鱼腥草滴眼液联合妥布霉素滴眼液治疗儿童急性细菌性结膜炎的临床研究
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摘要
目的探讨鱼腥草滴眼液联合妥布霉素滴眼液治疗儿童急性细菌性结膜炎的临床效果。方法选取2016年3月—2018年6月重庆北碚爱尔眼科医院收治的急性细菌性结膜炎患儿126例,随机分成对照组(63例)和治疗组(63例)。对照组眼睑内滴入妥布霉素滴眼液,1滴/次,6次/d。治疗组在对照组基础上眼睑内滴入鱼腥草滴眼液,1滴/次,6次/d。两组均治疗7d后。观察两组患者临床疗效,同时比较治疗前后两组患者眼部症状评分及血浆C反应蛋白(CRP)、白细胞介素-6(IL-6)水平。结果治疗后,对照组临床有效率为84.1%,显著低于治疗组的95.2%,两组比较差异具有统计学意义(P<0.05)。治疗后,两组眼部症状评分及总分均显著降低(P<0.05),且治疗组这些眼部症状评分明显低于对照组(P<0.05)。治疗后,两组患儿血浆CRP、IL-6浓度显著降低(P<0.05),且治疗组患儿血浆CRP和IL-6水平明显低于对照组(P<0.05)。结论鱼腥草滴眼液联合妥布霉素滴眼液治疗儿童急性细菌性结膜炎,可明显改善患儿症状,抑制炎症反应,减轻机体炎性损伤。
Objective To investigate the clinical effect of Yuxingcao Eye Drops combined with Tobramycin Eye Drops in treatment of acute bacterial conjunctivitis in children. Methods Children(126 cases) with acute bacterial conjunctivitis in Chongqing Aier General Hospital from March 2016 to June 2018 were randomly divided into control(63 cases) and treatment(63 cases) groups. Children in the control group were intraeyelid dropped administered with Tobramycin Eye Drops, 1 drop/time, six times daily. Children in the treatment group were intraeyelid dropped administered with Yuxingcao Eye Drops on the basis of the control group, 1 drop/time, six times daily. Children in two groups were treated for 7 d. After treatment, the clinical efficacy was evaluated, and the eye symptom scores, the plasma CRP and IL-6 levels in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control group was 84.1%, which was significantly lower than 95.2% in the treatment group, and there were differences between two groups(P < 0.05). After treatment, the eye symptom scores and total scores in two groups were significantly decreased(P < 0.05), and which in the treatment group were significantly lower than those in the control group(P < 0.05). After treatment, the plasma CRP and IL-6 levels in two groups were significantly decreased(P < 0.05), and the plasma CRP and IL-6 levels in the treatment group were significantly lower than those in the control group(P < 0.05). Conclusion Yuxingcao Eye Drops combined with Tobramycin Eye Drops in treatment of acute bacterial conjunctivitis in children can significantly improve the symptoms, suppres the inflammatory process, alleviate the inflammatory injury.
Objective To investigate the clinical effect of Yuxingcao Eye Drops combined with Tobramycin Eye Drops in treatment of acute bacterial conjunctivitis in children. Methods Children(126 cases) with acute bacterial conjunctivitis in Chongqing Aier General Hospital from March 2016 to June 2018 were randomly divided into control(63 cases) and treatment(63 cases) groups. Children in the control group were intraeyelid dropped administered with Tobramycin Eye Drops, 1 drop/time, six times daily. Children in the treatment group were intraeyelid dropped administered with Yuxingcao Eye Drops on the basis of the control group, 1 drop/time, six times daily. Children in two groups were treated for 7 d. After treatment, the clinical efficacy was evaluated, and the eye symptom scores, the plasma CRP and IL-6 levels in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control group was 84.1%, which was significantly lower than 95.2% in the treatment group, and there were differences between two groups(P < 0.05). After treatment, the eye symptom scores and total scores in two groups were significantly decreased(P < 0.05), and which in the treatment group were significantly lower than those in the control group(P < 0.05). After treatment, the plasma CRP and IL-6 levels in two groups were significantly decreased(P < 0.05), and the plasma CRP and IL-6 levels in the treatment group were significantly lower than those in the control group(P < 0.05). Conclusion Yuxingcao Eye Drops combined with Tobramycin Eye Drops in treatment of acute bacterial conjunctivitis in children can significantly improve the symptoms, suppres the inflammatory process, alleviate the inflammatory injury.
