气相色谱-质谱联用法测定驱蚊产品中6种合成麝香
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摘要
[目的]建立气相色谱-质谱联用法分离测定驱蚊产品中萨利麝香、葵子麝香、酮麝香、佳乐麝香、吐纳麝香、二甲苯麝香6种合成麝香定性定量的分析方法。[方法]采用TG-1MS,30 m×0.25 mm×0.25μm毛细柱和质谱(EI离子源)检测器,同时测定试样中6种合成麝香的含量。[结果] 6种合成麝香(萨利麝香、葵子麝香、酮麝香、佳乐麝香、吐纳麝香、二甲苯麝香)在1.0～100 mg/L质量浓度范围内线性关系良好,线性相关系数R为0.9927～0.9987;方法检出限(3S/N)为0.015～0.052 mg/L;定量限(10S/N)为0.049～0.173 mg/L;相对标准偏差(RSD)为0.6%～1.9%;平均回收率为81.3%～107.2%。[结论]该方法操作简便,分离效果好,精密度与准确度高,可同时快速测定驱蚊产品中6种合成麝香的含量。
[Aims] The GC-MS method for simultaneous determination of six synthetic musk compounds(sally musk, sunflawer musk, keton musk, musk xylene, galaxolide and tonalide) in mosquito repellent products was established. [Methods] The sample was analyzed with TG-1 MS 30 m×0.25 mm× 0.25 μm column and GC-MS(ion source) detector, while the six species of synthetic musk compounds were detected. [Results] The linear relationship was good when the concentrations of six synthetic musk compounds ranged from 1.0 to 100 mg/L, and the linear correlation coefficient was 0.9927-0.9987, the limit of detection was 0.015-0.052 mg/L, the limit of quantitation was0.049-0.173 mg/L, the relative standard deviations(RSD) were 0.6-1.9%, the average recoveries were 81.3-107.2%.[Conclusions] The method has the advantages of simple, convenient, good separation, high precision and accuracy. It could be used in the simultaneous determination of six synthetic musk compounds in mosquito repellent products.
[Aims] The GC-MS method for simultaneous determination of six synthetic musk compounds(sally musk, sunflawer musk, keton musk, musk xylene, galaxolide and tonalide) in mosquito repellent products was established. [Methods] The sample was analyzed with TG-1 MS 30 m×0.25 mm× 0.25 μm column and GC-MS(ion source) detector, while the six species of synthetic musk compounds were detected. [Results] The linear relationship was good when the concentrations of six synthetic musk compounds ranged from 1.0 to 100 mg/L, and the linear correlation coefficient was 0.9927-0.9987, the limit of detection was 0.015-0.052 mg/L, the limit of quantitation was0.049-0.173 mg/L, the relative standard deviations(RSD) were 0.6-1.9%, the average recoveries were 81.3-107.2%.[Conclusions] The method has the advantages of simple, convenient, good separation, high precision and accuracy. It could be used in the simultaneous determination of six synthetic musk compounds in mosquito repellent products.
引文
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[2]吴春英,白鹭,陆文龙,等.气相色谱-串联质谱法同时快速检测环境水样中11种合成麝香[J].分析科学学报,2016,32(2):188-192.
[3]顾越,李晓静,梁高峰,等.淀山湖水、沉积物和鱼体中的合成麝香及人体暴露评估[J].环境科学学报,2017,37(1):388-394.
[4]周静.上海地区合成麝香和有机氯农药的母婴暴露及人体传递特征研究(博士论文)[D].上海:上海大学,2012.
[5]中华人民共和国卫生部.化妆品卫生规范[M].北京:中国卫生出版社,2015.
[6]The Commission of the European Communities.Commission Directive 2008/42/EC[S/OL].The Commission of the European Communities,2008:13-23.
[7]孙长恩,朱利利,潘虹,等.气相色谱-质谱联用法测定驱蚊产品中七种驱避剂[J].农药,2017,56(12):890-892.
[8]闫俊秀.化妆品中2种限用硝基麝香和4种禁用亚硝基类物质的检测研究(硕士论文)[D].上海:上海应用技术研究院,2011.
[9]李懿睿,武晓剑,王东辉,等.气相色谱/质谱法测定化妆品中的5种麝香类禁限用物质[J].香料香精化妆品,2013,8(4):24-25.
[10]赵田甜,李慧勇,李焯原,等.气相色谱串联质谱法测定洗涤剂中的7种人工合成麝香[J].分析仪器,2015(3):1-4.
[2]吴春英,白鹭,陆文龙,等.气相色谱-串联质谱法同时快速检测环境水样中11种合成麝香[J].分析科学学报,2016,32(2):188-192.
[3]顾越,李晓静,梁高峰,等.淀山湖水、沉积物和鱼体中的合成麝香及人体暴露评估[J].环境科学学报,2017,37(1):388-394.
[4]周静.上海地区合成麝香和有机氯农药的母婴暴露及人体传递特征研究(博士论文)[D].上海:上海大学,2012.
[5]中华人民共和国卫生部.化妆品卫生规范[M].北京:中国卫生出版社,2015.
[6]The Commission of the European Communities.Commission Directive 2008/42/EC[S/OL].The Commission of the European Communities,2008:13-23.
[7]孙长恩,朱利利,潘虹,等.气相色谱-质谱联用法测定驱蚊产品中七种驱避剂[J].农药,2017,56(12):890-892.
[8]闫俊秀.化妆品中2种限用硝基麝香和4种禁用亚硝基类物质的检测研究(硕士论文)[D].上海:上海应用技术研究院,2011.
[9]李懿睿,武晓剑,王东辉,等.气相色谱/质谱法测定化妆品中的5种麝香类禁限用物质[J].香料香精化妆品,2013,8(4):24-25.
[10]赵田甜,李慧勇,李焯原,等.气相色谱串联质谱法测定洗涤剂中的7种人工合成麝香[J].分析仪器,2015(3):1-4.