986例新安王氏内科含茯苓处方用药规律及数据挖掘研究
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摘要
[目的]挖掘新安王氏内科医案中含茯苓方剂的临床用药特色。[方法]以《王任之医案》《王仲奇医案》作为方剂资料来源,筛选包含茯苓的处方,基于新安医学数据信息应用平台构建数据库,应用IBM SPSS Modeler 14.2,进行频数统计及关联规则分析,以Apriori算法为主要数据挖掘方法,分析并获得含茯苓处方中单味药物频次、治疗疾病频次、药物组合频次、关联规则等。[结果]共筛选含茯苓方剂986首,含茯苓的高频次组合的药物包括佩兰、半夏、苦杏仁、白术、枳壳,常用于治疗脾胃系统的泄泻、痢疾,以及肺系的咳嗽等病证。与茯苓配伍的高频次药物的组合中,支持度≥10%、置信度≥60%的关联规则包括"佩兰→枳壳""佩兰→半夏""半夏→枳壳""佩兰→白豆蔻"等。[结论]新安王氏内科医案中含茯苓处方所治疾病多有痰湿要素,王氏临床论治多从脾、胃、肺三脏入手,喜用芳香药物,多用温药,治痰治气并举,寓燥湿化痰于健脾降肺之中。
[Objective] To explore the clinical characteristics of the prescription of sputum-containing prescription in Xin'an Wang's internal medicine.[Methods] The "WANG Renzhi Medical Cases" and "WANG Zhongqi Medical Cases" were used as prescription sources to screen prescriptions containing sputum,build a database based on Xin'an medical data information application platform,apply IBM SPSS Modeler 14.2,and perform frequency statistics and association rules. Using Apriori algorithm as the main data mining method,analyze and obtain the frequency of single-dose drugs,the frequency of treatment of diseases,the frequency of drug combinations,association rules,etc. [Results] A total of 986 sputum-containing prescriptions were selected.The high-frequency combination of bismuth-containing drugs included Perrin,Pinellia,Bitter Almond,Atractylodes Rhizome and Clam Shell,which were commonly used to treat diarrhea,dysentery and cough in the lungs, spleen and stomach, and other diseases. In the combination of high-frequency drugs compatible with sputum,the association rules with support degree ≥10% and confidence ≥60% included "Peilan →Zhishi""Peland →Pinxia""Pinxia→Zhishi"" Perrin → White Cardamom, etc. [Conclusion] The Xin'an WANG's internal medicine cases contain more phlegm-dampening factors in the treatment of phlegm-containing prescriptions. WANG's clinical treatment mostly starts from the spleen,stomach and lungs,prefers aromatic drugs,and uses warm medicine to remove phlegm. The treatment of Qi is combined with the spleen and the lungs.
[Objective] To explore the clinical characteristics of the prescription of sputum-containing prescription in Xin'an Wang's internal medicine.[Methods] The "WANG Renzhi Medical Cases" and "WANG Zhongqi Medical Cases" were used as prescription sources to screen prescriptions containing sputum,build a database based on Xin'an medical data information application platform,apply IBM SPSS Modeler 14.2,and perform frequency statistics and association rules. Using Apriori algorithm as the main data mining method,analyze and obtain the frequency of single-dose drugs,the frequency of treatment of diseases,the frequency of drug combinations,association rules,etc. [Results] A total of 986 sputum-containing prescriptions were selected.The high-frequency combination of bismuth-containing drugs included Perrin,Pinellia,Bitter Almond,Atractylodes Rhizome and Clam Shell,which were commonly used to treat diarrhea,dysentery and cough in the lungs, spleen and stomach, and other diseases. In the combination of high-frequency drugs compatible with sputum,the association rules with support degree ≥10% and confidence ≥60% included "Peilan →Zhishi""Peland →Pinxia""Pinxia→Zhishi"" Perrin → White Cardamom, etc. [Conclusion] The Xin'an WANG's internal medicine cases contain more phlegm-dampening factors in the treatment of phlegm-containing prescriptions. WANG's clinical treatment mostly starts from the spleen,stomach and lungs,prefers aromatic drugs,and uses warm medicine to remove phlegm. The treatment of Qi is combined with the spleen and the lungs.
引文
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[8]赵洪英,蔡乐才,李先杰.关联规则挖掘的Apriori算法综述[J].四川理工学院学报(自然科学版),2011,24(1):66-69.
