than those of good prognosis group, the differences were statistically significant(P<0.05).According to Spearman correlation analysis, serum AOPP and Cys-C levels were correlated with prognostic conditions(r=0.721 541,P<0.05).ROC curve analysis showed that the serum AOPP and Cys-C levels predicted the prognosis of pregnant women with severe preeclampsia in combination with fetal growth restriction had good evaluation value.Conclusion:The serum AOPP and Cys-C levels of severe preeclampsia in combination with fetal growth restriction women in the second trimester is higher than normal pregnant women,which is related to genesis of preeclampsia and adverse pregnant outcomes.
引文
[1]张敏.早发型重度子痫前期对母婴结局的影响分析[J].河南医学研究,2015,24(2):137.
[2]黄团明,罗世福,李发科,等.24小时尿蛋白定量和血清白蛋白与未足月重度子痫前期母儿结局的关系分析[J].实用妇产科杂志,2015,31(12):912-916.
[3]熊周怡,张桦,杨力,等.高级氧化蛋白产物对大鼠胰岛微血管内皮细胞凋亡的影响及机制研究[J].中国糖尿病杂志,2015,23(8):751-755.
[4]张双双,张振,杨蕾,等.胰升血糖素样肽-1减轻晚期氧化蛋白产物所致足细胞氧化应激损伤的实验观察[J].中国糖尿病杂志,2016,24(11):1007-1011.
[5]姚磊,刘保廷.血清Cys-C浓度检测对慢性肾功能衰竭患者的早期诊断价值研究[J].医学检验与临床,2017,28(3):18-19.
[6]龚伦彬,谢祥红,杜宇.血清CYS-C与CRP在原发性高血压肾损害早期诊断中价值探讨[J].中国实验诊断学,2017,21(3):417-420.
[7]蔡本硕,刘芳,夏亚军.重度子痫前期合并胎儿生长受限胎盘组织VCAM-1表达的研究[J].中国现代医学杂志,2012,22(7):69-72.
[8]庄旭,林建华.子痫前期患者24 h尿蛋白值与不良妊娠结局的相关性[J].中华妇产科杂志,2014,49(7):538-540.
[9]柴利强,陈大立,彭兰,等.子痫前期孕妇尿蛋白水平与妊娠结局的关系[J].江苏医药,2017,43(5):337-340.
[10]任艳芳.早发型子痫前期孕妇出现不良妊娠结局与血清胱抑素C水平的相关性研究[J].中国妇幼保健,2015,30(26):4446-4448.
[11]许旭,朱启英.维吾尔族早发型子痫前期患者血清晚期氧化蛋白产物和胱抑素C水平及其与妊娠结局的相关性[J].中国免疫学杂志,2014,30(12):1701-1704.
[12]黄启涛,王硕石,陈剑,等.晚期氧化蛋白产物在子痫前期孕妇胎盘高表达及其临床意义[J].中国实用妇科与产科杂志,2013,29(10):813-817.
[13]梁鉴文,陈伟泉.急性心功能不全患者血清Cys-C和BNP水平对判断急性肾损伤发生的临床价值[J].热带医学杂志,2017,17(7):959-962.
[14]王丽.Cys-C、UREA、Scr检测在急性肾小球肾炎早期肾损伤评估中的意义[J].标记免疫分析与临床,2017,24(4):422-424.
[15]夏宏林,郝维敏,钟平,等.血清胱抑素C对子痫前期早期肾损伤的诊断价值[J].现代妇产科进展,2016,25(8):614-616.
[16]姜帆,罗徳梅.血清Cys-C、Hcy、NAG及mALB水平检测诊断妊娠期高血压疾病早期肾损害的价值[J].中国妇幼保健,2017,32(15):3437-3439.
[2]黄团明,罗世福,李发科,等.24小时尿蛋白定量和血清白蛋白与未足月重度子痫前期母儿结局的关系分析[J].实用妇产科杂志,2015,31(12):912-916.
[3]熊周怡,张桦,杨力,等.高级氧化蛋白产物对大鼠胰岛微血管内皮细胞凋亡的影响及机制研究[J].中国糖尿病杂志,2015,23(8):751-755.
[4]张双双,张振,杨蕾,等.胰升血糖素样肽-1减轻晚期氧化蛋白产物所致足细胞氧化应激损伤的实验观察[J].中国糖尿病杂志,2016,24(11):1007-1011.
[5]姚磊,刘保廷.血清Cys-C浓度检测对慢性肾功能衰竭患者的早期诊断价值研究[J].医学检验与临床,2017,28(3):18-19.
[6]龚伦彬,谢祥红,杜宇.血清CYS-C与CRP在原发性高血压肾损害早期诊断中价值探讨[J].中国实验诊断学,2017,21(3):417-420.
[7]蔡本硕,刘芳,夏亚军.重度子痫前期合并胎儿生长受限胎盘组织VCAM-1表达的研究[J].中国现代医学杂志,2012,22(7):69-72.
[8]庄旭,林建华.子痫前期患者24 h尿蛋白值与不良妊娠结局的相关性[J].中华妇产科杂志,2014,49(7):538-540.
[9]柴利强,陈大立,彭兰,等.子痫前期孕妇尿蛋白水平与妊娠结局的关系[J].江苏医药,2017,43(5):337-340.
[10]任艳芳.早发型子痫前期孕妇出现不良妊娠结局与血清胱抑素C水平的相关性研究[J].中国妇幼保健,2015,30(26):4446-4448.
[11]许旭,朱启英.维吾尔族早发型子痫前期患者血清晚期氧化蛋白产物和胱抑素C水平及其与妊娠结局的相关性[J].中国免疫学杂志,2014,30(12):1701-1704.
[12]黄启涛,王硕石,陈剑,等.晚期氧化蛋白产物在子痫前期孕妇胎盘高表达及其临床意义[J].中国实用妇科与产科杂志,2013,29(10):813-817.
[13]梁鉴文,陈伟泉.急性心功能不全患者血清Cys-C和BNP水平对判断急性肾损伤发生的临床价值[J].热带医学杂志,2017,17(7):959-962.
[14]王丽.Cys-C、UREA、Scr检测在急性肾小球肾炎早期肾损伤评估中的意义[J].标记免疫分析与临床,2017,24(4):422-424.
[15]夏宏林,郝维敏,钟平,等.血清胱抑素C对子痫前期早期肾损伤的诊断价值[J].现代妇产科进展,2016,25(8):614-616.
[16]姜帆,罗徳梅.血清Cys-C、Hcy、NAG及mALB水平检测诊断妊娠期高血压疾病早期肾损害的价值[J].中国妇幼保健,2017,32(15):3437-3439.