应用萆薢分清饮治疗28例痛风性关节炎临床分析
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摘要
目的观察分析临床治疗中应用萆薢分清饮对痛风性关节炎所具有的治疗效果及影响。方法回顾分析2017年6月—2018年6月期间该院收治的以痛风性关节炎为就医主诉的患者28例,根据患者临床疗法的选择将其分为对照组与观察组各14例。对照组采用常规西药口服治疗,观察组在对照组治疗基础上联合萆薢分清饮及六味地黄丸治疗。对比两组治疗前后炎性因子指标、痛风临床检验指标、关节疼痛评分变化及临床疗效。结果相较对照组,观察组患者治疗前炎性因子指标、痛风临床指标检验结果及关节疼痛评分对比差异无统计学意义(P>0.05);治疗后,两组患者各项上述指标较治疗前均有改善,但观察组各指标改善幅度均具有较高临床治疗价值[IL-6 (47.46±6.89)ng/L、IL-1β(35.36±5.44)pg/mL、COX-2 (8.54±2.48)pg/mL、TNF-α(45.63±9.49)pg/mL、血尿酸(336.56±82.75)μmol/L、红细胞沉降率(17.59±6.74)mm/h、VAS(2.08±1.44)(P<0.05);且观察组治疗有效率(100.00%)较对照组(71.43%)优势明显(χ~2=4.666 7,P<0.05)。结论在临床治疗中予以痛风性关节炎患者萆薢分清饮治疗,可对患者临床症状起到较好缓解作用,且可通过药物实现对患者机体炎症反应的有效降低,进一步提升临床疗效,具有较高临床应用价值。
Objective To observe and analyze the therapeutic effect and influence of Bixie Fenqing Yin on gouty arthritis in clinical treatment. Methods Retrospective analysis of 28 patients with gouty arthritis who were admitted to the hospital during the period from June 2017 to June 2018. According to the choice of clinical therapy, the patients were divided into the control group and the observation group, with 14 cases each. The control group was treated with conventional western medicine orally, while the observation group was treated with Bixie Fenqing Yin and Liuwei Dihuang Wan on the basis of the control group. The inflammatory factor index, the clinical test index of gout, the change of joint pain score and the clinical efficacy were compared before and after treatment between the two groups. Results Compared with the control group, there was no significant difference in the pre-treatment inflammatory factor index, gout clinical index test results and joint pain scores in the observation groupw(P>0.05). After treatment, the above indicators of the two groups were improved compared with those before treatment; but the improvement range of each index in the observation group had higher clinical therapeutic value(IL-6(47.46±6.89)ng/L, IL-1β(35.36±5.44)pg/mL, COX-2(8.54±2.48)pg/mL, TNF-α(45.63±9.49)pg/mL, UA(336.56±82.75)μmol/L, ESR(17.59±6.74)mm/h, VAS(2.08±1.44),(P<0.05). And the effective rate of treatment in the observation group(100.00%) was significantly better than that of the control group(71.43%),(χ~2=4.666 7,P<0.05).Conclusion In the clinical treatment of gouty arthritis patients, Bixie Fenqing Yin treatment can better relieve the clinical symptoms of patients, effectively reduce the inflammatory response of patients through drugs, and further improve clinical efficacy, which has high clinical value.
Objective To observe and analyze the therapeutic effect and influence of Bixie Fenqing Yin on gouty arthritis in clinical treatment. Methods Retrospective analysis of 28 patients with gouty arthritis who were admitted to the hospital during the period from June 2017 to June 2018. According to the choice of clinical therapy, the patients were divided into the control group and the observation group, with 14 cases each. The control group was treated with conventional western medicine orally, while the observation group was treated with Bixie Fenqing Yin and Liuwei Dihuang Wan on the basis of the control group. The inflammatory factor index, the clinical test index of gout, the change of joint pain score and the clinical efficacy were compared before and after treatment between the two groups. Results Compared with the control group, there was no significant difference in the pre-treatment inflammatory factor index, gout clinical index test results and joint pain scores in the observation groupw(P>0.05). After treatment, the above indicators of the two groups were improved compared with those before treatment; but the improvement range of each index in the observation group had higher clinical therapeutic value(IL-6(47.46±6.89)ng/L, IL-1β(35.36±5.44)pg/mL, COX-2(8.54±2.48)pg/mL, TNF-α(45.63±9.49)pg/mL, UA(336.56±82.75)μmol/L, ESR(17.59±6.74)mm/h, VAS(2.08±1.44),(P<0.05). And the effective rate of treatment in the observation group(100.00%) was significantly better than that of the control group(71.43%),(χ~2=4.666 7,P<0.05).Conclusion In the clinical treatment of gouty arthritis patients, Bixie Fenqing Yin treatment can better relieve the clinical symptoms of patients, effectively reduce the inflammatory response of patients through drugs, and further improve clinical efficacy, which has high clinical value.