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[12]孙娟,李姿慧,郜峦.新安王氏内科论治泄泻经验[J].安徽中医药大学学报,2017,36(3):9-11.
[13]张介宾.景岳全书·杂证谟·脾胃[M].北京:人民卫生出版社,2007:399-403.
[14]姚慧,郭锦晨,马翠翠,等.《孙文垣医案》泄泻辨治特色探析[J].甘肃中医药大学学报,2016,33(5):16-18.
[15]齐卓操,郭锦晨,徐慧,等.新安医家汪机咳嗽辨治特色初探[J].江西中医药大学学报,2017,29(4):6-8.
[16]叶桂.本草经解[M].上海:上海卫生出版社,1957:72.
[17]冯烨,杨勤军,郭锦晨.《孙文垣医案》咳嗽从脾肺调治验案选评[J].江西中医药大学学报,2016,28(2):19-20+23.
[18]陈勇,孙晓波,张廷模.论《本草求真》对中药功效理论的贡献[J].四川中医,2005,23(6):5.
[19]汪瑶,郭锦晨,胡楠,等.《孙文垣医案》孙一奎运用二陈汤验案探析[J].江西中医药大学学报,2014,26(5):14-15.
[20]沈淑华,童宏选,王坤根.基于数据挖掘的王坤根教授对功能性消化不良证治规律的研究[J].浙江中医药大学学报,2014,38(10):1159-1162.
[21]苗婷婷.茯苓在《金匮要略》中的配伍运用规律探析[J].浙江中医药大学学报,2015,39(11):820-823.
[2]聂多锐,刘兰林,郭锦晨,等.201例新安王氏内科脾胃病医案组方用药规律及数据挖掘研究[J].西南医科大学学报,2017,40(5):484-487.
[3]尚志钧.神农木草经校注[M].北京:学苑出版社,2008:341.
[4]梁学清,李丹丹,黄忠威.茯苓药理作用研究进展[J].河南中医药大学报,2012,30(2):4-156.
[5]马玲,尹蕾,王兵,等.茯苓研究进展[J].亚太传统医药,2015,11(12):55-59.
[6]国家药典委员会.中华人民共和国药典[M].北京:中国医药科技出版社,2015.
[7]陈蔚文.中药学[M].北京:人民卫生出版社,2015.
[8]赵洪英,蔡乐才,李先杰.关联规则挖掘的Apriori算法综述[J].四川理工学院学报(自然科学版),2011,24(1):66-69.
[9]于彩娜,窦德强.茯苓性味与效用源流考证[J].中华中医药杂志,2015,30(1):232-234.
[10]贾所学.药品化义[M].北京:学苑出版社,2011:44.
[11]宋家欣,侯丽辉,吴效科.浅谈历代医家论治痰病[J].时珍国医国药,2008,19(2):491-492.
[12]孙娟,李姿慧,郜峦.新安王氏内科论治泄泻经验[J].安徽中医药大学学报,2017,36(3):9-11.
[13]张介宾.景岳全书·杂证谟·脾胃[M].北京:人民卫生出版社,2007:399-403.
[14]姚慧,郭锦晨,马翠翠,等.《孙文垣医案》泄泻辨治特色探析[J].甘肃中医药大学学报,2016,33(5):16-18.
[15]齐卓操,郭锦晨,徐慧,等.新安医家汪机咳嗽辨治特色初探[J].江西中医药大学学报,2017,29(4):6-8.
[16]叶桂.本草经解[M].上海:上海卫生出版社,1957:72.
[17]冯烨,杨勤军,郭锦晨.《孙文垣医案》咳嗽从脾肺调治验案选评[J].江西中医药大学学报,2016,28(2):19-20+23.
[18]陈勇,孙晓波,张廷模.论《本草求真》对中药功效理论的贡献[J].四川中医,2005,23(6):5.
[19]汪瑶,郭锦晨,胡楠,等.《孙文垣医案》孙一奎运用二陈汤验案探析[J].江西中医药大学学报,2014,26(5):14-15.
[20]沈淑华,童宏选,王坤根.基于数据挖掘的王坤根教授对功能性消化不良证治规律的研究[J].浙江中医药大学学报,2014,38(10):1159-1162.
[21]苗婷婷.茯苓在《金匮要略》中的配伍运用规律探析[J].浙江中医药大学学报,2015,39(11):820-823.