引文
[1]中华医学会.临床诊疗指南·眼科学分册[M].北京:人民卫生出版社, 2006:39-40.
[2]严红霞.急性卡他性结膜炎临床治疗[J].中国当代医药, 2009, 16(20):144-145.
[3]中国药典[M].二部. 2015:513-514.
[4]国家药典委员会.国家食品药品监督管理局国家药品标准:新药转正标准(第65册)WS3-675(Z-120)-2004(Z)[M].北京:中国医药科技出版社, 2008:85-87.
[5]赵堪兴,杨培增.眼科学[M].第8版.北京:人民卫生出版社, 2013:97-106.
[6]郑筱萸.中药新药临床研究指导原则(试行)[M].北京:中国医药科技出版社, 2002:305-308.
[7]严红霞,赵玉霞.浅析急性卡他性结膜炎临床治疗[J].中外医疗, 2009, 28(34):191.
[8]商晓华,张利利,曹悦,等.妥布霉素滴眼液药效学研究[J].辽宁药物与临床, 1999, 2(1):4-6.
[9]曾庆华.中医眼科学:供中医药类专业用[M].北京:中国中医药出版社, 2003:137-138.
[10]赵旭红,黄逸玲.鱼腥草滴眼药治疗儿童急性卡他性结膜炎疗效观察[J].实用中医药杂志, 2012, 28(9):777.
[11]潘颖,魏亚超,王乐,等.鱼腥草滴眼液治疗流行性角结膜炎的临床疗效及经济效益学分析[J].现代药物与临床, 2013, 28(4):562-566.
[12]张玮,刘蓉,王林农.急性结膜炎患者治疗前后血清TNF-α、IL-6和IL-10测定的临床意义[J].放射免疫学杂志, 2006, 19(3):168-169.
[13]过钦群.急性结膜炎血浆炎性细胞因子水平变化的研究[J].南通大学学报:医学版, 2011, 31(6):477-478.
[2]严红霞.急性卡他性结膜炎临床治疗[J].中国当代医药, 2009, 16(20):144-145.
[3]中国药典[M].二部. 2015:513-514.
[4]国家药典委员会.国家食品药品监督管理局国家药品标准:新药转正标准(第65册)WS3-675(Z-120)-2004(Z)[M].北京:中国医药科技出版社, 2008:85-87.
[5]赵堪兴,杨培增.眼科学[M].第8版.北京:人民卫生出版社, 2013:97-106.
[6]郑筱萸.中药新药临床研究指导原则(试行)[M].北京:中国医药科技出版社, 2002:305-308.
[7]严红霞,赵玉霞.浅析急性卡他性结膜炎临床治疗[J].中外医疗, 2009, 28(34):191.
[8]商晓华,张利利,曹悦,等.妥布霉素滴眼液药效学研究[J].辽宁药物与临床, 1999, 2(1):4-6.
[9]曾庆华.中医眼科学:供中医药类专业用[M].北京:中国中医药出版社, 2003:137-138.
[10]赵旭红,黄逸玲.鱼腥草滴眼药治疗儿童急性卡他性结膜炎疗效观察[J].实用中医药杂志, 2012, 28(9):777.
[11]潘颖,魏亚超,王乐,等.鱼腥草滴眼液治疗流行性角结膜炎的临床疗效及经济效益学分析[J].现代药物与临床, 2013, 28(4):562-566.
[12]张玮,刘蓉,王林农.急性结膜炎患者治疗前后血清TNF-α、IL-6和IL-10测定的临床意义[J].放射免疫学杂志, 2006, 19(3):168-169.
[13]过钦群.急性结膜炎血浆炎性细胞因子水平变化的研究[J].南通大学学报:医学版, 2011, 31(6):477-478.