伊维菌素在不同动物中安全性、药效学和药代动力学的差异性研究进展
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摘要
伊维菌素是一种被广泛应用于多种畜禽线虫病和外寄生虫病防控的抗寄生虫药物。由于伊维菌素具有非常突出的优点,在不同种属动物上使用时,其安全性、药效学和药代动力学的差异更容易被人们忽略。忽略动物种属差异,可能会导致寄生虫病防治失败,甚至安全事故的发生。对伊维菌素在不同动物中的安全性、药效学和药代动力学差异做一综述,以期为伊维菌素的临床用药提供参考,保障伊维菌素在不同动物中用药的安全性和有效性。
Ivermectin is an antiparasitic agent which has been widely used in various livestock to control nematodes and ectoparasites infection. Due to its outstanding properties, the difference of safety,pharmacodynamics and pharmacokinetics of ivermectin in various animals is easily to be ignored by people,probably leading to failed control of parasitic disease or even the occurrence of safety accidents. This article will make a review of the difference of safety,pharmacodynamics and pharmacokinetics of ivermectin in various animals in order to provide a reference for the clinical application of ivermectin and ensure its safety and effectiveness of ivermectin in different animals.
Ivermectin is an antiparasitic agent which has been widely used in various livestock to control nematodes and ectoparasites infection. Due to its outstanding properties, the difference of safety,pharmacodynamics and pharmacokinetics of ivermectin in various animals is easily to be ignored by people,probably leading to failed control of parasitic disease or even the occurrence of safety accidents. This article will make a review of the difference of safety,pharmacodynamics and pharmacokinetics of ivermectin in various animals in order to provide a reference for the clinical application of ivermectin and ensure its safety and effectiveness of ivermectin in different animals.
引文
[1]Omura S,Crump A.The Life and Times of Ivermectin-A Success Story[J].Nature Reviews Microbiology,2004,2(12):984-989.
[2]Cully D F,Vassilatis D K,Liu K K,et al.Cloning of An Avermectin-sensitive Glutamate-gated Chloride Channel from Caenorhabditis Elegans[J].Nature,1994,(371):707-711.
[3]王卫明,韩志国.波尔山羊虫克星中毒的诊治[J].中国畜牧兽医,2005,(10):39.Wang W M,Han Z G.The diagnosis and treatment of Boer Goat of avermectin poisoning[J].China Animal Husbandry and Veterinary Medicine,2005,(10):39.
[4]Campbell W C,Fisher M H,Stapley E O,et al.Ivermectin-A Potent New Anti-parasitic Agent[J].Science,1983,221(4613):823-828.
[5]Gonzalez Canga A,Sahagun Prieto A M,Diez Liebana M J,et al.The Pharmacokinetics and Metabolism of Ivermectin in Domestic Animal Species[J].Veterinary Journal,2009,179(1):25-37.
[6]Panayotova-Pencheva M S.Experience in the Ivermectin Treatment of Internal Parasites in Zoo and Captive Wild Animals:A Review[J].Zoologische Garten,2016,85(5):280-308.
[7]Szell Z,Sreter T,Varga I.Ivermectin Toxicosis in A Chameleon(Chamaeleo Senegalensis)Infected with Foleyella Furcata[J].Journal of Zoo and Wildlife Medicine,2001,32(1):115-117.
[8]Kornegay R W,Giddens W E,Morton W R,et al.Verminous Vasculitis,Pneumonia and Pulmonary Infarction in A Cynomolgus Monkey after Treatment with Ivermectin[J].Laboratory Animal Science,1986,36(1):45-47.
[9]王成东,兰景超,沈富军,等.大熊猫伊维菌素中毒性休克[J].野生动物学报,2015,(3):337-341.Wang C D,Lan J C,Shen F J,et al.Toxic shock of giant pandas caused by ivermectin[J].Chinese Journal of Wildlife,2015,(3):337-341.
[10]黄国城.国外应用伊维菌素(Ivermectin)治疗寄生虫病研究概况[J].中国人兽共患病杂志,1986,(4):44-46.Huang G C.Survey of foreign researches on application of ivermectin in treatment of parasitic diseases[J].Chinese Journal of Zoonoses,1986,(4):44-46.
