摘要
目的探讨新生儿缺氧缺血性脑病(HIE)患儿外周血单核细胞CD14、TLR4和TRIF表达水平与HIE严重程度和预后的相关性。方法选取2017年1-10月在中国人民解放军第101医院住院的HIE患儿36例为HIE组,另选取同期在该院体检的健康新生儿23例为对照组,采用实时荧光定量PCR方法检测两组新生儿外周血单核细胞CD14、TLR4和TRIF mRNA的表达水平,分析CD14、TLR4和TRIF表达差异及与HIE严重程度和预后的相关性。结果 HIE患儿外周血单核细胞CD14、TLR4和TRIF水平高于对照组,差异有统计学意义(P<0. 05)。CD14、TLR4和TRIF与HIE严重程度呈正相关关系(P<0. 05),与预后效果呈负相关关系(P<0. 05)。结论 CD14,TLR4和TRIF表达水平与HIE的发生发展有关。
引文
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