VPI-7分子筛的合成及生物学性能
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摘要
采用水热法,通过调变反应溶胶的量合成了不同尺寸的不规则圆片状多孔锌硅分子筛VPI-7,并研究了其生物学性能.扫描电子显微镜观测结果表明,制备的样本由VPI-7条状晶体聚集成微球,并进一步相互交联形成微米级孔隙,其形貌可以促进钙磷化合物在样品表面的沉积,同时可以负载并缓释蛋白.细胞学检测结果表明,VPI-7分子筛有利于细胞黏附增殖,具有良好的生物相容性.
Porous zincosilicate zeolite,VPI-7,was synthesized through hydrothermal approach,and the size of samples were adjusted by varying amounts of sol. Also,the biological properties of the samples were charactered. The characteristic results showed that the prepared samples were aggregated into microspheres by VPI-7 rod-shaped crystals,and the crystals further cross-linked and formed numerous micron-sized pores,which provided good morphological features for their biological properties. In addition,the surface topography for VPI-7 had the ability to promote the deposition of calcium phosphate,and load/release protein. The in vitro experiments suggested that VPI-7 was conducive to cell adhesion and proliferation,with good biocompatibility.VPI-7 showed excellent biological properties,and has potential to be applied as implant used in bone repair and replacement.
Porous zincosilicate zeolite,VPI-7,was synthesized through hydrothermal approach,and the size of samples were adjusted by varying amounts of sol. Also,the biological properties of the samples were charactered. The characteristic results showed that the prepared samples were aggregated into microspheres by VPI-7 rod-shaped crystals,and the crystals further cross-linked and formed numerous micron-sized pores,which provided good morphological features for their biological properties. In addition,the surface topography for VPI-7 had the ability to promote the deposition of calcium phosphate,and load/release protein. The in vitro experiments suggested that VPI-7 was conducive to cell adhesion and proliferation,with good biocompatibility.VPI-7 showed excellent biological properties,and has potential to be applied as implant used in bone repair and replacement.
引文
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[16]Zhang Z.Y.,Teoh S.H.,Chong M.S.,Schantz J.T.,Fisk N.M.,Choolani M.A.,Chan J.,Stem Cells,2009,27(1),126—137
[17]Kokubo T.,Takadama H.,Biomaterials,2006,27(15),2907—2915
[18]Huang R.,Pan C.L.,Zhang L.,Chem.J.Chinese Universities,2017,38(4),522—529(黄润,潘成岭,张兰.高等学校化学学报,2017,38(4),522—529)
[19]Mellott M.B.,Searcy K.,Pishko M.V.,Biomaterials,2001,22(9),929—941
[20]R9hrig C.,Dierdorf I.,Gies H.,J.Phys.Chem.Solids,1995,56(10),1369—1376