醒脑静在重度酒精中毒患者中的疗效及对神经递质的影响观察
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摘要
目的:探讨针对于重度酒精中毒患者的临床可靠治疗方法,为重度酒精中毒患者的临床治疗实践提供参考依据。方法:选取重度酒精中毒患者88例为研究对象,根据患者临床治疗方案情况将其分成研究组和对照组,每组各44例。对照组患者给予纳洛酮进行治疗,研究组患者给予醒脑静进行治疗。对两组患者治疗前后的血清神经递质指标、抗氧化能力指标等进行观察和比较。结果:治疗前两组患者的各项神经递质指标和抗氧化能力指标差异不大,且无统计学意义;治疗后12 h和24 h,研究组患者的各项神经递质指标和抗氧化能力指标均优于对照组,且差异显著;研究组治疗后12 h和24 h的各项神经递质指标和抗氧化能力指标均优于治疗前。结论:醒脑静能够有效地改善重度酒精中毒患者的神经递质指标和抗氧化能力指标,提升临床治疗效果,是临床治疗重度酒精中毒的理想方式之一。
Objective To explore the clinical reliable treatment for severe alcoholism in patients with severe alcoholism, and provide reference for the clinical treatment of patients with severe alcoholism. Method 88 patients with severe alcoholism admitted were selected as the study subjects. According to the clinical treatment plan, the patients were divided into study group and control group, and 44 cases in each group. The patients in the control group were treated with naloxone and the patients in the study group were treated with restoring consciousness jing for treatment. The serum neurotransmitter index and antioxidant capacity of the two groups were observed and compared before and after treatment. Results There were no significant differences in neurotransmitter and antioxidant capacity between the two groups before treatment, and there were no statistical significance. At 12 h and 24 h after treatment, the neurotransmitters and antioxidant indexes were superior to the control group, and the differences were significant. The neurotransmitter index and antioxidant capacity indicators in the study group after 12 h and 24 h were better than before treatment. Conclusion Restoring consciousness jing can effectively improve the neurotransmitter and anti-oxidative capacity of patients with severe alcoholism and improve the clinical therapeutic effect,which is one of the ideal ways to treat severe alcoholism.
Objective To explore the clinical reliable treatment for severe alcoholism in patients with severe alcoholism, and provide reference for the clinical treatment of patients with severe alcoholism. Method 88 patients with severe alcoholism admitted were selected as the study subjects. According to the clinical treatment plan, the patients were divided into study group and control group, and 44 cases in each group. The patients in the control group were treated with naloxone and the patients in the study group were treated with restoring consciousness jing for treatment. The serum neurotransmitter index and antioxidant capacity of the two groups were observed and compared before and after treatment. Results There were no significant differences in neurotransmitter and antioxidant capacity between the two groups before treatment, and there were no statistical significance. At 12 h and 24 h after treatment, the neurotransmitters and antioxidant indexes were superior to the control group, and the differences were significant. The neurotransmitter index and antioxidant capacity indicators in the study group after 12 h and 24 h were better than before treatment. Conclusion Restoring consciousness jing can effectively improve the neurotransmitter and anti-oxidative capacity of patients with severe alcoholism and improve the clinical therapeutic effect,which is one of the ideal ways to treat severe alcoholism.
引文
[1]王彦霞,张瑛琪,苏冠丽,等.醒脑静对急性重度酒精中毒患者氧化应激的影响研究[J].山西医药杂志,2017,46(3):305.
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[11]王雪敏,杨昆,杜超,等.纳美芬联合丹参多酚酸盐治疗急性重度酒精中毒患者心肌保护作用的临床研究[J].河北医药,2016,38(19):3004.
[12]张静,赵强,赖红梅,等.乙醛脱氢酶2改善亚急性酒精中毒对急性心肌梗死损害的作用及机制研究[J].中华急诊医学杂志,2017,26(5):560.
[13]汤银娟,王建钧,王祥海,等.茶多酚对慢性酒精中毒肝损伤影响的实验研究[J].中国临床解剖学杂志,2016,34(2):198.
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[15]程益锋,卢阳,范笙艳.参麦注射液联合布地奈德治疗急性酒精中毒合并吸入性肺炎的临床研究[J].中国现代医学杂志,2015,25(7):100.
[16]温慧军.硫辛酸对慢性酒精中毒性周围神经病的临床疗效[J].中风与神经疾病杂志,2017,34(1):68.
[17]余红胜,许红莉,鲁杰.慢性酒精中毒性脑病CT与事件相关电位P300对照研究[J].中国医学计算机成像杂志,2015,21(5):475.