[11]肖田安,许颖,李帅鹏,等.伊维菌素微球在山羊体内的药效学研究[J].中国兽医杂志,2014,(3):66-68.Xiao T A,Xu Y,Li S P,et al.Pharmacodynamics study of ivermectin microspheres in goats[J].Chinese Journal of Veterinary Medicine,2014,(3):66-68.
[12]吴中兴,钱益新.伊维菌素的药效、药理和临床研究[J].热带病与寄生虫学,2003,(3):184-187.Wu Z X,Qian Y X.Pharmacodynamic,pharmacological and clinical studies of ivermectin[J].Journal of Tropical Diseases and Parasitology,2003,(3):184-187.
[13]朱模忠.兽药手册[M].北京:化学工业出版社,2002:167-170.Zhu M Z.Veterinary Medicine Manual[M].Beijing:Chemical Industry Press,2002:167-170.
[14]闻礼永,夏昭华,姚善滢,等.国产伊维菌素(Ivermectin)驱除犬钩虫、巴西日圆线虫、鼠蛲虫的效果[J].中国人兽共患病杂志,1999,(1):25-27.Wen L Y,Xia Z H,Yao S Y,et al.Anthelmintic efficacy of national ivermectin on Ancylostoma caninum,Nippostrongylus brazilienses and Syphacia mesocoriceti[J].Chinese Journal of Zoonoses,1999,(1):25-27.
[15]Matevsky,S.,Mutafova,T.Effects of Ivomec on Some Helminths and Ectoparasites of Hedgehogs,Snakes and Tortoises[J].Medical&Veterinary Entomology,1987,9(1):77-84.
[16]Jr.Hill R E,Zimmerman J J,Greve J H,et al.Use of Ivermectin against Several Nematodes in Naturally Infected Raccoons(Procyon Lotor)[J].Journal of Zoo and Wildlife Medicine,1991,22(4):417-420.
[17]Suresh K,Choudhuri P C,Nalini Kumari K,et al.Symptomatology and Therapy of Ancylostomiasis in Leopards[J].Zoos'Print Journal,2000,15(8):312-313.
[18]徐英江,任传博,刘慧慧,等.液相色谱荧光法测定水产品中伊维菌素、阿维菌素、莫能菌素、埃普里诺菌素和多拉菌素含量[J].中国渔业质量与标准,2011,(1):70-74.Xu Y J,Ren C B,Liu H H,et al.Determination of residual ivermectin,avermectin,moxdectin,eprinomectin and doramectin in aquatic products using HPLC with fluorescence detection[J].Chinese Fishery Quality and Standards,2011,(1):70-74.
[19]Samaee S.Experimental Assessment of the Efficacy of Five Veterinary Broad-Spectrum Anthelmintics to Control the Intestinal Capillariasis in Zebrafish(Danio Rerio)[J].Zebrafish,2015,12(3):255-267.
[20]Cripps J,Beveridge I,Coulson G.The Efficacy of Anthelmintic Drugs Against Nematodes Infecting Free-Ranging Eastern Grey Kangaroos,Macropus Giganteus[J].Journal of Wildlife Diseases,2013,49(3):535-544.
[21]D'Alterio G L,Jackson A P,Knowles T G,et al.Comparative Study of the Efficacy of Eprinomectin Versus Ivermectin,and Field Efficacy of Eprinomectin only,for the Treatment of Chorioptic Mange in Alpacas[J].Veterinary Parasitology,2005,130(34):267-275.
[22]韩娇娇,夏茂华,吴秀山,等.北京动物园羊驼感染疥螨病例诊治情况初报[J].中国动物传染病学报,2016,(1):70-74.Han J J,Xia M H,Wu X S,et al.Preliminary report of diagnosis and treatment of scabies mite infection in alpacas in Beijing zoo[J].Chinese Journal of Animal Infectious Diseases,2016,(1):70-74.
[23]R A Gillespie,L H Williamson,T H Terrill,et al.Efficacy of Anthelmintics on South American Camelid(Llama Andalpaca)Farms in Georgia[J].Veterinary Parasitology,2010,172(12):168.
