骨膜蛋白在恶性肿瘤发生发展中的作用和机制研究进展
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摘要
骨膜蛋白(POSTN)是一种细胞黏着蛋白。在生理状况下,其在骨与牙齿的形成过程起重要作用,并可促进心脏瓣膜发育并参与多种心脏疾病的病理生理过程。近年来,POSTN被发现高度表达于多种恶性肿瘤中,并且通常与复发转移及较差的预后密切相关。作为一种细胞外基质蛋白,其在肿瘤发生发展过程中的作用和机制引起了越来越多研究的关注。笔者就POSTN在肿瘤的研究进展进行综述。
Periostin(POSTN) is a cell adhesion protein. Under physiological conditions, it plays an important role in the formation of bone and teeth, can promote development of the heart valves and participate in the pathophysiological processes of various heart diseases. In recent years, POSTN has been found to be highly expressed in a variety of malignancies and is often associated with recurrence and metastasis as well as poor prognosis. As an extracellular matrix protein, its role and mechanism in the development of tumors has att racted increasingly att ention in many researches. Here, the authors address the research progress of POSTN in tumors.
Periostin(POSTN) is a cell adhesion protein. Under physiological conditions, it plays an important role in the formation of bone and teeth, can promote development of the heart valves and participate in the pathophysiological processes of various heart diseases. In recent years, POSTN has been found to be highly expressed in a variety of malignancies and is often associated with recurrence and metastasis as well as poor prognosis. As an extracellular matrix protein, its role and mechanism in the development of tumors has att racted increasingly att ention in many researches. Here, the authors address the research progress of POSTN in tumors.
引文
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[2]Ribatti D,Mangialardi G,Vacca A.Stephen Paget and the'seed and soil'theory of metastatic dissemination[J].Clin Exp Med,2006,6(4):145-149.doi:10.1007/s10238-006-0117-4.
[3]Bornstein P,Sage EH.Matricellular proteins:extracellular modulators of cell function[J].Curr Opin Cell Biol,2002,14(5):608-616.
[4]González-González L,Alonso J.Periostin:A Matricellular Protein With Multiple Functions in Cancer Development and Progression[J].Front Oncol,2018,8:225.doi:10.3389/fonc.2018.00225.
[5]Murphy-Ullrich JE,Sage EH.Revisiting the matricellular concept[J].Matrix Biol,2014,37:1-14.doi:10.1016/j.matbio.2014.07.005.
[6]Takeshita S,Kikuno R,Tezuka K,et al.Osteoblast-specifi c factor 2:cloning of a putative bone adhesion protein with homology with the insect protein fasciclin I[J].Biochem J,1993,294(Pt 1):271-278.
[7]Hoersch S,Andrade-Navarro MA.Periostin shows increased evolutionary plasticity in its alternatively spliced region[J].BMCEvol Biol,2010,10:30.doi:10.1186/1471-2148-10-30.
[8]Litvin J,Selim AH,Montgomery MO,et al.Expression and function of periostin-isoforms in bone[J].J Cell Biochem,2004,92(5):1044-1061.doi:10.1002/jcb.20115.
[9]Gillan L,Matei D,Fishman DA,et al.Periostin secreted by epithelial ovarian carcinoma is a ligand for alpha(V)beta(3)and alpha(V)beta(5)integrins and promotes cell motility[J].Cancer Res,2002,62(18):5358-5364.
[10]Sugiura T,Takamatsu H,Kudo A,et al.Expression and characterization of murine osteoblast-specific factor 2(OSF-2)in a baculovirus expression system[J].Protein Expr Purif,1995,6(3):305-311.doi:10.1006/prep.1995.1040.
[11]Bonnet N,Garnero P,Ferrari S.Periostin action in bone[J].Mol Cell Endocrinol,2016,432:75-82.doi:10.1016/j.mce.2015.12.014.
