血清尿酸与糖尿病肾病的相关性
摘要
目的探讨血清尿酸水平与糖尿病肾病的相关性。方法 2型糖尿病患者98例(糖尿病组)及体检的健康对照患者100例(健康对照组),比较两组患者血清尿酸水平。同时在糖尿病患者中进一步分析出现糖尿病肾病患者血清尿酸水平,分析血清尿酸水平与糖尿病肾病的关系。结果 98例糖尿病患者中36例出现糖尿病肾病。糖尿病组的血清尿酸水平高于对照组,但差异无统计学意义(P>0.05);女性患者高尿酸比例显著增加,而男性患者血清尿酸的水平显著增加(P<0.01)。在出现糖尿病肾病的患者中,不论男性或女性,血清尿酸的水平显著高于非糖尿病肾病患者(P<0.01)。另外糖尿病肾病患者血清尿酸的升高水平与患者蛋白尿水平高低呈正相关(P<0.05)。结论血清尿酸水平能够作为诊断糖尿病肾病的发生及蛋白尿严重程度的重要指标。
引文
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2 Sheikhbahaei S,Fotouhi A,Hafezi-Nejad N,et al.Serum uric acid,the metabolic syndrome,and the risk of chronic kidney disease in patients with type 2 diabetes [J].Metab Syndr Relat Disord,2014;12(2):102-9.
3 Wang T,Bi Y,Xu M,et al.Serum uric acid associates with the incidence of type 2 diabetes in a prospective cohort of middle-aged and elderly Chinese [J].Endocrine,2011;40(1):109-16.
4 Johnson RJ,Kang DH,Feig D,et al.Is there a pathogenetic role for uric acid in hypertension and cardiovascular and renal disease [J]?Hypertension,2003;41(6):1183-90.
5 Abdulnaby NK,Sayed AO,Shalaby NM.Predictive value of serum uric acid in hospitalized adolescents and adults with acute asthma [J].Ther Clin Risk Manag,2016;12:1701-8.
6 Hsu CY,Iribarren C,McCulloch CE,et al.Risk factors for end-stage renal disease:25-year follow-up [J].Arch Internal Med,2009;169(4):342-50.
7 Wu J,Qiu L,Cheng XQ,et al.Hyperuricemia and clustering of cardiovascular risk factors in the Chinese adult population [J].Sci Rep,2017;7(1):5456.
8 Lim AK.Diabetic nephropathy-complications and treatment [J].Int J Nephrol Renovasc Dis,2014;7:361-81.
9 Altemtam N,Russell J,El Nahas M.A study of the natural history of diabetic kidney disease (DKD) [J].Nephrol Dial Transplantat,2012;27(5):1847-54.
10 Johnson RJ,Nakagawa T,Jalal D,et al.Uric acid and chronic kidney disease:which is chasing which [J]?Nephrol Dial Transplant,2013;28(9):2221-8.
11 Ito H,Abe M,Mifune M,et al.Hyperuricemia is independently associated with coronary heart disease and renal dysfunction in patients with type 2 diabetes mellitus [J].PLoS One,2011;6(11):e27817.
12 Miyaoka T,Mochizuki T,Takei T,et al.Serum uric acid levels and long-term outcomes in chronic kidney disease [J].Heart Vessels,2014;29(4):504-12.
13 Cai XL,Han XY,Ji LN.High-normal serum uric acid is associated with albuminuria and impaired glomerular filtration rate in chinese type 2 diabetic patients [J].Chin Med J,2011;124(22):3629-34.
14 Zoppini G,Targher G,Chonchol M,et al.Serum uric acid levels and incident chronic kidney disease in patients with type 2 diabetes and preserved kidney function [J].Diab Care,2012;35(1):99-104.
15 Nakagawa T,Tanabe K,Croker BP,et al.Endothelial dysfunction as a potential contributor in diabetic nephropathy [J].Nature Rev Nephrol,2011;7(1):36-44.
16 Kohagura K,Kochi M,Miyagi T,et al.An association between uric acid levels and renal arteriolopathy in chronic kidney disease:a biopsy-based study [J].Hypertens Res,2013;36(1):43-9.
17 Kao MP,Ang DS,Gandy SJ,et al.Allopurinol benefits left ventricular mass and endothelial dysfunction in chronic kidney disease [J].J Am Soc Nephrol,2011;22(7):1382-9.