[24]Schankova S,Marsalek M,Wagnerova P,et al.Treatment Failure of Ivermectin for Oxyuris Equi in Naturally Infected Ponies in Czech Republic[J].Helminthologia,2013,50(3):232-234.
[25]Waghorn T S,Miller C M,Leathwick D M.Confirmation of Ivermectin Resistance in Ostertagia Ostertagi in Cattle in New Zealand[J].Veterinary Parasitology,2016,229:139-143.
[26]Rodriguez-Vivas R I,Ojeda-Chi M M,Trinidad-Martinez I,et al.First Documentation of Ivermectin Resistance in Rhipicephalus Sanguineus Sensu Lato(Acari:Ixodidae)[J].Veterinary Parasitology,2017,233:9-13.
[27]韩娇娇.伊维菌素固体分散体混悬注射剂在山羊与绵羊体内的药代动力学研究[D].北京:中国农业大学,2017.Han J J.Pharmacokinetics of solid dispersion suspension of ivermectin in goats and sheep[D].Beijing:China Agricultural University,2017.
[28]Bogan J A,Mckellar Q A.The Pharmacodynamics of Ivermectin in Sheep and Cattle[J].Journal of Veterinary Pharmacology&Therapeutics,1988,11(3):260.
[29]魏海涛,倪姮佳,方秋华,等.伊维菌素药动学研究进展[J].中国兽药杂志,2010,44(9):50-52.Wei H T,Ni H J,Fang Q H,et al.Research progress on pharmacokinetics of ivermectin[J].Chinese Journal of Veterinary Drug,2010,44(9):50-52.
[30]Lifschitz A,Virkel G,Pis A,et al.Ivermectin Disposition Kinetics after Subcutaneous and Intramuscular Administration of An Oilbased Formulation to Cattle[J].Veterinary Parasitology,1999,86(3):203-215.
[31]Perez R,Cabezas I,Godoy C,et al.Pharmacokinetics of Doramectin and Ivermectin after Oral Administration in Horses[J].Veterinary Journal,2002,163(2):161-167.
[32]Gokbulut C,Boyacioglu M,Karademir U.Plasma Pharmacokinetics and Faecal Excretion of Ivermectin(Eqvalan(R)paste)and Doramectin(Dectomax(R),1%)Following Oral Administration in Donkeys[J].Research in Veterinary Science,2005,79(3):233-238.
[33]肖田安,怀彬彬,李帅鹏,等.伊维菌素PLA及PLGA微球混悬液在犬体内的药代动力学研究[J].华南农业大学学报,2014,(3):8-12.Xiao T A,Huai B B,Li S P,et al.Pharmacokinetics of ivermectin loaded PLA/PLGA microspheres suspension in dogs[J].Journal of South China Agricultural University,2014,(3):8-12.
[34]王敏儒,陈杖榴,冯淇辉.伊维菌素微球在家兔体内的药动学[J].畜牧兽医学报,2000,(2):171-178.Wang M R,Chen Z L,Feng Q H.Pharmacokinetic properties of ivermectin loaded PLA microspheres in rabbits[J].Acta Veterinaria et Zootechnica Sinica,2000,(2):171-178.
[35]刘磊.伊维菌素微乳的靶动物安全性和药代动力学研究[D].甘肃:甘肃农业大学,2014.Liu L.Safety evaluation and pharmacokinetic of ivermectin microemulsion in cattle[D].Gansu:Gansu Agricultural University,2014.
[36]文豪.伊维菌素微乳在羊体内的药代动力学与残留研究[D].兰州:中国农业科学院,2016.Wen H.The pharmacokinetics and residue of ivermectin microemulsion in sheep[D].Lanzhou:Chinese Academy of Agricultural Sciences,2016.
[37]Craven J,Bjorn H,Hennessy D R,et al.The Effects of Body Composition on the Pharmacokinetics of Subcutaneously Injected Ivermectin and Moxidectin in Pigs[J].Journal of Veterinary Pharmacology and Therapeutics,2002,25(3):227-232.
