益气补肾止喘汤联合西药治疗小儿哮喘疗效研究
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摘要
目的:探讨益气补肾止喘汤联合常规西医方法对小儿哮喘的干预效果。方法:选择我院进行哮喘治疗的小儿患者共124名,按照随机数字的方法分为两组,对照组和观察组,每个组62名患者,对照组患儿使用常规西医治疗方案,观察组患儿在对照组治疗方案基础上,使用益气补肾止喘汤进行治疗,对治疗的效果进行比较。结果:两组患儿在进行治疗后,肺功能指标,超敏C反应蛋白,白细胞介素-1β,肿瘤坏死因子-α,中医症状积分均出现了明显的改善,观察组的改善幅度高于对照组,数据差异具有统计学意义(P<0.05),观察组的治疗效果优于对照组,数据差异具有统计学意义(z=6.180,P<0.05),在为期半年的随访过程中,观察组患儿的呼吸道感染次数与哮喘发作次数均小于对照组患儿,数据差异具有统计学意义(P<0.05)。结论:使用益气补肾止喘汤联合常规西医方法对于小儿哮喘进行干预,可以提高治疗的效果,减少发作次数。
Objective:To explore the effect of Yiqi Bushen Zhichuan decoction combined with conventional western medicine on asthma in children.Methods:124 children were treated with asthma in our hospital.According to the random number method was divided into two groups,the control group and the treatment group,each group of 62 patients.In the control group,the patients were treated with conventional western medicine.The children in the observation group were treated with Yiqi Bushen Zhichuan decoction on the control plan of the control group,and the effect of the treatment was compared.Results:After treatment,the lung function index,high sensitivity C-reactive protein,interleukin-1β,tumor necrosis factor-αand TCM syndrome scores were significantly improved in the two groups.The improvement rate of the observation group was higher than that of the control group,The difference was statistically significant(P<0.05).The therapeutic effect of the observation group was better than that of the control group,the difference was statistically significant(z= 6.180,P<0.05).During the follow-up period of six months,the number of respiratory infections and the number of asthma attacks in the observation group were lower than those in the control group,the difference was statistically significant(P<0.05).Conclusion:The use of Yiqi Bushen Zhichuan combined with conventional western medicine for intervention in children with asthma,can improve the treatment effect,reduce the number of attacks,and it is worth to promote the scope of clinical.
Objective:To explore the effect of Yiqi Bushen Zhichuan decoction combined with conventional western medicine on asthma in children.Methods:124 children were treated with asthma in our hospital.According to the random number method was divided into two groups,the control group and the treatment group,each group of 62 patients.In the control group,the patients were treated with conventional western medicine.The children in the observation group were treated with Yiqi Bushen Zhichuan decoction on the control plan of the control group,and the effect of the treatment was compared.Results:After treatment,the lung function index,high sensitivity C-reactive protein,interleukin-1β,tumor necrosis factor-αand TCM syndrome scores were significantly improved in the two groups.The improvement rate of the observation group was higher than that of the control group,The difference was statistically significant(P<0.05).The therapeutic effect of the observation group was better than that of the control group,the difference was statistically significant(z= 6.180,P<0.05).During the follow-up period of six months,the number of respiratory infections and the number of asthma attacks in the observation group were lower than those in the control group,the difference was statistically significant(P<0.05).Conclusion:The use of Yiqi Bushen Zhichuan combined with conventional western medicine for intervention in children with asthma,can improve the treatment effect,reduce the number of attacks,and it is worth to promote the scope of clinical.
引文
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[9]周晴,傅玉,胡良安,等.支气管哮喘患者外周血Th17与Th9细胞的变化及临床意义[J].中国免疫学杂志,2017,33(4):569-573.
[10]王国强,王昱博,张维杰,等.Th17转录因子RORγt和BATF及Th17相关细胞因子在中性粒细胞亚型哮喘发病中的作用[J].吉林大学学报:医学版,2017,43(1):106-110.
[11]陈金妮,王灵.哮喘患儿皮肤点刺试验、嗜酸性粒细胞计数与肺功能变化的相关性分析[J].海南医学,2016,27(14):2370-2371,2372.
[12]湛洁谊,卢慧敏,林穗玲,等.哮喘患儿外周血CD4+CD25nt/hi CD127lo调节性T细胞的测定及临床意义[J].中国实验诊断学,2016,(1):78-80.
[13]蒋鲲,张慧燕,陆小霞,等.支气管哮喘患儿血清25-羟维生素D3水平与血清及支气管肺泡灌洗液基质金属蛋白酶-9的关系[J].中华实用儿科临床杂志,2016,(4):279-283.
