消化内科胃食管反流病的临床治疗效果
|
摘要
目的评价消化内科胃食管反流病治疗的临床疗效影响因素。方法选择2017年2月-2018年4月茌平县人民医院收治的胃食管反流疾病患者240例,按照患者的疗效进行分组,其中一个标准疗程(6个月)症状体征消失或基本消失,或内镜表现明显改善的104例纳入痊愈组,其余136例纳入对照组。并在疗程结束后对患者采用问卷调查进行因素分析。结果多因素Logistic回归分析显示,症状积分[OR=0.984,95%CI(0.965～0.990)]、饮酒[OR=1.362,95%CI(1.245～1.506)]、有巩固治疗[OR=0.412,95%CI(1.255～1.362)]、联合胃动力药物[OR=0.871,95%CI(0.743～0.927)]成为独立影响因素,差异有统计学意义(P<0.05)。结论消化内科胃食管反流病的临床疗效尚可,但影响因素较多;对于病情较重的患者需要加强治疗干预,尽可能地劝导戒酒,症状控制后也需要巩固治疗,同时联合胃动力药物,以预防复发。
Objective To evaluate the efficacy of gastroesophageal reflux disease in gastroenterology department, analyze the influencing factors of curative effect. Methods 240 patients with gastroesophageal reflux disease admitted to Chiping County People's Hospital from February 2017 to April 2018 were divided into two groups according to the curative effect of the patients. 104 patients with symptoms and signs disappeared or endoscopic manifestations improved significantly during one standard course of treatment(6 months) were included in the recovery group, while 136 patients remained were included in the control group. At the end of the course of treatment, the patients were investigated by questionnaire and the factors were analyzed. Results Multivariate Logistic regression analysis showed that symptoms score[OR=0.984, 95%CI(0.965-0.990)], drinking [OR=1.362, 95%CI(1.245-1.506)], consolidation therapy[OR=0.412, 95%CI(1.255-1.362)], combined gastric motility drugs [OR=0.871, 95%CI(0.743-0.927)] were independent influencing factors, the differences were statistically significant(P<0.05). Conclusion The clinical treatment effect of gastroesophageal reflux disease in gastroenterology department is acceptable, but there are many influencing factors. For patients with severe illness, we need to strengthen treatment intervention,persuade them to abstain from alcohol as much as possible, consolidate treatment after symptom control, and combine with gastric motility drugs to prevent recurrence.
Objective To evaluate the efficacy of gastroesophageal reflux disease in gastroenterology department, analyze the influencing factors of curative effect. Methods 240 patients with gastroesophageal reflux disease admitted to Chiping County People's Hospital from February 2017 to April 2018 were divided into two groups according to the curative effect of the patients. 104 patients with symptoms and signs disappeared or endoscopic manifestations improved significantly during one standard course of treatment(6 months) were included in the recovery group, while 136 patients remained were included in the control group. At the end of the course of treatment, the patients were investigated by questionnaire and the factors were analyzed. Results Multivariate Logistic regression analysis showed that symptoms score[OR=0.984, 95%CI(0.965-0.990)], drinking [OR=1.362, 95%CI(1.245-1.506)], consolidation therapy[OR=0.412, 95%CI(1.255-1.362)], combined gastric motility drugs [OR=0.871, 95%CI(0.743-0.927)] were independent influencing factors, the differences were statistically significant(P<0.05). Conclusion The clinical treatment effect of gastroesophageal reflux disease in gastroenterology department is acceptable, but there are many influencing factors. For patients with severe illness, we need to strengthen treatment intervention,persuade them to abstain from alcohol as much as possible, consolidate treatment after symptom control, and combine with gastric motility drugs to prevent recurrence.
引文
[1]胡晔东,王波,徐文,等.上海张江中老年人群的胃食管反流病患病率及其与生活习惯的关系[J].国际消化病杂志,2018,38(2):116-120.
[2]张玲,邹多武.胃食管反流病的流行病学及危险因素[J].临床荟萃,2017,32(1):1-4.
[3]李光耀,吴旭晗,廖俊茗,等.针灸结合中药治疗胃食管反流病的系统评价和Meta分析[J].天津中医药,2018,35(10):756-761.
[4]赵丽伟,刘改芳,吴婧,等.长期服用质子泵抑制剂对老年胃食管反流患者骨密度、骨代谢指标及胃泌素水平的影响[J].中国老年学杂志,2017,37(14):3525-3526.
[5]廖卫民.胃功能三项检测对胃食管反流病患者使用质子泵抑制剂的效果观察[J].白求恩医学杂志,2017,15(6):793-794
[2]张玲,邹多武.胃食管反流病的流行病学及危险因素[J].临床荟萃,2017,32(1):1-4.
[3]李光耀,吴旭晗,廖俊茗,等.针灸结合中药治疗胃食管反流病的系统评价和Meta分析[J].天津中医药,2018,35(10):756-761.
[4]赵丽伟,刘改芳,吴婧,等.长期服用质子泵抑制剂对老年胃食管反流患者骨密度、骨代谢指标及胃泌素水平的影响[J].中国老年学杂志,2017,37(14):3525-3526.
[5]廖卫民.胃功能三项检测对胃食管反流病患者使用质子泵抑制剂的效果观察[J].白求恩医学杂志,2017,15(6):793-794