[38]朱晓娟.伊维菌素脂质体的制备及其在山羊体内药动学、驱虫效果的研究[D].陕西:西北农林科技大学,2010.Zhu X J.Preparation of ivermectin liposome and its pharmacokinetics and treatments in goats[D].Shanxi:Northwest A&F University,2010.
[39]孙博.伊维菌素脂质体的制备及其对药物在绵羊体内分布的影响[D].北京:中国农业大学,2003.Sun B.The preparation of ivermectin liposome and its affection on the distribution of ivermectin in ewes[D].Beijing:China Agricultural University,2003.
[40]徐霞.伊维菌素脂质体的毒理学、药动学及对猪疥螨病疗效的研究[D].长沙:湖南农业大学,2006.Xu X.Studies on the toxicology,pharmacokinetics and swine sarcoptic acariasis treatment of liposomal ivermectin[D].Hunan:Hunan Agricultural University,2006.
[2]Cully D F,Vassilatis D K,Liu K K,et al.Cloning of An Avermectin-sensitive Glutamate-gated Chloride Channel from Caenorhabditis Elegans[J].Nature,1994,(371):707-711.
[3]王卫明,韩志国.波尔山羊虫克星中毒的诊治[J].中国畜牧兽医,2005,(10):39.Wang W M,Han Z G.The diagnosis and treatment of Boer Goat of avermectin poisoning[J].China Animal Husbandry and Veterinary Medicine,2005,(10):39.
[4]Campbell W C,Fisher M H,Stapley E O,et al.Ivermectin-A Potent New Anti-parasitic Agent[J].Science,1983,221(4613):823-828.
[5]Gonzalez Canga A,Sahagun Prieto A M,Diez Liebana M J,et al.The Pharmacokinetics and Metabolism of Ivermectin in Domestic Animal Species[J].Veterinary Journal,2009,179(1):25-37.
[6]Panayotova-Pencheva M S.Experience in the Ivermectin Treatment of Internal Parasites in Zoo and Captive Wild Animals:A Review[J].Zoologische Garten,2016,85(5):280-308.
[7]Szell Z,Sreter T,Varga I.Ivermectin Toxicosis in A Chameleon(Chamaeleo Senegalensis)Infected with Foleyella Furcata[J].Journal of Zoo and Wildlife Medicine,2001,32(1):115-117.
[8]Kornegay R W,Giddens W E,Morton W R,et al.Verminous Vasculitis,Pneumonia and Pulmonary Infarction in A Cynomolgus Monkey after Treatment with Ivermectin[J].Laboratory Animal Science,1986,36(1):45-47.
[9]王成东,兰景超,沈富军,等.大熊猫伊维菌素中毒性休克[J].野生动物学报,2015,(3):337-341.Wang C D,Lan J C,Shen F J,et al.Toxic shock of giant pandas caused by ivermectin[J].Chinese Journal of Wildlife,2015,(3):337-341.
[10]黄国城.国外应用伊维菌素(Ivermectin)治疗寄生虫病研究概况[J].中国人兽共患病杂志,1986,(4):44-46.Huang G C.Survey of foreign researches on application of ivermectin in treatment of parasitic diseases[J].Chinese Journal of Zoonoses,1986,(4):44-46.
[11]肖田安,许颖,李帅鹏,等.伊维菌素微球在山羊体内的药效学研究[J].中国兽医杂志,2014,(3):66-68.Xiao T A,Xu Y,Li S P,et al.Pharmacodynamics study of ivermectin microspheres in goats[J].Chinese Journal of Veterinary Medicine,2014,(3):66-68.
[12]吴中兴,钱益新.伊维菌素的药效、药理和临床研究[J].热带病与寄生虫学,2003,(3):184-187.Wu Z X,Qian Y X.Pharmacodynamic,pharmacological and clinical studies of ivermectin[J].Journal of Tropical Diseases and Parasitology,2003,(3):184-187.
[13]朱模忠.兽药手册[M].北京:化学工业出版社,2002:167-170.Zhu M Z.Veterinary Medicine Manual[M].Beijing:Chemical Industry Press,2002:167-170.
