血根碱的生物学活性及博落回提取物在动物生产中的应用
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摘要
血根碱作为博落回提取物的主要活性成分,在抗炎、抑菌、抗肿瘤等方面具有多种药理作用,农业部也已经批准博落回提取物(血根碱为主要成分)作为二类新中兽药应用于动物生产。本文通过对血根碱在抗炎、抗氧化、肠道健康、抗肿瘤、抑菌等生物学活性及其机制和博落回提取物在动物生产中的应用情况进行综述,为博落回提取物在动物生产中应用提供一些理论参考。
Sanguinarine is mainly active component of total alkaloid of Macleaya cordata extract( MCE),which possess multiple biolological activities,such as anti-inflammation,bacteriostasis,anti-tumor and so on.China's Ministry of Agriculture had given a licence to MCE( active ingredient is sanguinarine) for the class Ⅱtraditional veterinary drugs to use in animal production. Here,we present a review about sanguinarine on antiinflammation,antioxidant,intestinal health,anti-tumor,anti-bacterial and other biological activities,and application of MCE in animal production,to provides some theoretical references for the application of MCE in animal production.
Sanguinarine is mainly active component of total alkaloid of Macleaya cordata extract( MCE),which possess multiple biolological activities,such as anti-inflammation,bacteriostasis,anti-tumor and so on.China's Ministry of Agriculture had given a licence to MCE( active ingredient is sanguinarine) for the class Ⅱtraditional veterinary drugs to use in animal production. Here,we present a review about sanguinarine on antiinflammation,antioxidant,intestinal health,anti-tumor,anti-bacterial and other biological activities,and application of MCE in animal production,to provides some theoretical references for the application of MCE in animal production.
引文
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[22]WANG Y,ZHANG B L,LIU W,et al.Noninvasive bioluminescence imaging of the dynamics of sanguinarine induced apoptosis via activation of reactive oxygen species[J].Oncotarget,2016,7(16):22355-22367.
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[38]YANG X J,MIAO F,YAO Y,et al.In vitro antifungal activity of sanguinarine and chelerythrine derivatives against phytopathogenic fungi[J].Molecules,2012,17(12):13026-13035.
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[40]BIANCO F,BASINI G,GRASSELLI F.The plant alkaloid sanguinarine affects swine granulosa cell activity[J].Reproductive Toxicology,2006,21(3):335-340.
[41]BASINI G,SANTINI S E,BUSSOLATI S,et al.The plant alkaloid sanguinarine is a potential inhibitor of follicular angiogenesis[J].Journal of Reproduction and Development,2007,53(3):573-579.
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[2]GODOWSKI K C,WOLFF E D,THOMPSON D M,et al.Whole mouth microbiota effects following subgingival delivery of sanguinarium[J].Journal of Periodontology,1995,66(10):870-877.
[3]LENFELD J,KROUTIL M,MARLEK E,et al.Antiinflammatory activity of quaternary benzophenanthridine alkaloids from Chelidonium majus[J].Planta Medica,1981,43(10):161-165.
[4]CHATURVEDI M M,KUMAR A,DARNAY B G,e t al.Sanguinarine(pseudochelerythrine)is a potent inhibitor of NF-κB activation,IκBαphosphorylation,and degradation[J].Journal of Biological Chemistry,1997,272(48):30129-30134.
[5]NIU X F,FAN T,LI W F,et al.The anti-inflammatory effects of sanguinarine and its modulation of inflammatory mediators from peritoneal macrophages[J].European Journal of Pharmacology,2012,689(1/2/3):262-269.
[6]PENCKOVK,KOLLR P,MLLERZVALOVV M,et al.Investigation of sanguinarine and chelerythrine effects on LPS-induced inflammatory gene expression in THP-1 cell line[J].Phytomedicine,2012,19(10):890-895.
[7]LI H W,ZHAI Z J,LIU G W,et al.Sanguinarine inhibits osteoclast formation and bone resorption via suppressing RANKL-induced activation of NF-κB and ERK signaling pathways[J].Biochemical and Biophysical Research Communications,2013,430(3):951-956.
