基于网络药理学研究肝经中药与治疗疾病的关系
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摘要
目的:研究尝试以网络药理学的方法对肝经中药及治疗疾病的关系进行研究,探索网络药理学研究中药归经的可能性。方法:选取从分子对接筛选出2015版《中华人民共和国药典》中肝经中药的活性靶点,并寻找中药归经与疾病的共同活性靶点,通频次频率的统计分析,探索中药归经与治疗疾病的关系。结果:肝经中药蛋白靶点在精神和行为障碍疾病、血液及造血器官疾病和涉及免疫机制的某些疾患,妊娠、分娩和产褥期相关疾病上有较高频率的分布。结论:在网络药理学基础上得到的肝经中药与治疗疾病的关系与中医基础理论中肝的生理功能有一定关联。
Objective: The study of meridian tropism has great significance to the development of Chinese herbal medicine theory.In recent years network pharmacology had been widely used in the study of traditional Chinese medicine( TCM). This study aims to explore the relationship between liver meridian and treatment based on network pharmacology for the possibility of meridian tropism theory adopting network pharmacology. Methods: Molecular docking was used to screen the active targets of Chinese medicine of liver meridian in Pharmacopoeia of the People's Republic of China( 2015). Common active targets were searched between Chinese medicine of liver meridian and diseases. The frequency of Chinese medicine and protein with liver meridian in different disease would be analyzed to explore the relationship between tropism and indication. Results: The albumen targets of Chinese medicine of liver meridian has a high frequency in the diseases of mental and behavioural disorders,diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism,pregnancy,childbirth and the puerperium. Conclusion: The relationship between treatment and Chinese medicine of liver tropism based on network pharmacology is related to physiological function of liver.
Objective: The study of meridian tropism has great significance to the development of Chinese herbal medicine theory.In recent years network pharmacology had been widely used in the study of traditional Chinese medicine( TCM). This study aims to explore the relationship between liver meridian and treatment based on network pharmacology for the possibility of meridian tropism theory adopting network pharmacology. Methods: Molecular docking was used to screen the active targets of Chinese medicine of liver meridian in Pharmacopoeia of the People's Republic of China( 2015). Common active targets were searched between Chinese medicine of liver meridian and diseases. The frequency of Chinese medicine and protein with liver meridian in different disease would be analyzed to explore the relationship between tropism and indication. Results: The albumen targets of Chinese medicine of liver meridian has a high frequency in the diseases of mental and behavioural disorders,diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism,pregnancy,childbirth and the puerperium. Conclusion: The relationship between treatment and Chinese medicine of liver tropism based on network pharmacology is related to physiological function of liver.
引文
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[18]李洁颖,晏勇,蔡志友,等.胰岛素信号通路磷脂酰肌醇-3激酶/丝氨酸苏氨酸蛋白激酶对海马神经元β-淀粉样前体蛋白裂解酶1表达的影响[J].中华神经科杂志,2009,42(11):737-741.
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[20]郑偕扣,徐强.王保和从肝藏血主疏泄论治高血压病的经验[J].江苏中医药,2014,46(10):24-25.
[21]Cao Y,Chen H,Zhou L,et al.Heterodimers of placenta growth factor/vascular endothelial growth factor.Endothelial activity,tumor cell expression,and high affinity binding to Flk-1/KDR[J].J Biol Chem,1996,271(6):3154-3162.
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[24]张莉,王慧君,李洪强,等.再生障碍性贫血患者骨髓微血管密度及血管内皮生长因子表达的意义[J].中华血液学杂志,2007,28(8):528-531.
[25]王欢,张嵘,刘卓刚,等.良性贫血病人血浆中血管内皮生长因子水平的研究[J].中国医科大学学报,2006,35(1):92-92.
[26]魏强,李静,刘艺,等.MAPK信号转导通路在人参多糖诱导白血病K562细胞凋亡中的作用[J].中草药,2013,44(2):193-198.
[27]安欣.MAPK家族成员活化表达参与高血压心脏重构的实验研究[D].银川:宁夏医科大学,2010.
[2]高振,李风森,哈木拉提·吾甫尔.A Study of the Law of Herbal Administration in Treating Lung-distension by TCM Physicians through History Using Cluster Analysis[J].中医杂志(英文版),2011,31(4):303-307.
[3]Zhao Y,Li Y,Wang X,et al.The experimental study of Cortex Eucommiae on meridian tropsim:the distribution study of aucubin in rat tissues[J].J Pharm Biomed Anal,2008,46(2):368-373.