[18]蒋曦,田福荣,赵应征.小鼠慢性酒精中毒及戒断过程中抑郁样行为的改变及其共病机制[J].中国病理生理杂志,2016,32(2):296.
[19]梅俊华,王俊力,高珊,等.神经心理因素与针刺治疗男性慢性酒精中毒性周围神经病得气及疗效的关系[J].中国康复理论与实践,2015,(10):1212.
[20]朱红潮.纳洛酮联合醒脑静治疗急性重度酒精中毒的临床效果观察[J].河南医学研究,2016,25(4):737.
[21]栗全英.葛根素注射液联合西医治疗对酒精中毒患者神经递质及氧化应激的影响观察[J].世界中西医结合杂志,2016,11(6):844.
[2]徐磊,姜洪波,安娜,等.丁苯酞对慢性酒精中毒大鼠海马内硫化氢和纤维状肌动蛋白的影响[J].中国老年学杂志,2015,(8):2161.
[3]梅俊华,罗利俊,胡明,等.慢性酒精中毒性周围神经病患者神经心理因素特点及影响研究[J].中华行为医学与脑科学杂志,2015,24(6):513.
[4]黄卫华.纳洛酮与醒脑静联合治疗急性重度酒精中毒的疗效探讨[J].临床医药实践,2015,(5):345.
[5]葛璐,胡昌龙,胡江鸿,等.甲氯芬酯联合纳洛酮治疗急性重度酒精中毒疗效性的Meta分析[J].江苏医药,2017,43(16):1157.
[6]张松林.醒脑静联合纳洛酮治疗急性重度酒精中毒的临床疗效分析[J].河南医学研究,2015,(7):79.
[7]曹林,赵建生.微创术中用无水乙醇治疗病灶致全身麻醉术后酒精中毒一例[J].临床麻醉学杂志,2015,31(2):120.
[8]朱海荣,谢扬,李炯,等.醒脑静联合果糖、纳洛酮治疗急性重度酒精中毒的疗效分析[J].现代诊断与治疗,2015,(3):483.
[9]梅俊华,王俊力,罗利俊,等.米氮平联合治疗对慢性酒精中毒性周围神经病患者神经心理状态及临床症状的影响研究[J].中国全科医学,2016,19(13):1581.
[10]朱红潮.纳洛酮联合醒脑静治疗急性重度酒精中毒的临床效果观察[J].河南医学研究,2016,25(4):737.
[11]王雪敏,杨昆,杜超,等.纳美芬联合丹参多酚酸盐治疗急性重度酒精中毒患者心肌保护作用的临床研究[J].河北医药,2016,38(19):3004.
[12]张静,赵强,赖红梅,等.乙醛脱氢酶2改善亚急性酒精中毒对急性心肌梗死损害的作用及机制研究[J].中华急诊医学杂志,2017,26(5):560.
[13]汤银娟,王建钧,王祥海,等.茶多酚对慢性酒精中毒肝损伤影响的实验研究[J].中国临床解剖学杂志,2016,34(2):198.
[14]谢春香,宋晓南.大鼠慢性酒精中毒性周围神经病的电生理及超微结构改变[J].中风与神经疾病杂志,2015,32(2):123.
[15]程益锋,卢阳,范笙艳.参麦注射液联合布地奈德治疗急性酒精中毒合并吸入性肺炎的临床研究[J].中国现代医学杂志,2015,25(7):100.
[16]温慧军.硫辛酸对慢性酒精中毒性周围神经病的临床疗效[J].中风与神经疾病杂志,2017,34(1):68.
[17]余红胜,许红莉,鲁杰.慢性酒精中毒性脑病CT与事件相关电位P300对照研究[J].中国医学计算机成像杂志,2015,21(5):475.
[18]蒋曦,田福荣,赵应征.小鼠慢性酒精中毒及戒断过程中抑郁样行为的改变及其共病机制[J].中国病理生理杂志,2016,32(2):296.
[19]梅俊华,王俊力,高珊,等.神经心理因素与针刺治疗男性慢性酒精中毒性周围神经病得气及疗效的关系[J].中国康复理论与实践,2015,(10):1212.
[20]朱红潮.纳洛酮联合醒脑静治疗急性重度酒精中毒的临床效果观察[J].河南医学研究,2016,25(4):737.
[21]栗全英.葛根素注射液联合西医治疗对酒精中毒患者神经递质及氧化应激的影响观察[J].世界中西医结合杂志,2016,11(6):844.