[14]闻礼永,夏昭华,姚善滢,等.国产伊维菌素(Ivermectin)驱除犬钩虫、巴西日圆线虫、鼠蛲虫的效果[J].中国人兽共患病杂志,1999,(1):25-27.Wen L Y,Xia Z H,Yao S Y,et al.Anthelmintic efficacy of national ivermectin on Ancylostoma caninum,Nippostrongylus brazilienses and Syphacia mesocoriceti[J].Chinese Journal of Zoonoses,1999,(1):25-27.
[15]Matevsky,S.,Mutafova,T.Effects of Ivomec on Some Helminths and Ectoparasites of Hedgehogs,Snakes and Tortoises[J].Medical&Veterinary Entomology,1987,9(1):77-84.
[16]Jr.Hill R E,Zimmerman J J,Greve J H,et al.Use of Ivermectin against Several Nematodes in Naturally Infected Raccoons(Procyon Lotor)[J].Journal of Zoo and Wildlife Medicine,1991,22(4):417-420.
[17]Suresh K,Choudhuri P C,Nalini Kumari K,et al.Symptomatology and Therapy of Ancylostomiasis in Leopards[J].Zoos'Print Journal,2000,15(8):312-313.
[18]徐英江,任传博,刘慧慧,等.液相色谱荧光法测定水产品中伊维菌素、阿维菌素、莫能菌素、埃普里诺菌素和多拉菌素含量[J].中国渔业质量与标准,2011,(1):70-74.Xu Y J,Ren C B,Liu H H,et al.Determination of residual ivermectin,avermectin,moxdectin,eprinomectin and doramectin in aquatic products using HPLC with fluorescence detection[J].Chinese Fishery Quality and Standards,2011,(1):70-74.
[19]Samaee S.Experimental Assessment of the Efficacy of Five Veterinary Broad-Spectrum Anthelmintics to Control the Intestinal Capillariasis in Zebrafish(Danio Rerio)[J].Zebrafish,2015,12(3):255-267.
[20]Cripps J,Beveridge I,Coulson G.The Efficacy of Anthelmintic Drugs Against Nematodes Infecting Free-Ranging Eastern Grey Kangaroos,Macropus Giganteus[J].Journal of Wildlife Diseases,2013,49(3):535-544.
[21]D'Alterio G L,Jackson A P,Knowles T G,et al.Comparative Study of the Efficacy of Eprinomectin Versus Ivermectin,and Field Efficacy of Eprinomectin only,for the Treatment of Chorioptic Mange in Alpacas[J].Veterinary Parasitology,2005,130(34):267-275.
[22]韩娇娇,夏茂华,吴秀山,等.北京动物园羊驼感染疥螨病例诊治情况初报[J].中国动物传染病学报,2016,(1):70-74.Han J J,Xia M H,Wu X S,et al.Preliminary report of diagnosis and treatment of scabies mite infection in alpacas in Beijing zoo[J].Chinese Journal of Animal Infectious Diseases,2016,(1):70-74.
[23]R A Gillespie,L H Williamson,T H Terrill,et al.Efficacy of Anthelmintics on South American Camelid(Llama Andalpaca)Farms in Georgia[J].Veterinary Parasitology,2010,172(12):168.
[24]Schankova S,Marsalek M,Wagnerova P,et al.Treatment Failure of Ivermectin for Oxyuris Equi in Naturally Infected Ponies in Czech Republic[J].Helminthologia,2013,50(3):232-234.
[25]Waghorn T S,Miller C M,Leathwick D M.Confirmation of Ivermectin Resistance in Ostertagia Ostertagi in Cattle in New Zealand[J].Veterinary Parasitology,2016,229:139-143.
[26]Rodriguez-Vivas R I,Ojeda-Chi M M,Trinidad-Martinez I,et al.First Documentation of Ivermectin Resistance in Rhipicephalus Sanguineus Sensu Lato(Acari:Ixodidae)[J].Veterinary Parasitology,2017,233:9-13.