[12]Horiuchi K,Amizuka N,Takeshita S,et al.Identification and characterization of a novel protein,periostin,with restricted expression to periosteum and periodontal ligament and increased expression by transforming growth factor beta[J].J Bone Miner Res,1999,14(7):1239-1249.DOI:10.1359/jbmr.1999.14.7.1239
[13]Rios H,Koushik SV,Wang H,et al.periostin null mice exhibit dwarfism,incisor enamel defects,and an early-onset periodontal disease-like phenotype[J].Mol Cell Biol,2005,25(24):11131-11144.doi:10.1128/MCB.25.24.11131-11144.2005.
[14]Hong LZ,Wei XW,Chen JF,et al.Overexpression of periostin predicts poor prognosis in non-small cell lung cancer[J].Oncol Lett,2013,6(6):1595-1603.doi:10.3892/ol.2013.1590.
[15]Sasaki H,Lo KM,Chen LB,et al.Expression of Periostin,homologous with an insect cell adhesion molecule,as a prognostic marker in non-small cell lung cancers[J].Jpn J Cancer Res,2001,92(8):869-873.
[16]Nitsche U,Stangel D,Pan Z,et al.Periostin and tumor-stroma interactions in non-small cell lung cancer[J].Oncol Lett,2016,12(5):3804-3810.doi:10.3892/ol.2016.5132.
[17]Murakami D,Takamori S,Kawahara A,et al.Periostin Expression in Non-Small Cell Lung Cancer:Clinical Signifi cance[J].Kurume Med J,2018,64(1/2):13-20.doi:10.2739/kurumemedj.MS640012.
[18]Ben QW,Zhao Z,Ge SF,et al.Circulating levels of periostin may help identify patients with more aggressive colorectal cancer[J].Int J Oncol,2009,34(3):821-828.
[19]Xiao ZM,Wang XY,Wang AM.Periostin induces chemoresistance in colon cancer cells through activation of the PI3K/Akt/survivin pathway[J].Biotechnol Appl Biochem,2015,62(3):401-406.doi:10.1002/bab.1193.
[20]Oh HJ,Bae JM,Wen XY,et al.Overexpression of POSTN in Tumor Stroma Is a Poor Prognostic Indicator of Colorectal Cancer[J].J Pathol Transl Med,2017,51(3):306-313.doi:10.4132/jptm.2017.01.19.
[21]Jang SY,Park SY,Lee HW,et al.The Combination of Periostin Overexpression and Microvascular Invasion Is Related to a Poor Prognosis for Hepatocellular Carcinoma[J].Gut Liver,2016,10(6):948-954.doi:10.5009/gnl15481.
[22]Chen G,Nakamura I,Dhanasekaran R,et al.Transcriptional Induction of Periostin by a Sulfatase 2-TGFβ1-SMAD Signaling Axis Mediates Tumor Angiogenesis in Hepatocellular Carcinoma[J].Cancer Res,2017,77(3):632-645.doi:10.1158/0008-5472.CAN-15-2556.
[23]Liu Y,Gao F,Song W.Periostin contributes to arsenic trioxide resistance in hepatocellular carcinoma cells under hypoxia[J].Biomed Pharmacother,2017,88:342-348.doi:10.1016/j.biopha.2017.01.052.
[24]Puglisi F,Puppin C,Pegolo E,et al.Expression of periostin in human breast cancer[J].J Clin Pathol,2008,61(4):494-498.doi:10.1136/jcp.2007.052506.
[25]Nuzzo PV,Rubagotti A,Zinoli L,et al.The prognostic value of stromal and epithelial periostin expression in human breast cancer:correlation with clinical pathological features and mortality outcome[J].BMC Cancer,2016,16:95.doi:10.1186/s12885-016-2139-y.
[26]Li C,Xu J,Wang Q,et al.Prognostic value of periostin in early-stage breast cancer treated with conserving surgery and radiotherapy[J].Oncol Lett,2018,15(5):8072-8078.doi:10.3892/ol.2018.8310.
[27]Ryner L,Guan Y,Firestein R,et al.Upregulation of Periostin and Reactive Stroma Is Associated with Primary Chemoresistance and Predicts Clinical Outcomes in Epithelial Ovarian Cancer[J].Clin Cancer Res,2015,21(13):2941-2951.doi:10.1158/1078-0432.CCR-14-3111.