[8]LI W F,LI H N,YAO H,et al.Pharmacokinetic and anti-inflammatory effects of sanguinarine solid lipid nanoparticles[J].Inflammation,2014,37(2):632-638.
[9]NIU X F,FAN T,LI W F,et al.Protective effect of sanguinarine against acetic acid-induced ulcerative colitis in mice[J].Toxicology and Applied Pharmacology,2013,267(3):256-265.
[10]LI W F,LI H N,MU Q L,et al.Protective effect of sanguinarine on LPS-induced endotoxic shock in mice and its effect on LPS-induced COX-2 expression and COX-2 associated PGE2 release from peritoneal macrophages[J].International Immunopharmacology,2014,22(2):311-317.
[11]VRBA J,HRBCJ,ULRICHOVJ,et al.Sanguinarine is a potent inhibitor of oxidative burst in DMSOdifferentiated HL-60 cells by a non-redox mechanism[J].Chemico-Biological Interactions,2004,147(1):35-47.
[12]LIU Y,JIAO R,MA Z G,et al.Sanguinarine inhibits angiotensinⅡinduced apoptosis in H9c2 cardiac cells via restoring reactive oxygen speciesmediated decreases in the mitochondrial membrane potential[J].Molecular Medicine Reports,2015,12(3):3400-3408.
[13]VRBA J,OROLINOVA E,ULRICHOVA J.Induction of heme oxygenase-1 by Macleaya cordata extract and its constituent sanguinarine in RAW264.7 cells[J].Fitoterapia,2012,83(2):329-335.
[14]姚雯.血根碱抗氧化活性及其对MKN-45和TE-1癌细胞凋亡的研究[D].硕士学位论文.杨凌:西北农林科技大学,2014.
[15]漆俊.血根碱对大鼠肠平滑肌细胞活性和细胞凋亡的影响[D].硕士学位论文.长沙:湖南农业大学,2012.
[16]王慧.血根碱对大鼠小肠平滑肌收缩的抑制作用及信号传导通路研究[D].博士学位论文.长沙:湖南农业大学,2012.
[17]WANG H,YIN G H,YU C H,et al.Inhibitory effect of sanguinarine on PKC-CPI-17 pathway mediating by muscarinic receptors in dispersed intestinal smooth muscle cells[J].Research in Veterinary Science,2013,95(3):1125-1133.
[18]李杰,伍树松,熊兴耀,等.博落回生物碱对猪肠上皮细胞增殖的影响[J].动物营养学报,2014,26(6):1632-1637.
[19]VRUBLOVA E,VOSTLOVJ,EHRMANN J,et al.The phytogenic feed additive modulates dextran sulfate sodium-induced colitis in rats[J].VeterinárníMedicína,2010,55(12):610-618.
[20]DRSATA J,ULRICHOVJ,WALTEROVD.Sanguinarine and chelerythrine as inhibitors of aromatic amino acid decarboxylase[J].Journal of Enzyme Inhibition,1996,10(4):231-237.
[21]GU S,YANG X C,XIANG X Y,et al.Sanguinarineinduced apoptosis in lung adenocarcinoma cells is dependent on reactive oxygen species production and endoplasmic reticulum stress[J].Oncology Reports,2015,34(2):913-919.
[22]WANG Y,ZHANG B L,LIU W,et al.Noninvasive bioluminescence imaging of the dynamics of sanguinarine induced apoptosis via activation of reactive oxygen species[J].Oncotarget,2016,7(16):22355-22367.
[23]LEE T K,PARK C,JEONG S J,et al.Sanguinarine induces apoptosis of human oral squamous cell carcinoma kb cells via inactivation of the PI3K/Akt signaling pathway[J].Drug Development Research,2016,77(5):227-240.
[24]RAHMAN A,THAYYULLATHIL F,PALLICHANKANDYS,et al.Hydrogen peroxide/ceramide/Akt signaling axis play a critical role in the antileukemic potential of sanguinarine[J].Free Radical Biology and Medicine,2016,96:273-289.
