干扰素诱导单核因子和干扰素诱导蛋白10水平与颈动脉内膜中膜厚度的相关性
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摘要
目的探讨干扰素诱导单核因子(MIG)和干扰素诱导的蛋白10(IP-10)水平与颈动脉内膜中膜厚度(IMT)的相关性。方法对研究纳入的164例患者进行临床基线特征测定和随访观察,并记录患者IMT值以及MIG和IP-10血清水平;分析MIG和IP-10血清水平与IMT之间的关系。结果 IMT最大值0. 991±0. 127 mm,平均值0. 796±0. 136 mm。血清MIG和IP-10水平与颈动脉IMT呈显著正相关;血清MIG或IP-10水平与随访期间IMT的变化无显著相关性。当调整混杂因素和药物因素后,血清MIG独立与颈动脉IMT相关(max-IMT:β=0. 198,P=0. 010; mean-IMT:β=0. 186,P=0. 017)。结论血清MIG水平与颈动脉IMT具有独立相关性,这可能预示着血清MIG水平检测在早期动脉粥样硬化诊断方面的潜在临床意义。
Objective To evaluate the correlation of the levels of monokine induced by interferon-γ( MIG) and interferon-γ-inducible protein-10( IP-10) with carotid intima-media thickness( IMT). Methods A total of 164 patients were enrolled as subjects. Clinical and follow-up studies of baseline characteristics,IMT,and serum levels of MIG and IP-10 were performed among those patients. The relationship of serum levels of MIG and IP-10 with carotid IMT was analyzed. Results The maximum and mean values of IMT were 0. 991 ± 0. 127 mm and 0. 796 ± 0. 136 mm,respectively. The serum levels of MIG and IP-10 were positively correlated with carotid IMT. No significant correlation could be demonstrated of the serum levels of MIG or IP-10 with the changes in IMT during follow-up.After correction for confounding and drug factors,the serum level of MIG was independently correlated with carotid IMT( max-IMT: β= 0. 198,P = 0. 010; mean-IMT: β = 0. 186,P = 0. 017). Conclusions Serum MIG level is independently correlated with carotid IMT,suggesting that the serum Mig level probably has potential clinical significance in the early diagnosis of atherosclerosis.
Objective To evaluate the correlation of the levels of monokine induced by interferon-γ( MIG) and interferon-γ-inducible protein-10( IP-10) with carotid intima-media thickness( IMT). Methods A total of 164 patients were enrolled as subjects. Clinical and follow-up studies of baseline characteristics,IMT,and serum levels of MIG and IP-10 were performed among those patients. The relationship of serum levels of MIG and IP-10 with carotid IMT was analyzed. Results The maximum and mean values of IMT were 0. 991 ± 0. 127 mm and 0. 796 ± 0. 136 mm,respectively. The serum levels of MIG and IP-10 were positively correlated with carotid IMT. No significant correlation could be demonstrated of the serum levels of MIG or IP-10 with the changes in IMT during follow-up.After correction for confounding and drug factors,the serum level of MIG was independently correlated with carotid IMT( max-IMT: β= 0. 198,P = 0. 010; mean-IMT: β = 0. 186,P = 0. 017). Conclusions Serum MIG level is independently correlated with carotid IMT,suggesting that the serum Mig level probably has potential clinical significance in the early diagnosis of atherosclerosis.
引文
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[2]于泽谋,龚涛.血管稳态对动脉粥样硬化发生发展影响的研究进展[J].国际神经病学神经外科学杂志,2016,43(4):346-349.
[3]刘时武,王喜玉,马建林,等.H型高血压患者血浆炎性细胞因子水平变化及与颈动脉内膜中层厚度相关性研究[J].中国全科医学,2015,18(11):1236-1239.
[4]马元婧,邱润泽,袁冬平,等.动脉粥样硬化中炎症免疫反应的研究进展[J].现代免疫学,2017,37(6):509-512.
[5]Youn JC,Yu HT,Lim BJ,et al.Immunosenescent CD8+T Cells and C-X-C Chemokine Receptor Type 3 Chemokines Are Increased in Human Hypertension[J].Hypertension,2013,62(1):126-132.
[6]Gallo A,Saad A,Ali R,et al.Circulating interferon-γ-inducible Cys-X-Cys chemokine receptor 3 ligands are elevated in humans with aortic aneurysms and Cys-X-Cys chemokine receptor 3 is necessary for aneurysm formation in mice[J].JThor Cardiov Surg,2012,143(3):704-710.
[7]Amsellem V,Abid S,Poupel L,et al.Roles for the CX 3 CL 1/CX 3 CR 1 and CCL 2/CCR 2 Chemokine Systems in Hypoxic Pulmonary Hypertension[J].Am J Respir Cell Mol Biol,2017,56(5):597.
[8]Niwa A,Osuka K,Nakura T,et al.Interleukin-6,MCP-1,IP-1 0,and MIG are sequentially expressed in cerebrospinal fluid after subarachnoid hemorrhage[J].J Neuroinflammation,2016,13(1):217.
[9]郁东明.影响社区老年患者颈动脉内膜中膜厚度的相关因素分析[J].中华保健医学杂志,2017,19(2):160-162.
[10]卢浩,李梦豪,王媛媛,等.5项炎症指标对动脉粥样硬化及冠心病风险判断的价值[J].实用医学杂志,2016,32(2):203-207.
[11]李晓阳,张强,易显富,等.趋化因子CXCL10启动子区-201 G/A多态性与慢性乙型肝炎易感相关性研究[J].海南医学,2015,26(14):2093-2097.
[12]Heikkil O,Nygrdas M,Paavilainen H,et al.Interleukin-2 7 Inhibits Herpes Simplex Virus Type 1 Infection by Activating STAT 1 and 3,Interleukin-6,and Chemokines IP-1 0and MIG[J].J Interferon Cytokine Res,2016,36(11):617-629.
[13]Fallahi P,Elia G.Interferon-γ-induced protein 10 in Dengue virus infection[J].La Clinica Terapeutica,2016,167(6):e186.
[14]Bracaglia C,De GK,Pires MD,et al.Elevated circulating levels of interferon-γand interferon-γ-induced chemokines characterise patients with macrophage activation syndrome complicating systemic juvenile idiopathic arthritis[J].Ann Rhe Dis,2016,76(1):166.
[15]Baragetti A,Ramirez GA,Magnoni M,et al.Disease Trends Over Time and CD 4+CCR 5+,T-Cells Expansion Predict Carotid Atherosclerosis Development in Patients with Systemic Lupus Erythematosus[J].Nutr Metab Cardiov Dis,2018,28(1):53-63.