[28]Thuwajit C,Thuwajit P,Jamjantra P,et al.Clustering of patients with intrahepatic cholangiocarcinoma based on serum periostin may be predictive of prognosis[J].Oncol Lett,2017,14(1):623-634.doi:10.3892/ol.2017.6250.
[29]Li JS,Sun GW,Wei XY,et al.Expression of periostin and its clinicopathological relevance in gastric cancer[J].World JGastroenterol,2007,13(39):5261-5266.
[30]Wang W,Sun QK,He YF,et al.Overexpression of periostin is significantly correlated to the tumor angiogenesis and poor prognosis in patients with esophageal squamous cell carcinoma[J].Int J Clin Exp Pathol,2014,7(2):593-601.
[31]Kim CJ,Yoshioka N,Tambe Y,et al.Periostin is down-regulated in high grade human bladder cancers and suppresses in vitro cell invasiveness and in vivo metastasis of cancer cells[J].Int J Cancer,2005,117(1):51-58.doi:10.1002/ijc.21120.
[32]Malanchi I,Santamaria-Martínez A,Susanto E,et al.Interactions between cancer stem cells and their niche govern metastatic colonization[J].Nature,2011,481(7379):85-89.doi:10.1038/nature10694.
[33]Bao S,Ouyang G,Bai X,et al.Periostin potently promotes metastatic growth of colon cancer by augmenting cell survival via the Akt/PKB pathway[J].Cancer Cell,2004,5(4):329-339.
[34]Zhou W,Ke SQ,Huang Z,et al.Periostin secreted by glioblastoma stem cells recruits M2 tumour-associated macrophages and promotes malignant growth[J].Nat Cell Biol,2015,17(2):170-182.doi:10.1038/ncb3090.
[35]Qin X,Yan M,Zhang J,et al.TGFβ3-mediated induction of Periostin facilitates head and neck cancer growth and is associated with metastasis[J].Sci Rep,2016,6:20587.doi:10.1038/srep20587.
[36]Tilman G,Mattiussi M,Brasseur F,et al.Human periostin gene expression in normal tissues,tumors and melanoma:evidences for periostin production by both stromal and melanoma cells[J].Mol Cancer,2007,6:80.doi:10.1186/1476-4598-6-80.
[37]Sasaki H,Yu CY,Dai M,et al.Elevated serum periostin levels in patients with bone metastases from breast but not lung cancer[J].Breast Cancer Res Treat,2003,77(3):245-252.
[38]Lambert AW,Wong CK,Ozturk S,et al.Tumor Cell-Derived Periostin Regulates Cytokines That Maintain Breast Cancer Stem Cells[J].Mol Cancer Res,2016,14(1):103-113.doi:10.1158/1541-7786.MCR-15-0079.
[39]Brabletz T,Kalluri R,Nieto MA,et al.EMT in cancer[J].Nat Rev Cancer,2018,18(2):128-134.doi:10.1038/nrc.2017.118.
[40]Kim DH,Xing T,Yang Z,et al.Epithelial Mesenchymal Transition in Embryonic Development,Tissue Repair and Cancer:AComprehensive Overview[J].J Clin Med,2017,7(1).pii:E1.doi:10.3390/jcm7010001.
[41]Wang L,Yang F,Jia LT,et al.Missing Links in EpithelialMesenchymal Transition:Long Non-Coding RNAs Enter the Arena[J].Cell Physiol Biochem,2017,44(4):1665-1680.doi:10.1159/000485766.
[42]Marcucci F,Stassi G,De Maria R.Epithelial-mesenchymal transition:a new target in anticancer drug discovery[J].Nat Rev Drug Discov,2016,15(5):311-325.doi:10.1038/nrd.2015.13.
[43]Lv YJ,Wang W,Ji CS,et al.Association between periostin and epithelial-mesenchymal transition in esophageal squamous cell carcinoma and its clinical significance[J].Oncol Lett,2017,14(1):376-382.doi:10.3892/ol.2017.6124.
[44]Hu Q,Tong S,Zhao X,et al.Periostin Mediates TGF-β-Induced Epithelial Mesenchymal Transition in Prostate Cancer Cells[J].Cell Physiol Biochem,2015,36(2):799-809.doi:10.1159/000430139.
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