[4]Chang YX,Sun YG,Li J,et al.The experimental study of Astragalus membranaceus on meridian tropsim:the distribution study of astragaloside IV in rat tissues[J].J Chromatogr B Analyt Technol Biomed Life Sci,2012,911:71-75.
[5]孟明洋,梁卓.基于数据挖掘对中医药治疗慢性前列腺炎用药规律的研究[J].新中医,2018,50(1):151-154.
[6]李巧元,刘梦超,刘梅颜,等.中西医结合治疗精神压力引起心肌缺血的效果研究[J].中国医药,2014,9(5):624-627.
[7]尹培辛,王晓彤,林海雄,等.数据挖掘《傅青主女科》的中药规律[J].现代中药研究与实践,2018,32(1):68-70,79.
[8]宋亚南,蒋燕,邓艳芳,等.“金元四大家”高频用药比较分析[J].中医药学报,2016,44(1):21-24.
[9]岳广欣,陈家旭,王竹风.肝主疏泄的生理学基础探讨[J].北京中医药大学学报,2005,28(2):1-4.
[10]黄娜娜,孙晓倩,杨倩,李晓宇,孙蓉.大鼠急性肝损伤(肝郁脾虚证)病证结合模型的研究[J].中国中药杂志,2016,41(23):4400-4407.
[11]Baroncini M,Jissendi P,Balland E,et al.MRI atlas of the human hypothalamus[J].Neuroimage,2012,59(1):168-180.
[12]Vandewalle G,Hébert M,Beaulieu C,et al.Abnormal hypothalamic response to light in seasonal affective disorder[J].Biol Psychiatry,2011,70(10):954-961.
[13]Schindler S,Geyer S,StrauβM,et al.Structural studies of the hypothalamus and its nuclei in mood disorders[J].Psychiatry Res,2012,201(1):1-9.
[14]Bao AM,Hestiantoro A,Van Someren EJ,et al.Colocalization of corticotropin-releasing hormone and oestrogen receptor-alpha in the paraventricular nucleus of the hypothalamus in mood disorders[J].Brain,2005,128(Pt 6):1301-1313.
[15]Lee YB,Yu J,Choi HH,et al.The association between peptic ulcer diseases and mental health problems:A population-based study:a STROBE compliant article[J].Medicine(Baltimore),2017,96(34):e7828.
[16]Cowen PJ.Not fade away:the HPA axis and depression[J].Psychol Med,2010,40(1):1-4.
[17]郑在予,段树民.LKB1对大鼠海马神经元轴突发育的调控途径初探[J].上海:中国科学院上海生命科学研究院神经科学研究所,2006.
[18]李洁颖,晏勇,蔡志友,等.胰岛素信号通路磷脂酰肌醇-3激酶/丝氨酸苏氨酸蛋白激酶对海马神经元β-淀粉样前体蛋白裂解酶1表达的影响[J].中华神经科杂志,2009,42(11):737-741.
[19]洪亚庆,常玉双,沈舒文.沈舒文教授从肝藏血治疗原发性血小板减少性紫癜临床经验[J].陕西中医,2010,31(1):73-74.
[20]郑偕扣,徐强.王保和从肝藏血主疏泄论治高血压病的经验[J].江苏中医药,2014,46(10):24-25.
[21]Cao Y,Chen H,Zhou L,et al.Heterodimers of placenta growth factor/vascular endothelial growth factor.Endothelial activity,tumor cell expression,and high affinity binding to Flk-1/KDR[J].J Biol Chem,1996,271(6):3154-3162.
[22]Plou3t J.Angiogenesis[J].Pathol Biol(Paris),1999,47(4):300.
[23]Charpentier MS,Conlon FL.Cellular and molecular mechanisms underlying blood vessel lumen formation[J].Bioessays,2014,36(3):251-259.
[24]张莉,王慧君,李洪强,等.再生障碍性贫血患者骨髓微血管密度及血管内皮生长因子表达的意义[J].中华血液学杂志,2007,28(8):528-531.
[25]王欢,张嵘,刘卓刚,等.良性贫血病人血浆中血管内皮生长因子水平的研究[J].中国医科大学学报,2006,35(1):92-92.
[26]魏强,李静,刘艺,等.MAPK信号转导通路在人参多糖诱导白血病K562细胞凋亡中的作用[J].中草药,2013,44(2):193-198.
[27]安欣.MAPK家族成员活化表达参与高血压心脏重构的实验研究[D].银川:宁夏医科大学,2010.