[25]张鸿.血根碱对细胞的增殖抑制和凋亡诱导作用研究[D].硕士学位论文.呼和浩特:内蒙古工业大学,2010.
[26]MALKOVJ,ZDA RILOVA,HLOBILKOVA,et al.The effect of chelerythrine on cell growth,apoptosis,and cell cycle in human normal and cancer cells in comparison with sanguinarine[J].Cell Biology and Toxicology,2006,22(6):439-453.
[27]VOGT A,TAMEWITZ A,SKOKO J,et al.The benzo[c]phenanthridine alkaloid,sanguinarine,is a selective,cell-active inhibitor of mitogen-activated protein kinase phosphatase-1[J].Journal of Biological Chemistry,2005,280(19):19078-19086.
[28]LOPUS M,PANDA D.The benzophenanthridine alkaloid sanguinarine perturbs microtubule assembly dynamics through tubulin binding.A possible mechanism for its antiproliferative activity[J].FEBS Journal,2006,273(10):2139-2150.
[29]DZINK J L,SOCRANSKY S S.Comparative in vitro activity of sanguinarine against oral microbial isolates[J].Antimicrobial Agents and Chemotherapy,1985,27(4):663-665.
[30]刘靖.博落回生物碱对黄羽肉鸡生长的影响[D].硕士学位论文.长沙:湖南农业大学,2010.
[31]苏红,白华,骆延波,等.Sangrovit对临床多抗菌株的抑制作用及对肉鸡生长促进的饲养试验[J].饲料工业,2012,33(7):27-33.
[32]HAMOUD R,REICHLING J,WINK M.Synergistic antibacterial activity of the combination of the alkaloid sanguinarine with EDTA and the antibiotic streptomycin against multidrug resistant bacteria[J].Journal of Pharmacy and Pharmacology,2015,67(2):264-273.
[33]OBIANG-OBOUNOU B W,KANG O H,CHOI J G,et al.The mechanism of action of sanguinarine against methicillin-resistant Staphylococcus aureus[J].The Journal of Toxicological Sciences,2011,36(3):277-283.
[34]HAMOUD R,REICHLING J,WINK M.Synergistic antimicrobial activity of combinations of sanguinarine and EDTA with vancomycin against multidrug resistant bacteria[J].Drug Metabolism Letters,2014,8(2):119-128.
[35]OBIANG-OBOUNOU B W,KANG O H,CHOI J G,et al.In vitro potentiation of ampicillin,oxacillin,norfloxacin,ciprofloxacin,and vancomycin by sanguinarine against methicillin-resistant Staphylococcus aureus[J].Foodborne Pathogens and Disease,2011,8(8):869-874.
[36]BEURIA T K,SANTRA M K,PANDA D.Sanguinarine blocks cytokinesis in bacteria by inhibiting FtsZassembly and bundling[J].Biochemistry,2005,44(50):16584-16593.
[37]王静慧.血根碱对细菌生物被膜的作用研究[D].硕士学位论文.杭州:浙江工商大学,2012.
[38]YANG X J,MIAO F,YAO Y,et al.In vitro antifungal activity of sanguinarine and chelerythrine derivatives against phytopathogenic fungi[J].Molecules,2012,17(12):13026-13035.
[39]WATAMOTO T,EGUSA H,SAWASE T,et al.Screening of pharmacologically active small molecule compounds identifies antifungal agents against Candida biofilms[J].Frontiers in Microbiology,2015,6:1453.
[40]BIANCO F,BASINI G,GRASSELLI F.The plant alkaloid sanguinarine affects swine granulosa cell activity[J].Reproductive Toxicology,2006,21(3):335-340.
[41]BASINI G,SANTINI S E,BUSSOLATI S,et al.The plant alkaloid sanguinarine is a potential inhibitor of follicular angiogenesis[J].Journal of Reproduction and Development,2007,53(3):573-579.
[42]CHAN W H.Hazardous effects of sanguinarine on maturation of mouse oocytes,fertilization,and fetal development through apoptotic processes[J].Environmental Toxicology,2015,30(8):946-955.
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