引文
[1]孙晶,于永军,陈宝忠.中医药治疗痛风病的研究进展[J].中医药信息, 2016, 33(5):126-128.
[2]徐丹,姜兆荣,董巡,等.中西医结合治疗湿热痹阻型痛风性关节炎的疗效观察[J].世界中西医结合杂志,2018,13(9):1198-1202.
[3] Khanna D, Khanna PP, Fitzgerald JD,et al. 2012 American College of Rheumatology guidelines for management of gout.Part 2:Therapy and antiinflammatory prophylaxis of acute gouty arthritis[J]. Arthritis Care&Research, 2012, 64(10):1447-1461.
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[5]谭春棋.急性痛风性关节炎中西医结合治疗分析[J].深圳中西医结合杂志,2017,27(23):40-41.
[6]张国浩,杨豪.桂枝葛根汤合程氏萆薢分清饮治疗湿热型类风湿性关节炎26例[J].中国中医药现代远程教育, 2015,13(13):41-42.
[7]刘林海.中西医结合治疗急性痛风性关节炎的临床效果分析[J].中国当代医药,2017,24(32):156-158.
[8]黄阳,董文霞.中西医结合治疗急性痛风性关节炎临床疗效及对血清炎症因子的影响[J].中国中医急症,2017,26(11):2025-2027.
[9]范海霞,刘健,黄传兵,等.中西医结合治疗急性痛风性关节炎临床疗效观察[J].世界中西医结合杂志,2016,11(7):987-989.
[10]庄丽华,胡家才,吴昊.中西医结合治疗急性痛风性关节炎meta分析[J].辽宁中医药大学学报,2015,17(12):128-132.
[11]饶莉,沈春瑾,石哲群,等.中西医结合治疗类风湿性关节炎的临床研究[J].中华中医药杂志, 2016, 35(2):546-548.
[12]龚学忠.萆薢分清丸临床运用体会[N].上海中医药报,2018-08-17(004).
[13]杨秦雁,李博.中西药结合治疗类风湿性关节炎的临床效果分析[J].西北药学杂志, 2016,31(4):428-430.
[2]徐丹,姜兆荣,董巡,等.中西医结合治疗湿热痹阻型痛风性关节炎的疗效观察[J].世界中西医结合杂志,2018,13(9):1198-1202.
[3] Khanna D, Khanna PP, Fitzgerald JD,et al. 2012 American College of Rheumatology guidelines for management of gout.Part 2:Therapy and antiinflammatory prophylaxis of acute gouty arthritis[J]. Arthritis Care&Research, 2012, 64(10):1447-1461.
[4]王士朋,李春雷.中西医结合治疗急性痛风性关节炎及其对炎性因子的影响[J].长春中医药大学学报,2018,34(4):743-746.
[5]谭春棋.急性痛风性关节炎中西医结合治疗分析[J].深圳中西医结合杂志,2017,27(23):40-41.
[6]张国浩,杨豪.桂枝葛根汤合程氏萆薢分清饮治疗湿热型类风湿性关节炎26例[J].中国中医药现代远程教育, 2015,13(13):41-42.
[7]刘林海.中西医结合治疗急性痛风性关节炎的临床效果分析[J].中国当代医药,2017,24(32):156-158.
[8]黄阳,董文霞.中西医结合治疗急性痛风性关节炎临床疗效及对血清炎症因子的影响[J].中国中医急症,2017,26(11):2025-2027.
[9]范海霞,刘健,黄传兵,等.中西医结合治疗急性痛风性关节炎临床疗效观察[J].世界中西医结合杂志,2016,11(7):987-989.
[10]庄丽华,胡家才,吴昊.中西医结合治疗急性痛风性关节炎meta分析[J].辽宁中医药大学学报,2015,17(12):128-132.
[11]饶莉,沈春瑾,石哲群,等.中西医结合治疗类风湿性关节炎的临床研究[J].中华中医药杂志, 2016, 35(2):546-548.
[12]龚学忠.萆薢分清丸临床运用体会[N].上海中医药报,2018-08-17(004).
[13]杨秦雁,李博.中西药结合治疗类风湿性关节炎的临床效果分析[J].西北药学杂志, 2016,31(4):428-430.