[14]李翠兵,陈穗琛.吸入型糖皮质激素治疗儿童咳嗽变异性哮喘的药物经济学分析[J].中国基层医药,2016,23(16):2438-2441.
[15]杨敏,李林瑞,孟燕妮,等.布地奈德辅助治疗小儿支气管哮喘对T淋巴细胞亚群及相关细胞因子的影响[J].疑难病杂志,2018,27(3):255-258,263.
[16]任志红,赵璇,曾玲,等.哮喘及肺炎患儿血浆白细胞介素-18、白细胞介素-16、白细胞介素-4及γ-干扰素水平的相关性及临床意义[J].安徽医药,2018,30(1):85-87.
[17]彭波,刘青,梁红英.糖皮质激素吸入治疗小儿支气管哮喘对患儿外周血sICAM-1、EOS和NT-3的影响[J].解放军医药杂志,2017,30(12):64-66.
[18]熊仙华.益气补肾活血方剂对小儿哮喘患者ET-1、NO和CEC水平的影响分析[J].临床医药文献杂志,2016,26(3):5265-5266.
[2]李军文,陈凛凛,周芳,等.布地奈德气雾剂联合肺力咳糖浆治疗小儿咳嗽变异性哮喘的临床效果研究[J].陕西医学杂志,2016,45(8):1084-1085.
[3]周玲,张伟,刘世青,等.匹多莫德对支气管哮喘患儿免疫因子水平影响及临床疗效研究[J].陕西医学杂志,2016,45(7):875-876.
[4]林忠嗣,张雅凤,于雪峰.固本平喘膏防治小儿支气管哮喘临床观察[J].长春中医药大学学报,2017,31(3):455-458.
[5]经晶,王宝琮.穴位敷贴Ⅰ方对小儿支气管哮喘的疗效观察[J].陕西中医,2016,37(12):1592-1593.
[6]龚君芳,王春燕,陈娇磊,等.小儿哮喘非急性发作期IgE、EOS、LTE-4含量的变化及其临床意义[J].中国生化药物杂志,2017,37(2):300-301,304.
[7]中华医学会儿科学会分会呼吸学组,中华儿科杂志编辑委员会.儿童支气管哮喘诊断与防治指南(2016年版)[J].中华儿科杂志,2016,54(3):167-181.
[8]国家中医药管理局.中药新药临床研究指导原则[M].北京:中国医药科技出版社,2002:61-66.
[9]周晴,傅玉,胡良安,等.支气管哮喘患者外周血Th17与Th9细胞的变化及临床意义[J].中国免疫学杂志,2017,33(4):569-573.
[10]王国强,王昱博,张维杰,等.Th17转录因子RORγt和BATF及Th17相关细胞因子在中性粒细胞亚型哮喘发病中的作用[J].吉林大学学报:医学版,2017,43(1):106-110.
[11]陈金妮,王灵.哮喘患儿皮肤点刺试验、嗜酸性粒细胞计数与肺功能变化的相关性分析[J].海南医学,2016,27(14):2370-2371,2372.
[12]湛洁谊,卢慧敏,林穗玲,等.哮喘患儿外周血CD4+CD25nt/hi CD127lo调节性T细胞的测定及临床意义[J].中国实验诊断学,2016,(1):78-80.
[13]蒋鲲,张慧燕,陆小霞,等.支气管哮喘患儿血清25-羟维生素D3水平与血清及支气管肺泡灌洗液基质金属蛋白酶-9的关系[J].中华实用儿科临床杂志,2016,(4):279-283.
[14]李翠兵,陈穗琛.吸入型糖皮质激素治疗儿童咳嗽变异性哮喘的药物经济学分析[J].中国基层医药,2016,23(16):2438-2441.
[15]杨敏,李林瑞,孟燕妮,等.布地奈德辅助治疗小儿支气管哮喘对T淋巴细胞亚群及相关细胞因子的影响[J].疑难病杂志,2018,27(3):255-258,263.
[16]任志红,赵璇,曾玲,等.哮喘及肺炎患儿血浆白细胞介素-18、白细胞介素-16、白细胞介素-4及γ-干扰素水平的相关性及临床意义[J].安徽医药,2018,30(1):85-87.
[17]彭波,刘青,梁红英.糖皮质激素吸入治疗小儿支气管哮喘对患儿外周血sICAM-1、EOS和NT-3的影响[J].解放军医药杂志,2017,30(12):64-66.
[18]熊仙华.益气补肾活血方剂对小儿哮喘患者ET-1、NO和CEC水平的影响分析[J].临床医药文献杂志,2016,26(3):5265-5266.