[27]韩娇娇.伊维菌素固体分散体混悬注射剂在山羊与绵羊体内的药代动力学研究[D].北京:中国农业大学,2017.Han J J.Pharmacokinetics of solid dispersion suspension of ivermectin in goats and sheep[D].Beijing:China Agricultural University,2017.
[28]Bogan J A,Mckellar Q A.The Pharmacodynamics of Ivermectin in Sheep and Cattle[J].Journal of Veterinary Pharmacology&Therapeutics,1988,11(3):260.
[29]魏海涛,倪姮佳,方秋华,等.伊维菌素药动学研究进展[J].中国兽药杂志,2010,44(9):50-52.Wei H T,Ni H J,Fang Q H,et al.Research progress on pharmacokinetics of ivermectin[J].Chinese Journal of Veterinary Drug,2010,44(9):50-52.
[30]Lifschitz A,Virkel G,Pis A,et al.Ivermectin Disposition Kinetics after Subcutaneous and Intramuscular Administration of An Oilbased Formulation to Cattle[J].Veterinary Parasitology,1999,86(3):203-215.
[31]Perez R,Cabezas I,Godoy C,et al.Pharmacokinetics of Doramectin and Ivermectin after Oral Administration in Horses[J].Veterinary Journal,2002,163(2):161-167.
[32]Gokbulut C,Boyacioglu M,Karademir U.Plasma Pharmacokinetics and Faecal Excretion of Ivermectin(Eqvalan(R)paste)and Doramectin(Dectomax(R),1%)Following Oral Administration in Donkeys[J].Research in Veterinary Science,2005,79(3):233-238.
[33]肖田安,怀彬彬,李帅鹏,等.伊维菌素PLA及PLGA微球混悬液在犬体内的药代动力学研究[J].华南农业大学学报,2014,(3):8-12.Xiao T A,Huai B B,Li S P,et al.Pharmacokinetics of ivermectin loaded PLA/PLGA microspheres suspension in dogs[J].Journal of South China Agricultural University,2014,(3):8-12.
[34]王敏儒,陈杖榴,冯淇辉.伊维菌素微球在家兔体内的药动学[J].畜牧兽医学报,2000,(2):171-178.Wang M R,Chen Z L,Feng Q H.Pharmacokinetic properties of ivermectin loaded PLA microspheres in rabbits[J].Acta Veterinaria et Zootechnica Sinica,2000,(2):171-178.
[35]刘磊.伊维菌素微乳的靶动物安全性和药代动力学研究[D].甘肃:甘肃农业大学,2014.Liu L.Safety evaluation and pharmacokinetic of ivermectin microemulsion in cattle[D].Gansu:Gansu Agricultural University,2014.
[36]文豪.伊维菌素微乳在羊体内的药代动力学与残留研究[D].兰州:中国农业科学院,2016.Wen H.The pharmacokinetics and residue of ivermectin microemulsion in sheep[D].Lanzhou:Chinese Academy of Agricultural Sciences,2016.
[37]Craven J,Bjorn H,Hennessy D R,et al.The Effects of Body Composition on the Pharmacokinetics of Subcutaneously Injected Ivermectin and Moxidectin in Pigs[J].Journal of Veterinary Pharmacology and Therapeutics,2002,25(3):227-232.
[38]朱晓娟.伊维菌素脂质体的制备及其在山羊体内药动学、驱虫效果的研究[D].陕西:西北农林科技大学,2010.Zhu X J.Preparation of ivermectin liposome and its pharmacokinetics and treatments in goats[D].Shanxi:Northwest A&F University,2010.
[39]孙博.伊维菌素脂质体的制备及其对药物在绵羊体内分布的影响[D].北京:中国农业大学,2003.Sun B.The preparation of ivermectin liposome and its affection on the distribution of ivermectin in ewes[D].Beijing:China Agricultural University,2003.
[40]徐霞.伊维菌素脂质体的毒理学、药动学及对猪疥螨病疗效的研究[D].长沙:湖南农业大学,2006.Xu X.Studies on the toxicology,pharmacokinetics and swine sarcoptic acariasis treatment of liposomal ivermectin[D].Hunan:Hunan Agricultural University,2006.